Article
Anesthesiology
Carolyne Pehora, David Faraoni, Soichiro Obara, Reshma Amin, Brenda Igbeyi, Adel Al-Izzi, Aman Sayal, Aarti Sayal, Conor Mc Donnell
Summary: The study aimed to determine the incidence and risk factors of PRAEs in children with SDB undergoing general anesthesia. Factors associated with PRAEs were identified, suggesting potential for developing a predictive model and improving preoperative risk assessment.
ANESTHESIA AND ANALGESIA
(2021)
Article
Clinical Neurology
Phoebe K. Yu, Jerilynn Radcliffe, H. Gerry Taylor, Raouf S. Amin, Cristina M. Baldassari, Thomas Boswick, Ronald D. Chervin, Lisa M. Elden, Susan L. Furth, Susan L. Garetz, Alisha George, Stacey L. Ishman, Erin M. Kirkham, Christopher Liu, Ron B. Mitchell, S. Kamal Naqvi, Carol L. Rosen, Kristie R. Ross, Jay Shah, Ignacio E. Tapia, Lisa R. Young, David A. Zopf, Rui Wang, Susan Redline
Summary: The relationship between the severity of obstructive sleep apnea and neurobehavioral morbidity is unclear. This study compares the neurobehavioral symptoms of mild sleep-disordered breathing and obstructive sleep apnea, finding that children with mild sleep-disordered breathing have more abnormal executive function scores and higher rates of inattention and hyperactivity compared to children with obstructive sleep apnea.
Article
Peripheral Vascular Disease
Min Ru Chee, Jesse Hoo, Renata Libianto, Stella M. Gwini, Garun Hamilton, Om Narayan, Morag J. Young, Peter J. Fuller, Jun Yang
Summary: This study found a high prevalence of possible or likely primary aldosteronism among patients with both obstructive sleep apnea and hypertension, suggesting that they should be routinely screened for PA. No correlation was found between aldosterone, renin, or aldosterone:renin ratio and the apnea-hypopnea index, indicating the need for further research on the relationship between these conditions.
Article
Pediatrics
Marie-Eva Rossi, Claire Le Treut, Laure Allali, Julie Mazenq, Richard Nicollas, Eric Moreddu
Summary: This study used drug-induced sleep endoscopy (DISE) to determine the cause of obstructive sleep-disordered breathing in infants without co-morbidities and normal clinical examination. The results showed that obstructive sites were identified in 94% of cases, with sleep laryngomalacia (37.4%) and adenotonsillar hypertrophy (21.8%) being the most common causes. DISE identified obstructive sites in 93.8% of patients and guided surgical management in 81.3% of cases during the same anesthesia.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Clinical Neurology
Thomas J. Dye, Sumalee Hantragool, Christopher Carosella, Guixia Huang, Md M. Hossain, Narong Simakajornboon
Summary: This study retrospectively reviewed the sleep disordered breathing in children receiving VNS therapy, and found that OSA and hypoventilation were relatively common in this population. Management mainly involves positive airway pressure therapy and upper airway surgeries.
Article
Clinical Neurology
Jackie Chiang, Lena Xiao, Elisa Nigro, Aaron St-Laurent, Lauren Weinstock, Eugenia Law, Joanna Janevski, Sarah Kuyntjes, Nisha Cithiravel, Tuyen Tran, Nikolaus E. Wolter, Hernan Gonorazky, Reshma Amin
Summary: This study retrospectively investigated sleep disordered breathing in infants with spinal muscular atrophy (SMA) who received gene replacement therapy. The results showed improvement in sleep disordered breathing after treatment. However, the clinical significance of abnormal polysomnogram parameters for children without sleep disordered breathing or neuromuscular weakness remains unclear.
