Article
Biophysics
Monica Notarbartolo, Marina Massaro, Raquel de Melo Barbosa, Carlotta Emili, Leonarda Francesca Liotta, Paola Poma, Francisco M. Raymo, Rita Sanchez-Espejo, Riccardo Vago, Cesar Viseras-Iborra, Serena Riela
Summary: In recent years, there has been an increasing use of clay minerals in the pharmaceutical field. This study investigates the cellular uptake mechanisms of hectorite (Ht), a clay mineral with potential applications as a drug carrier. The study also explores the concept of covalently grafting the anticancer molecule methotrexate (MTX) onto Ht to form a nanomaterial. The results demonstrate the potential of Ht as a promising material for anticancer therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Multidisciplinary Sciences
Patrick M. Perrigue, Agata Henschke, Bartosz F. Grzeskowiak, Lucja Przysiecka, Kaja Jaskot, Angelika Mielcarek, Emerson Coy, Sergio E. Moya
Summary: Understanding the interaction between nanoparticles and cells is crucial for designing more effective nanomedicines. This study investigates the biological fate of silica nanoparticles in senescent cells, which do not divide, using various methods including microscopy and flow cytometry. The results show that the nanoparticles readily enter the senescent cells and accumulate in the cytoplasm for a long time. This study lays the foundation for the development of NP-based tools for detecting and targeting senescent cells for therapeutic purposes.
SCIENTIFIC REPORTS
(2023)
Review
Chemistry, Multidisciplinary
Ankit Kumar, Hiroaki Sasai, Shinobu Takizawa
Summary: In this article, the use of vanadium catalyst in coupling reactions for the synthesis of chiral molecules is summarized. Various chiral compounds, such as biarenol derivatives and polycyclic biphenols, can be synthesized using vanadium catalysts. These catalysts exhibit high activity and stereoselectivity, tolerate various functional groups, and avoid overoxidation of coupling products.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Ivana R. Scolari, Ximena Volpini, Maria L. Fanani, Benjamin De La Cruz-Thea, Lautaro Natali, Melina M. Musri, Gladys E. Granero
Summary: The study demonstrated that the designed RIF/ASC NPs have favorable lung biocompatibility and even distribution in lung lobules. Moreover, these nanoparticles are primarily uptaken by lung macrophages, showing promising prospects for treating intracellular lung infections.
MOLECULAR PHARMACEUTICS
(2021)
Review
Chemistry, Multidisciplinary
Ankit Kumar, Hiroaki Sasai, Shinobu Takizawa
Summary: This paper summarizes the applications of vanadium-catalyzed coupling reactions in the synthesis of chiral compounds and their mechanisms.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Article
Chemistry, Physical
Digdem Erdener, Gokhan Dervisoglu, Fethi Ahmet Ozdemir, Zafer Serbetci, Namik Ozdemir, Osman Dayan
Summary: A new dimeric Ru(II) complex, C1, was synthesized by reacting hydrazine hydrate with [RuCl2(p-cymene)]2 dimer in dichloromethane. The C1 complex was structurally characterized using various techniques and theoretically analyzed using DFT techniques. Furthermore, the electrochemical and optical properties of the C1 complex were investigated, and it exhibited significant antibacterial activity and cell cytotoxicity against various cell lines.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Ke Chen, Hongdan Zhu, Shuang Liu, Jiahui Bai, Yinlong Guo, Kuiling Ding, Qian Peng, Xiaoming Wang
Summary: This study demonstrates the use of binuclear metal complexes as catalysts to switch the selectivity of 1,3-dienes from 4,3-regioselectivity to 1,4-hydroarylation with Z-stereoselectivity. The findings highlight the potential of binuclear catalysis in achieving new isomers that were previously inaccessible.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Tiago P. Camargo, Jose A. F. Oliveira, Thiago G. Costa, Bruno Szpoganicz, Adailton J. Bortoluzzi, Ivana M. Marzano, Priscila P. Silva-Caldeira, Monica Bucciarelli-Rodriguez, Elene C. Pereira-Maia, Eduardo E. Castellano, Rosely A. Peralta, Ademir Neves
Summary: In this study, two novel Al-III-Zn and Al-III-Cu complexes were synthesized and characterized, showing good antimicrobial activity against bacterial strains. These complexes also exhibited cytotoxicity against chronic myelogenous leukemia cells, suggesting potential anti-tumor activity.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Giovanni Tabbi, Lorena Maria Cucci, Calogero Pinzino, Alessia Munzone, Tiziano Marzo, Silvia Pizzanelli, Cristina Satriano, Antonio Magri, Diego La Mendola
