Article
Chemistry, Multidisciplinary
Kateryna V. Vygranenko, Yevgen M. Poronik, Manon H. E. Bousquet, Olena Vakuliuk, Denis Jacquemin, Daniel T. Gryko
Summary: The lactone carbonyl group of coumarin derivatives can participate in intramolecular Knoevenagel condensations, allowing the unprecedented direct transformation of coumarins into rhodols. The resulting rhodols, which have two ester groups, exhibit intense orange-red fluorescence.
CHEMICAL COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Claire Deo, Ahmed S. Abdelfattah, Hersh K. Bhargava, Adam J. Berro, Natalie Falco, Helen Farrants, Benjamien Moeyaert, Mariam Chupanova, Luke D. Lavis, Eric R. Schreiter
Summary: Functional imaging in biology has been revolutionized by the use of fluorescent indicators, but there is a need for additional sensor scaffolds with properties such as bright, far-red emission. This study introduces a new platform for 'chemigenetic' fluorescent indicators using self-labeling HaloTag protein conjugated to synthetic fluorophores, enabling the creation of highly tunable calcium and voltage sensors with bright, far-red emission.
NATURE CHEMICAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Wuyu Mao, Jie Tang, Liqun Dai, Xinyu He, Jie Li, Larry Cai, Ping Liao, Ruotian Jiang, Jingwei Zhou, Haoxing Wu
Summary: A novel strategy has been developed to create highly fluorescent Huaxi-Fluor probes that exhibit significantly increased fluorescence upon forming the bioorthogonal reaction product, pyridazine. These probes have large Stokes shifts and high quantum yields, with emission wavelengths fine-tunable from 556 to 728 nm by manipulating the fluorophore skeleton. Highly photo-stable and biocompatible, these probes are suitable for live cell organelle visualization without washing steps and imaging tumors in live small animals to depths of 500 μm by two-photon excitation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Optics
Rupesh A. Talewar, Sk. Mahamuda, A. S. Rao, S. V. Moharil
Summary: Novel and efficient broadband excited far-red emitting NaLiTi3O7:Mn4+ phosphors were synthesized. The phase purity of NaLiTi3O7 was analyzed using X-ray powder diffraction technique. The luminescence properties and fluorescence decay curves were explored to characterize the phosphors. Under UV/VIS excitation, Mn4+ doped NaLiTi3O7 shows intense emission around 681 nm. The crystal field strength (Dq) and Racah parameters (B and C) were determined to analyze the nephelauxetic impact of Mn4+ in the NaLiTi3O7 host lattice. The results are in good agreement with the linear dependency of 2E on the beta 1 parameter, which indicates the position of the Mn4+ emission based on beta 1. A Tanabe-Sugano energy level diagram was used to evaluate the luminescence process. Fluorescence decay measurement was used to discuss the concentration quenching phenomenon.
JOURNAL OF LUMINESCENCE
(2023)
Article
Materials Science, Biomaterials
Liu Yang, Suyuan Chen, Dong Yi, Qingxin Chen, Jie Zhang, Yusheng Xie, Hongyan Sun
Summary: A new class of red-to-near-infrared-emitting small molecular dyes called VBDfluors have been developed, demonstrating excellent photophysical properties and cell permeability. By introducing electron-withdrawing group-substituted vinyl groups, the conjugation system was extended to achieve bathochromic shift of both absorption and emission wavelengths. The optimized molecular geometry using density functional theory and time-dependent DFT methods showed promising results for bioimaging applications.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Review
Chemistry, Applied
Suryapratap J. Sharma, Nagaiyan Sekar
Summary: Dyes with a coumarin core are highly valuable for their ability to absorb and emit light in the deep-red to NIR region. They play essential roles in biology, DSSC, NLO materials, and LASER dyes. This review summarizes the photophysical features, synthetic methodologies, and applications of these dyes. The relevance of DFT and TD-DFT techniques in obtaining the desired photophysical characteristics of coumarin dyes before synthesis is also discussed.
