Article
Immunology
Harpreet Kaur, Taruna Gupta, Suman Kapila, Rajeev Kapila
Summary: It has been found that probiotic fermented whey can improve and repair impaired intestinal barrier function caused by inflammatory bowel diseases. Consumption of probiotic fermented whey can alleviate colitis symptoms, enhance gut immune protection and barrier integrity, and reduce inflammation and the risk of diseases.
MICROBIAL PATHOGENESIS
(2022)
Article
Biotechnology & Applied Microbiology
Shalaka Bhawal, Ankita Kumari, Suman Kapila, Rajeev Kapila
Summary: The study extracted surface layer protein and cell-bound exopolysaccharide from L. fermentum and evaluated their adhesive, immunomodulatory, and anti-oxidative potential. The components were found to promote bacterial adhesion and phagocytosis, and exhibited strong radical scavenging, chelating, and reducing potential.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2022)
Article
Agriculture, Multidisciplinary
Shalaka Bhawal, Ankita Kumari, Suman Kapila, Rajeev Kapila
Summary: This study investigated the physicochemical characteristics and antioxidative role of a novel acidic cell-bound exopolysaccharide (EPS-b) from probiotic Limosilactobacillus fermentum (MTCC 5898), and found that the structural features significantly influenced the antioxidative activity of EPS-b, maintaining the oxidative balance in cells.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Xianrong Zhou, Guan-sheng Shang, Qian Tan, Qin He, Xiaoyu Tan, Kun-Young Park, Xin Zhao
Summary: L. fermentum TKSN041 shows potential preventive and therapeutic effects on type 2 diabetes in rats, reducing water intake, controlling blood glucose levels, decreasing harmful substances, and protecting organ functions.
Article
Oncology
Xiang Liu, Ge Jin, Qiang Tang, Shumin Huang, Yujie Zhang, Yue Sun, Tianyu Liu, Zixuan Guo, Cheng Yang, Bangmao Wang, Kui Jiang, Weilong Zhong, Hailong Cao
Summary: Early life colonisation with Lactobacillus rhamnosus GG (LGG) can inhibit intestinal tumour formation in offspring by influencing gut microbiota composition and regulating signaling pathways.
BRITISH JOURNAL OF CANCER
(2022)
Article
Biotechnology & Applied Microbiology
T. Gupta, H. Kaur, S. Kapila, R. Kapila
Summary: The study showed that Lactobacillus fermentum can alleviate Escherichia coli-induced inflammatory responses by modulating immune-related gene expression, reducing overexpression of proinflammatory cytokines, and regulating the NF-kappa B signaling pathway. This probiotic not only suppresses the excessive production of pro-inflammatory cytokines, but also modulates regulatory cytokines and NF-kappa B to alleviate inflammation.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Microbiology
Taruna Gupta, Harpreet Kaur, Suman Kapila, Rajeev Kapila
Summary: Probiotic Lacticaseibacillus rhamnosus has the potential to prevent gastrointestinal disorders by modulating the immune response and countering inflammatory cytokine expression during exclusion of Escherichia coli in intestinal cells.
