Article
Virology
Zhiqiang Li, Huanyu Zhang, Zhuorui Li, Yan Fu, Xi Wang, Jiang Li, Kangxiaoya Wang, Zhiying Wang, Tao Zhang, Manli Wang, Zhihong Hu, Sheng Cao
Summary: Baculoviruses initiate oral infection in the highly alkaline midgut of insects via per os infectivity factors (PIFs). This study presents the crystal structure of the PIF5 ectodomain from Autographa californica multiple nucleopolyhedrovirus (AcMNPV), providing new insights into the structural stability and crucial interactions involved in oral infectivity of baculoviruses.
JOURNAL OF VIROLOGY
(2022)
Review
Cell Biology
Kevin G. Chen, Kyeyoon Park, Jason R. Spence
Summary: Complex organoids play important roles in studying SARS-CoV-2 infection, modeling COVID-19 pathology, and developing drugs, antibodies, and vaccines. There are significant opportunities and challenges in the application of organoids in COVID-19 research.
NATURE CELL BIOLOGY
(2021)
Article
Virology
Xi Wang, Cheng Chen, Nan Zhang, Qingxiu Chen, Fenghua Zhang, Xijia Liu, Fang Li, Zheng-Li Shi, Just M. Vlak, Manli Wang, Zhihong Hu
Summary: White spot disease caused by WSSV is a major problem in shrimp farming. This study identified the existence of a PIF complex in WSSV, which plays a critical role in the entry of the virus into shrimp and has biochemical properties important for infectivity in marine environments.
JOURNAL OF VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Flavio De Maio, Valentina Palmieri, Gabriele Babini, Alberto Augello, Ivana Palucci, Giordano Perini, Alessandro Salustri, Patricia Spilman, Marco De Spirito, Maurizio Sanguinetti, Giovanni Delogu, Laura Giorgia Rizzi, Giulio Cesareo, Patrick Soon-Shiong, Michela Sali, Massimiliano Papi
Summary: The recent advancements in production of bidimensional nanoparticles like graphene and graphene oxide have the potential to enhance the efficacy of personal protective equipment against SARS-CoV-2 by inhibiting virus infection and transmission. Soluble graphene oxide pre-incubation was shown to inhibit SARS-CoV-2 infection in cells, and fabric functionalized with graphene/graphene oxide significantly reduced virus infectivity upon contact.
Article
Biochemistry & Molecular Biology
Yafei Liu, Wai Tuck Soh, Jun-ichi Kishikawa, Mika Hirose, Emi E. Nakayama, Songling Li, Miwa Sasai, Tatsuya Suzuki, Asa Tada, Akemi Arakawa, Sumiko Matsuoka, Kanako Akamatsu, Makoto Matsuda, Chikako Ono, Shiho Torii, Kazuki Kishida, Hui Jin, Wataru Nakai, Noriko Arase, Atsushi Nakagawa, Maki Matsumoto, Yukoh Nakazaki, Yasuhiro Shindo, Masako Kohyama, Keisuke Tomii, Koichiro Ohmura, Shiro Ohshima, Toru Okamoto, Masahiro Yamamoto, Hironori Nakagami, Yoshiharu Matsuura, Atsushi Nakagawa, Takayuki Kato, Masato Okada, Daron M. Standley, Tatsuo Shioda, Hisashi Arase
Summary: The research found that antibodies against different domains of the SARS-CoV-2 spike protein have different effects, with some antibodies inducing an open conformation of the RBD and enhancing the virus infectivity. Structural and mutational analysis revealed the mechanisms of these antibodies, and infectivity-enhancing antibodies were detected at higher levels in severe patients.
