期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 4, 页码 1457-1462出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b12552
关键词
-
资金
- NIH [R01 GM113105]
- JSPS
We report a general protocol for the light-driven isomerization of cyclic aliphatic alcohols to linear carbonyl compounds. These reactions proceed via proton-coupled electron-transfer activation of alcohol O-H bonds followed by subsequent C-C beta-scission of the resulting alkoxy radical intermediates. In many cases, these redox-neutral isomerizations proceed in opposition to a significant energetic gradient, yielding products that are less thermodynamically stable than the starting materials. A mechanism is presented to rationalize this out-of-equilibrium behavior that may serve as a model for the design of other contrathermodynamic transformations driven by excited-state redox events.
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