Article
Rheumatology
Sicilia Rezende Oliveira, Jose Alcides Almeida de Arruda, Ayda Henriques Schneider, Valessa Florindo Carvalho, Caio Cavalcante Machado, Joice Dias Correa, Marcela Faria Moura, Leticia Fernanda Duffles, Flavio Falcao Lima de Souza, Gilda Aparecida Ferreira, Fernando Oliveira Costa, Lucas Guimaraes Abreu, Mario Taba Junior, Sandra Yasuyo Fukada, Rene Donizeti Ribeiro de Oliveira, Paulo Louzada-Junior, Fernando de Queiroz Cunha, Tarcilia Aparecida Silva
Summary: This study reveals a potential link between periodontitis and RA through the involvement of NETs, and periodontal therapy can dramatically affect circulating NET levels.
Article
Multidisciplinary Sciences
Y. Shi, J. S. Gauer, S. R. Baker, H. Philippou, S. D. Connell, R. A. S. Ariens
Summary: Neutrophils and NETs have procoagulant effects in plasma, but not in purified fibrinogen, indicating other factors mediate the interaction. NETs increase clot density, while neutrophils induce less stable and more porous clots. Additionally, neutrophils and NETs may induce clotting through different pathways, with NETs possibly mediated by FXI.
SCIENTIFIC REPORTS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Joao Luiz Guilherme Neto, Lucas Gabriel Rodrigues Venturini, Ayda Henriques Schneider, Thaise Mayumi Taira, Leticia Fernanda Duf fles Rodrigues, Favio Protasio Veras, Sicilia Rezende Oliveira, Tarcilia Aparecida da Silva, Fernando Queiroz Cunha, Sandra Yasuyo Fukada
Summary: Neutrophil extracellular traps (NETs) play an important role in the pathogenesis of apical periodontitis by regulating local inflammation and osteoclast activity, leading to bone resorption. Depletion of NETs reduces apical lesion size and alveolar bone resorption in mice.
JOURNAL OF ENDODONTICS
(2023)
Article
Medicine, General & Internal
Mathieu Godement, Jaja Zhu, Charles Cerf, Antoine Vieillard-Baron, Agathe Maillon, Benjamin Zuber, Valerie Bardet, Guillaume Geri
Summary: The study demonstrated a negative association between the level of NETs in the blood at admission and the number of days with severe hypoxemia in COVID-19 patients admitted to the ICU. Additionally, a significant decrease in NET levels from day 1 to day 3 was observed in surviving patients, while levels remained stable in patients who did not survive.
FRONTIERS IN MEDICINE
(2021)
Review
Immunology
Edgar Ramos-Martinez, Leticia Hernandez-Gonzalez, Ivan Ramos-Martinez, Laura Perez-Campos Mayoral, Georgina Lopez-Cortes, Eduardo Perez-Campos, Gabriel Mayoral Andrade, Maria Teresa Hernandez-Huerta, Marco Jose
Summary: Extracellular DNA traps (ETs) are evolutionarily conserved antimicrobial mechanisms found in protozoa, plants, and animals. By comparing similarities in ETs across different taxa, it is suggested that ETs may have multiple origins. The presence of a mechanism initiating the formation of ETs in multicellular organisms indicates a relationship between multicellularity and the development of ETs.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Dragana C. Markovic, Irina S. Maslovaric, Marijana Kovacic, Sanja Vignjevic Petrinovic, Vesna Lj. Ilic
Summary: Myeloproliferative neoplasms (MPNs) are hematologic malignancies characterized by gene mutations and abnormal signaling pathways. Chronic inflammation is believed to play a key role in the progression of MPNs. Neutrophils in MPNs show abnormal activation and apoptotic machinery, leading to inflammation and the formation of neutrophil extracellular traps (NETs). NETs induce hematopoietic precursor proliferation in the bone marrow microenvironment, affecting hematopoietic disorders. This review discusses the potential pathophysiological significance of NET formation in MPNs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Weronika Kuzmicka, Aneta Manda-Handzlik, Adrianna Cieloch, Agnieszka Mroczek, Urszula Demkow, Malgorzata Wachowska, Olga Ciepiela
Summary: This study demonstrated that zinc impacts several basic functions of neutrophils, including inhibiting NETs release and degranulation. Additionally, low zinc levels in mice resulted in increased NETs release and enhanced neutrophils degranulation. Overall, zinc affects neutrophils' functions both in vivo and in vitro, highlighting the importance of proper zinc levels for maintaining efficient innate immune response.
Review
Biochemistry & Molecular Biology
Jia Zeng, Min Wu, Yamei Zhou, Manhui Zhu, Xiaojuan Liu
Summary: This article discusses the pathogenesis of neutrophil extracellular traps (NETs) in the field of ophthalmology, emphasizing their importance as potential targets for the treatment of ocular diseases.
