Review
Biochemistry & Molecular Biology
Arpad Szallasi
Summary: Resiniferatoxin (RTX) is a potent analgesic with a wide range of pharmacological actions. Targeted RTX therapy shows promise in cancer pain management and treatment of knee pain in patients with osteoarthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Heng Zhang, Jia-Jia Lin, Ya-Kai Xie, Xiu-Zu Song, Jia-Yi Sun, Bei-Lei Zhang, Yun-Kun Qi, Zhen-Zhong Xu, Fan Yang
Summary: The authors have engineered a peptide called s-RhTx as a positive allosteric modulator of the TRPV1 channel. It enhances the activity of TRPV1, allowing for reversible elimination of pain-sensing nerve terminals, providing long-lasting analgesia without affecting mice body temperature.
NATURE COMMUNICATIONS
(2023)
Review
Pharmacology & Pharmacy
Vipin Arora, James N. Campbell, Man-Kyo Chung
Summary: Capsaicin, the pungent ingredient in chili peppers, can cause intense burning pain in humans, but it has also been used as an analgesic for chronic pain conditions. The analgesic effects of capsaicin depend on concentration, with low concentrations inducing short-term defunctionalization and high concentrations leading to long-term defunctionalization.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Pharmacology & Pharmacy
Amanda Spring de Almeida, Laura de Barros Bernardes, Gabriela Trevisan
Summary: Chronic pain is common during cancer progression, often complicated by bone pain from metastasis, leading to exploration of new mechanisms such as TRP channels for managing cancer-related pain. Studies have shown the potential of TRPV1 and TRPA1 in cancer pain mechanisms, with TRP agonists/antagonists showing promising results in reducing sensitivity in cancer pain models.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Phiwayinkosi V. Dludla, Bongani B. Nkambule, Ilenia Cirilli, Fabio Marcheggiani, Sihle E. Mabhida, Khanyisani Ziqubu, Yonela Ntamo, Babalwa Jack, Tawanda M. Nyambuya, Sidney Hanser, Sithandiwe E. Mazibuko-Mbeje
Summary: Diabetic neuropathy is a serious condition that can lead to various complications and severely impact a patient's quality of life. The use of topical capsaicin cream has shown promising results in reducing pain symptoms and improving walking, working, and sleeping in patients with painful diabetic neuropathy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Nuray Erin, Arpad Szallasi
Summary: Both sensory neurons and immune cells express TRPV1, which can induce neurogenic inflammation and modify tumor growth and metastasis. TRPV1 is also found in various immune cells, and the effects of TRPV1 agonists and antagonists depend on the cell type(s) activated and/or inhibited. A comprehensive understanding of TRPV1 activity on immune cells and nerve endings is necessary to predict the outcome of therapies targeting TRPV1 channels. This review focuses on the neuro-immune modulation of cancer growth and metastasis caused by TRPV1 activation and discusses the potential use of TRPV1 modulators in cancer therapy.
Review
Oncology
Christian Maihoefner, Ingo Diel, Hans Tesch, Tamara Quandel, Ralf Baron
Summary: Cancer diagnosis and treatment are significant events with potential severe side effects, including chemotherapy-induced peripheral neuropathy (CIPN). Some patients may face chronic symptoms, highlighting the importance of prevention and treatment strategies. Improved survival rates for cancer patients may lead to an increased incidence of CIPN in the future.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Clinical Neurology
Praveen Anand, Rosario Privitera, Philippe Donatien, Hassan Fadavi, Solomon Tesfaye, Vassiliki Bravis, V. Peter Misra
Summary: The study evaluated the effects of 8% capsaicin patch treatment on pain relief and nerve regeneration in painful and non-painful diabetic peripheral neuropathy, indicating that capsaicin 8% patch treatment can provide pain relief and restore nerve density and function through nerve regeneration.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ariana Hudita, Bianca Galateanu, Marieta Costache, Carolina Negrei, Rodica-Mariana Ion, Lorena Iancu, Octav Ginghina
Summary: This study investigated the therapeutic effects of alginate-microencapsulated capsaicin on neuropathic pain, revealing that this new formulation has lower cytotoxic effects, significant improvements in cell morphology and oxidative stress status, and can alter the expression profile of inflammatory cytokines compared to the control group.
