Article
Chemistry, Multidisciplinary
Seung Hun Park, Richard S. Kim, Wesley R. Stiles, Minjoo Jo, Lingxue Zeng, Sunghoon Rho, Yoonji Baek, Jonghan Kim, Moon Suk Kim, Homan Kang, Hak Soo Choi
Summary: Deferoxamine (DFO) is an FDA-approved iron-chelating agent with good therapeutic efficacy, but its short blood half-life poses challenges for patients who require frequent administrations. By integrating crosslinked hyaluronic acid and Pluronic F127 into an injectable hydrogel formulation, a prolonged release of DFO nanochelators is achieved, significantly extending the half-life and demonstrating potential for the treatment of iron overload disorders.
Article
Engineering, Biomedical
Sijie Wu, Gaodan Liu, Ping Shao, Xingyu Lin, Jiahao Yu, Hanchi Chen, Huiliang Li, Simin Feng
Summary: This study developed a carboxymethyl-modified chitosan/hyaluronic acid thermosensitive hydrogel for sustained transdermal delivery of liposomes. The hydrogel exhibited suitable gel properties and structure, resulting in delayed liposomes release and improved skin retention. The liposome-hydrogel system more efficiently promoted the effects of anti-aging agents on the skin.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Haoran Cheng, Haishan Wu, Ting Guo, Hyun Jin Park, Jinglei Li
Summary: A zinc insulin hexamer-loaded alginate hydrogel was prepared and characterized for oral insulin administration. The hydrogel showed controlled release of insulin in simulated gastric and intestinal fluids, with no cytotoxicity observed. In diabetic mice, the hydrogel demonstrated significant and prolonged hypoglycemic effect.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Robin Vinck, Laetitia Anvi Nguyen, Mathilde Munier, Lucie Caramelle, Diana Karpman, Julien Barbier, Alain Pruvost, Jean-Christophe Cintrat, Daniel Gillet
Summary: Retro-2.1, an inhibitor of retrograde transport, has shown promising broad-spectrum activity against intracellular pathogens. Researchers have developed formulations using nanoparticles and biocompatible polymers to improve its pharmacokinetic properties and metabolism, providing guidance for further efficacy studies of this potential drug.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Aline Yen Ling Wang, Kuan-Hung Chen, Hsiu-Chao Lin, Charles Yuen Yung Loh, Yun-Ching Chang, Ana Elena Avina, Chin-Ming Lee, I-Ming Chu, Fu-Chan Wei
Summary: Vascularized composite allotransplantation is a strategy for reconstructing unique defects like amputated limbs. To ensure the function of transplanted limbs, the recovery of the anastomosed nerves is crucial. Tacrolimus has been shown to promote nerve recovery but has risks of systemic complications. A mixed thermosensitive hydrogel was developed for sustained release of tacrolimus, which improved functional recovery of injured nerves without adverse effects.
Article
Engineering, Biomedical
Jun You Li, Yun Hao Feng, Yu Ting He, Liu Fu Hu, Ling Liang, Ze Qiang Zhao, Bo Zhi Chen, Xin Dong Guo
Summary: In this study, a physical entanglement crosslinked hydrogel microneedles (MNs) patch was fabricated using gelatin grafted with carboxylic end-capped PNIPAm. The MNs patch demonstrated the ability to control drug release after application on the skin. Additionally, a rapidly separating MNs system (RS-GP-MNs) was developed by mounting the gelatin-g-PNIPAm (GP) MNs patch onto solid MNs, enabling efficient drug delivery into the skin and controlled drug release.
ACTA BIOMATERIALIA
(2022)
Article
Multidisciplinary Sciences
Han Jo Jeon, Hyuk Soon Choi, Eun Ju Bang, Kang Won Lee, Sang Hyun Kim, Jae Min Lee, Eun Sun Kim, Bora Keum, Yoon Tae Jeen, Hong Sik Lee, Hoon Jai Chun, Seung Jeong, Jong Hyuk Kim
Summary: This study investigated the efficacy and safety of thermo-sensitive chitosan hydrogels for endoscopic submucosal dissections (ESD). Different fluids were compared during the ESD procedures, showing significant differences in fluid power and consumption rate between chitosan hydrogel and normal saline, with a similar efficacy to hyaluronic acid. Further evaluation of long-term histological changes is needed before clinical implementation.
Article
Polymer Science
Chengjun Peng, Guichun Wang, Yuxiao Wang, Maomao Tang, Xiaodong Ma, Xiangwei Chang, Jian Guo, Shuangying Gui
Summary: This study develops a novel thermosensitive hydrogel delivery system to improve the therapeutic potential of natural active ingredients for periodontitis therapy.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Review
Biochemistry & Molecular Biology
Ilker S. Bayer
Summary: Polymer nanofibers have high surface area for efficient transport, while hydrogels combine flexibility and customizable transport properties. Combining nanofibers with hydrogels advances biomedical applications, especially in sustained drug delivery. Nanofiber hydrogels can maintain drug release rates for days to months and are crucial for 3D or 4D printable systems.