Article
Multidisciplinary Sciences
Yongfei Cai, Jun Zhang, Tianshu Xiao, Christy L. Lavine, Shaun Rawson, Hanqin Peng, Haisun Zhu, Krishna Anand, Pei Tong, Avneesh Gautam, Shen Lu, Sarah M. Sterling, Richard M. Walsh, Sophia Rits-Volloch, Jianming Lu, Duane R. Wesemann, Wei Yang, Michael S. Seaman, Bing Chen
Summary: The study found that the B.1.1.7 variant has increased receptor binding affinity, while the B.1.351 variant has developed resistance to some neutralizing antibodies by reshaping antigenic surfaces on the spike protein.
Article
Virology
Cormac J. Lucas, Bennett J. Davenport, Kathryn S. Carpentier, Alex N. Tinega, Thomas E. Morrison
Summary: In this study, the researchers found that two highly conserved phenylalanine residues in the alphavirus E1 glycoprotein are critical for fusion of viral and host cell membranes and viral entry into target cells.
JOURNAL OF VIROLOGY
(2022)
Article
Pharmacology & Pharmacy
Petra Salamunova, Tereza Krejci, Pavel Rysanek, Ivan Salon, Jirina Kroupova, Anna Hubatova-Vackova, Jakub Petrik, Tomas Grus, Peter Lukac, Petr Kozlik, Tomas Krizek, Ondrej Dammer, Josef Beranek, Martin Sima, Ondrej Slanar, Frantisek Stepanek
Summary: In this study, the encapsulation of nilotinib into yeast glucan particles (GPs) was investigated as a strategy to improve its bioavailability. The amorphization of nilotinib in GPs led to an increased dissolution rate, as confirmed by in vitro experiments. Additionally, GPs containing nilotinib were effectively taken up by macrophages, as quantified in cell culture studies. Overall, GPs significantly improved the oral bioavailability of nilotinib, with a 10.8-fold increase in lymphatic absorption compared to the reference formulation and a cumulative uptake of 0.54 mg in the lymph after a single dose of 50 mg.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Polymer Science
Afroditi Kapourani, Alexandra-Eleftheria Manioudaki, Konstantinos N. Kontogiannopoulos, Panagiotis Barmpalexis
Summary: This study focuses on enhancing the solubility of Dronedarone (DRN) through the use of amorphous solid dispersions (ASDs). Soluplus (R) was identified as the most promising carrier, and DRN ASDs were successfully prepared using the melt-quench method. The prepared systems exhibited physical stability and sustained drug supersaturation.
Article
Developmental Biology
Qian-Qian Li, Zhan Zhang, Chao-Xing Zhang, Ya-Ling Wang, Chu-Bin Liu, Jia-Chen Wu, Mei-Ling Han, Qiu-Xia Wang, Dai-Yin Chao
Summary: Adventitious roots (ARs) exhibit high phenotypic plasticity in response to environmental stimuli. This study reveals that phytochrome-interacting factors (PIFs) play a central role in darkness-induced hypocotyl adventitious root (HAR) formation by inducing the expression of genes involved in auxin biosynthesis, auxin transport, and root primordium initiation.
Article
Virology
Philippe Gatault, Iris K. A. Jones, Christine Meyer, Craig Kreklywich, Timothy Alexander, Patricia P. Smith, Michael Denton, Josh Powell, Susan L. Orloff, Daniel N. Streblow
Summary: Herpesviruses encode multiple glycoproteins for various stages of viral processes; HCMV UL116 forms a stable complex with glyocoprotein H; RCMV R116 is involved in viral infectivity.
Article
Cell Biology
Judith Mary Reyes Ballista, Kerri L. Miazgowicz, Marissa D. Acciani, Ariana R. Jimenez, Ryan S. Belloli, Katherine E. Havranek, Melinda A. Brindley
Summary: Chikungunya virus (CHIKV) causes chikungunya fever and currently there are no licensed vaccines or antivirals available. Therefore, preventing viral attachment to host cells is a potential intervention strategy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hao Wang, Zixuan Yuan, Mahmud Arif Pavel, Sonia Mediouni Jablonski, Joseph Jablonski, Robert Hobson, Susana Valente, Chakravarthy B. Reddy, Scott B. Hansen
Summary: Increasing the localization of ACE2 near endocytic lipids enhances viral infectivity, shedding light on the selective severity of COVID-19 in aged and diseased populations.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Virology
Sara A. Thannickal, Sophie N. Spector, Kenneth A. Stapleford
Summary: Arthropod-borne viruses, including the La Crosse virus, pose a global public health threat. This study reveals that La Crosse virus uses a cholesterol-dependent entry mechanism similar to chikungunya virus and identifies specific amino acid residues in the Gc ij loop that are important for virus infectivity and replication. The findings contribute to understanding the mechanisms of La Crosse virus infection and provide potential targets for broad-spectrum antiviral drugs.