Review
Pharmacology & Pharmacy
Barbara Gierlikowska, Albert Stachura, Wojciech Gierlikowski, Urszula Demkow
Summary: Neutrophils play a crucial role in the innate immune system by carrying out effector functions such as phagocytosis, degranulation, and NET formation. Research suggests that modulation of neutrophil effector functions can impact treatment efficacy, with pharmacological modulation influencing molecular mechanisms involved in these processes. This review highlights the versatility and plasticity of neutrophils in physiology, bacterial and viral infections, as well as the potential impact of plant extracts, plant-derived compounds, and synthetic drugs on neutrophil effector functions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Eda Cetin Ozdemir, Emrah Bilen, Fatih M. Yazar
Summary: The study found that DNI, IG, CRP, and neutrophil count were positively correlated with periodontal parameters, with the highest levels observed in Stage 3 Grade A periodontitis patients.
JOURNAL OF APPLIED ORAL SCIENCE
(2022)
Review
Microbiology
Juliana da Costa Silva, Glaucia de Azevedo Thompson-Souza, Marina Valente Barroso, Josiane Sabbadini Neves, Rodrigo Tinoco Figueiredo
Summary: Fungal infections are a global health problem, with neutrophils and eosinophils playing key roles in controlling fungal infections by releasing extracellular traps (ETs) that exhibit antifungal activities.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Immunology
Alexandre Le Joncour, Patrice Cacoub, Yacine Boulaftali, David Saadoun
Summary: Behcet's disease (BD) is a chronic systemic vasculitis characterized by recurrent oral and genital ulcers, skin lesions, articular, neurological, vascular and sight-threatening ocular inflammation. BD is thought to share both autoimmune and autoinflammatory disease features. Neutrophils seem to play an instrumental role in BD and recent works regarding the role of neutrophils extracellular traps (NETs) provides new insight in the pathophysiology of BD and the mechanisms involved in immune thrombosis. This review provides a recent overview on the role of neutrophils and NETs in the pathogenesis of BD.
CLINICAL IMMUNOLOGY
(2023)
Review
Oncology
Jingxuan Xia, Zhiyuan Zhang, Yijin Huang, Yufei Wang, Guangwei Liu
Summary: This article summarizes the formation process of neutrophil extracellular traps (NETs), their regulatory role in tumor development, and treatment methods based on NETs. NETs have the ability to awaken latent tumor cells and promote their proliferation and development, while also inhibiting tumor growth. These advancements provide a theoretical basis for the development of NET-targeted drugs.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Caren Linnemann, Filiz Sahin, Yangmengfan Chen, Karsten Falldorf, Michael Ronniger, Tina Histing, Andreas K. Nussler, Sabrina Ehnert
Summary: This study aimed to evaluate the effect of a 16 Hz extremely low-frequency pulsed electromagnetic field (ELF-PEMF) on neutrophil extracellular trap (NET) formation. The study found that ELF-PEMF exposure did not induce reactive oxygen species and Ca2+-influx in neutrophils, and it reduced the amount of NET release. Therefore, ELF-PEMF exposure can be started immediately after fracture treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Sonia Aguila, Ascension M. de los Reyes-Garcia, Maria P. Fernandez-Perez, Laura Reguilon-Gallego, Laura Zapata-Martinez, Inmaculada Ruiz-Lorente, Vicente Vicente, Rocio Gonzalez-Conejero, Constantino Martinez
Summary: This article summarizes the formation mechanism and regulatory elements of Neutrophil extracellular traps (NETs), as well as the role of miRNAs associated with various inflammatory pathologies. miRNAs, as small non-coding RNAs, play important regulatory roles in various pathological processes and may become therapeutic targets for preventing inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Lucia Diaz-Faes, Ana Soriano-Lerma, Antonio Magan-Fernandez, Maria Lopez, Juan Gijon, Jose Antonio Garcia-Salcedo, Miguel Soriano, Francisco Mesa
Article
Dentistry, Oral Surgery & Medicine
Francisco Mesa, Miguel Angel Arrabal-Polo, Antonio Magan-Fernandez, Miguel Arrabal, Amada Martin, Ricardo Munoz, Alejandro Rodriguez-Agurto, Manuel Bravo
Summary: This study found that patients with periodontitis and erectile dysfunction (ED) had a 3.7 times higher risk of major adverse cardiovascular events after an average follow-up of 4.2 years.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Endocrinology & Metabolism
Dragana Nikolic, Angelo M. Patti, Rosaria Giglio, Roberta Chianetta, Giuseppa Castellino, Antonio Magan-Fernandez, Roberto Citarrella, Nikolaos Papanas, Andrej Janez, Anca Pantea Stoian, Ali A. Rizvi, Manfredi Rizzo
Summary: Liraglutide has beneficial effects on glycemic parameters and cardiometabolic risk factors in patients with type 2 diabetes, with greater efficacy in obese patients. These findings reinforce the benefits of liraglutide for the cardiometabolic outcomes of obese patients with type 2 diabetes in real-world settings.
