Article
Pharmacology & Pharmacy
Gokcen Birlik Demirel, Seyma Bayrak
Summary: We have developed a triple pH/redox/ultrasound-triggered hybrid nanocarrier system for controlled drug delivery. This system consists of a mesoporous silica coated magnetic core and a pH/redox-responsive polymer layer. The results showed that the hybrid nanoparticles exhibited efficient drug release in cellular pH environment and in the presence of specific conditions (10 mM GSH, pH = 5.5, 37 degrees C). Ultrasound-triggered release was also effective in controlling drug release. In vitro cytotoxicity tests demonstrated that the hybrid nanoparticles had strong cell-killing effects on MCF-7 cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Applied
Shumin Chen, Xiaoguo Ji, Mengyao Zhao, Jiayang Jin, Haiping Zhang, Liming Zhao
Summary: A chitooligosaccharide-based nanoparticle with enhanced delivery efficiency and endocytosis was constructed in this study, which improved the therapeutic effect of AZD9291 and overcame drug resistance. The surface charge of the nanoparticles changed in the weakly acidic tumor microenvironment and released drugs in the cytoplasm.
CARBOHYDRATE POLYMERS
(2022)
Article
Polymer Science
Nour M. AlSawaftah, Nahid S. Awad, William G. Pitt, Ghaleb A. Husseini
Summary: Stimuli-responsive nanoparticles have shown promising potential in overcoming the limitations of conventional chemotherapy. pH-sensitive nanoparticles, in particular, have proven to be highly efficient in delivering drugs to tumors compared to conventional nanoparticles. This review summarizes the different strategies used to develop pH-sensitive nanoparticles for cancer therapy.
Article
Pharmacology & Pharmacy
Mengru Chen, Yunyun Chen, Yanbao Zhao, Xueyan Zou, Lei Sun
Summary: In this study, three types of mesoporous silica nanoparticles with different aspect ratios were prepared. The samples showed that aspect ratio affects specific surface area, cell uptake rate, and drug loading capacity. The MS3 sample, with higher cell uptake rate and specific surface area, was used as a carrier for drug delivery system, displaying redox/pH-responsive and sustained release behavior.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qian Liu, Zhenrong Tan, Dafeng Zheng, Xueqing Qiu
Summary: A magnetic delivery system for targeted drug was developed using aminated lignosulfonate (ALS) and carboxymethyl chitosan (CMCS) to fabricate nano Fe3O4 with pH responsiveness. The system successfully loaded doxorubicin hydrochloride (DOX) and demonstrated controlled release of the drug. The particle size ranged from 79.9-169.9 nm under optimized conditions and exhibited excellent pH responsiveness. The drug-loaded particles showed significant growth inhibition on cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Madhappan Santhamoorthy, Vanaraj Ramkumar, Kokila Thirupathi, Lalitha Gnanasekaran, Vanitha Karuppannan, Thi Tuong Vy Phan, Seong-Cheol Kim
Summary: In this study, L-lysine modified mesoporous silica nanoparticles (MS@Lys NPs) were synthesized for the delivery of the anticancer drug curcumin (Cur) to cancer cells. The functionalization of L-lysine groups onto the mesopore channel surfaces of MS@GPTS NPs was achieved through a ring-opening reaction. The structural properties of MS@Lys NPs were examined using various instrumental techniques. The drug loading and pH-responsive drug delivery behavior of MS@Lys NPs were investigated using curcumin as a model drug, and their cytocompatibility and cell uptake behavior were evaluated using MDA-MB-231 cells. The results suggest that MS@Lys NPs have potential for pH-responsive drug delivery in cancer therapy.