Review
Biochemistry & Molecular Biology
Reyhaneh Vali, Ali Azadi, Ashkan Tizno, Tahereh Farkhondeh, Fariborz Samini, Saeed Samarghandian
Summary: This review explores the connection between neuropathic pain (NP) and microRNAs (miRNAs), and discusses the potential role of miRNAs in the treatment and prevention of chronic pain and NP.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Abdullah F. AlAsmari, Metab Alharbi, Faleh Alqahtani, Fawaz Alasmari, Mohammed AlSwayyed, Sami I. Alzarea, Ibrahim A. Al-Alallah, Adel Alghamdi, Hassan M. Hakami, Meshal K. Alyousef, Youssef Sari, Nemat Ali
Summary: The study showed that diosmin has a protective effect against doxorubicin-induced hepatotoxicity by restoring hepatic antioxidant factors, reducing inflammatory and apoptotic proteins and genes.
Article
Anesthesiology
Emmanuel Backryd, Andreas Themistocleous, Anders Larsson, Torsten Gordh, Andrew S. C. Rice, Solomon Tesfaye, David L. Bennett, Bjorn Gerdle
Summary: This study aims to explore the pathophysiological mechanisms underlying neuropathic pain in patients with diabetic DSP. It suggests that low-grade systemic inflammation is related to the severity of neuropathy and neuropathic pain, and identifies specific inflammation-related proteins such as hepatocyte growth factor, colony-stimulating factor 1, and CD40 that may play a crucial role in neuropathic pain.
Article
Immunology
Emily Pickering, Elizabeth L. Steels, Kathryn J. Steadman, Amanda Rao, Luis Vitetta
Summary: This study demonstrated that a palmitoylethanolamide (PEA) formulation can reduce diabetic peripheral neuropathic pain and inflammation, while improving mood and sleep. Further research is needed to investigate the effectiveness of PEA as an adjunct medicine or monotherapy pain analgesic.
INFLAMMOPHARMACOLOGY
(2022)
Review
Clinical Neurology
Juan P. Cata, Megan L. Uhelski, Aysegul Gorur, Patrick M. Dougherty
Summary: The exchange of information between cells relies on the release of various molecules, including exosomes, which play a role in cell-to-cell communication in the nervous system. Exosomes are implicated in the pathogenesis of neurological conditions and are also found to regulate sensory processes, including nociception. This review summarizes exosome biogenesis, methods of isolation and purification of small vesicles, and discusses their potential applications as pain biomarkers or novel therapeutics.
Review
Plant Sciences
Elena Lucarini, Laura Micheli, Lorenzo Di Cesare Mannelli, Carla Ghelardini
Summary: This review investigates the therapeutic effects of glucosinolates (GLs) and their derivatives isothiocyanates (ITCs) in chronic inflammatory and neuropathic conditions, focusing on their ability to modulate pain perception and prevent the establishment of chronic pain.
PHYTOCHEMISTRY REVIEWS
(2022)
Article
Chemistry, Applied
Mario F. C. Santos, Cristiane dos R. Feliciano, Albert K. Neto, Daniela A. Chagas de Paula, Marisi G. Soares
Summary: This study describes the isolation and identification of a new bicyclic octane neolignan 1 with unique structural features and biological activities through NMR analysis and mass spectrometry data.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Analytical
Luzio G. Bocalon, Marcos G. Tozatti, Ana H. Januario, Patricia M. Pauletti, Marcio L. A. Silva, Lucas A. Rocha, Eduardo F. Molina, Mario F. C. Santos, Wilson R. Cunha
Summary: Drug delivery systems are technologies that have been extensively studied and applied to enhance the application of existing drugs and improve the bioavailability of compounds of interest. This study successfully incorporated betulinic acid (BA) into mesoporous silica materials and investigated the characteristics and release mechanisms of the nanoparticles. The results demonstrate the potential use of these nanoparticles in drug delivery systems.
