Article
Multidisciplinary Sciences
Shivangi Shree, Delphine Lagarde, Laurent Lombez, Cedric Robert, Andrea Balocchi, Kenji Watanabe, Takashi Taniguchi, Xavier Marie, Iann C. Gerber, Mikhail M. Glazov, Leonid E. Golub, Bernhard Urbaszek, Ioannis Paradisanos
Summary: Efficient second-harmonic generation (SHG) occurs for crystals with broken inversion symmetry, such as transition metal dichalcogenide monolayers. Here the authors show SHG tuning in bilayer MoS2 - an inversion-symmetric crystal - mediated by interlayer excitons.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Gaelle Martin-Gassin, Erwan Paineau, Pascale Launois, Pierre-Marie Gassin
Summary: This study investigates the organization of water molecules around Imogolite nanotubes using the nonlinear optical technique of polarization resolved second harmonic scattering (SHS). The results demonstrate that water organization depends on the electric field induced by the nanotube walls and the ionic strength of the suspension.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Emma Berger, Sasawat Jamnuch, Can B. Uzundal, Clarisse Woodahl, Hari Padmanabhan, Angelique Amado, Paul Manset, Yasuyuki Hirata, Yuya Kubota, Shigeki Owada, Kensuke Tono, Makina Yabashi, Cuixiang Wang, Youguo Shi, Venkatraman Gopalan, Craig P. Schwartz, Walter S. Drisdell, Iwao Matsuda, John W. Freeland, Tod A. Pascal, Michael Zuerch
Summary: The coexistence of ferroelectricity and metallicity in LiOsO3 is a surprising phenomenon, where the novel technique of XUV-SHG reveals sensitivity to the broken inversion symmetry in the polar metal phase. This opens up possibilities for studying symmetry-breaking structural phase transitions with element specificity on femtosecond time scales.
Article
Optics
Thomas Possmayer, Benjamin Tilmann, Lauro J. Q. Maia, Stefan A. Maier, Leonardo de S. Menezes
Summary: We have investigated the nonlinear optical properties of single beta-barium borate nanocrystals and demonstrated their ability to generate multiple harmonics. The particles' polarization response was compared with simulations based on bulk nonlinear tensors, showing good agreement. The nonlinear susceptibilities of different orders were also estimated.
Article
Materials Science, Multidisciplinary
Elena N. Gerasimova, Vitaly V. Yaroshenko, Lidia Mikhailova, Dmitry M. Dolgintsev, Alexander S. Timin, Mikhail Zyuzin, Dmitry A. Zuev
Summary: This article presents a thermally sensitive mechanically driven platform based on pNIPAM microspheres to probe temperature-dependent reversible mechanical transformations and switch the second-harmonic generation signal. The results provide a foundation for the creation of nanophotonic devices based on thermo-sensitive polymers that combine reversible tuning of optical signals with local probing of mechanical changes.
ADVANCED OPTICAL MATERIALS
(2022)
Article
Optics
Anton A. Matrokhin, Mikhail A. Shevchenko, Sofia F. Umanskaya, Maria Tareeva, Anna D. Kudryavtseva, Nikolay Tcherniega
Summary: This paper demonstrates a significant increase in the efficiency of second-harmonic generation in a suspension of lithium niobate particles during freezing, and attributes it to the formation of close-packed structures. It also explores the application of this effect in other lithium niobate particle-based samples and proposes potential uses in phase transition sensing and particle organization process visualization in ice-templating.
Article
Chemistry, Analytical
Jinchun Xu, Yaoqi Liu, Fucai Li, Liyun Deng, Chaoqing Dong, Jicun Ren
Summary: The article introduces a novel single nanoparticle spectroscopy method for measuring unnatural amino acid proteins in single living cells, successfully achieving quantification of UAA-proteins. This method avoids intracellular background interference and provides information on nanoparticle concentration, rotation, and diffusion.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Elena-Alina Moaca, Claudia-Geanina Watz, Vlad Socoliuc, Roxana Racoviceanu, Cornelia Pacurariu, Robert Ianos, Simona Cinta-Pinzaru, Lucian Barbu Tudoran, Fran Nekvapil, Stela Iurciuc, Codruta Soica, Cristina-Adriana Dehelean
Summary: This study presents a method for preparing a highly stable and biocompatible magnetic colloidal suspension, which has significant effects on breast adenocarcinoma cells in hyperthermia treatment, while exhibiting minimal impact on non-tumorigenic cells. Further research is needed to explore the clinical biological potential of the synthesized magnetic colloidal suspension for magnetically triggered hyperthermia.