JOURNAL OF VIROLOGY
(2023)
Article
Materials Science, Multidisciplinary
Francisco Colmenero, Xingxing Jiang, Xiaodong Li, Yanchun Li, Zheshuai Lin
Summary: A recent study has discovered extremely large negative linear compressibilities in crystalline silver oxalate, confirming the presence of this phenomenon even under positive pressure. Experimental verification through high-pressure X-ray diffraction experiments and analysis of lattice parameters under pressure revealed the unique negative compressibility behavior of silver oxalate.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Chemistry, Inorganic & Nuclear
Liling Cao, Shengzi Zhang, Dan Zhao, Bingxuan Li, Tao Yan, Guangsai Yang, Zheshuai Lin, Min Luo, Ning Ye
Summary: Cd-3(IO3)(IO4)F-2·0.1CdO is a new transition-metal iodate fluoride with excellent properties, including a strong second-harmonic-generation response, large birefringence, and high power laser damage threshold.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Yingwei Lu, Xingxing Jiang, Chao Wu, Lin Lin, Zhipeng Huang, Zheshuai Lin, Mark G. Humphrey, Chi Zhang
Summary: This study synthesized rare-earth-metal sulfates NCSO and NBSO, which exhibit structural differences and performance disparities, with NBSO showing superior properties in SHG effect and band gap compared to NCSO, indicating its potential application in the short-wavelength region.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Mengran Sun, Xingyu Zhang, Wenhao Xing, Zhuang Li, Wenhao Liu, Zheshuai Lin, Wenlong Yin, Jiyong Yao
Summary: The discovery of two new chain tellurides with detailed crystal structures is reported, and first-principles calculations show that one of the materials has the potential to be used as an IR birefringent material. These findings may guide the exploration of new IR birefringent crystals.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Jingcheng Feng, Youquan Liu, Yanling Cheng, Feidi Fan, Jun Shen, Zheshuai Lin, Heng Tu, Guochun Zhang
Summary: A new praseodymium-based borate crystal, PCB, has been grown with similar second harmonic response intensity and intense orange fluorescence emission at 610 nm when excited by a xenon lamp light of 466 nm. The crystal structure consists of B5O12 groups and PrO10 and CaO8 polyhedra forming a three-dimensional framework. The band gap, partial density of states, and birefringence have been investigated through theoretical calculations.
INORGANIC CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Xianghe Meng, Pifu Gong, Chunlan Tang, Wenlong Yin, Zheshuai Lin, Mingjun Xia
Summary: In this study, a partial anion substitution strategy was used to develop NLO materials with remarkable properties while maintaining outstanding linear optical properties, using NaY(CO3)(2) and YOHCO3 crystals as examples.
ADVANCED OPTICAL MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Wenhao Xing, Chunlan Tang, Naizheng Wang, Chunxiao Li, Ece Uykur, Jieyun Wu, Zheshuai Lin, Jiyong Yao, Wenlong Yin, Bin Kang
Summary: A series of novel chalcohalides with excellent optical properties and water resistance have been synthesized, showcasing the effectiveness of using mixed-anion as building units in NLO materials for achieving a balance between strong SHG efficiency and large bandgap.
