期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 83, 期 23, 页码 14617-14625出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b02439
关键词
-
资金
- National Natural Science Foundation of China [21272150, 21672137]
Asymmetric Mannich-type addition of 3,5-disubstituted-4-nitroisoxazoles to isatin-derived Boc-protected imines has been realized by using 0.01 equiv of amide phosphonium salt as a phase transfer catalyst. Our current methodology allows for the formation of 3-isoxazolylmethyl-substituted 3-aminooxindoles in excellent yields with good to excellent enantioselectivities. The practical value of this methodology was exemplified by a gram-scale synthesis of 5an, a key intermediate for the formal synthesis (+)-AG-041R.
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