Article
Oncology
Vishnu Mohan, Jean P. Gaffney, Inna Solomonov, Maxim Levin, Mordehay Klepfish, Sophia Akbareian, Barbara Grunwald, Orly Dym, Miriam Eisenstein, Kenneth H. Yu, David P. Kelsen, Achim Kruger, Dylan R. Edwards, Irit Sagi
Summary: The study successfully developed a monoclonal antibody GSM-192 targeting matrix metalloproteinase 7, which induced pancreatic cancer cell apoptosis, reduced migration, and increased sensitivity to chemotherapy.
Article
Chemistry, Multidisciplinary
Dingkang Liu, Lichen Bao, Haichao Zhu, Yali Yue, Jing Tian, Xiangdong Gao, Jun Yin
Summary: This study developed a Protease-Activated PSTAGylated BiTE called PAPB, which showed long-acting and highly effective anti-tumor activity in solid tumors. PAPB could release BiTE core to exert its therapeutic effect, and significantly increase T lymphocyte infiltration in tumor tissue. This engineered protein has potential as a promising drug candidate for solid tumor immunotherapy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Biochemistry & Molecular Biology
Sang Yeol Lee
Summary: Matrix metalloproteinases (MMPs) play crucial roles in cancer metastasis and chronic inflammatory diseases, while ginsenosides have therapeutic potentials. Ginsenosides exhibit anti-metastatic and anti-inflammatory activities by suppressing MMPs through regulation of various signaling pathways.
Article
Oncology
Yoshikazu Nagase, Kosuke Hiramatsu, Masashi Funauchi, Mayu Shiomi, Tatsuo Masuda, Mamoru Kakuda, Satoshi Nakagawa, Ai Miyoshi, Shinya Matsuzaki, Eiji Kobayashi, Toshihiro Kimura, Satoshi Serada, Yutaka Ueda, Tetsuji Naka, Tadashi Kimura
Summary: This study found that lipolysis-stimulated lipoprotein receptor (LSR) contributes to tumor growth, invasion, metastasis, and poor prognosis of endometrial cancer (EC) through MAPK signaling. The anti-LSR monoclonal antibody (mAb) developed in this study showed potential as a therapeutic agent for EC.
Review
Chemistry, Medicinal
Sandip Kumar Baidya, Sk Abdul Amin, Tarun Jha
Summary: Matrix metalloproteinases (MMPs) play roles in various pathological and physiological functions, with gelatinases as therapeutic targets against cancer. Although gelatinase inhibitors have shown effectiveness in several diseases, developing them as therapeutic agents is a challenging task. Various studies and patents have been ongoing to expand knowledge and develop better gelatinase inhibitors in recent years.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Chuandong Cai, Wei Wang, Jing Liang, Yuange Li, Mingkuan Lu, Wenguo Cui, Cunyi Fan, Lianfu Deng, Yusheng Li, Fei Wang, Shen Liu
Summary: In this study, an innovative composite anti-adhesion patch was designed for on-demand and unidirectional delivery of polyplexes to inhibit fibroblasts proliferation and collagen deposition by silencing the fibrosis gene TGF-beta 1. The patch showed MMP-2-responsive and unidirectional release behaviors, resulting in effective gene silencing effects and inhibition of fibroblasts proliferation. Overall, the composite bilayer patch presents a promising approach for peritendinous anti-adhesion with targeted drug delivery.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Vibha Rani, Dhananjay Yadav, Neha Atale
Summary: This review discusses the recent research on MMP inhibitors for preventing tumor progression. While MMPIs have shown success in in vitro and some in vivo studies, their efficacy in clinical trials has been inconsistent. Novel delivery approaches of MMP inhibitors may enhance their therapeutic effects towards cancer prevention.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Chemistry, Medicinal
Xianzhang Wang, Yumeng Zhuang, Yuankun Wang, Maokai Jiang, Lei Yao
Summary: This review article summarizes the structural modifications made on camptothecin (CPT), a potent cytotoxic natural alkaloid. The aim of these modifications is to enhance the therapeutic potential of CPT derivatives by improving their efficacy, selectivity, and pharmacokinetic properties. The article reviews the advancements in hybridizing CPT with other bioactive compounds, synthesizing novel CPT analogs, and exploring the structure-activity relationship (SAR) of these modified derivatives.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Jina Ryu, Eun-Jung Kim, Joo-Kyung Kim, Tai Hyun Park, Byung-Gee Kim, Hee-Jin Jeong
Summary: A stable CHO cell line was established for the production of antibodies against hMMP9. Recombinant anti-hMMP9 antibody fragments were successfully expressed in CHO cells, resulting in a full-sized antibody with high purity and sensitivity. The developed antibody showed efficient antigen-binding capability, suggesting its potential for medical and industrial applications.
