Article
Polymer Science
Ana Mateos-Maroto, Laura Fernandez-Pena, Irene Abelenda-Nunez, Francisco Ortega, Ramon G. Rubio, Eduardo Guzman
Summary: This review provides an updated perspective on the various applications of polyelectrolyte multilayered capsules (PEMUCs) obtained using the Layer-by-Layer (LbL) method in the biomedical field, emphasizing the significant advantages offered by the LbL method for fabricating platforms for different disease detection and treatment.
Article
Materials Science, Multidisciplinary
Carmen Stavarache, Mircea Vinatoru, Timothy Mason
Summary: Microcapsules consisting of multiple layers of polyelectrolyte and one layer of iron oxide nanoparticles were fabricated. These magnetic microcapsules showed the ability to accumulate in liquid environments when pumped through a tube over a permanent magnet, with an accumulation capacity of more than 90% within a minute. The applications of these magnetic microcapsules are extensive, including cancer treatment and molecular communication.
Review
Chemistry, Multidisciplinary
Anna S. Vikulina, Jack Campbell
Summary: An undeniable trend in modern bioengineering and nanotechnology is the use of various biomolecules, primarily polymeric, for designing novel functional materials in controlled drug delivery, bioimaging, tissue engineering, and other bioapplications. Biogenic polymers with features like biocompatibility, biodegradability, replicating natural cellular microenvironments, and minimal toxicity, have gained growing interest as building blocks for fourth-generation biomaterials. Recent studies highlight the promise of hard-templating approach in fabricating nano- and microparticles using biopolymers, covering up-to-date knowledge on this topic and assessing the progress and challenges in the field.
Review
Pharmacology & Pharmacy
Clea Chesneau, Laura Larue, Sabrina Belbekhouche
Summary: This review focuses on the design and application of polysaccharide-based capsules, which can be used as a versatile platform for drug delivery purposes. By utilizing porous particles as a template and using the layer-by-layer technique, biopolyelectrolyte capsules can be fabricated. The major steps of capsule design, including fabrication, coating, removal of the template, characterization, and application in the biomedical field are discussed.
Article
Biochemistry & Molecular Biology
Yasmin Kabalan, Xavier Montane, Bartosz Tylkowski, Silvia de la Flor, Marta Giamberini
Summary: In this study, the successful encapsulation of a blue dye in biodegradable capsules made of alginate hydrogel and polyethylene glycol network was achieved for the first time. Different types of capsules were synthesized and their properties were characterized, with the incorporation of PEGDMA and different irradiation times being found to significantly affect the final properties of the capsules. These results will contribute to the understanding of dye release from the capsules.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
N. Jaya Prakash, D. Shanmugarajan, B. Kandasubramanian, P. Khot, K. Kodam
Summary: The production of biodegradable dressing capable of sustained drug release, along with the monitoring of wound conditions, represents new heights of multifunctional platforms for wound care. The reported curcumin-loaded silk fibroin has shown sustained drug release over the time of 10 days through a non-Fickian diffusion process satisfying Korsmeyer-Peppas' model along with the visual monitoring of wound healing through notable color variation with pH as a biomarker. The superhydrophobic nature (water contact angle = 163.7) of the SF, along with the lipophilicity (CA = 0 (Blood)) and hygroscopic nature prevents wetting of wound surface, whereas the excess exudates from wounds are absorbed along with sufficient water and oxygen permeability. The pH responsiveness as a result of the keto-enol tautom-erism in curcumin was utilized for wound monitoring through visual indication enabling even ordinary people to detect the state of the wound. The in-situ biodegradation studies verified using cow-dung slurry, the degradability of the material with 25.3% weight loss within 30 days following first-order kinetics (R2 = 0.994), as a result of the attack of proteolytic enzymes on the amino acid units of SF, mitigating the concerns of medical wastes. (c) 2022 Elsevier Ltd. All rights reserved.
MATERIALS TODAY CHEMISTRY
(2023)
Review
Biotechnology & Applied Microbiology
Sihang Ren, Shuaichen Guo, Liqun Yang, Chenchao Wang
Summary: Repairing diabetic wounds has always been a challenge in plastic surgery. A potential solution is to use biocompatible biodegradable biomaterials as scaffolds or dressings loaded with active substances or cells to create a wound repair system. This review discusses the integration of biomaterials with drugs, stem cells, and active agents, highlighting their potential in promoting wound healing. However, there is still a need for further development of biomaterials that can be effectively translated into clinical practice.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Harri Hakula, Laurent Daudeville
Summary: The focus of this study is on the challenges posed by biodegradable materials in computational mechanics, particularly the resulting domain uncertainty. The proposed computational approach introduces a novel method of restricting variation to specific parts of the structure using a posteriori filtering. The stochastic elasticity problems are solved using a collocation method and validated against standard Monte Carlo.
