Novel 1,3,4-Oxadiazole Fused Thiadiazole Derivatives: Synthesis and Study of Anticancer Activities

Background: In search of novel anticancer agents, a series of 1,3,4-oxadiazole derivatives (12a-j) containing 1,3,4-thiadiazole moieties were synthesized, and their structures were confirmed by (HNMR)-H-1, (CNMR)-C-13 and ESI-MS spectral analysis. Methods: Cytotoxicity of these compounds was evaluated by MTT assay in vitro against four human tumor cell lines, i.e. A549 (lung), MCF-7 (breast), A375 (melanoma) and HT-29 (colon). Results: Here, CA4 used as positive control. Among them, compounds 12b, 12c, 12f, 12g, 12h and 12j were exhibited promising activity than control drug. Conclusion: In conclusion, we have synthesized a novel series of 1,3,4-oxadiazole fused 1,3,4-thiazdiazole derivatives and their structures were confirmed by spectral analysis