期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 5, 页码 1862-1866出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b12636
关键词
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资金
- Spanish grants (FPU fellowship)
- Conselleria de Cultura, Educacion e Ordenacion Universitaria [ED431C 2017/19, 2015-CP082]
- Conselleria de Cultura, Educacion e Ordenacion Universitaria (Centro Singular de Investigacion de Galicia accreditation 2016-2019) [ED431G/09]
- European Regional Development Fund (ERDF)
- European Research Council [340055]
- orfeo-cinqa network [CTQ2016-81797-REDC]
- [SAF2016-76689-R]
- [CTQ2016-77047-P]
Benzyl and allyltriflamides can engage in Pd-catalyzed oxidative (4+2) annulations with allenes, to produce highly valuable tetrahydroisoquinoline or dihydropyridine skeletons. The reaction is especially efficient when carried out in the presence of designed N-protected amino acids as metal ligands. More importantly, using this type of chiral ligands, it is possible to perform desymmetrizing, annulative C-H activations of prochiral diarylmethylphenyl amides, and thus obtain the corresponding isoquinolines with high enantiomeric ratios.
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