ADVANCED OPTICAL MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Qingchen Wu, Fei Liang, Lei Kang, Jian Wu, Zheshuai Lin
Summary: Two-dimensional van der Waals transition metal ternary chalcogenides (TMTCs) have unique advantages in nano-NLO modulation compared to 2D transition metal dichalcogenides (e.g., MoS2). The layered Cu2MoS4 exhibits a rare sliding-modulated second harmonic effect with high fluctuation and a stable response to large strains.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Chao Wu, Xingxing Jiang, Yilei Hu, Chunbo Jiang, Tianhui Wu, Zheshuai Lin, Zhipeng Huang, Mark G. Humphrey, Chi Zhang
Summary: This study reports the targeted synthesis of deep-UV non-linear optical material La(NH4)(SO4)(2) using a double-salt strategy. Optical studies show that this material exhibits a short-wavelength deep-UV absorption edge and the strongest SHG response among deep-UV NLO sulfates, attributed to the synergistic interaction of La3+ and [NH4]+.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Dandan Wang, Xiaoqing Jiang, Pifu Gong, Xinyuan Zhang, Zheshuai Lin, Zhanggui Hu, Yicheng Wu
Summary: A novel alkali metal gallium iodate, CGIO, was synthesized via traditional hydrothermal method, featuring a unique I3O93- fundamental building block and a wide bandgap of 4.05 eV. First-principles calculations revealed that the optical properties of CGIO are mainly determined by the iodate anion units.
Article
Chemistry, Inorganic & Nuclear
Chunlan Tang, Wenhao Xing, Naizheng Wang, Jian Tang, Zheshuai Lin, Jieyun Wu, Wenlong Yin, Bin Kang
Summary: Two new metal chalcohalides Cs2InPS4X2 (X = Cl, Br) with mixed-anion structure were successfully synthesized using the mixed-anion strategy, showing excellent optical and thermal stability and enriching the structural diversity of inorganic chalcohalides.
DALTON TRANSACTIONS
(2022)
Article
Materials Science, Multidisciplinary
Chunlan Tang, Wenhao Xing, Fei Liang, Mengran Sun, Jian Tang, Zheshuai Lin, Jiyong Yao, Kaixin Chen, Jieyun Wu, Wenlong Yin, Bin Kang
Summary: The study introduces a new strategy for constructing NCS structures using mixed alkali metals, resulting in the successful synthesis of (Na3Rb)Hg2Ge2S8. The material exhibits strong second harmonic generation response at 2090 nm, wide band gap, and low melting point.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Materials Science, Multidisciplinary
Zhen Qian, Qiang Bian, Hongping Wu, Hongwei Yu, Zheshuai Lin, Zhanggui Hu, Jiyang Wang, Yicheng Wu
Summary: Rationally designing new inorganic materials with specific functional properties is a fascinating challenge, especially in the case of nonlinear optical (NLO) crystals. The discovery and synthesis of high-performance IR NLO crystal beta-BaGa4Se7 through structural rearrangement optimization opens up new possibilities for the rational design of IR NLO crystals. The material exhibits excellent NLO properties and stable physicochemical properties, making it a promising candidate for various applications.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)
Article
Chemistry, Physical
Jindong Chen, Xiaotian Jiang, Qingchen Wu, Zheshuai Lin, Min Luo, Ning Ye
Summary: This review summarizes the achievements in infrared nonlinear optical (IR NLO) pnictide crystals, including their crystal structures, key NLO indexes, and the structure-property correlations. The existing issues and prospective development of NLO pnictides are also discussed.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Chemistry, Physical
Wenhao Liu, Xiaomeng Liu, Xianghe Meng, Chunxiao Li, Mengran Sun, Zheshuai Lin, Jiyong Yao
Summary: The spontaneous crystallization method was used to synthesize two non-centrosymmetric scandium borate crystal materials with wide band gaps and good second harmonic generation (SHG) effects. First-principles calculations revealed that the arrangement of [B5O10](5-) groups and the distortion of ScO6 polyhedra were responsible for the SHG response. The materials may have potential applications in UV nonlinear optical devices.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)