Article
Chemistry, Inorganic & Nuclear
I. Elhamdi, F. Mselmi, S. Kammoun, E. Dhahri, A. J. Carvalho, P. Tavares, B. F. O. Costa
Summary: ZnAl2-xCrxO4 (x = 0 and 0.05) samples were synthesized and investigated for their structure, photoluminescence properties, EPR measurements, thermal stability, and chromaticity diagram. It was found that ZnAl1.95Cr0.05O4 is a potential far-red phosphor for plant growth applications.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Wuyu Mao, Weijie Chi, Xinyu He, Chao Wang, Xueyi Wang, Haojie Yang, Xiaogang Liu, Haoxing Wu
Summary: In this study, a generalizable molecular design strategy was reported to construct ultra-fluorogenic dyes by simple substitution at the meso-positions of various far-red and NIR fluorophores. The probes showed significant fluorescence turn-on ratios in the range of 586-806 nm. These results will greatly expand the applications of bioorthogonal chemistry in NIR bioimaging and biosensing.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Junwei Zhang, Xiaohong Peng, Yunxiang Wu, Huixia Ren, Jingfu Sun, Shiyan Tong, Tianyan Liu, Yiwen Zhao, Shusen Wang, Chao Tang, Liangyi Chen, Zhixing Chen
Summary: This study presents a class of red- and far-red-emitting Zn2+ probes, suitable for real-time monitoring high concentrations of Zn2+ co-released with insulin during vesicular secretion. Introduction of morpholino auxochromes in the probes eliminates phototoxicity, enabling long-term live recording of isolated islets. Additionally, a Si-rhodamine-based Zn2+ probe with high turn-on ratio allows simultaneous recording of various signals in isolated islets, showcasing the potential impact of biocompatible fluorophores in islet endocrinology and system biology.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Materials Science, Multidisciplinary
Jilong Xiao, Jianchen Zhang, Chaoyang Tu, Jinsheng Liao, Herui Wen, Guoliang Gong
Summary: The study synthesized far red-emitting Mn4+-activated SrGd2Al2O7 phosphors which showed good compatibility with plant phytochromes under specific conditions, indicating potential for improving efficiency of indoor plant growth LEDs.
Article
Optics
Fengfeng Chi, Wenjuan Dai, Liting Qiu, Shengli Liu, Xiantao Wei, Yonghu Chen, Min Yin
Summary: In this study, a Cr3+-activated Lu2CaAl4GeO12 phosphor with far-red emitting was prepared, and its thermally stable luminescence was observed.
JOURNAL OF LUMINESCENCE
(2022)
Article
Chemistry, Physical
B. Yadagiri, Prem Jyoti Singh Rana, Surya Prakash Singh
Summary: The two new compounds exhibit excellent sensing properties towards Fe3+ transition metal ions, and have remarkable fluorescence properties.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Article
Optics
Shuxin Wang, Yongjie Liu, Chenwei Liu, Wenlong Shao, Chen Wang, Meng Xiao, Guoyi Chen, Zhiqiu Yu, Chen Tao, Weijun Ke, Guojia Fang
Summary: This study demonstrates a strategy to achieve high-performance far-red perovskite light-emitting diodes (PeLEDs) through antisolvent engineering. By introducing 1,3,5-tris(1-phenyl-1H-benzimidazole-2-yl) benzene (TPBi) into the perovskite matrix, the defects are passivated, carrier mobility is balanced, and the energy level alignment between perovskite and the electron transport layer is adjusted. The PeLEDs with TPBi-modified perovskite emitters show a consistent far-red emission peak at around 735 nm with a champion external quantum efficiency of 14.22%.
LASER & PHOTONICS REVIEWS
(2023)
Article
Optics
Linlin Wang, Yan-gai Liu, Haojun Yu, Ruiyu Mi, Xiaoya Bu, Lefu Mei, Hao Ding
Summary: Pc-LEDs have numerous advantages but are limited in practical applications due to the lack of red-light emission. This study successfully synthesized Mn4+-doped Ca2GdZr2Al3O12 (CGZA: Mn4+) phosphors that emit far-red light and demonstrated their potential application in plant breeding.
JOURNAL OF LUMINESCENCE
(2022)
Article
Materials Science, Multidisciplinary
Zhiwen Yan, Xiaoliang Yang, Siguo Xiao
Summary: The Li6SrLa2Sb2O12:Mn4+ phosphor exhibits a broad excitation band and far-red emission, suitable for plant growth LED applications at a certain concentration.
MATERIALS RESEARCH BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Joaquin Bonelli, Enrique Ortega-Forte, Anna Rovira, Manel Bosch, Oriol Torres, Cristina Cusco, Josep Rocas, Jose Ruiz, Vicente Marchan
Summary: Encapsulation of mitochondria-targeted coumarin photosensitizers within nanocapsules improves their photoactivity and reduces cytotoxicity, making them promising agents for nano-photodynamic therapy.
