期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 47, 页码 32102-32107出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b11960
关键词
cellulose; paper; giant unilamellar vesicles; encapsulation; synthetic cells
资金
- NSF [CBET-1512686]
- NASA [NNX15AQ01A]
- Direct For Education and Human Resources
- Division Of Human Resource Development [1547848] Funding Source: National Science Foundation
- Directorate For Engineering [1512686] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys [1512686] Funding Source: National Science Foundation
We report a facile and scalable method to fabricate biomimetic giant liposomes by using a cellulose paper-based materials platform. Termed PAPYRUS for Paper-Abetted lipid hYdRation in aqUeous Solutions, the method is general and can produce liposomes in various aqueous media and at elevated temperatures. Encapsulation of macromolecules and production of liposomes with membranes of complex compositions is straightforward. The ease of manipulation of paper makes practical massive parallelization and scale-up of the fabrication of giant liposomes, demonstrating for the first time the surprising usefulness of paper as a platform for macromolecular self-assembly.
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