APPLIED SCIENCES-BASEL
(2023)
Article
Materials Science, Multidisciplinary
Jianhui Liu, Sarah L. Perry, Ben Zhong Tang, Matthew V. Tirrell
Summary: This study reports pH-responsive complex coacervates that remain intact under acidic conditions and dissolve in alkaline conditions, showing potential for oral delivery to the gastrointestinal tract.
Article
Multidisciplinary Sciences
Guleid M. Awale, Mohammed A. Barajaa, Ho-Man Kan, Amir Seyedsalehi, Ga Hie Nam, Fatemeh S. Hosseini, Chinedu C. Ude, Tannin A. Schmidt, Kevin W. -H. Lo, Cato T. Laurencin
Summary: Bone grafting procedures are common in the US, with a high societal cost. The use of recombinant human bone morphogenetic proteins (rhBMPs) has limitations, leading to the search for small-molecule therapeutics for bone regeneration. This study successfully applied a novel small-molecule treatment approach in a large bone defect model, promoting bone formation with minimal side effects.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Radheshyam Samanta, Sukanta Nayak, Biswarup Das, Amit Kumar Nayak
Summary: This research aimed to develop and assess a sustained stomach-specific ofloxacin delivery system using single-unit hydrodynamically balanced system (HBS)-based floating capsules. The floating capsules were prepared by incorporating cationic-natured low molecular mass chitosan (LMMCH) and anionic-natured carboxymethyl tamarind gum (CMTG). The results showed that no drug-polymer interaction occurred within these formulated ofloxacin HBS capsules. The best formulation, composed of 75 mg LMMCH and 25 mg CMTG, exhibited excellent in vitro floatation behavior in simulated gastric fluid (pH 1.2) for 6 hours and demonstrated prolonged stomach-specific retention in an in vivo X-ray imaging study. These HBS floating capsules have the potential for stomach-specific delivery of other drugs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Pouire Yameogo, Nathalie Majeau, Cedric Happi Mbakam, Jacques P. Tremblay
Summary: The small size of CjCas9 allows for easier vectorization in in vivo gene therapy. However, it is generally less efficient than SpCas9 in generating indels in target genes, and the factors affecting its efficiency have not been determined. In our study, we found that the protein levels of CjCas9 expressed in HEK293T cells were significantly lower than those of SpCas9. We investigated the effect of proteasome inhibitors on CjCas9 protein stability and its efficiency in editing the FXN gene.
Article
Polymer Science
Fengrong Gong, Lihui Jiang, Yanni Gao, Juan Xu, Ting Wang
Summary: To enhance the solubility of ethinylestradiol (EE) in water, researchers prepared diethylenetriamine-beta-cyclodextrin/ethinylestradiol (DETA-beta-CD/EE) complex and designed core-shell composite hydrogel capsules with aldocellulose and hydroxyethyl cellulose as the core and sodium alginate as the shell. The prepared hydrogel capsules exhibited controlled and sustained release of soluble DETA-beta-CD/EE, pH-responsiveness to intestinal fluid, and non-toxicity to normal human cells.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Dan Xu, Jinwei Cao, Fengyuan Zhang, Xin Gao, Shengbin Li, Fei Liu, Shengding Wang, Shiying Li, Jinyun Liu, Yuanzhao Wu, Yiwei Liu, Jie Shang, Run-Wei Li
Summary: Liquid metal nano-capsules with high conductivity and compact, reconfigurable profiles were developed to address the electrical barrier issue found in naturally formed oxide layer on liquid metal nanoparticles. These capsules, encapsulated by platinum@redox graphene oxide, show stability against external stimuli and can be used to fabricate highly conductive circuits.
MATERIALS TODAY PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Anastasia Gileva, Daria Trushina, Anne Yagolovich, Marine Gasparian, Leyli Kurbanova, Ivan Smirnov, Sergey Burov, Elena Markvicheva
Summary: Recently, biodegradable polyelectrolyte multilayer capsules have been proposed for targeted drug delivery of anticancer drugs. In this study, the researchers aimed to develop PMC loaded with a subtoxic concentration of doxorubicin (DOX) and functionalized with the tumor-specific DR5-B ligand to achieve a combined antitumor effect. The effects of PMC surface modification with the DR5-B ligand on cell uptake were studied in both 2D monolayer cultures and 3D tumor spheroids. The results showed that the DR5-B-modified capsules loaded with DOX exhibited enhanced cytotoxicity in both in vitro models, suggesting their potential as a targeted drug delivery system.