Article
Chemistry, Inorganic & Nuclear
Robin Vinck, Albert Gandioso, Pierre Burckel, Bruno Saubamea, Kevin Cariou, Gilles Gasser
Summary: Four new ruthenium(II) polypyridyl complexes were synthesized and their properties were studied. It was found that these complexes could self-assemble into nanoparticles and accumulate in lysosomes upon internalization by cells. Conjugation with biotin increased cellular uptake but did not increase phototoxicity. However, these complexes showed high phototoxicity upon irradiation at long wavelengths (645-670 nm) and self-assembling behavior, making them promising for the development of new lysosome-targeted photosensitizers for photodynamic therapy.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Jorge Leal, Gema Dura, Felix A. Jalon, Elisenda Zafon, Anna Massaguer, Jose Vicente Cuevas, Lucia Santos, Ana M. Rodriguez, Blanca R. Manzano
Summary: Luminescent platinum cyclometalated complexes have applications in optoelectronic and biological fields, especially in anticancer activity. A series of these complexes with different ligands were synthesized, and their emission wavelengths could be tuned. Density-functional theory provided descriptions of their molecular orbital characteristics, and time-dependent DFT calculations showed different excited states for different complexes. Biological studies demonstrated that some complexes exhibited cytotoxic activity against human cervical and lung carcinoma cells, and microscopy assays showed their accumulation in cytoplasmic organelles. The disruption of mitochondrial metabolism was observed, leading to a decrease in cellular ATP content. These complexes may have potential as alternative anticancer drugs.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Eduardo Izquierdo, Marta L. opez-Corrales, Diego Abad-Montero, Anna Rovira, Gemma Fabria, Manel Bosch, Jose Luis Abad, Vicente Marchan
Summary: Researchers have developed a series of new fluorescent sphingolipid probes with excellent emission quantum yields and different subcellular localization patterns.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Joao P. M. Antonio, Albert Gandioso, Fariba Nemati, Nancy Soliman, Robin Vinck, Fan Sun, Carine Robert, Pierre Burckel, Didier Decaudin, Christophe M. Thomas, Gilles Gasser
Summary: The translation of metal-based cytotoxic drugs from in vitro to in vivo has been a challenge in their development as effective anti-cancer alternatives. This study presents a simple and efficient one-pot procedure for the preparation of covalently-attached Ru-polylactide nanoparticles. These nanoparticles have demonstrated good stability, predictable release kinetics, and comparable cytotoxicity to cisplatin in ovarian cancer cells. Furthermore, the nanoparticles showed significantly higher internalization in tumor cells compared to free ruthenium complex. In vivo experiments in mice also showed improved pharmacokinetics and biodistribution of the drug. These results highlight the potential of covalently-loaded ruthenium polylactide nanoparticles for the treatment of ovarian cancer.
Article
Pharmacology & Pharmacy
Joaquin Bonelli, Maria Velasco-de Andres, Neus Isidro, Cristina Bayo, Sergi Chumillas, Laura Carrillo-Serradell, Sergi Casado-Llombart, Cheryl Mok, Daniel Benitez-Ribas, Francisco Lozano, Josep Rocas, Vicente Marchan
Summary: This study reports a technology that encapsulates water-soluble bioactive compounds in double-walled polyurethane-polyurea hybrid nanocapsules (NCs) loaded with indocyanine green (ICG). The NCs demonstrate specific accumulation in tumor tissues while avoiding premature clearance in the bloodstream, making them promising for cancer theragnosis.
Article
Chemistry, Medicinal
Alvaro Simba-Lahuasi, Angel Cantero-Camacho, Romel Rosales, Briana Lynn McGovern, M. Luis Rodriguez, Vicente Marchan, Kris M. White, Adolfo Garcia-Sastre, Jose Gallego
Summary: Researchers have identified and characterized RNA-binding compounds that can inhibit the replication of SARS-CoV-2. These compounds were discovered by screening a small library of antiviral compounds and showed promising activity against SARS-CoV-2. Further investigation revealed that these compounds recognize conserved RNA elements in the SARS-CoV-2 genome. These findings provide new possibilities for developing RNA-targeted antivirals and therapeutic agents against coronaviruses.