ANALYTICAL LETTERS
(2023)
Article
Chemistry, Applied
Ranieli P. Lopes, Luciana A. Parreira, Aldino N. Venancio, Mario F. C. Santos, Luciano Menini
Summary: This study evaluated the acaricidal action of essential oil from rosemary leaves and its major compound, alpha-pinene, on two-spotted spider mite using fumigation. The results showed that alpha-pinene exhibited higher toxicity than rosemary essential oil.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Ana Carolina Gomes, Alexandre Borges, Daniela Garcia Zoca, Marcio Luis Andrade e Silva, Aline Rafaela da Silva Rodrigues Machado, Alex Martins Machado, Mario F. C. Santos, Rosangela da Silva de Laurentiz
Summary: This study evaluated the larvicidal potential of Piper cubeba extracts and compounds against Aedes aegypti larvae, the primary vector of dengue, yellow fever, chikungunya, and zika viruses. The results demonstrated the larvicidal action of hinokinin and extracts, suggesting their potential for the development of new natural larvicides. Scanning electron microscopy analysis revealed structural damage to the larvae's tegument caused by the extracts and compounds.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Icaro E. F. Da Silva, Daniela G. Zoca, Gabriela N. Andrade e Silva, Albert Katchborian-Neto, Pedro S. dos S. R. Cavallari, Samarah G. de Almeida, Ana H. Januario, Patricia M. Pauletti, Joao Victor Andrade, Raquel P. Morais-Urano, Wilson Roberto Cunha, Mario F. C. Santos, Marcio L. A. e Silva
Summary: This study demonstrates the analgesic and anti-inflammatory properties of hydroalcoholic extracts from the Handroanthus impetiginosus plant, commonly known as 'Ipe roxo' in Brazil. The extracts showed significant anti-inflammatory activity in mice and potent analgesic action in a hot plate test. Analysis of the extracts identified various metabolites, indicating their potential as complementary herbal medicine for pain and inflammation disorders.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Adriano Lopes da Silva, Lucas Santos Azevedo, Thais Paula Rodrigues Goncalves, Mairon Cesar Coimbra, Ezequias Pessoa de Siqueira, Stenio Nunes Alves, Luciana Alves Rodrigues dos Santos Lima
Summary: Hexane extract (HE) and fatty acids (FA) obtained from the pericarps of Tecoma stans have larvicidal potential for the control of Culex quinquefasciatus mosquitoes.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Daniele de Oliveira Silva, Mario Ferreira Conceicao Santos, Karen de Jesus Nicacio, Albert Katchborian Neto, Joao Henrique Ghilardi Lago, Daniela Aparecida Chagas-Paula, Danielle F. F. Dias, Marisi G. G. Soares
Summary: This study aimed to identify compounds responsible for the anti-inflammatory activity of A. polyphylla through phytochemical analysis. Among the evaluated fractions, the BH fraction showed the highest percentage of PGE(2) inhibition, indicating its excellent potential for anti-inflammatory activity. Astragalin and a new compound were isolated from the A. polyphylla extract, contributing to the phytochemical studies of this plant and confirming its anti-inflammatory potential.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Sandra Vaz Soares Martins, Angelica Cristina Coelho Britto, Marcos Gomide Tozzati, Lizandra Guidi Magalhaes, Marcio Luis Andrade e Silvaa, Ana Helena Januario, Patricia Mendonca Pauletti, Antonio Eduardo Miller Crotti, Amanda Vargas dos Passos, Ester Goncalves de Jesus, Amanda Diniz Peixoto, Gabriela dos Santos Medeiros, Mario F. C. Santos, Wilson Roberto Cunha
Summary: Neglected tropical diseases are a major cause of death and disability in developing countries. This study aimed to identify the major constituents of Capsicum frutescens and Capsicum baccatum fruit extracts and evaluate their schistosomicidal, leishmanicidal, and trypanocidal activities. The results showed that C. frutescens extracts had better activity, possibly due to higher concentrations of capsaicin (1). Capsaicin (1) exhibited significant trypanocidal activity with an IC50 value of 6.23 mu M, suggesting it as a potential active constituent.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Ana Terra Bravim dos Santos, Vanessa Sessa Dian, Luciana Alves Parreira, Maicon Pierre Lourenco, Jose Salazar Zanuncio Jr, Ester Goncalves de Jesus, Mario Ferreira Conceicao Santos, Luciano Menini
Summary: Strawberry, a food rich in bioactive compounds, has great antioxidant potential. However, the control methods for agroecological cultivation of strawberries are lacking due to the high incidence of pests. This research evaluated the chemical composition and potential of essential oil from Piper macedoi leaves in controlling Cerosipha forbesi, showing high mortality rates with small doses of oil under laboratory and semi-field conditions.
