Article
Engineering, Biomedical
Mengqing Xu, Jin Zhang, Yongli Mu, Mohamed Frahat Foda, Heyou Han
Summary: A study introduces an acid-responsive CaCO3 nanoparticle loaded with capsaicin that can specifically activate TRPV1 channels and trigger tumor calcium ion therapy. The nanoparticles have excellent biocompatibility and show potential for important clinical applications.
Article
Cell Biology
Sreepadaarchana Munjuluri, Dru A. Wilkerson, Gagandeep Sooch, Xingjuan Chen, Fletcher A. White, Alexander G. Obukhov
Summary: This review discusses the effects of capsaicin on vascular function, indicating that excessive consumption of capsaicin may lead to vasoconstriction and myocardial infarction, while emphasizing the role of inflammation in sensitizing the vascular channels to capsaicin activation.
Article
Pharmacology & Pharmacy
Chenfei Wang, Wei Huang, Jia Lu, Hongzhuan Chen, Zhihua Yu
Summary: Autophagy plays a crucial role in regulating the ageing process and neurodegeneration. Dysfunction of autophagy is implicated in Alzheimer's disease pathogenesis. The activation of TRPV1 using capsaicin induces autophagy, which could potentially be a therapeutic target for Alzheimer's disease.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jia Lu, Wei Zhou, Fangfang Dou, Chenfei Wang, Zhihua Yu
Summary: Microglia energy metabolism is suppressed during chronic A beta-tolerant processes, but pharmacological activation of TRPV1 can rescue microglial dysfunction and restore immune responses, leading to reduced amyloid pathology and reversed memory deficits in AD mice. This study suggests that TRPV1 is an important target for regulating metabolic reprogramming in microglial functions for AD treatment.
Article
Multidisciplinary Sciences
Liying Zhang, Charlotte Simonsen, Lucie Zimova, Kaituo Wang, Lavanya Moparthi, Rachelle Gaudet, Maria Ekoff, Gunnar Nilsson, Ute A. Hellmich, Viktorie Vlachova, Pontus Gourdon, Peter M. Zygmunt
Summary: This study uses cryo-EM and electrophysiology to identify a cannabinoid binding site in TRPV2 that is distinct from cannabidiol, which could potentially be a drug target for the treatment of inflammation and immune-mediated diseases.
NATURE COMMUNICATIONS
(2022)
Review
Food Science & Technology
Qunran Xiang, Weiling Guo, Xin Tang, Shumao Cui, Feng Zhang, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Bingyong Mao, Wei Chen
Summary: Long-term and high levels of capsaicin ingestion may cause gastrointestinal discomfort and affect gastrointestinal digestion, with a more pronounced impact on specific gastrointestinal disorders. Capsaicin can regulate visceral pain and immune response through mechanisms involving the TRPV1 receptor and neuropeptides, impacting oxidative stress and tissue permeability of the gastrointestinal tract. Probiotics have the potential to alleviate capsaicin-induced gastrointestinal discomfort based on their effects on gastrointestinal disorders and their correlation with TRPV1.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kaihua Zhang, David Julius, Yifan Cheng
Summary: This study utilized cryo-EM to visualize conformational transitions of TRPV1, revealing the dynamic transitions of its selectivity filter in response to algogenic agents. The findings also demonstrate a general framework for understanding how TRP channels function as polymodal signal integrators.
Article
Food Science & Technology
Qunran Xiang, Xin Tang, Shumao Cui, Qiuxiang Zhang, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Bingyong Mao, Wei Chen
Summary: This study investigated the effects of different doses of capsaicin on gastrointestinal health in mice. The results showed that high doses (60 and 80 mg/kg) of capsaicin caused intestinal inflammation and increased levels of serum neuropeptides. The levels of short-chain fatty acids in the cecum also significantly increased. These changes may be related to alterations in gut microbiota.
Review
Biochemistry & Molecular Biology
Nuray Erin, Arpad Szallasi
Summary: Both sensory neurons and immune cells express TRPV1, which can induce neurogenic inflammation and modify tumor growth and metastasis. TRPV1 is also found in various immune cells, and the effects of TRPV1 agonists and antagonists depend on the cell type(s) activated and/or inhibited. A comprehensive understanding of TRPV1 activity on immune cells and nerve endings is necessary to predict the outcome of therapies targeting TRPV1 channels. This review focuses on the neuro-immune modulation of cancer growth and metastasis caused by TRPV1 activation and discusses the potential use of TRPV1 modulators in cancer therapy.