Article
Chemistry, Multidisciplinary
Asma Mani, Tao Feng, Albert Gandioso, Robin Vinck, Anna Notaro, Lisa Gourdon, Pierre Burckel, Bruno Saubamea, Olivier Blacque, Kevin Cariou, Jamel-Eddine Belgaied, Hui Chao, Gilles Gasser
Summary: Five osmium(II) polypyridyl complexes with different ligands were synthesized as photosensitizers for photodynamic therapy. These complexes exhibited high absorption in the near-infrared region and showed promising phototoxicity against cancer cells in vitro and in multicellular tumor spheroids upon irradiation at 740 nm. The complex with 2,2'-bipyridine ligand showed the highest phototoxicity against various cancer cell lines. Experiments on tumor-bearing mice also demonstrated significant tumor growth reduction with laser irradiation at 740 nm. This structurally simple complex has great potential as a photosensitizer for cancer treatment.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Medicinal
Anna Rovira, Enrique Ortega-Forte, Cormac Hally, Mireia Jorda-Redondo, Diego Abad-Montero, Gloria Vigueras, Jesus I. Martinez, Manel Bosch, Santi Nonell, Jose Ruiz, Vicente Marchan
Summary: Photodynamic therapy shows potential as a non-invasive anticancer tool, but the development of highly effective and non-toxic photosensitizers that can work under hypoxic conditions is still needed. In this study, Ir(III)-COUPY conjugates were developed based on the advantageous properties of COUPY fluorophores and cyclometalated Ir(III) complexes, aiming to explore structure-activity relationships. The structural modifications within the coumarin scaffold had a significant impact on the photophysical properties and cellular uptake of the conjugates. All Ir(III)-COUPY conjugates exhibited high phototoxicity under green light irradiation, attributed to the photogeneration of reactive oxygen species (ROS), while remaining non-toxic in the dark. Two hit conjugates showed excellent phototherapeutic indexes in cisplatin-resistant A2780cis cancer cells, indicating the potential of photoactive therapy approaches based on the conjugation of far-red/NIR-emitting COUPY dyes and transition metal complexes to overcome acquired resistance to cisplatin.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Organic
Marta Lopez-Corrales, Anna Rovira, Albert Gandioso, Santi Nonell, Manel Bosch, Vicente Marchan
Summary: Releasing bioactive molecules in specific subcellular locations from caged precursors using visible light is a promising approach in photopharmacology. A series of COUPY-caged model compounds with inherent affinity for mitochondria and absorption in the visible region were synthesized and characterized. The incorporation of a methylgroup near the photocleavable bond was found to be crucial for fine-tuning the photochemical properties of the caging group. The use of a COUPY-caged protonophore confirmed the possibility of photoactivation within mitochondria of living cells under low-dose yellow light irradiation. These new photolabile protecting groups have potential in facilitating the delivery of photocages of biologically active compounds into mitochondria.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Albert Gandioso, Eduardo Izquierdo-Garcia, Pierre Mesdom, Philippe Arnoux, Nurikamal Demeubayeva, Pierre Burckel, Bruno Saubamea, Manel Bosch, Celine Frochot, Vicente Marchan, Gilles Gasser
Summary: A novel strategy for developing near infrared (NIR)-activatable Ru(II) polypyridyl-based photosensitizers (PSs) was successfully developed, enabling high photocytotoxicities towards cancer cell lines under both normoxic and hypoxic conditions. The lead PS exhibited good photocytotoxic activity under low-oxygen concentration conditions and has potential for the treatment of deep-seated hypoxic tumors. This study presents a promising PDT agent with the ability to be photoactivated at 770nm under hypoxic conditions.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Sergi Chumillas, Saurabh Loharch, Manuela Beltran, Mateusz P. Szewczyk, Silvia Bernal, Maria C. Puertas, Javier Martinez-Picado, Jose Alcami, Luis M. Bedoya, Vicente Marchan, Jose Gallego
Summary: This study explored the optimization of the antiretroviral properties of benfluron and found that both the benzo[c] and cyclopentanone components are essential for its activity. The results provide insights for the design of new anti-HIV agents targeting the inhibition of Rev function.
Article
Chemistry, Inorganic & Nuclear
Joaquin Bonelli, Enrique Ortega-Forte, Gloria Vigueras, Manel Bosch, Natalia Cutillas, Josep Rocas, Jose Ruiz, Vicente Marchan
Summary: By encapsulating poorly soluble cyclometalated Ir(III) complexes using polyurethane-polyurea hybrid nanocapsules, their solubility is improved and the nanocapsules can enhance cellular uptake and cytotoxicity, leading to inhibition of tumor growth.
INORGANIC CHEMISTRY FRONTIERS
(2022)