Article
Chemistry, Multidisciplinary
Ari-Pekka Forsback, Panu Noppari, Jesse Viljanen, Jari Mikkola, Mika Jokinen, Lasse Leino, Simon Bjerregaard, Camilla Borglin, Janet Halliday
Summary: The study encapsulated triptorelin acetate into silica microparticles and combined them with silica nanoparticles to form an injectable silica-triptorelin acetate depot. In vivo pharmacokinetics showed that the depot had lower Cmax values compared to Pamorelin(R) injections, but had sustained drug release and comparable pharmacodynamic effects. Plasma concentrations of triptorelin remained detectable in the depot even after 91 days, while testosterone levels stayed below the human castration limit for the same period.
Article
Materials Science, Biomaterials
Pavel Yanev, Geralda A. F. van Tilborg, Kristel W. M. Boere, Ann M. Stowe, Annette van der Toorn, Max A. Viergever, Wim E. Hennink, Tina Vermonden, Rick M. Dijkhuizen
Summary: Researchers have developed a noninvasive MRI method to monitor the release of proteins from hydrogels in vitro and in vivo. The study showed that the release of proteins and the volume expansion of hydrogels differed significantly between in vitro and in vivo experiments, with higher concentration hydrogels releasing more protein and expanding more in size in vivo. This study provides insights for the development and optimization of drug delivery systems for brain disorders.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Biotechnology & Applied Microbiology
Biyun Lan, Liming Zhang, Liqun Yang, Junfeng Wu, Na Li, Chenglin Pan, Xiaoyi Wang, Lexiang Zeng, Li Yan, Chuan Yang, Meng Ren
Summary: The hybrid hydrogel dressing developed for localized delivery of MMP-9 siRNA showed significant reduction in MMP-9 expression and improved diabetic wound closure in diabetic rats. The dressing exhibited negligible cytotoxicity in vitro and sustained release of siMMP-9 for up to 7 days. This delivery system offers a platform for in vivo delivery of siRNA for the treatment of various diseases.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ana V. Torres-Figueroa, Cinthia J. Perez-Martinez, J. Carmelo Encinas, Silvia Burruel-Ibarra, Maria I. Silvas-Garcia, Alejandro M. Garcia Alegria, Teresa del Castillo-Castro
Summary: The development of thermosensitive bioadhesive hydrogels for the controlled delivery of microbicides is valuable for in situ treatment of vaginal infections. In this study, novel semi-interpenetrating network (s-IPN) hydrogels were prepared by entrapping linear poly(methyl vinyl ether-alt-maleic anhydride) (PVME-MA) chains within crosslinked 3D structures of poly(N-isopropylacrylamide) (PNIPAAm). The hydrogels exhibited promising performance for the controlled release of metronidazole in the vaginal environment.
Article
Polymer Science
Rahil Salehi, Bahman Ebrahimi-Hosseinzadeh, Ashrafalsadat Hatamian-Zarmi, Razi Sahraeian, Hale Alvandi, Zahra Beagom Mokhtari-Hosseini, Elham Ansari
Summary: This study developed a novel temperature-sensitive gel loaded with curcumin and thiolated chitosan nanoparticles for vaginal applications. The results showed that the nanoparticle-loaded gel released the drug slowly, had high gel elasticity, and longer residence time. Furthermore, the thermosensitive PF127-CRC-TCNPs may also be used as a carrier for cervical cancer prevention.
IRANIAN POLYMER JOURNAL
(2022)
Article
Chemistry, Medicinal
Michael Flanagan, Qi Gan, Saahil Sheth, Rachel Schafer, Samuel Ruesing, Linda E. Winter, Karoly Toth, Silviya P. Zustiak, Adriana M. Montano
Summary: Morquio A disease is a genetic disorder caused by GALNS deficiency, and patients are treated with enzyme replacement therapy. This study explored PEG hydrogels as a drug delivery system for sustained release of rhGALNS. The optimized hydrogel formulation achieved sustained release of active rhGALNS for up to 28 days in vitro and up to 20 days in vivo, suggesting that PEG hydrogels could be a promising method for improving patient quality of life.