Article
Mathematics, Interdisciplinary Applications
Hadi Susanto, Boris A. Malomed
Summary: This paper discusses the search for embedded solitons in discrete systems with quadratic and cubic nonlinearities, constructing these solitons using analytical approximations and numerical calculations. Various types of discrete embedded solitons are produced, and it is found that some of them exhibit linear stability, making them genuinely robust modes.
CHAOS SOLITONS & FRACTALS
(2021)
Article
Engineering, Electrical & Electronic
Roberto G. Ramirez-Chavarria, Celia Sanchez-Perez, Luisa Romero-Ornelas, Eva Ramon-Gallegos
Summary: Impedance measurement is a common technique used for detecting the electrical properties of biological cells. This study introduces a label-free method for sensing biological cells based on impedance and the DRT model, which maps impedance data to a time-constant-domain spectrum for data analysis, providing a high sensitivity and resolution electrical fingerprint for the sample.
IEEE SENSORS JOURNAL
(2021)
Article
Chemistry, Physical
Krzysztof Nadolski, Christian Jonin, Estelle Salmon, Zacharie Behel, Katarzyna Matczyszyn, Pierre-Francois Brevet
Summary: In this study, the sensitivity of the Second Harmonic response from gold nanoparticles is explored. The response primarily comes from the nanoparticle surface at small sizes as opposed to the whole volume of the nanoparticle at larger sizes. Upon addition of Glycerol to an aqueous solution of nanoparticles, Surface Plasmon Resonance peak shifts are observed, but cannot fully explain the Second Harmonic intensity changes recorded. Polarization-resolved Second Harmonic measurements are performed to gain further insights into the origin of the observed changes in the experimental data. A mechanism involving modification of the first hyperpolarizability of the nanoparticles followed by nanoparticle aggregation is proposed. The potential alternative use of this nonlinear optical method of Second Harmonic scattering for sensing purposes is discussed based on a proposed figure of merit to describe the observed sensing sensitivity.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Nanoscience & Nanotechnology
Florian Spreyer, Jungho Mun, Hyeohn Kim, Ryeong Myeong Kim, Ki Tae Nam, Junsuk Rho, Thomas Zentgraf
Summary: The study found that helicoid-III nanoparticles exhibit strong chiroptical responses in both the linear and nonlinear optical regime, and these responses can be quantified through calculations. The results demonstrate that the chirality of the helicoid-III nanoparticles is significantly enhanced in the nonlinear regime.
Article
Chemistry, Analytical
Shan Lin, Jun Chang, Jiachen Sun, Zihan Wang, Minghui Mao
Summary: The relationship between line width, modulation amplitude and the amplitude of the second harmonic at the center frequency is theoretically proven, and a novel line width measurement method is proposed. Numerical simulation and experimental validation results show that the method is effective with a relative error of about 1% compared to theoretical data. Furthermore, the advantages of wavelength modulation can be utilized while reducing the difficulty of data acquisition by only measuring the peaks of the second harmonic.
Article
Optics
Mathias Hedegaard Kristensen, Peter Kjaer Kristensen, Kjeld Pedersen, Esben Skovsen
Summary: This communication demonstrates a new characterization technique that combines FT spectroscopy and SHG to achieve high spectral resolution with broadband femtosecond laser pulses. By showcasing the capabilities of the method with the strong and narrow exciton resonances of ZnO, FT-SHG offers high reproducibility and resolution within the bandwidth of the input pulse.
OPTICS COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Lara Hauke, Shwetha Narasimhan, Andreas Primessnig, Irina Kaverina, Florian Rehfeldt
Summary: FAFCK is a tool for fast and accurate analysis of FAs and SFs, enabling automated detection and recording of relevant information, facilitating the study and evaluation of force transmission mechanisms between cells and their surrounding environment.
Article
Rheumatology
Margot Van Mechelen, Tobie Martens, Pieter Vanden Berghe, Rik Lories, Giulia R. Gulino
Summary: The study found that local induction of inflammation can trigger a systemic response, leading to splenomegaly, loss of bone mass, and bone marrow changes. Physical activity does not affect the severity of systemic inflammation, but independently impacts joint homeostasis.
Editorial Material
Gastroenterology & Hepatology
Pieter Vanden Berghe
Article
Chemistry, Multidisciplinary
Yovan de Coene, Stijn Jooken, Olivier Deschaume, Valerie Van Steenbergen, Pieter Vanden Berghe, Chris Van den Haute, Veerle Baekelandt, Geert Callewaert, Stijn Van Cleuvenbergen, Thierry Verbiest, Carmen Bartic, Koen Clays
Summary: In this study, it is found that endogenous second-harmonic generation (SHG) from live cells is highly sensitive to changes in transmembrane potential (TMP), indicating the potential of using SHG as a label-free read-out tool for electrogenic cells.