Summary: The study characterized copper complex species formed with peptide fragments derived from the N-terminal domain of the angiogenin protein. The amino group was identified as the main copper anchoring site for Ang1-17, with different coordination environments affecting the peptides' activity. Additionally, different protein isoforms showed varying effects on cellular copper uptake.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Anzhela Malysheva, Angela Ivask, Casey L. Doolette, Nicolas H. Voelcker, Enzo Lombi
Summary: The study demonstrates the presence of silver nanoparticles in nanoparticulate form after being taken up by human lymphocytes. Biotransformation of AgNPs is primarily dominated by sulfidation, serving as a detoxification pathway for cells. Toxicity of AgNPs is mainly driven by internalized silver, with differences in toxicity between nanoparticles of different coatings and sizes being minimized when expressed as intracellular mass of silver per cell.
NATURE NANOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Merten Grupe, Pit Boden, Patrick Di Martino-Fumo, Xin Gui, Cecilia Bruschi, Roumany Israil, Marcel Schmitt, Martin Nieger, Markus Gerhards, Wim Klopper, Christoph Riehn, Claudia Bizzarri, Rolf Diller
Summary: Chemical and spectroscopic characterization of mononuclear and dinuclear photosensitizers sheds light on the complex influence of charge, nuclearity, and structural flexibility on UV-induced photophysical pathways. Experimental results from transient absorption and luminescence spectroscopy confirm the lifetime of triplet states and energetics of thermally activated delayed luminescence, essential parameters for the application of these materials in photocatalysis and luminescent devices.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Jesica Paola Rada, Jeremy Forte, Geoffrey Gontard, Claude-Marie Bachelet, Nicolas A. Rey, Michele Salmain, Vincent Corce
Summary: Two novel unsymmetrical binucleating aroylhydrazonic ligands and four dicopper(II) complexes carrying fluorescent benzopyranothiophene (BPT) or boron dipyrromethene (BODIPY) entities were synthesized and characterized. The compounds exhibited moderate to high cytotoxicity towards the triple negative human breast cancer cell line MDA-MB-231, with BPT derivatives showing the highest cytotoxicity. Fluorescence microscopy imaging studies suggested that the BODIPY-carrying ligand was highly cell permeant and preferentially accumulated in the mitochondria.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Salah S. Massoud, Febee R. Louka, Nahed M. H. Salem, Roland C. Fischer, Ana Torvisco, Franz A. Mautner, Jan Vanco, Jan Belza, Zdenek Dvorak, Zdenek Travnicek
Summary: In this study, six copper complexes were synthesized and characterized. The complexes exhibited significant antiproliferative activity against human cancer cells, with the sixth complex showing the highest cytotoxicity compared to the reference drug cisplatin. Complex seven was able to induce apoptosis in A2780 cells, while complexes four and six showed considerable induction of autophagy and a potential cuproptosis effect.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yoshimasa Wada, Takahiro Maruchi, Reon Ishii, Yusuke Sunada
Summary: This study demonstrates for the first time a dinuclear Zn(II) complex that exhibits visible light absorption, revealing that intermetallic orbital interaction is the key factor in producing color. This research challenges the notion that zinc is unresponsive to visible light and expands the field of photophysical studies in zinc chemistry.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Aleksandra M. Bondzic, Jelena J. Zakula, Lela B. Koricanac, Otilija D. Keta, Goran Janjic, Ivana S. Dordevic, Snezana U. Rajkovic
Summary: The stability, lipophilicity, in vitro cytotoxicity, and influence on acetylcholinesterase of five dinuclear platinum(II) complexes were evaluated. Some of the complexes showed promising anticancer activity and selectivity, with minimal effects on normal cells. Docking studies provided insights into the binding modes with acetylcholinesterase.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Parasitology
John Jacob, Ghee Tan, Ingo Lange, Hiwa Saeed, Abhijit Date, Susan Jarvi
Summary: This study quantified the in vitro efficacy of nine clinically established anthelmintics on Angiostrongylus cantonensis larvae, with some drugs showing significant effects on larval death and motility. Further in vivo studies are needed to determine the optimal dose and treatment time frame post-infection.
