期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 5, 页码 3079-3091出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b10378
关键词
silica-based biomaterials; hybrid elastomers; mechanical properties; biodegradation; osteogenic differentiation
资金
- scientific research starting foundation from Xi'an Jiaotong University [DW011798-N3000010]
- Fundamental Research Funds for the Central Universities [XJJ2014090]
- Natural Science Basic Research Plan in Shaanxi Province of China [2015JQ5165]
- National Natural Science Foundation of China [51502237]
- National 973 Project of China [2012CB619100]
Biodegradable elastomeric biomaterials have attracted much attention in tissue engineering due to their biomimetic viscoelastic behavior and biocothpatibility. However, the low mechanical stability at hydrated state, fast biodegradation in vivo, and poor osteogenic activity greatly limited bioelastomers applications in bone tissue regeneration. Herein, we develop a series of poly(octanediol citrate) polyhedral oligomeric silsesquioxanes (POC-POSS) hybrids with highly tunable elastomeric behavior (hydrated state) and biodegradation and osteoblasts biocompatibility through a facile one-pot thermal polymerization strategy. POC POSS hybrids show significantly improved stiffness and ductility in either dry or hydrated conditions, as well as good antibiodegradation ability (20-50% weight loss in 3 months). POC POSS hybrids exhibit significantly enhanced osteogenic differentiation through upregulating alkaline phosphatase (ALP) activity, calcium deposition, and expression of osteogenic markers (ALPL, BGLAP, and Runx2). The high mechanical stability at hydrated state and enhanced osteogenic activity make POC POSS hybrid elastorriers promising as scaffolds and nanoscale vehicles for bone tissue regeneration and drug delivery. This study may also provide a new strategy (controlling the stiffness under hydrated condition) to design advanced hybrid biomaterials with high mechanical properties under physiological Condition for tissue regeneration applications.
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