Article
Multidisciplinary Sciences
Franziska Bierbuesse, Anais C. Bourges, Vincent Gielen, Viola Monkemoller, Wim Vandenberg, Yi Shen, Johan Hofkens, Pieter Vanden Berghe, Robert E. Campbell, Benjamien Moeyaert, Peter Dedecker
Summary: The authors present a method, called photochromism-enabled absolute quantification (PEAQ) biosensing, that utilizes the photochromic properties of biosensors to provide an absolute measure of analyte concentration or activity. By developing photochromic variants of the popular GCaMP family of Ca2+ biosensors, they are able to resolve dynamic changes in the absolute Ca2+ concentration in live cells. They also demonstrate how this method can be applied to other biosensors with photochromic properties, expanding the possibilities for fully quantitative measurements in complex and dynamic systems.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Rachael Taitt, Mathias Urbain, Kevin Bredillet, Zacharie Behel, Giacomo Ceccone, Jorge Banuls-Ciscar, Sandrine Beauquis, Yannick Mugnier, Pierre-Francois Brevet, Ronan Le Dantec, Yann Chevolot, Virginie Monnier
Summary: This study presents a method for preparing nanoparticles containing a lithium niobate core and a gold shell using a combination of seeded-growth and layer-by-layer approaches. The influence of three synthesis parameters on the nanoparticles' characteristics is studied, and the growth of the gold shell is investigated using various techniques. The optical and photothermal properties of the core-shell nanoparticles are also analyzed.
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
(2022)
Article
Chemistry, Multidisciplinary
Derick Yongabi, Mehran Khorshid, Patricia Losada-Perez, Soroush Bakhshi Sichani, Stijn Jooken, Wouter Stilman, Florian Thesseling, Tobie Martens, Toon Van Thillo, Kevin Verstrepen, Peter Dedecker, Pieter Vanden Berghe, Minne Paul Lettinga, Carmen Bartic, Peter Lieberzeit, Michael J. Schoning, Ronald Thoelen, Marc Fransen, Michael Wubbenhorst, Patrick Wagner
Summary: In this study, a fast and facile label- and receptor-free method for cell characterization is proposed, using the natural response of cells to mild thermal stimuli. The time-patterns of synchronized and spontaneous cell detachment provide cell-specific indicators that can distinguish different cell types.
Article
Clinical Neurology
Wenting Guo, Haibo Wang, Arun Kumar Tharkeshwar, Julien Couthouis, Elke Braems, Pegah Masrori, Evelien Van Schoor, Yannan Fan, Karan Ahuja, Matthieu Moisse, Maarten Jacquemyn, Rodrigo Furtado Madeiro da Costa, Madhavsai Gajjar, Sriram Balusu, Tine Tricot, Laura Fumagalli, Nicole Hersmus, Rekin's Janky, Francis Impens, Pieter Vanden Berghe, Ritchie Ho, Dietmar Rudolf Thal, Rik Vandenberghe, Muralidhar L. Hegde, Siddharthan Chandran, Bart De Strooper, Dirk Daelemans, Philip Van Damme, Ludo Van den Bosch, Catherine Verfaillie
Summary: In this study, we identified NEK6 as a novel therapeutic target for C9orf72 FTD/ALS by performing a kinome-wide CRISPR/Cas9 knock-out screen in human induced pluripotent stem cell-derived cortical neurons. NEK6 was found to regulate poly(PR)-mediated p53-related DNA damage.
ALZHEIMERS & DEMENTIA
(2023)
Article
Gastroenterology & Hepatology
Zhiling Li, Werend Boesmans, Youcef Kazwiny, Marlene M. Hao, Pieter Vanden Berghe
Summary: Live calcium imaging is a valuable tool for simultaneous analysis of neuronal activity. This study investigated how enteric neurons respond to different modes of depolarization using electrophysiology and calcium imaging techniques. The research found that single action potentials can elicit calcium transients in both AH-neurons and S-neurons, and nicotinic acetylcholine receptor stimulation can be used to distinguish between these two classes.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Valerie Van Steenbergen, Flavie Lavoie-Cardinal, Youcef Kazwiny, Marianna Decet, Tobie Martens, Patrik Verstreken, Werend Boesmans, Paul De Koninck, Pieter Vanden Berghe
Summary: The correct distribution of organelles and vesicles in cells is crucial for cell functioning. In polarized cells such as neurons, the transport of mitochondria, which play a key role in producing energy and buffering calcium, is especially important. This study found that the molecular conformation of tubulin affects mitochondrial transport in neurons. The position of a mitochondrion within or at the rim of a microtubule bundle determines the impact of tubulin conformation on mitochondrial transport.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Adrian Gheata, Alessandra Spada, Manon Wittwer, Ameni Dhouib, Emilie Molina, Yannick Mugnier, Sandrine Gerber-Lemaire
Summary: Inorganic nanoparticles can be surface-functionalized to enhance their biomedical applications. Silanization is a versatile coating strategy that allows the introduction of reactive moieties on the oxide surface of nanoparticles. In this study, silica coating of LiNbO3 nanoparticles was achieved through optimized microemulsion conditions, resulting in the formation of coated nanoparticles with carboxyl or azide reactive groups.