Article
Biochemistry & Molecular Biology
Lei Liu, Yuhua Tian
Summary: The presence of TRPV1 ion channels in brain regions other than the hypothalamus has been debated. By injecting capsaicin directly into the lateral ventricle of rats and recording EEGs, we found that capsaicin perturbed brain electrical activity during sleep, suggesting TRPV1 expression in specific brain regions dominant during this stage.
Review
Biotechnology & Applied Microbiology
Ana Emilia Nava-Ochoa, Marilena Antunes-Ricardo, Daniel Guajardo-Flores
Summary: Capsaicinoids in chili peppers not only provide pungency, but also possess beneficial traits such as analgesic and anti-inflammatory properties. Using nano-sized drug delivery systems have been proven to reduce the secondary effects of capsaicinoids while enhancing their bioavailability and absorption.
JOURNAL OF BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jing-xian Sun, Ke-ying Zhu, Yu-meng Wang, Dan-jie Wang, Mi-zhen Zhang, Heela Sarlus, Irene Benito-Cuesta, Xiao-qiang Zhao, Zao-feng Zou, Qing-yang Zhong, Yi Feng, Shuai Wu, Yan-qing Wang, Robert A. Harris, Jun Wang
Summary: The role of TRPV1 in demyelinating diseases has been investigated, and it has been found to be an important regulator in the context of demyelination. TRPV1 deficiency exacerbates motor dysfunction and demyelination, while TRPV1 agonist CAP improves behavioral performance and facilitates remyelination. The activation of TRPV1 enhances microglial function and promotes myelin debris clearance.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Joanna K. Bujak, Daria Kosmala, Kinga Majchrzak-Kuligowska, Piotr Bednarczyk
Summary: The study confirmed the expression of the TRPV1 ion channel on both mRNA and protein levels in canine PBMC, and indicated that the ion channel is functional.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Si-Lu Zhu, Mei-Ling Wang, Yue-Teng He, Shu-Wen Guo, Ting-Ting Li, Wei-Jie Peng, Dan Luo
Summary: Capsaicin elevates SIRT1 levels through TRPV1 pathway and suppresses IHG-induced endothelial cell senescence.
Article
Chemistry, Medicinal
Jesse Xu, Maliheh Ghadiri, Maree Svolos, Brent McParland, Daniela Traini, Hui Xin Ong, Paul M. Young
Summary: The study investigated the regulation effects of TRPV1 activity on cytokines and proteins in airway epithelial cells. Results showed that TRPV1 protein expression did not change significantly after activation, but inflammatory cytokines IL-6 and IL-8 were partially affected by acidity and heat exposure. More complex mechanisms may be involved in TRPV1 upregulation in patients with airway diseases.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2021)
Review
Biochemistry & Molecular Biology
Puneet Gupta, Yan-Ruide Li
MOLECULAR BIOLOGY REPORTS
(2018)
Article
Critical Care Medicine
Babak Sarani, Rebecca Allen, Fredric M. Pieracci, Andrew R. Doben, Evert Eriksson, Zachary M. Bauman, Puneet Gupta, Greg Semon, Patrick Greiffenstein, Alistair J. Chapman, Brian D. Kim, Lawrence Lottenberg, Scott Gardner, Silvana Marasco, Tom White
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2019)
Article
Integrative & Complementary Medicine
Abraham Benavides, Nicholas Gregorio, Puneet Gupta, Mikhail Kogan
COMPLEMENTARY THERAPIES IN MEDICINE
(2020)
Review
Medicine, General & Internal
Dan Li, Puneet Gupta, Nicholas A. Sgaglione, Daniel A. Grande
Summary: Osteoarthritis of the knee is a common chronic musculoskeletal condition, and current conservative treatments are unsatisfactory, prompting the need for alternative options such as exosomes. In vivo studies have shown the potential clinical use of exosomes derived from non-classical sources for knee osteoarthritis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Letter
Rehabilitation
Puneet Gupta, Karthik Dhanireddy, Keerthi Vemulapalli, Richard Amdur, Geet Paul
Article
Orthopedics
Tom G. Pollard, Puneet Gupta, Theodore Quan, Pradip Ramamurti, Safa C. Fassihi, Alex Gu, James DeBritz
Summary: This study compared the complications after surgical management of tibial plateau fractures between patients aged 65 to 79 years and those aged 80 to 89 years. Results showed that patients aged 80 to 89 years had increased risks of postoperative anemia requiring transfusion and extended length of hospital stay compared to patients aged 65 to 79 years.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS GLOBAL RESEARCH AND REVIEWS
(2021)
Article
Orthopedics
Puneet Gupta, Theodore Quan, Magid G. Abdo, Joseph E. Manzi, Brock Knapp, Gene Shaffer
Summary: Patients with COPD undergoing ORIF for ankle fractures have an increased risk of postoperative morbidity, including pneumonia, unplanned intubation, and hospital readmission within 30 days. However, COPD alone should not be a barrier to surgery.