Review
Chemistry, Analytical
Olga A. Goryacheva, Tatiana D. Ponomaryova, Daniil D. Drozd, Alina A. Kokorina, Tatiana Yu Rusanova, Pradyumna K. Mishra, Irina Yu Goryacheva
Summary: Rapid assessment of biomarker levels in patients is an effective approach in the diagnosis and treatment of heart failure. BNP and NT-proBNP, as biomarkers of HF, have a high negative predictive value and are particularly useful in excluding HF as a cause of non-specific symptoms.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Olga A. Goryacheva, K. David Wegner, Aleksandr M. Sobolev, Ines Haeusler, Nikolai Gaponik, Irina Y. Goryacheva, Ute Resch-Genger
Summary: Light-emitting nanoparticles, known as quantum dots (QDs), have great potential for biosensing and bioimaging applications. However, their use in biological systems requires them to be water-dispersible without affecting their optical properties. In this study, researchers developed a new surface silanization method to preserve the optical properties of QDs and successfully prepared water-dispersible QDs.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Daniil D. Drozd, Nadezhda A. Byzova, Pavel S. Pidenko, Daria V. Tsyupka, Pavel D. Strokin, Olga A. Goryacheva, Anatoly V. Zherdev, Irina Yu. Goryacheva, Boris B. Dzantiev
Summary: A new bioanalytical labeling system based on alloyed quantum dots' photoluminescence quenching caused by an enzymatic reaction has been developed and tested. The use of alloyed luminescent QDs provides high sensitivity and the ability to vary the detecting time, leading to improved assay sensitivity.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Correction
Chemistry, Analytical
T. S. Ponomaryova, A. S. Novikova, A. M. Abramova, O. A. Goryacheva, D. D. Drozd, P. D. Strokin, I. Yu. Goryacheva
Summary: An erratum has been published for this paper.
JOURNAL OF ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Zhuofeng Li, Inna L. Soroka, Nadezda V. Tarakina, Maria Antonietta Sabatino, Emanuela Muscolino, Marta Walo, Mats Jonsson, Clelia Dispenza
Summary: In this study, inorganic-organic hybrid nanoparticles were synthesized via radiation synthesis in aqueous dispersions containing radiation-synthesized poly(N-vinyl pyrrolidone) (PVP) nanogels. The experiments indicated strong interactions between the inorganic precursors (Ag+ and Ce3+) and the nanogel prior to irradiation. Characterization using X-ray diffraction (XRD) and transmission electron microscopy (TEM) confirmed the formation of crystalline Ag and CeO2. Both techniques revealed that the inorganic nanoparticles were evenly distributed in/on the nanogel, and their size was controlled by the nanogel.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Andrea Rogolino, Ingrid F. Silva, Nadezda V. Tarakina, Marcos A. R. da Silva, Guilherme F. S. R. Rocha, Markus Antonietti, Ivo F. Teixeira
Summary: This study reveals that functionalized poly(heptazine imides) (PHIs) and fully protonated PHIs have high photocatalytic activity for efficient production of H2O2 under visible light. Functionalization with transition metals is not beneficial for H2O2 synthesis and may catalyze its decomposition.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Oleksandr Savateev, Nadezda V. Tarakina, Alexander P. Tyutyunnik, Salvador Martinez Rivadeneira, Julian Heske, Thomas D. Kuhne
Summary: The aza-pinacol coupling of N-benzyl-1-phenylmethanimine using Zn dust results in a mixture ofR,S and R,R diastereomers in a 1:1 ratio. The R,S diastereomer is a solid with a melting point of 135 degrees C, while the R,R diastereomer is a liquid at room temperature. The configuration of stereocenters was determined through X-ray powder diffraction and density functional theory (DFT) modeling.