Article
Dentistry, Oral Surgery & Medicine
Monica Zamora-Pasadas, Rafael Marfil-Alvarez, Pablo Gonzalez-Bustos, Antonio Magan-Fernandez, Francisco Mesa
Summary: The prevalence of periodontitis is higher in patients with systemic lupus erythematosus (SLE) and those with periodontitis have a higher risk of subclinical atherosclerosis. Patients with higher gingival bleeding are also at a higher risk of SLE.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Review
Environmental Sciences
Maria Jose Mesa-Lopez, Carina Martinez-Camacho, Francisco Mesa
Summary: Swallowing a toothbrush is a rare event and there is no documented case of spontaneous elimination of the foreign body through the gastrointestinal tract. The article describes the common sites of retention and the appropriate therapeutic approach. A case of a woman who swallowed a toothbrush and presented with abdominal pain and anxiety is also presented with details of diagnosis and treatment.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Simona Terzo, Antonella Amato, Antonio Magan-Fernandez, Giuseppa Castellino, Pasquale Calvi, Roberta Chianetta, Rosaria V. Giglio, Angelo M. Patti, Dragana Nikolic, Alberto Firenze, Flavia Mule, Marcello Ciaccio, Manfredi Rizzo
Summary: Pre-obesity is a condition that increases the risk of obesity, cardiovascular diseases, and diabetes. A study found that Altilix(R), a nutraceutical containing chlorogenic acid and luteolin extracts, can improve hepatic and cardio-metabolic parameters. In a post-hoc analysis, Altilix(R) was shown to effectively improve anthropometry, glucose metabolism, lipid profile, hepatic functionality, carotid-media thickness, and endothelial function in pre-obesity subjects.
Article
Multidisciplinary Sciences
Alejandro Rodriguez-Agurto, Manuel Bravo, Antonio Magan-Fernandez, Ana Lopez-Toruno, Ricardo Munoz, Joaquin Ferrer, Francisco Mesa
Summary: This study compared the effects of using toothpaste with extra-virgin olive oil, xylitol, and betaine to a placebo or commercial toothpaste on gingival bleeding, dental biofilm, and salivary flow and pH in patients with gingivitis. The test group showed significant decreases in gingival bleeding and biofilm, as well as increased salivary flow and pH, compared to the control groups. Therefore, toothpaste with EVOO, xylitol, and betaine demonstrated better outcomes in treating gingivitis.
SCIENTIFIC REPORTS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Pilar Barragan-Reyes, Antonio Magan-Fernandez, Ana Mesa-Lopez, Natalia Calvente-Vera, Manuel Gallardo-Medina, Tomas Munoz, Francisco Mesa
Summary: This article presents three successful cases of dental implant screwdriver aspiration that were removed by flexible bronchoscopy. It highlights preventive measures and clinical signs of screwdriver presence in the bronchial tree. The report also reviews nine previously published reports on this phenomenon and proposes an action protocol for dental practitioners, anaesthetists, and pulmonologists to address this emergency. It further describes early and late complications.
INTERNATIONAL JOURNAL OF ORAL IMPLANTOLOGY
(2023)
Review
Medicine, General & Internal
Giuseppe Mainas, Mark Ide, Manfredi Rizzo, Antonio Magan-Fernandez, Francisco Mesa, Luigi Nibali
Summary: Periodontitis is a host-mediated disease caused by microbes, which leads to the loss of periodontal attachment and bone. It is associated with elevated systemic inflammatory markers and systemic co-morbidities. Periodontal treatment induces acute local and systemic inflammatory response, which may be more burdensome for patients with compromised medical history and/or uncontrolled systemic diseases. This article discusses the correlation between periodontitis and systemic diseases, the impact on quality of life and public health, the effects of periodontal treatment on systemic health and disease, and methods to manage systemic inflammation after periodontal therapy.
MEDICINA-LITHUANIA
(2022)
Review
Medicine, General & Internal
Francisco Mesa, Maria Jose Mesa-Lopez, Juan Egea-Valenzuela, Cristina Benavides-Reyes, Luigi Nibali, Mark Ide, Giuseppe Mainas, Manfredi Rizzo, Antonio Magan-Fernandez
Summary: This review explores the relationship between gingival dysbiosis and Fusobacterium nucleatum, a key bacterium related to periodontitis, and its connection to colorectal cancer. The article provides updated knowledge on the microbiome, epidemiology, risk factors, prognosis, and treatment of colorectal cancer, and highlights the emerging mechanisms uncovered by scientific evidence. A comprehensive diagram summarizes the pathogenic mechanisms of this relationship. The review concludes with important questions and future research perspectives.
MEDICINA-LITHUANIA
(2022)
