Review
Immunology
Jonathan W. Wallace, David A. Constant, Timothy J. Nice
Summary: IFN-lambda plays a complex and diverse role in IBD, promoting colonic epithelial tissue healing while potentially exacerbating small intestinal epithelial cell death. Additionally, IFN-lambda acts through non-epithelial cell types to protect against excessive inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Agostino Di Ciaula, Leonilde Bonfrate, Mohamad Khalil, Piero Portincasa
Summary: Bile acids (BA) are important for fat digestion and absorption and act as signaling molecules. Disturbed BA homeostasis and inflammatory bowel diseases (IBD) can lead to gut inflammation. Understanding BA-dependent mechanisms can lead to innovative therapies involving administration of hydrophilic BA and manipulation of gut microbiota.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Immunology
Sunil Kumar, Awanish Kumar
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal system that is increasing globally. The alteration in intestinal microbiota is associated with IBD, but the role of microbes in IBD is still controversial.
MICROBIAL PATHOGENESIS
(2022)
Review
Nutrition & Dietetics
Lewis Steell, Stuart R. Gray, Richard K. Russell, Jonathan MacDonald, John Paul Seenan, Sze Choong Wong, Daniel R. Gaya
Summary: Musculoskeletal deficits are commonly reported in patients with inflammatory bowel disease (IBD), particularly Crohn's disease. The adverse effects on bone and muscle are multifactorial, including inflammation, nutritional deficits, and therapies, leading to increased risk of osteoporosis and sarcopenia. Ib children with IBD, these factors may impact optimal bone and muscle accrual.
Review
Cell Biology
Sheng Liu, Wenjing Zhao, Ping Lan, Xiangyu Mou
Summary: Inflammatory bowel disease (IBD) is a global disease with accelerating incidence worldwide, and dysbiosis of gut microbiota has been consistently associated with IBD. Some alterations in microbiome may have protective or causative effects on IBD. Therapeutic approaches targeting microbiome are a promising strategy for alleviating and curing IBD.
Review
Immunology
John P. Thomas, Dezso Modos, Simon M. Rushbrook, Nick Powell, Tamas Korcsmaros
Summary: This review examines the interaction between bile acid metabolites and intestinal inflammation in inflammatory bowel disease (IBD), highlighting their role in regulation of the inflammatory milieu through pathways such as autophagy, apoptosis, and the inflammasome pathway. The study also discusses the potential of novel experimental and bioinformatics approaches to further advance our understanding of the role of bile acids in IBD and inform therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Aoife P. Smith, Emma M. Creagh
Summary: This review discusses the association between inflammatory caspase activity and inflammatory bowel disease (IBD) in both human and murine models. Caspases-4/-5/-11 show increased expression during IBD and are implicated in chronic inflammation. The review also explores the differences in expression and functions of caspases-4, -5, and -11, as well as their activation, function, and regulation mechanisms, and how these mechanisms may contribute to the pathogenesis of IBD.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Aleksandra Korta, Julia Kula, Krzysztof Gomulka
Summary: Interleukin-23 (IL-23) is a proinflammatory cytokine that plays a role in tissue damage. It interacts with both the innate and adaptive immune systems, and the IL-23/Th17 axis appears to be involved in the development of chronic intestinal inflammation. Despite the incomplete understanding of the etiology and pathophysiology of inflammatory bowel disease (IBD), research on IL-23 shows potential for clinical applications as therapeutic targets in IBD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Lu Zhang, Dickson Kofi Wiredu Ocansey, Lianqin Liu, Chinasa Valerie Olovo, Xu Zhang, Hui Qian, Wenrong Xu, Fei Mao
Summary: Inflammatory bowel disease (IBD) is characterized by intense immune dysregulation, gut microbiota imbalance, and intestinal epithelium destruction. Recent studies suggest that the lymphatic system plays a significant role in gastrointestinal pathophysiology, affecting immune cells, gut microbiota, intestinal and mesenteric epithelial barrier integrity, and colorectal cancer (CRC) progression. Therapeutic targets of lymphatics in IBD studies aim to increase lymphangiogenesis to restore gut homeostasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
K. A. Dvornikova, E. Yu. Bystrova, L. P. Churilov, A. Lerner
Summary: The latest research indicates that SARS-CoV-2 can enter host cells through the gastrointestinal tract, triggering immune responses and potentially causing inflammation and intestinal damage, particularly in patients with IBD. The infection with SARS-CoV-2 in IBD patients may induce innate and adaptive immune responses, leading to increased inflammation and potential intestinal damage.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Pharmacology & Pharmacy
Xiaohua Pan, Qing Zhu, Li-Long Pan, Jia Sun
Summary: The article explains how metabolic alterations affect the function and phenotype of intestinal macrophages in inflammatory bowel disease (IBD), and discusses potential therapeutic approaches by manipulating cellular metabolism of macrophages.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Pediatrics
Stephen M. M. Borowitz
Summary: Inflammatory bowel disease (IBD) has been increasing globally over the past century and has spread to developing countries. Genetic factors and environmental exposures both contribute to the development of IBD. Urban areas and good domestic hygiene during childhood are associated with a higher risk of IBD. Migration from high to low incidence areas affects the risk of developing IBD. Early environmental exposures may trigger IBD in genetically susceptible individuals, but specific triggers remain unknown.
FRONTIERS IN PEDIATRICS
(2023)
Review
Pharmacology & Pharmacy
Anderson dos Santos Ramos, Giovana Cristina Santana Viana, Marcelo de Macedo Brigido, Juliana Franco Almeida
Summary: Neutrophils, particularly their ability to form extracellular traps (NETs), play a significant role in the pathophysiology of inflammatory bowel disease (IBD). Studies have shown increased levels of NETs in tissue and serum samples from IBD patients, indicating their involvement in disease progression. This highlights the potential of targeting NETs as a therapeutic strategy to expand the current spectrum of IBD therapies.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Immunology
Lingling Qv, Sunbing Mao, Yongjun Li, Jia Zhang, Lanjuan Li
Summary: Inflammatory bowel disease (IBD) is a chronic and relapsing intestinal inflammatory disorder, with Crohn's disease and ulcerative colitis as its main forms. The pathogenesis of IBD is believed to be influenced by genetic predisposition, host immune response, and environmental factors such as the intestinal microbiome, with a recent focus on the role of gut bacteria over enteroviruses. Of the enteroviruses, bacteriophages (phages) are the most abundant, having the potential to regulate the bacterial population and influence the host immune response in IBD.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Nutrition & Dietetics
Gabrielle Wark, Dorit Samocha-Bonet, Simon Ghaly, Mark Danta
Summary: Inflammatory bowel diseases are chronic inflammatory diseases of the gastrointestinal tract that are increasing globally. Diet may impact disease risk and activity through various mechanisms, making it an attractive therapeutic option. Current treatment strategies rely on immunosuppression, but diet offers a low-cost, few side effects alternative for patients and clinicians.
