Article
Engineering, Biomedical
Alessandra Soriente, Ines Fasolino, Alejandro Gomez-Sanchez, Evgen Prokhorov, Giovanna Giuliana Buonocore, Gabriel Luna-Barcenas, Luigi Ambrosio, Maria Grazia Raucci
Summary: This study focuses on the use of chitosan (CS)-based materials reinforced with inorganic bioactive signals like hydroxyapatite (HA) in bone tissue engineering. The CS/HA scaffolds were found to promote osteogenic differentiation of human mesenchymal stem cells (hMSC) while modulating cytokine production, showing potential for treating bone defects.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Engineering, Biomedical
Lei Zhou, Lei Fan, Feng-Miao Zhang, Yuhe Jiang, Min Cai, Cong Dai, Yi-An Luo, Ling-Jie Tu, Zheng-Nan Zhou, Xiao-Jun Li, Cheng-Yun Ning, Kai Zheng, Aldo R. Boccaccini, Guo-Xin Tan
Summary: In this study, hybrid gelatin/oxidized chondroitin sulfate hydrogels incorporating mesoporous bioactive glass nanoparticles were developed for bone regeneration. The addition of MBGNs enhanced the mechanical properties and accelerated gelation, while also promoting proliferation and osteogenic differentiation of stem cells in vitro and bone defect restoration in vivo. These hybrid hydrogels show promising potential as injectable biomaterials or scaffolds for bone regeneration applications.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Applied
Danya Chen, Pei Liu, Mengna Li, Changqing Zhang, Youshui Gao, Yaping Guo
Summary: Nacre-mimetic scaffolds with layered structure and incorporated SP peptides were fabricated, showing excellent mechanical strength and biocompatibility, promoting MSC proliferation and differentiation, and enhancing subchondral bone regeneration in vivo.
CARBOHYDRATE POLYMERS
(2022)
Article
Biotechnology & Applied Microbiology
Nianrou Mei, Yiwen Wu, Binglin Chen, Tian Zhuang, Xinge Yu, Baiyan Sui, Tingting Ding, Xin Liu
Summary: The integration of 3D printed GelMA-based scaffolds with mesoporous bioactive glass nanoparticles improves the structural stability and promotes the regeneration of periodontal tissues.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Konstantinos Loukelis, Foteini Machla, Athina Bakopoulou, Maria Chatzinikolaidou
Summary: This study investigates the impact of kappa-carrageenan on dental pulp stem cells and reveals that its integration in scaffolds significantly enhances the odontogenic potential of DPSCs, supporting dentin-pulp regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Xinran Tu, Liyang Guo, Yang Li, Guozhong Tan, Rongfeng Chen, Jingwen Wu, Guohou Miao, Lvhua Guo, Chengfei Zhang, Ting Zou, Yang Zhang, Qianzhou Jiang
Summary: In this study, 3D-printed scaffolds composed of gelatin, sodium alginate, and bioactive glass were fabricated and evaluated for their mechanical properties, biocompatibility, and osteoinductive properties. The results showed that the scaffolds had appropriate mechanical strength, no cytotoxicity, and could induce the formation of new bone. Therefore, these scaffolds could potentially be used as promising biomaterials for bone defect repair.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2023)
Article
Engineering, Environmental
Ahmad Reza Farmani, Mohammad Hossein Nekoofar, Somayeh Ebrahimi-Barough, Mahmoud Azami, Sohrab Najafipour, Somayeh Moradpanah, Jafar Ai