JOURNAL OF FOOT & ANKLE SURGERY
(2022)
Article
Sport Sciences
Puneet Gupta, George M. Thomas, Prudvi R. Arabandi, Magid G. Abdo, Karthik N. Dhanireddy, Richard Amdur, Teresa Doerre
Summary: In order to reduce injury rates in American football, this study conducted a descriptive epidemiology study on high school football athletes, finding that AC sprains were the most common injury and fractures resulted in the longest time lost. Injuries were more likely to occur in older athletes, related to tackling, and in running back and linebacker positions.
RESEARCH IN SPORTS MEDICINE
(2022)
Article
Clinical Neurology
Puneet Gupta, Fthimnir M. Hassan, George M. Thomas, Joseph M. Lombardi, Zeeshan M. Sardar
Summary: This study, using propensity-matched analysis, found that surgeon specialty does not affect the risk for any complication, any site complication, any operative infection, nor any medical complication following single-level CDA within the first 30 days after surgery.
GLOBAL SPINE JOURNAL
(2022)
Article
Orthopedics
Anna M. Ifarraguerri, Puneet Gupta, Theodore Quan, Jordan S. Cohen, Frank R. Chen, Jacob Zeitlin, Joseph E. Manzi, Benjamin Farley, Pradip Ramamurti, Sean Tabaie
Summary: Chronic steroid and immunosuppressant use increases the risk of complications in orthopedic surgery, including ankle fractures. This study aimed to determine if patients taking immunosuppressants are at higher risk of morbidity and mortality following ankle fracture surgeries.
JOURNAL OF FOOT & ANKLE SURGERY
(2023)
Article
Orthopedics
Puneet Gupta, Andrew Palosaari, Theodore Quan, Anna M. Ifarraguerri, Sean Tabaie
Summary: This study evaluated the risk differences for complications following upper extremity surgery between African American and Caucasian pediatric patients. The results show that African American pediatric patients are not at an increased risk for postoperative complications compared to Caucasian patients, and race should not be used independently as an indicator for evaluating the risk of postoperative complications.
JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B
(2023)
Review
Orthopedics
Puneet Gupta, Natalia Czerwonka, Sohil S. S. Desai, Alirio J. J. deMeireles, David P. P. Trofa, Alexander L. L. Neuwirth
Summary: Patient-reported outcome measures (PROMs) are crucial in clinical research and patient-centric care. In knee arthroplasty, PROMs like OKS, KOOS, and FJS are commonly used. The NIH-developed PROMIS has gained attention recently. This study aims to provide insights on utilizing PROMIS in knee arthroplasty and compare it with legacy PROMs.
KNEE SURGERY & RELATED RESEARCH
(2023)
Article
Orthopedics
Puneet Gupta, Theodore Quan, Chirag J. Patel, Joseph E. Manzi, Alex Gu, Sean Tabaie, Joshua C. Campbell
Summary: Diabetic octogenarian patients have an increased risk of postoperative complications and a prolonged hospital stay following revision total hip arthroplasty (rTHA) compared to younger diabetic geriatric patients.
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2023)