ARCHIVES OF MICROBIOLOGY
(2021)
Article
Thermodynamics
Cristiane Sachetti, Fabiana Tonial, Hamid Omidian, Luciana Grazziotin Rossato-Grando, Claudio Fernando Goelzer, Marcos Roberto Spassim, Charise Dallazem Bertol
Summary: This study determined the thermal degradation parameters of probiotic Lactobacillus fermentum using thermogravimetry, calculating the degradation rate constant and activation energy. The results obtained also provided a simulated shelf life value. Thermogravimetry is a useful tool for determining degradation rate parameters of compounds, including pharmaceuticals and nutraceuticals, and realistic data is essential for defining shelf life.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2021)
Article
Gastroenterology & Hepatology
Joshua A. Owens, Bejan J. Saeedi, Crystal R. Naudin, Sarah Hunter-Chang, Maria E. Barbian, Richard U. Eboka, Lauren Askew, Trevor M. Darby, Brian S. Robinson, Rheinallt M. Jones
Summary: The study shows that oral administration of Lactobacillus rhamnosus GG can enhance colonic CD8 T-cell responses in mice and reduce tumor burden. This suggests the potential use of LGG to augment antitumor immune responses in colorectal cancer patients and increase the efficacy of immunotherapy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Chemistry, Applied
Cong Xu, Jiage Ma, Zhijing Liu, Wan Wang, Xin Liu, Shanshan Qian, Lijun Chen, Liya Gu, Chuanqiang Sun, Juncai Hou, Zhanmei Jiang
Summary: In this study, shell-core fibers were prepared using coaxial electrospinning technology and were found to have higher thermal stability and higher survival rate of probiotics.
Article
Dentistry, Oral Surgery & Medicine
Davi N. A. Silva, Natalia T. S. Cruz, Agnes A. Martins, Regia C. M. Silva, Hursula C. Almeida, Heloisa E. S. Costa, Karina M. O. Santos, Basilio R. Vieira, Frederico B. Sousa, S. Junior Francisco, Raimundo F. A. Junior, Gerlane C. B. Guerra, Flavia Q. Pirih, Aurigena A. Araujo, Ana R. L. A. Martins
Summary: This study evaluated the antihyperglycemic, anti-bone-resorptive, and anti-inflammatory efficacy of the probiotic Lactobacillus rhamnosus EM1107 in an experimental model of ligature-induced periodontitis in diabetic rats treated with metformin. The results showed that Lactobacillus significantly reduced IL-1 beta and TNF-alpha levels, decreased blood glucose levels, and alleviated inflammation and bone loss. This suggests that Lactobacillus has immunoinflammatory effects in type 1 diabetes mellitus associated with periodontitis.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Food Science & Technology
Mengwei Wang, Yang Li, Jie Yang, Rui Shi, Liu Xiong, Qingjie Sun
Summary: This study investigated the adsorption amounts and antibacterial effects of inorganic nanoparticles on probiotic bacteria. Results showed that food-grade NPs have bactericidal effects on L. plantarum and L. fermentum.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Federico Bueno, Alexander Chouljenko, Subramaniam Sathivel
Summary: The addition of Lactobacilli to coffee kombucha shifted the proportion of microbial families and allowed them to survive in the beverage for 15 days, even after exposure to simulated gastrointestinal conditions.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Naiara Hennig Neuenfeldt, Carla Andressa Almeida Farias, Renius de Oliveira Mello, Silvino Sasso Robalo, Juliano Smanioto Barin, Leila Picolli da Silva, Edson Irineu Muller, Erico Marlon Moraes Flores, Milene Teixeira Barcia, Cristiano Ragagnin de Menezes
Summary: This study demonstrates that the co-microencapsulation of blueberry extract improves the survival rate of Lactobacillus rhamnosus and shows promising application in food.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Food Science & Technology
Bonilla Zavaleta, L. I. Lozano Coavichi, L. C. Velasco Rodriguez, E. Flores Andrade, Hugo S. Garcia, M. P. Rascon Diaz
Summary: Co-microcapsules containing L. rhamnosus and krill oil were prepared using whey protein as wall material through spray drying. Viability of the microcapsules and co-microcapsules at different drying process temperatures was above 1 x 1010 CFU/mL. The main phospholipid detected in the co-microcapsules was phosphatidylethanolamine, and the fatty acids profile revealed a low content of SFA but high levels of MUFA and PUFA. The survivability of L. rhamnosus in the co-microcapsules was influenced by storage temperature, with higher temperatures decreasing the water activity range for stable viability.