Article
Chemistry, Multidisciplinary
Hiwa K. Saeed, Yogesh Sutar, Pratikkumar Patel, Roopal Bhat, Sudipta Mallick, Alyssa E. Hatada, Dana-Lynn T. Koomoa, Ingo Lange, Abhijit A. Date
Summary: The study reported the synthesis and characterization of several lipophilic metformin salts containing anionic permeation enhancers. Results showed that metformin docusate exhibited significantly improved anticancer potency compared to other metformin salts.
Article
Chemistry, Multidisciplinary
Matthew D. Newton, Simon D. Fairbanks, Jim A. Thomas, David S. Rueda
Summary: The study demonstrates that the dinuclear ruthenium(II) complex can thread and lock into force-extended DNA in a two-step mechanism, with one stereoisomer showing the highest binding affinity reported. Interestingly, the complex behaves differently on torsionally constrained DNA and negatively supercoiled DNA, making it a potential long-lived luminescent label for biological applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Fabian Droge, Felicity F. Noakes, Stuart A. Archer, Sreejesh Sreedharan, Ahtasham Raza, Craig C. Robertson, Sheila MacNeil, John W. Haycock, Heather Carson, Anthony J. H. M. Meijer, Carl G. W. Smythe, Jorge Bernardino de la Serna, Benjamin Dietzek-Ivansic, Jim A. Thomas
Summary: By combining resonance Raman and time-resolved absorption spectroscopy, as well as computational studies, the excited state dynamics of the new complex were analyzed. It was found that the near-infrared (NIR) emission (λmax = 780 nm) of the complex is attributed to a low-lying Os -> TAP based (MCLT)-M-3 state, despite the existence of several closely lying excited states. The complex, while highly photostable and live-cell permeant, is not cytotoxic or photocytotoxic, making it an ideal probe for optical microscopy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Martin R. Gill, Paul J. Jarman, Vanessa Hearnden, Simon D. Fairbanks, Marcella Bassetto, John Palmer, Kathryn R. Ayscough, Jim A. Thomas, Carl Smythe
Summary: RuRuPhen blocks the transformation of G-actin monomers to F-actin filaments and disrupts the organization of actin stress fibers in cells. It interferes with actomyosin contractility, cell motility, and late-stage cytokinesis. RuRuPhen also interferes with the recruitment of endosomal sorting complexes required for transport (ESCRT) complex, leading to cytokinetic abscission failure.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Kirsty Smitten, Hannah M. Southam, Simon Fairbanks, Arthur Graf, Adrien Chauvet, Jim A. Thomas
Summary: The therapeutic action of luminescent dinuclear ruthenium(II) complexes based on the tetrapyridylphenazine, tpphz, bridging ligand on pathogenic strains of Escherichia coli and Enterococcus faecalis has been described previously. In this study, the antimicrobial activity of the complex against pernicious Gram-negative ESKAPE pathogenic strains of Acinetobacter baumannii and Pseudomonas aeruginosa is reported. The compound showed potent activity against A. baumannii and moderately high potency against carbapenem-resistant strains of P. aeruginosa.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Hiwa K. Saeed, Paul J. Jarman, Sreejesh Sreedharan, Rachel Mowll, Alexander J. Auty, Adrien A. P. Chauvet, Carl G. W. Smythe, Jorge Bernardino de la Serna, Jim A. Thomas