Article
Multidisciplinary Sciences
Maria Francesca Viola, Marta Chavero-Pieres, Elodie Modave, Marcello Delfini, Nathalie Stakenborg, Maria Cuende Estevez, Naomi Fabre, Iris Appeltans, Tobie Martens, Katy Vandereyken, Hannah Theobald, Jens Van Herck, Philippe Petry, Simon Verheijden, Sebastiaan De Schepper, Alejandro Sifrim, Zhaoyuan Liu, Florent Ginhoux, Mohamad Azhar, Andreas Schlitzer, Gianluca Matteoli, Katrin Kierdorf, Marco Prinz, Pieter Vanden Berghe, Thierry Voet, Guy Boeckxstaens
Summary: Development and maturation of the enteric nervous system (ENS) relies on the actions of resident macrophages, which prune synapses and phagocytose enteric neurons in early life. After weaning, these macrophages continue to interact closely with the ENS and acquire a neurosupportive phenotype. This interaction is mediated by transforming growth factor-beta produced by the ENS, and disruption of this communication leads to loss of enteric neurons and altered intestinal transit.
Correction
Multidisciplinary Sciences
Franziska Bierbuesse, Anais C. Bourges, Vincent Gielen, Viola Monkemoller, Wim Vandenberg, Yi Shen, Johan Hofkens, Pieter Vanden Berghe, Robert E. Campbell, Benjamien Moeyaert, Peter Dedecker
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Thomas Plum, Rebecca Binzberger, Robin Thiele, Fuwei Shang, Daniel Postrach, Candice Fung, Marina Fortea, Nathalie Stakenborg, Zheng Wang, Anke Tappe-Theodor, Tanja Poth, Duncan A. A. MacLaren, Guy Boeckxstaens, Rohini Kuner, Claudia Pitzer, Hannah Monyer, Cuiyan Xin, Joseph V. Bonventre, Satoshi Tanaka, David Voehringer, Pieter Vanden Berghe, Jessica Strid, Thorsten B. Feyerabend, Hans-Reimer Rodewald
Summary: The physiological functions of mast cells are not well understood. Mast cells are involved in type 2 immunity and promote allergic diseases through the interaction with immunoglobulin E (IgE). However, allergic symptoms may also facilitate the elimination of allergens, toxins, and parasites and trigger future antigen avoidance. In this study, mast cells were found to be crucial for antigen-specific avoidance behavior in inbred mice. This behavior prevented immune activation and inflammation in the stomach and small intestine. Antigen avoidance was dependent on IgE and regulated by Th2 cytokines in the immunization phase and by IgE in the execution phase. Mucosal mast cells quickly detected the ingestion of antigens. Multiple signaling pathways between mast cells and the brain were identified. Inhibition of leukotriene synthesis impaired avoidance, but no single pathway interruption completely abolished it, suggesting complex regulation. Overall, antigen avoidance mediated by mast cells may play an important role in preventing immunopathology and repeated ingestion of toxins.
Article
Nanoscience & Nanotechnology
Ana-Mariia Pablo-Sainz-Ezquerra, Rachael Taitt, Florian Riporto, Yannick Mugnier, Pyria D. Mariathomas, Ronan Le Dantec, Mimoun Aouine, Christophe Geantet, Rajesh Ramanathan, Vipul Bansal, Yann Chevolot, Virginie Monnier
Summary: In this study, LiNbO3/Au and LiNbO3/Pt nanoparticles were synthesized by a simple and efficient method. The nanocomposites were prepared by introducing branched poly(ethyleneimine) as a linker, and the loading of metal on the surface of LiNbO3 was controlled by varying the volume of metal seeds dispersion added. The as-prepared composites showed enhanced catalytic activity compared to the separated counterparts, making them potential candidates for biomedicine applications.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Doyoung Kim, Gabrielle A. Mandl, Marta Balkota, Jimmy Vernaz, Song Huang, Samuel Constant, Pierre Maechler, Christine Dewolf, John A. Capobianco, Luigi Bonacina
Summary: The impact of surface coating on the interaction between lanthanide-doped upconverting nanoparticles (UCNPs) and the mucus barrier is studied using a patient-derived 3D cell culture model. The results demonstrate significant differences in residence time in mucus and mucociliary clearance for UCNPs with different coatings.
ADVANCED FUNCTIONAL MATERIALS
(2023)