Article
Biochemistry & Molecular Biology
Natalia A. Shushunova, Oksana A. Mayorova, Ekaterina S. Prikhozhdenko, Olga A. Goryacheva, Oleg A. Kulikov, Valentina O. Plastun, Olga I. Gusliakova, Albert R. Muslimov, Olga A. Inozemtseva, Nikolay A. Pyataev, Alexander A. Shirokov, Dmitry A. Gorin, Gleb B. Sukhorukov, Olga A. Sindeeva
Summary: Complex immunosuppressive therapy is used to treat glomerulonephritis, but it has severe side effects. This study demonstrates the effectiveness of polymer capsules containing etanercept in the kidneys of mice. Intra-arterial administration of the capsules showed significant superiority over injection into the tail vein. The proposed strategy of endovascular surgery combined with polymer microcapsules can be applied to treat kidney diseases associated with glomerular pathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Enis Oguzhan Eren, Evgeny Senokos, Zihan Song, Elif Beguem Yilmaz, Irina Shekova, Bolortuya Badamdorj, Iver Lauermann, Nadezda V. Tarakina, Majd Al-Naji, Markus Antonietti, Paolo Giusto
Summary: To enhance the electrochemical performance of sodium-ion batteries, sustainable and high-performance carbonaceous anode materials are needed. By depositing a tunable thickness of nm-sized conformal coating of carbon nitride, we were able to improve the electrochemical performance of anode material derived from sodium lignosulfonate. This resulted in significantly enhanced electrode performance, including first cycle efficiency, rate-capability, and specific capacity. The design of interactive electrochemical interfaces, such as a homogeneous carbon nitride coating, played a crucial role in improving the performance of carbonaceous anodes without adding much weight.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Nanoscience & Nanotechnology
Junfang Zhang, Yuxin Liu, Christian Njel, Sebastian Ronneberger, Nadezda V. V. Tarakina, Felix F. F. Loeffler
Summary: Counterfeiting not only causes trillion-dollar economic losses annually, but also threatens human health, social equity, and national security. Researchers have developed a nanoprinting-assisted flash synthesis approach to create fluorescent nanofilms with physical unclonable function micropatterns in milliseconds. These unclonable patterns can be quickly and independently read out by fluorescence and topography scanning, greatly enhancing their security.
NATURE NANOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jing Hou, Zihan Song, Mateusz Odziomek, Nadezda V. V. Tarakina
Summary: In this study, nitrogen-doped porous hollow carbon spheres were used to analyze the behavior of sodium storage in a commercial liquid electrolyte. It was found that during the sodiation process, a solvated ionic layer forms on the surface of the carbon spheres, followed by irreversible expansion due to solid-electrolyte interphase (SEI) formation. The N-PHCSs layer acts as a protective layer, preventing the growth of dendrites at the anode.
Article
Chemistry, Multidisciplinary
Yi Yang, Pavel A. Korzhavyi, Pavel A. Nikolaychuk, Elena F. Bazarkina, Kristina O. Kvashnina, Sergei M. Butorin, Nadezda V. Tarakina, Inna L. Soroka
Summary: Transition metal-based catalysts have the potential to replace Pt-based materials in energy conversion devices due to their low cost, reasonable activity, stability, and corrosion resistance. This study demonstrates the synthesis of homogeneous alloy nanoparticles with controlled structure and varying Ni-to-Co ratios using a gamma-radiolytic reduction method. The presence of structural defects in the obtained samples influenced the catalysts' activity towards the oxygen evolution reaction but had a less pronounced effect on the oxygen reduction reaction. The activity of Ni-Co catalysts in the hydrogen evolution reaction was found to be affected by the formation of Ni-OH bonds on the surface.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Maria Jerigova, Yevheniia Markushyna, Ivo F. Teixeira, Bolortuya Badamdorj, Mark Isaacs, Daniel Cruz, Iver Lauermann, Miguel Angel Munoz-Marquez, Nadezda V. Tarakina, Nieves Lopez-Salas, Oleksandr Savateev, Pablo Jimenez-Calvo
Summary: By pre-organization of precursors and further co-polymerization, tunable semiconductors can be synthesized through anionic doping. These S-doped/C3N4-based materials demonstrate enhanced optical, electronic, structural, textural, and morphological properties, leading to higher performance in organic benzylamine photooxidation, oxygen evolution, and energy storage.
Article
Chemistry, Analytical
Svetlana A. Mescheryakova, Ivan S. Matlakhov, Pavel D. Strokin, Daniil D. Drozd, Irina Yu. Goryacheva, Olga A. Goryacheva
Summary: Doxorubicin (DOX) is a commonly used anti-tumor drug in chemotherapy, but it has high cardio-, neuro- and cytotoxicity. Therefore, continuous monitoring of DOX concentrations in biofluids and tissues is important. This study demonstrates the capabilities of analytical nanosensors based on the quenching of fluorescence of alloyed CdZnSeS/ZnS quantum dots (QDs) for operative DOX detection. Optimized turn-off fluorescence nanosensors were developed for direct DOX determination in undiluted human plasma.
Article
Chemistry, Multidisciplinary
Hannes Zschiesche, Inna L. Soroka, Mats Jonsson, Nadezda V. Tarakina
Summary: This study investigates the influence of irradiation dose on the growth mechanisms and morphology of CeO2 particles formed through the radiolytic oxidation of Ce3+ in aqueous solution. The results show that different dose rates do not affect the growth pathway of CeO2 particles and result in the formation of highly ordered structures. Additionally, locally applied irradiation induces Ce-ion concentration gradients, impacting the growth of CeO2 and leading to the appearance of branched morphologies.