Article
Clinical Neurology
Jennifer Schaefer, Margot J. Davey, Gillian M. Nixon
Summary: This study aimed to describe the nature and prevalence of sleep-disordered breathing (SDB) in school-aged children with Prader-Willi syndrome (PWS) in the growth hormone era. The study found that different types of SDB were prevalent in these children, including central sleep apnea, obstructive sleep apnea, and hypoventilation. Central sleep apnea, especially the presence of central hypopneas, predicted the occurrence of hypoventilation.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Article
Pediatrics
Eduardo Machado Rossi-Monteiro, Laura Rodrigues Sefair, Marcos Correia Lima, Maria Fernanda Lima Nascimento, Daniel Mendes-Pinto, Lukas Anschuetz, Maria Gloria Rodrigues-Machado
Summary: This study aimed to compare cardiovascular parameters between healthy children and those with obstructive sleep-disordered breathing (oSDB), as well as identify predictors of arterial stiffness indices in children with oSDB. Children with oSDB showed higher reflection coefficient and augmentation index compared to controls, indicating increased arterial stiffness. Multiple regression analysis revealed age, female sex, reflection coefficient, and systolic volume as independent predictors of augmentation index, while higher pulse wave velocity was associated with poorer quality of life.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Obstetrics & Gynecology
Janet A. DiPietro, Jiawei Bai, Francis P. Sgambati, Janice L. Henderson, Heather Watson, Radhika S. Raghunathan, Grace W. Pien
Summary: This study aimed to investigate the relationship between maternal sleep-disordered breathing events and fetal well-being. The results showed that episodes of maternal sleep apnea and hypopnea did not cause decelerations in fetal heart rate, despite the presence of risk factors such as maternal obesity. However, fetal heart rate variability increased during these events and returned to baseline levels soon after. There was no evidence that maternal sleep-disordered breathing posed an immediate threat to the near-term fetus.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Clinical Neurology
Heayon Lee, Hwan Hee Kim, Kyu Yean Kim, Chang Dong Yeo, Hyeon Hui Kang, Sang Haak Lee, Sei Won Kim
Summary: The prevalence of sleep-disordered breathing (SDB) and poor sleep quality is high in Korean patients with lung cancer. Moderate to severe SDB is significantly associated with underlying chronic obstructive pulmonary disease (COPD) and smoking history. Different types, mutations, stages, and survival of lung cancer do not significantly affect SDB, but small-cell lung cancer patients may have a higher risk of SDB.
SLEEP AND BREATHING
(2023)
Review
Pediatrics
Melissa Borrelli, Adele Corcione, Chiara Cimbalo, Anna Annunziata, Simona Basilicata, Giuseppe Fiorentino, Francesca Santamaria, Jun Kohyama
Summary: Obstructive sleep-disordered breathing (SDB) has a significant impact on health, and a timely and accurate diagnosis is important. Current diagnostic methods for SDB in children include clinical assessment, medical history evaluation, questionnaires, and objective measurements. Polysomnography (PSG) is the gold standard, but it is time-consuming and expensive. Alternative techniques such as respiratory polygraphy and nocturnal oximetry have their limitations and further research is needed on their use in children. Laboratory biomarkers and radiological findings show potential but require standardization in clinical practice.
Article
Clinical Neurology
Ning Xia, Hao Wang, Yu Chen, Xiao-Jun Fan, Xiu-Hong Nie
Summary: This study aimed to explore the relationship between sleep efficiency (SE) and the prevalence of hypertension in Chinese obstructive sleep apnea (OSA) patients. The results showed that OSA patients with low SE were more likely to have hypertension, especially in female, younger ages, obese, moderate and severe OSA patients, compared to primary snorers.
NATURE AND SCIENCE OF SLEEP
(2023)
Article
Clinical Neurology
Danielle L. Wilson, Alison M. Fung, Gabrielle Pell, Hannah Skrzypek, Maree Barnes, Ghada Bourjeily, Susan P. Walker, Mark E. Howard
Summary: This study examines the distribution of sleep positions during pregnancy and their relationships with sleep onset position, sleep-disordered breathing, and pregnancy outcomes. The results suggest that falling asleep on the left lateral position is more common, while sleeping in the supine position is less prevalent throughout the night. Falling asleep in the supine position is associated with fetal growth restriction and birthweight.
Review
Critical Care Medicine
Salam Zeineddine, James A. Rowley, Susmita Chowdhuri
Summary: Sleep-disordered breathing (SDB) has significant cardiovascular and neurological effects, with supplemental oxygen therapy showing mixed results in improving oxygen saturation and apnea severity compared to positive airway pressure therapy. Further research is needed to clarify the optimal dose and duration of nocturnal supplemental oxygen (NSO) and its combination with PAP in improving cardiovascular, sleep, and cognitive outcomes in SDB patients.
Article
Medicine, General & Internal
Hao Cui, Hartzell Schaff, Virend K. Somers, Rick A. Nishimura, Joseph A. Dearani, Jeffrey B. Geske, Katherine S. King, Steve R. Ommen
Summary: In patients with hypertrophic cardiomyopathy, more than half were found to have sleep-disordered breathing, which was mainly associated with aging, overweight, and male sex. However, sleep-disordered breathing did not impact survival following septal myectomy.