Summary: Bone tissue engineering with biomimetic nanocomposite scaffolds made from lithium-doped bioactive-glass nanoparticles and gelatin/PRGF shows potential in repairing large bone lesions. The study found that an optimal lithium content in the bioactive glass structure is 3% wt, and the hybrid scaffolds with up to 10% wt bioactive-glass and PRGF exhibited increased survival, cell adhesion, and osteogenic differentiation biomarkers expression. This approach of utilizing biopolymers, Li-doped bioactive-glass, and platelet extracts in hybrid scaffolds may provide a promising strategy for bone repair.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Materials Science, Multidisciplinary
Laura Tomasello, Calogero Fiorica, Rodolfo Mauceri, Annalisa Martorana, Fabio Salvatore Palumbo, Giovanna Pitarresi, Giuseppe Pizzolanti, Giuseppina Campisi, Carla Giordano, Gennara Cavallaro
Summary: This study aimed to produce a cellularized construct for the guided bone regeneration of dento-alveolar defects. A porous scaffold was created using an amine derivative of gellan gum to host gingival mesenchymal stem cells (GMSCs) and allow their osteochondral differentiation. The results showed that the scaffold did not negatively affect the proliferation or osteogenic capability of the GMSCs.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Henri Granel, Cedric Bossard, Anne-Margaux Collignon, Fabien Wauquier, Julie Lesieur, Gael Y. Rochefort, Edouard Jallot, Jonathan Lao, Yohann Wittrant
Summary: This study investigates the osteogenic potential of nutrient fisetin, delivered using a SiO2-CaO bioactive glass-poly(caprolactone) hybrid scaffold, to enhance bone regeneration. The sustained release of fisetin was demonstrated, with positive effects on cell adhesion and differentiation without cytotoxicity. In animal experiments, fisetin-doped scaffolds showed remarkable enhancement of bone regeneration.
Article
Materials Science, Multidisciplinary
Natasha Bokhari, Tatheer Fatima, Sadaf Nosheen, Farasat Iqbal, Faisal Moeen, Faiza Sharif
Summary: Periodontal defects caused by infections can be treated using freeze-dried composite scaffolds that reconstruct the shape and characteristics of periodontal tissues. These scaffolds are made from bacterial cellulose, chitosan, hydroxyapatite, and pomegranate peel extract. The extract has been characterized through UV, FTIR, and GCMS analysis. The scaffolds show porous, foam-like microstructures with interconnected channels, and the extract release is dose- and time-dependent with antimicrobial and wound-healing properties.
JOURNAL OF MATERIALS RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Huacui Xiong, Fujian Zhao, Yuqi Peng, Meimei Li, Huanhuan Qiu, Ke Chen
Summary: This study demonstrates a promising strategy for the repair of critical-size bone defects through the use of gelatin/bioactive glass scaffolds loaded with stem cells from exfoliated deciduous teeth. The scaffolds exhibited low immunogenicity and significantly enhanced new bone formation in the center of the defect.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Polymer Science
Yesenia Sanchez-Cardona, Claudia E. Echeverri-Cuartas, Marta E. Londono Lopez, Natalia Moreno-Castellanos
Summary: The study evaluated the properties of chitosan-gelatin-polyvinyl alcohol scaffolds for BRIN-BD11 beta-cells culturing, finding them to have high porosity and controllable degradation rates. Increasing gelatin concentration led to higher compressive strength and better cell viability in the ternary blend scaffolds P3 and P4.
