期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 84, 期 8, 页码 4704-4714出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b02254
关键词
-
资金
- BMS Senior Leadership Team
BMS-919373 is a highly functionalized quinazoline under investigation as a selective, potent I-Kur current blocker. By utilizing the aminomethylpyridine side chain at C-4, a selective C-H functionalization at C-5 was invented, enabling the efficient synthesis of this molecule. The strategy of leveraging this inherent directing group allowed the synthesis of this complex heterocycle in only six steps from commodity chemicals. The scope of the C-H activation was further investigated, and the generality of the transformation across a series of bicyclic aromatic heterocycles was explored.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据