期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 40, 页码 27207-27217出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b08893
关键词
PNIPAAm; switchable antimicrobial; quaternary ammonium salts; antifouling; implant
资金
- National Natural Science Foundation of China [51403158, 81271703, 31570959]
- Natural Science Foundation of Zhejiang Province [LY12H12005, LQ14C100002]
- Wenzhou Bureau of Science and Technology [2013S0458]
The adherence of bacteria and the formation of biofilm on implants is a serious problem that often leads to implant failure. A series of antimicrobial coatings have been constructed to resist bacterial adherence or to kill bacteria through contact with or release of antibacterial agents. The accumulation of dead bacteria facilitates further bacterial contamination and biofilm development. Herein, we have designed and constructed a novel, reversibly switchable bactericidal and antifouling surface through surface-initiated reversible addition fragmentation chain transfer (RAFT) polymerization to combine thermally responsive N-isopropylacrylamide (NIPAAm) and bactericidal quaternary ammonium salts (2-(dimethylamino)-ethyl methacrylate (DMAEMA(+))). Measurements of spectroscopic ellipsometry and water contact angle and X-ray photoelectron spectroscopy were used to examine the process of the surface functionalization. The temperature-responsive P(DMAEMA(+)-co-NIPAAm) copolymer coating can switch by phase transition between a hydrophobic capturing surface at high temperatures and a relatively hydrophilic antifouling surface at lower temperatures. The quaternary ammonium salts of PDMAEMA displayed bactericidal efficiency against both Escherichia coli and Staphylococcus aureus. The functionalized surface could efficiently prevent bovine, serum albumin adsorption and had good biocompatibility against human lens epithelial cells.
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