Article
Engineering, Biomedical
Priya Ranganathan, Vijayakumari Sugumaran, Bargavi Purushothaman, Ajay Rakkesh Rajendran, Balakumar Subramanian
Summary: The study aims to design and fabricate an ultra-easier multi-functional biomedical polymeric scaffold loaded with unique equimolar Ca:P phasic bioactive glass material. The results showed that the G:BG (1:2) ratio is the more appropriate composition for enhanced bio-mineralization and higher surface area. The scaffold can induce mitogenesis in osteoblast cells for hard tissue regeneration and rapid collagen secretion in fibroblast cells for soft tissue regeneration.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Materials Science, Multidisciplinary
Tanmoy Ghosh, Deveswaran Rajamanickam, Damodar Nayak, Bharath Srinivasan, B. V. Basavaraj
Summary: This study developed new antimicrobial scaffolds based on crosslinked CMCh/Gel biopolymers and conducted comprehensive investigations on their properties and applications. The results showed that the scaffolds had favorable physical and chemical characteristics, antibacterial properties, cytocompatibility, and potential for promoting wound healing. These scaffolds have high applicative potential in biomedical applications such as skin tissue regeneration and wound healing.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Polymer Science
Asmaa M. Abd El-Aziz, Ahmed Abd El-Fattah, Azza El-Maghraby, Doaa A. Ghareeb, Sherif Kandil
Summary: Chemical cross-linking was used to create nanocomposite hydrogels composed of gelatin and borosilicate bioactive glass with different content. The nanocomposite scaffolds showed promising properties such as hydrophilicity, biodegradability, increased compressive modulus, and facilitated apatite formation in simulated body fluid. The nanocomposite hydrogels exhibited a self-standing elastic structure with greater storage modulus than loss modulus.
Article
Materials Science, Biomaterials
Kanchan Maji, Krishna Pramanik
Summary: The growing trend of bone disorders caused by accidental injury and the increasing aging population demand more effective therapeutic intervention. Bone tissue engineering offers functional bone grafts, and electrospinning technology provides a potential solution to the limitations of traditional bone grafts, but scaffold matrix fabrication remains a significant challenge.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2022)
Article
Engineering, Biomedical
Sudip Dasgupta, Soumini Mondal, Sambit Ray, Yogendra Pratap Singh, Kanchan Maji
Summary: This study successfully developed photocurable biocomposites containing polyanhydride and Si, Sr doped hydroxyapatite-collagen nanoparticles that exhibited tremendous promise to regenerate bone tissues in complex-shaped musculoskeletal defect sites.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Chemistry, Inorganic & Nuclear
Balram Singh Yadav, Sudip Dasgupta
Summary: This study enhanced the adsorption performance of MgAl layered double hydroxide (MA LDH) by modifying with nitrate intercalation, showing that adsorption kinetics at different temperatures followed pseudo second order kinetics. At 40 degrees Celsius, the Langmuir isotherm model fitted well with experimental data, with a maximum adsorption capacity of 583 mg/g.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Review
Engineering, Biomedical
Yogendra Pratap Singh, Sudip Dasgupta
Summary: The rebuilding of damaged human bone tissue is an important objective in bone tissue engineering. Fabricated scaffolds, which mimic the native extracellular matrix of bone, are used as artificial supports and materials for regeneration of new bone tissues. Gelatin, a potential candidate, can be blended with other polymers or composites to enhance its performance as a bone graft. Freeze-drying and electrospinning are popular techniques for scaffold fabrication, providing a unique architecture with desired porosity and pore interconnectivity. These scaffolds resemble the natural bone extracellular matrix and have applications in bone tissue engineering.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2022)
Article
Dermatology
Charlie Bridgewood, Miriam Wittmann, Tom Macleod, Abdulla Watad, Darren Newton, Kanchan Bhan, Howard Amital, Giovanni Damiani, Sami Giryes, Nicola Luigi Bragazzi, Dennis McGonagle
Summary: The use of Dupilumab is associated with seronegative inflammatory arthritis and psoriasis, but not with classic polygenic humoral autoimmune diseases. Pathway analysis suggests that Dupilumab may affect certain cytokine pathways and contribute to immune disorders and other pathological processes.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Materials Science, Biomaterials
Yogendra Pratap Singh, Rakesh Bhaskar, Ashish Kumar Agrawal, Sudip Dasgupta
Summary: The composite scaffold based on chitosan and monetite nanoparticles has the potential for bone restoration, with customizable structures and properties.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2023)
Article
Polymer Science
Yogendra Pratap Singh, Balaram Mishra, Mukesh Kumar Gupta, Narayan Chandra Mishra, Sudip Dasgupta
Summary: In this study, monetite nanoparticles were successfully incorporated into a chitosan-based composite using the electrospinning technique. The resulting composite exhibited superior osteogenic properties and biomineralization capability, making it a promising material for bone tissue engineering.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Engineering, Biomedical
Sujata Swain, Rakesh Bhaskar, Kannan Badri Narayanan, Mukesh Kumar Gupta, Sonia Sharma, Sudip Dasgupta, Sung Soo Han, Pawan Kumar
Summary: Bone implants made of nanocomposites containing hydroxyapatite (HA) and barium titanate (BT) exhibit desirable properties for bone regeneration applications, including osteoconductive, osteoinductive, osteointegration, and piezoelectricity. These nanocomposites were synthesized through solid-state reactions and sintered to enhance their mechanical, dielectric, and biological properties. The resulting composites showed improved dielectric properties, mechanical strength, and hemocompatibility, making them suitable for orthopedic implants.