MAYO CLINIC PROCEEDINGS
(2021)
Letter
Rheumatology
Xenofon Baraliakos, Adrian Richter, Carsten O. Schmidt, Juergen Braun
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Clinical Neurology
Markus Krueger, Anne Obst, Olaf Bernhardt, Ralf Ewert, Thomas Penzel, Beate Stubbe, Ingo Fietze, Tatyana Ivanovska, Reiner Biffar, Amro Daboul
Summary: The study aims to determine the effects of socioeconomic factors on sleep apnea in the population of Pomerania, Germany. The results indicate that age, sex, and BMI have significant effects on sleep apnea, while socioeconomic factors do not show significant effects in the tested population.
SLEEP AND BREATHING
(2023)
Article
Clinical Neurology
Yan Wang, Ingo Fietze, Matthew Salanitro, Thomas Penzel
Summary: This study evaluated the value of the STOP-BANG questionnaire (SBQ) in screening for obstructive sleep apnea (OSA) and found that it has low specificity. Compared to SBQ, the oxygen desaturation index (ODI) has higher specificity and diagnostic value in diagnosing OSA.
SLEEP AND BREATHING
(2023)
Article
Clinical Neurology
Elin H. Thorarinsdottir, Thorarinn Gislason, Allan Pack, Samuel T. Kuna, Thomas Penzel, Fang Han, Qing Yun Li, Peter A. Cistulli, Ulysses J. Magalang, Nigel McArdle, Bhajan Singh, Brendan T. Keenan
Article
Psychiatry
Pei Xue, Ilona Merikanto, Frances Chung, Charles M. Morin, Colin Espie, Bjorn Bjorvatn, Jonathan Cedernaes, Anne-Marie Landtblom, Thomas Penzel, Luigi De Gennaro, Brigitte Holzinger, Kentaro Matsui, Harald Hrubos-Strom, Maria Korman, Damien Leger, Sergio Mota-Rolim, Courtney J. Bolstad, Michael Nadorff, Giuseppe Plazzi, Catia Reis, Rachel Ngan Yin Chan, Yun Kwok Wing, Juliana Yordanova, Adrijana Koscec Bjelajac, Yuichi Inoue, Markku Partinen, Yves Dauvilliers, Christian Benedict
Summary: Short and long sleep duration after receiving mRNA vaccines is associated with a higher risk of post-COVID symptoms. The study suggests that short and long sleepers are more likely to experience prolonged COVID-19 symptoms compared to normal sleepers. Further research is needed to validate these findings in cohorts with confirmed SARS-CoV-2 infection.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Orthopedics
Cornelius Sebastian Fischer, Till Ittermann, Christoph Emanuel Gonser, Matthias Floss, Robin Buelow, Carsten-Oliver Schmidt, Lyubomir Haralambiev, Tina Histing, Joern Lange
Summary: This study aimed to examine the glenohumeral subluxation index (GHSI) in a large general population cohort and define reference values. The study found associations between GHSI and age, sex, and body weight. Adjusted formulas were provided for individual, patient-specific diagnostics and therapy.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2023)
Article
Clinical Neurology
Antoine Weihs, Stefan Frenzel, Hanwen E. Bi, Julian Schiel, Mortaza Afshani, Robin Buelow, Ralf Ewert, Ingo Fietze, Felix Hoffstaedter, Neda Jahanshad, Habibolah Khazaie, Dieter Riemann, Masoumeh Rostampour, Beate I. Stubbe, Sophia M. Thomopoulos, Paul L. Thompson, Sofie Valk, Henry Voelzke, Mojtaba B. Zarei, Simon J. Eickhoff, Hans R. Grabe, Kaustubh Patil, Kai Spiegelhalder, Masoud Tahmasian
Summary: A large-scale meta-analysis was conducted to investigate structural brain alterations in insomnia disorder. The study did not find any significant associations between insomnia symptoms and cortical or subcortical volumes, nor a global insomnia-related brain atrophy pattern.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Max Hellrigel-Holderbaum, Nina Romanczuk-Seiferth, Martin Glos, Ingo Fietze
Summary: This study aimed to assess the effects of Mindfulness-Based Stress Reduction (MBSR) on symptoms of Obstructive Sleep Apnea (OSA), specifically excessive daytime sleepiness (EDS). A parallel randomized controlled trial was conducted, with 16 OSA patients with residual EDS (rEDS) randomly assigned to either an 8-week MBSR program or a time-matched program on Acceptance and Commitment Therapy (ACT). The results showed that ACT can be a potential adjunctive therapy for OSA with rEDS, but further studies are needed, especially with tailored approaches for this patient group.