Summary: The synthesis of a new heterodinuclear metallointercalator containing Ru-II(dppz) and Re-I(dppn) moieties is reported. Cell-free studies show that the complex has similar photophysical properties and DNA binding affinity as its homoleptic M(dppz) analogue. However, it exhibits different in-cell properties, accumulating preferentially in mitochondria and displaying phototoxicity. These observations demonstrate the impact of small structural changes on the mechanism of action of metal-based therapeutic leads.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Ahtasham Raza, Stuart A. A. Archer, Jim A. A. Thomas, Sheila MacNeil, John W. W. Haycock
Summary: This study reports the anti-metastatic effect of a Ru(ii) complex, which disrupts actin fiber assembly and inhibits the migration and invasiveness of melanoma cells. The complex also inhibits the growth and invasion of melanoma-based tumor models and penetrates the epidermis to inhibit melanoma cell invasion in a skin tissue model.
RSC MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Sumit Kumar Pramanik, Sreejesh Sreedharan, Rajeshwari Tiwari, Sourav Dutta, Noufal Kandoth, Surajit Barman, Stephen O. Aderinto, Samit Chattopadhyay, Amitava Das, Jim A. Thomas
Summary: This review provides an overview of the approaches and techniques used in super-resolution microscopy, and focuses on the advantages of using nanoparticle-based probes in these applications. Different classes of nanoparticles developed for these purposes are critically described, and illustrated with various examples from recent literature.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
James D. Grayson, Matthew P. Baumgartner, Cleide Dos Santos Souza, Samuel J. Dawes, Imane Ghafir El Idrissi, Jennifer C. Louth, Sasha Stimpson, Emma Mead, Charlotte Dunbar, Joanna Wolak, Gary Sharman, David Evans, Anastasia Zhuravleva, Margarita Segovia Roldan, Nicola Antonio Colabufo, Ke Ning, Claire Garwood, James A. Thomas, Benjamin M. Partridge, Antonio de la Vega de Leon, Valerie J. Gillet, Amelia P. Rauter, Beining Chen
Summary: This study presents a new approach for identifying functional Aβo binding compounds to treat Alzheimer's disease. Two compounds were found to disrupt the toxic effects of Aβo in HEK293 cells and neural cells derived from hiPSC.
Article
Chemistry, Medicinal
Adam M. Varney, Kirsty L. Smitten, Jim A. Thomas, Samantha McLean
Summary: Research into developing alternatives to antibiotic treatment has revealed a dinuclear ruthenium(II) complex that shows slow evolution of resistance in uropathogenic E. coli and causes downregulation of genes involved in membrane transport and the tricarboxylic acid cycle. The compound also displays activity comparable to clinically relevant antibiotics in a range of Gram-negative pathogens.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Sreejesh Sreedharan, Rajeshwari Tiwari, Deepak Tyde, Stephen O. Aderinto, Sumit Kumar Pramanik, Amitava Das, James A. Thomas
Summary: Super-resolution microscopy (SRM) has transformed the field of cell biology, allowing researchers to visualize cellular structures at nanometer resolution with single-molecule sensitivity. Luminescent nanocarriers (LNC) play a crucial role in controlling emissive states and organelle-specific delivery, enabling the development of novel optical-switched systems. Challenges related to molecular targeting in biological systems are discussed, providing practical guidance for super-resolution imaging in nanomedicine research.
MATERIALS CHEMISTRY FRONTIERS
(2021)