Article
Oncology
Jian Song, Bingbing Xu, Hui Yao, Xiaofang Lu, Yang Tan, Bingyang Wang, Xing Wang, Zheng Yang
Summary: The study demonstrated a pH-responsive PEGylated doxorubicin prodrug that could achieve high drug loading and pH-responsive drug release within tumor cells, with good stability. Furthermore, the nanoparticles showed similar cytotoxicity to MCF-7 tumor cells as free DOX drug, and were able to encapsulate small DOX drugs with enhanced therapeutic effects.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Inorganic & Nuclear
Qianqian Zhang, Xinli Li, Lichao Peng, Xueyan Zou, Yanbao Zhao
Summary: Porous silica nanoparticles engineered with disulfide-linked gatekeepers were used for controlled drug release. The large-pored drug carriers were coated with PEI/gCDs shell which can detach at tumor-relevant GSH levels to release encapsulated cargo. The pH/redox-responsive behavior of the system was shown to be effective for drug release, with gCDs serving as drug release monitoring tools.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Nanoscience & Nanotechnology
Guang-Rong Tan, Chin-Ying Stephen Hsu, Yong Zhang
Summary: Engineering highly sensitive nanomaterials for monitoring spatiotemporal pH changes has broad applications in studying biological systems. However, current technology lacks the capability to accurately probe both micro-pH profiles in dentin tissues and acidogenic oral biofilms simultaneously. Developing a highly sensitive pH-responsive hybrid nanoparticle (pH-NP) allows for simulating and studying key cariogenic factors/steps.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Zhou-Yan Jia, Hao Zhou, Li-Shuang Hou, Fang Kou, Tang-Rui Zhang, Bao-Long Wang, Wei Wang, Si-Yuan Zhou, Bang-Le Zhang
Summary: This study constructed a nanocarrier-mediated cisplatin co-delivery system that can release hyaluronidase to degrade hyaluronan in the tumor stroma, achieving deeper tumor tissue penetration and more effective chemotherapy to pancreatic cancer in vivo. This provides potential clinical application prospects for the treatment of pancreatic cancer.
Review
Oncology
Shunli Chu, Xiaolu Shi, Ye Tian, Fengxiang Gao
Summary: The complexity of the tumor microenvironment can be overcome by using pH-responsive polymers for targeted drug delivery, improving treatment efficacy and reducing adverse reactions.
FRONTIERS IN ONCOLOGY
(2022)
Article
Engineering, Biomedical
Xuan Meng, Lin Wang, Ning Zhao, Delong Zhao, Yongli Shen, Yuan Yao, Wenjie Jing, Shuli Man, Yujie Dai, Yanjun Zhao
Summary: This study reports a hybrid nanocarrier that targets glycolysis and redox balance simultaneously for cancer therapy. The nanocarrier, composed of pH-and ATP-responsive ZIF-8 core and poloxamer 407 coating, delivers glucose oxidase and 3-bromopyruvate to liver hepatocellular carcinoma cells, effectively inhibiting cellular energy metabolism and reducing cell viability. This approach enriches the available strategies for anti-tumor treatment.
ACTA BIOMATERIALIA
(2023)
Article
Biophysics
Daquan Wang, Na Zhou, Ning Zhang, Zhe Zhi, Yongping Shao, Lingjie Meng, Demei Yu
Summary: A novel redox/pH dual-responsive and biodegradable polyphosphazene (PPZ) nano-prodrugs have been prepared, which can achieve controlled drug release in tumor microenvironment, exhibit significant cytotoxicity to cancer cells, and have negligible side effects on normal cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Miguel Gisbert-Garzaran, Maria Vallet-Regi
Summary: Mesoporous silica nanoparticles are widely used in cancer treatment, with a focus on redox-responsive systems. This trend in design includes biological rationale, gatekeeper types, and nucleic acid scaffold nanoparticles.
Article
Pharmacology & Pharmacy
Hao Chi, Guang Zhu, Yalin Yin, He Diao, Zicheng Liu, Shibo Sun, Zhaoming Guo, Weiping Xu, Jianqiang Xu, Changhao Cui, Xiao-Jin Xing, Kun Ma
Summary: In this study, acid and redox dual-responsive multifunctional magnetic nanoparticles were developed for tumor ferroptosis therapy. The nanoparticles showed magnetic targeting and active targeting properties, and were able to induce cell death in tumor cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)