Article
Multidisciplinary Sciences
Julia Schlagintweit, Naima Laharnar, Martin Glos, Maria Zemann, Artem V. Demin, Katharina Lederer, Thomas Penzel, Ingo Fietze
Summary: We conducted a crossover study to compare the effects of sleep fragmentation and partial sleep restriction on cardiac autonomic tone. Our results showed that sleep restriction increased sympathetic tone and decreased vagal tone, leading to increased autonomic stress, while fragmented sleep did not affect cardiac autonomic parameters. These findings suggest that sleep disruption may have negative effects on the cardiovascular system.
SCIENTIFIC REPORTS
(2023)
Review
Health Care Sciences & Services
Jason Ellis, Luigi Ferini-Strambi, Diego Garcia-Borreguero, Anna Heidbreder, David O'Regan, Liborio Parrino, Hugh Selsick, Thomas Penzel
Summary: One in ten adults in Europe suffer from chronic insomnia, which is characterized by ongoing sleep difficulties and impaired daily functioning. Different clinical care practices and healthcare accessibility across Europe result in varied treatment approaches. This article provides an update on the clinical management of chronic insomnia in Europe, summarizing old and new treatments, discussing challenges, and offering suggestions for optimal clinical management.
Article
Clinical Neurology
Youmeng Wang, Ying Huang, Mengdi Xia, Matthew Salanitro, Jan F. Kraemer, Theresa Toncar, Ingo Fietze, Christoph Schoebel, Thomas Penzel
Summary: A meta-analysis was conducted to evaluate the efficacy of phrenic nerve stimulation (PNS) in patients with central sleep apnea (CSA). The results showed that PNS significantly reduced the apnea-hypopnea index (AHI), central apnea index (CAI), and arousal index, but did not significantly affect T90, Epworth Sleepiness Scale (ESS), and sleep efficiency.
SLEEP MEDICINE REVIEWS
(2023)
Article
Psychology, Multidisciplinary
Ty Lees, Taryn Chalmers, David Burton, Eugene Zilberg, Thomas Penzel, Sara Lal
Summary: This study examined monotonous driving, fatigue, and sleepiness in a group of passenger train drivers and a group of non-professional drivers. The results showed that fatigue and sleepiness scores did not significantly differ between the groups, but train drivers generally scored lower, indicating potential efforts to reduce fatigue. Additionally, fatigue and sleepiness scores were negatively correlated with EEG variables, suggesting a blunting of neural activity associated with self-reported fatigue.
BEHAVIORAL SCIENCES
(2023)
Article
Medicine, General & Internal
Philipp Arens, Thomas Fischer, Ingo Fietze, Thomas Penzel, Steffen Dommerich, Heidi Olze, Markus Herbert Lerchbaumer
Summary: This study investigated the relationship between stiffness of genioglossi (GG) and geniohyoidei (GH) muscles under electric hypoglossal nerve stimulation therapy (HNS) and the success of therapy, with a focus on tongue movement. The results showed that stiffness of the target muscle is not the only measure of the success of HNS therapy.
Proceedings Paper
Computer Science, Interdisciplinary Applications
Carsten Oliver Schmidt, Stephan Struckmann, Maik Scholz, Janka Schoessow, Doerte Radke, Adrian Richter, Achim Reineke, Elisa Kasbohm, Joany Marino Coronado, Birgit Schauer, Kristin Henselin, Susanne Westphal, Darko Balke, Torsten Leddig, Henry Voelzke, Joerg Henke
Summary: This article provides an overview of the software tools used in large-scale epidemiological studies and introduces the main tools used in the Study of Health in Pomerania (SHIP) project. The article also discusses approaches taken to improve the findability, accessibility, interoperability, and reusability of the data collected in the project.
CARING IS SHARING-EXPLOITING THE VALUE IN DATA FOR HEALTH AND INNOVATION-PROCEEDINGS OF MIE 2023
(2023)
Proceedings Paper
Computer Science, Interdisciplinary Applications
Christian Draeger, Erik Tute, Carsten Oliver Schmidt, Dagmar Waltemath, Martin Boeker, Alfred Winter, Matthias Loebe
Summary: The German Medical Informatics Initiative provides clinical routine data for biomedical research through data integration centers and the use of HL7 FHIR standard. FHIR is becoming increasingly popular for exchanging patient care data, highlighting the importance of data quality assessments.
CARING IS SHARING-EXPLOITING THE VALUE IN DATA FOR HEALTH AND INNOVATION-PROCEEDINGS OF MIE 2023
(2023)