Article
Food Science & Technology
Mohd Iqbal Bhat, Suman Kapila, Rajeev Kapila
LWT-FOOD SCIENCE AND TECHNOLOGY
(2020)
Review
Food Science & Technology
Ankita Kumari, Shalaka Bhawal, Suman Kapila, Hariom Yadav, Rajeev Kapila
Summary: The epigenome, as important as the genome, plays a crucial role in the normal development and functioning of an organism. Environmental factors and bioactive compounds in the diet can influence epigenetic modifications, making these compounds potential therapeutic agents for treating inflammatory diseases and cancers while reducing the side effects of chemotherapy.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Virology
Taruneet Kaur, Suman Kapila, Rajeev Kapila, Sandeep Kumar, Divya Upadhyay, Manjeet Kaur, Chandresh Sharma
Summary: The study aims to computationally screen and identify potential miRNAs for early prevention of COVID-19 by suppressing Tmprss2, with in vitro experimental validation confirming silencing of Tmprss2 with certain miRNAs.
Article
Food Science & Technology
Rohit Kumar, Sanusi Bello Mada, Srinu Reddi, Taruneet Kaur, Rajeev Kapila, Suman Kapila
Summary: The study found that feeding goat, buffalo, and cow milk can effectively suppress glucocorticoid-induced bone loss, with goat milk showing the most significant reversal effects. Therefore, the study suggests using milk in functional foods to efficiently prevent glucocorticoid-mediated bone loss.
INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
T. Gupta, H. Kaur, S. Kapila, R. Kapila
Summary: The study showed that Lactobacillus fermentum can alleviate Escherichia coli-induced inflammatory responses by modulating immune-related gene expression, reducing overexpression of proinflammatory cytokines, and regulating the NF-kappa B signaling pathway. This probiotic not only suppresses the excessive production of pro-inflammatory cytokines, but also modulates regulatory cytokines and NF-kappa B to alleviate inflammation.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Shalaka Bhawal, Ankita Kumari, Suman Kapila, Rajeev Kapila
Summary: This study investigated the physicochemical characteristics and antioxidative role of a novel acidic cell-bound exopolysaccharide (EPS-b) from probiotic Limosilactobacillus fermentum (MTCC 5898), and found that the structural features significantly influenced the antioxidative activity of EPS-b, maintaining the oxidative balance in cells.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Shalaka Bhawal, Ankita Kumari, Suman Kapila, Rajeev Kapila
Summary: The study extracted surface layer protein and cell-bound exopolysaccharide from L. fermentum and evaluated their adhesive, immunomodulatory, and anti-oxidative potential. The components were found to promote bacterial adhesion and phagocytosis, and exhibited strong radical scavenging, chelating, and reducing potential.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2022)
Article
Microbiology
Ankita Kumari, Shalaka Bhawal, Suman Kapila, Rajeev Kapila
Summary: The epigenome of an organism is influenced by various environmental factors, and the present study investigates the temporal changes in DNA and histone modifiers in intestinal epithelial cells by probiotic lactobacilli and the opportunistic commensal pathogen Escherichia coli. The results indicate that lactobacilli can enhance the transcription of epigenetic modifiers, while E. coli reduces their expression. Moreover, lactobacilli were found to resist the changes made by E. coli in the transcription of some of the epigenetic modifiers.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Microbiology
Savita Devi, Rajeev Kapila, Suman Kapila
Summary: Inflammatory bowel disease is on the rise globally. This study establishes a new model of gut inflammation using peptidoglycan from Staphylococcus aureus, which can be used for studying the mechanism of the disease and screening drugs. The results show that the peptidoglycan enhances macrophage phagocytic function, spleen lymphocytes' proliferation, acid secretion, and causes changes in the expression of immune-related genes and cytokines.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Harpreet Kaur, Taruna Gupta, Suman Kapila, Rajeev Kapila
Summary: This study demonstrates that pre-consumption of whey fermented with probiotic Lactobacillus rhamnosus can significantly improve symptoms of inflammation and immune response in a murine ulcerative colitis model, while also maintaining intestinal barrier integrity.