BIOMEDICAL MATERIALS
(2023)
Article
Engineering, Biomedical
Yogendra Pratap Singh, Balaram Mishra, Mukesh Kumar Gupta, Rakesh Bhaskar, Sung Soo Han, Narayan Chandra Mishra, Sudip Dasgupta
Summary: This study is dedicated to the preparation and characterization of electrospun gelatin/monetite nanofibrous scaffold for bone tissue engineering. The addition of monetite nanoparticles in the gelatin matrix improved the physicochemical, mechanical, and biological properties of the scaffold. The incorporation of 7 wt% monetite resulted in decreased swelling ratio, higher tensile strength and modulus, and better cell adhesion, proliferation, biomineralization, and ALP activity.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Balram Singh Yadav, Sudip Durgawati, Sudip Dasgupta
Summary: Nitrate-intercalated MgAl layered double hydroxide (LDH) nanoparticles were successfully synthesized and used to adsorb acid yellow dye (AY) from contaminated water. The optimized conditions resulted in a maximum adsorption rate of 0.00515 g mg(-1) min(-1) and a maximum adsorption capacity of 412.55 mg g(-1). The study showed that the synthesized nitrate intercalated MgAl LDH nanoparticles have great potential for the adsorption of acid yellow dye.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Ceramics
Sambit Ray, Jayprakash Yadav, Amrita Mishra, Sudip Dasgupta
Summary: Bioactive glass is a promising material with biocompatibility and bioactivity for tissue regeneration. This study synthesized un-doped and Ag-doped submicron bioactive glass particles and evaluated their properties. The results showed that the Ag-doped SBG exhibited enhanced antimicrobial activity and minimal cytotoxicity, making it a potential candidate for biomedical applications.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Yogendra Pratap Singh, ShivDutt Purohit, Mukesh Kumar Gupta, Rakesh Bhaskar, Sung Soo Han, Sudip Dasgupta
Summary: Chitosan-gelatin-monetite (CGM)-based electrospun scaffolds have been developed that mimic the microstructure and composition of natural bone. The incorporation of 7% monetite into the scaffold enhances its mechanical properties and osteogenic potential, making it a potential candidate for bone tissue regeneration.
BIOMEDICAL MATERIALS
(2023)
Article
Engineering, Biomedical
Sambit Ray, Samit Kumar Nandi, Sudip Dasgupta
Summary: Highly interconnected porous scaffolds of Antheraea mylitta silk fibroin (SF) and chitosan (CH) were fabricated using the freeze-drying method. The SF80/CH20 scaffold exhibited the most suitable properties for bone tissue engineering application according to optimization of microstructure, porosity, and mechanical properties. In vitro and in vivo experiments showed excellent biocompatibility, cell attachment, and bone healing capacity of the SF80/CH20 scaffold.
BIOMEDICAL MATERIALS
(2023)
Meeting Abstract
Cell & Tissue Engineering
Yogendra Pratap Singh, Sudip Dasgupta
TISSUE ENGINEERING PART A
(2022)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)