期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 1, 页码 47-53出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b13844
关键词
antifouling; manganese oxide nanoparticles; L-cysteine; blood circulation time; tumor magnetic resonance imaging
资金
- National Natural Science Foundation of China [21273032, 81501518, 81371623]
- Science and Technology Commission of Shanghai Municipality [15520711400]
- Sino-German Center for Research Promotion [GZ899]
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
Antifouling manganese oxide (Mn3O4) nanoparticles (NPs) were synthesized by Solvothermal decomposition of tris(2,4-pentanedionato) manganese(III), in the presence of trisodium citrate, followed by surface modification with polyethylene glycol and L-cysteine. The as-prepared nanoparticles have a uniform size distribution, good colloidal stability and good cytocompatibility. The modification of L-cysteine rendered the particles with much longer blood circulation time (half-decay time of 28.4 h) than those without L-cysteine modification (18,5 h), and decreased Macrophage cellular uptake. Thanks to desirable antifouling property and relatively high r(1) relaxivity (3.66 mM(-1) s(-1)), the L-cysteine-modified Mn3O4 NPs can be used for enhanced tumor magnetic resonance imaging applications.
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