Article
Polymer Science
Qian Ma, Kewen Lei, Jian Ding, Lin Yu, Jiandong Ding
Review
Immunology
Yugang Guo, Kewen Lei, Li Tang
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Nanoscience & Nanotechnology
Jiabin Luan, Zheng Zhang, Wenjia Shen, Yipei Chen, Xiaowei Yang, Xiaobin Chen, Lin Yu, Jian Sun, Jiandong Ding
ACS APPLIED MATERIALS & INTERFACES
(2018)
Article
Materials Science, Biomaterials
Hantao Yang, Kewen Lei, Feng Zhou, Xiaowei Yang, Qingzhu An, Wei Zhu, Lin Yu, Jiandong Ding
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Review
Chemistry, Multidisciplinary
Kewen Lei, Armand Kurum, Li Tang
ACCOUNTS OF CHEMICAL RESEARCH
(2020)
Article
Engineering, Biomedical
Kewen Lei, Armand Kurum, Murat Kaynak, Lucia Bonati, Yulong Han, Veronika Cencen, Min Gao, Yu-Qing Xie, Yugang Guo, Melanie T. M. Hannebelle, Yangping Wu, Guanyu Zhou, Ming Guo, Georg E. Fantner, Mahmut Selman Sakar, Li Tang
Summary: The study demonstrates that cancer cells enriched in cholesterol inhibit T-cell-mediated cytotoxicity, while stiffening cancer cells through cholesterol depletion enhances T-cell cytotoxicity, thereby improving the efficacy of adoptive T-cell therapy. This enhancement is attributed to increased T-cell forces at the immunological synapse, rather than influencing other T-cell functions like receptor signaling or production of cytolytic proteins. These findings suggest a mechanical immune checkpoint that could be targeted for improving cancer immunotherapies.
NATURE BIOMEDICAL ENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Shaohua Zhang, Wei Li, Jiabin Luan, Abhinav Srivastava, Vincenzo Carnevale, Michael L. Klein, Jiawei Sun, Danni Wang, Serena P. Teora, Sjoerd J. Rijpkema, Johannes D. Meeldijk, Daniela A. Wilson
Summary: Researchers report an adaptive non-covalent binding strategy for surface functionalization using a hydrophobic anchor to insert into a poly(ethylene glycol) (PEG) host. This strategy allows for spontaneous loading of hydrophilic charged and non-charged functional modules onto the PEG surface without the need for catalysts or binding groups. The reversible insertion of the hydrophobic anchor enables programmable surface functionalization, challenging the current understanding of PEG in hydrophilicity and potentially advancing nanomedicine, advanced materials, and nanotechnology.
Article
Multidisciplinary Sciences
Jiawei Sun, Sandra Kleuskens, Jiabin Luan, Danni Wang, Shaohua Zhang, Wei Li, Gizem Uysal, Daniela A. Wilson
Summary: The authors demonstrate control over the local curvature formation in polymeric vesicles by adding salt ions and stimuli responsive polymers to modulate its interaction with the polymeric membrane. The enhanced membrane stability and chemical versatility of polymeric vesicles make them promising for various applications such as micro/nanoreactors, drug delivery, and cell mimicking.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Jiabin Luan, Danni Wang, Shaohua Zhang, Yusuke Miyazaki, Wataru Shinoda, Daniela A. Wilson
Summary: The field of supramolecular chemistry has made significant progress in accessing traditionally inaccessible structures and functions by bringing the system away from equilibrium. However, vesicular assemblies with complex energy landscapes and pathways resembling cellular vesicles are still rare. This study demonstrates the activation of oligo(ethylene glycol) interdigitation in Janus dendrimers, revealing a rich vesicular landscape and pathway selection. The findings suggest that synthetic vesicles with activated OEG corona conformation emulate dynamic cellular vesicles and hold potential for nanomedicine and advanced materials.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Jiabin Luan, Peter F. Kuijken, Wen Chen, Danni Wang, Levy A. Charleston, Daniela A. Wilson
Summary: Biodegradable streamlined alginate hydrogel micromotors with a teardrop shape are fabricated by microfluidics, enabling high-throughput production and precise variation in size. By tuning the localization regions of catalysts, the micromotors exhibit improved propulsion efficiency and achieve distinct motion patterns.
Article
Chemistry, Multidisciplinary
Kewen Lei, Li Tang
MATERIALS HORIZONS
(2020)
Review
Chemistry, Multidisciplinary
Jiabin Luan, Danni Wang, Daniela A. Wilson
Review
Materials Science, Biomaterials
Kewen Lei, Li Tang
BIOMATERIALS SCIENCE
(2019)
Article
Nanoscience & Nanotechnology
Wenjia Shen, Xiaobin Chen, Jiabin Luan, Danni Wang, Lin Yu, Jiandong Ding
ACS APPLIED MATERIALS & INTERFACES
(2017)
Article
Engineering, Biomedical
Kewen Lei, Yipei Chen, Jinyao Wang, Xiaochun Peng, Lin Yu, Jiandong Ding
ACTA BIOMATERIALIA
(2017)