NATURAL PRODUCT RESEARCH
(2023)
Article
Cell Biology
Diessica Padilha Dalenogare, Daniel Souza Monteiro de Araujo, Lorenzo Landini, Mustafa Titiz, Gaetano De Siena, Francesco De Logu, Pierangelo Geppetti, Romina Nassini, Gabriela Trevisan
Summary: This study evaluated the role of transient receptor potential ankyrin 1 (TRPA1) in neuroinflammation underlying pain-like symptoms in multiple sclerosis (MS). The results indicate that TRPA1 primarily promotes spinal neuroinflammation and further strengthens the inhibition of this channel to treat neuropathic pain in MS.
Article
Chemistry, Physical
Lorrana Vietro Barbosa, Mona Stefany de Souza Castro, Katia Jorge Ciuffi, Eduardo J. Nassar, Liziane Marcal, Lorena Rodrigues Pereira, Mario Ferreira Conceicao Santos, Sergio Ricardo Ambrosio, Pietra Stefany da Silva Gomes, Flavia Aparecida Resende Nogueira, Raquel Alves Santos, Emerson Henrique de Faria
Summary: In this study, kaolinite-titanium photocatalysts were synthesized and characterized. The photocatalysts showed excellent degradation performance for cisplatin through photodegradation studies. The presence of well-dispersed anatase on layered kaolinite contributed to the high photodegradation efficiency.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Environmental Sciences
Tabata Rodrigues Esperandim, Arthur Barcelos Ribeiro, Iara Silva Squarisi, Leticia Teixeira Marcos de Souza, Thiago Olimpio de Souza, Nathalia Oliveira Acesio, Mario Ferreira Conceicao Santos, Jairo Kenupp Bastos, Sergio Ricardo Ambrosio, Denise Crispim Tavares
Summary: The study evaluated the safety and chemopreventive potential of Brazilian brown propolis (BBP). The results showed that BBP exhibited cytotoxic effects and chemopreventive potential, but also displayed greater toxicity compared to other propolis types. These findings contribute to a better understanding of the biological properties and potential applications of BBP.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2023)
Article
Chemistry, Applied
Andriely B. Silva, Daniel L. Montagnini, Albert Katchborian-Neto, Joao V. Andrade, Hallana A. Manuquian, Pedro S. S. R. Cavallari, Samarah G. Almeida, Enes P. Barbosa, Wilson R. Cunha, Marisi G. Soares, Mario F. C. Santos, Marcio L. A. Silva, Alessandra M. Vacari
Summary: This study evaluated the insecticidal activity of extracts from Handroanthus impetiginosus on Plutella xylostella larvae, with the seed extract showing the highest toxicity and mortality rate. These findings suggest the potential of using H. impetiginosus seed extract as a basis for insecticide development.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Tatiane Cristina Silva Maiolini, Karen de Jesus Nicacio, Welton Rosa, Daniel de Oliveira Miranda, Mario Ferreira Conceicao Santos, Paula Carolina Pires Bueno, Joao Henrique Ghilardi Lago, Patricia Sartorelli, Danielle Ferreira Dias, Daniela Aparecida Chagas de Paula, Marisi Gomes Soares
Summary: This study evaluated the anti-inflammatory activity of essential oils from 18 species of Myrtaceae and found that 6 species displayed anti-inflammatory activity, with corresponding biomarkers identified.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Mario F. C. Santos, Edvaldo S. Costa, Humberto Matos, Raquel P. Morais-Urano, Geraldo H. Silva
Summary: Kojic acid, produced by different types of fungi, has great potential for industrial application. In this study, the fungus Aspergillus sp. isolated from the leaves of Hancornia speciosa was found to yield a kojic acid-rich ethyl acetate extract, which exhibited potent antioxidant activity.
REVISTA VIRTUAL DE QUIMICA
(2023)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.