Article
Materials Science, Multidisciplinary
Wanda Celentano, Marco Pizzocri, Filippo Moncalvo, Federico Pessina, Michela Matteoli, Francesco Cellesi, Lorena Passoni
Summary: Doxorubicin-loaded polymer nanoparticles based on poly(ethylene glycol)-poly(epsilon-caprolactone) copolymers with complex macromolecular topology were developed for targeting the tumor microenvironment rich in matrix metalloproteinase (MMP). Different copolymers with varied structures were synthesized to control the size and DOX loading of self-assembled nanoparticles. The optimized nanocarriers were conjugated with MMP2-cleavable polyanionic inhibitory domain peptides. The results showed that these nanocarriers exhibited excellent cellular uptake and cytotoxicity in MMP2-overexpressing tumor cells.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Medicinal
Mathilde Fourniere, Gilles Bedoux, Nicolas Lebonvallet, Raphael Leschiera, Claudie Le Goff-Pain, Nathalie Bourgougnon, Thomas Latire
Summary: This study investigated the regulation of ECM by poly- and oligosaccharide fractions from Ulva sp. on human dermal fibroblasts, showing an enhancement in cell proliferation and synthesis of key ECM components without cytotoxic effects. The findings suggest the potential use of Ulva sp. fractions in skin renewal and anti-aging dermo-cosmetic applications.
Article
Biotechnology & Applied Microbiology
Mingtao Ao, Fei Yu, Yixiang Li, Mengya Zhong, Yonghe Tang, Hua Yang, Xiaojing Wu, Yifan Zhuang, Huiyun Wang, Xiaolian Sun, Xuehui Hong, Xiao Dong Chen
Summary: A novel activatable amphiphilic small molecular prodrug IR820-SS-CPT has been developed in this study, which integrated multiple advantages of GSH-triggered drug release, high therapeutic agent content, and combined chemo-photothermal therapy into one drug delivery system. The IR820-SS-CPT NPs displayed extremely high therapeutic agent loading efficiency (approaching 100%) and exhibited remarkable tumor cell killing efficiency both in vitro and in vivo.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Cell Biology
Jingya Guo, Yong Liang, Diyuan Xue, Jiao Shen, Yueqi Cai, Jiankun Zhu, Yang-Xin Fu, Hua Peng
Summary: A next-generation IL-15 cytokine has been developed in this study, which can be activated inside the tumor microenvironment without causing systemic toxicity by avoiding peripheral expansion of NK and T cells. The anti-tumor effect of pro-IL-15 depends on intratumoral CD8(+) T cells and IFN-gamma, and it helps overcome immune checkpoint blockade resistance and synergizes with current targeted-therapy. This novel IL-15 cytokine shows potent anti-tumor activity while minimizing severe toxicity.
Article
Chemistry, Multidisciplinary
Wenhui Zeng, Luyan Wu, Yidan Sun, Yuqi Wang, Jinfang Wang, Deju Ye
Summary: The study developed a ratiometric fluorescent probe (SPN-MMP-RGD) by integrating Cy5.5 and PCPDTBT, enabling sensitive detection of MMP-2 activity and noninvasive imaging of tumor cells.
Article
Biochemistry & Molecular Biology
Yang Liu, Fei Wang, Zhe Li, Yanling Mu, Voon Wee Yong, Mengzhou Xue
Summary: This study found that chlorogenic acid (CGA) can provide neuroprotection in intracerebral hemorrhage (ICH) by inhibiting the expression of EMMPRIN and MMP-2/9, alleviating neuroinflammation, blood-brain barrier disruption, cell death, and brain injury.