Article
Medicine, General & Internal
Sasin Sritara, Yoshiro Matsumoto, Yixin Lou, Jia Qi, Jun Aida, Takashi Ono
Summary: This study investigated the association between temporomandibular joint (TMJ) morphology and chewing patterns, taking into account skeletal morphology, sex, age, and symptoms of temporomandibular disorder (TMD). A cross-sectional observational study of 102 TMJs of 80 patients was conducted using imaging, records, and questionnaires. The findings suggest that the morphology of the mandibular condyles might be related to skeletal and masticatory function, including chewing patterns.
Review
Engineering, Biomedical
Shoushan Hu, Yating Yi, Chengxinyue Ye, Jin Liu, Jun Wang
Summary: Temporomandibular joint (TMJ) osteoarthritis leads to fibrocartilage damage, causing local pain and functional impairment. Tissue engineering provides a potential treatment for fibrocartilage regeneration in TMJ. However, the heterogeneous structure of TMJ fibrocartilage poses challenges for biomimetic scaffold fabrication. Research progress, challenges, and emerging strategies for TMJ fibrocartilage regeneration using 3D-printed scaffolds are reviewed.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Surgery
Xiangshen Wang, Xiumei Sun, Guomin Wu
Summary: The study found significant changes in condyle position of the temporomandibular joint after bilateral sagittal split mandibular ramus osteotomy, with consistent and persistent medial shift observed on the non-deviated side.
JOURNAL OF CRANIOFACIAL SURGERY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Shuang Bai, Yao Yu, Wen-Bo Zhang, Ya-Qing Mao, Yang Wang, Chi Mao, Xin Peng
Summary: This retrospective case-series study aimed to investigate the attachment features and volumetric changes of masticatory muscles after free fibular flap reconstruction of the mandibular condyle. The study found that the lateral pterygoid muscle achieved reattachment in most cases, while the masseter muscle showed limited reattachment. The volume of masticatory muscles on the affected side decreased significantly after surgery, while on the normal side, it almost returned to the preoperative level. Further high-quality clinical trials are needed to determine the functional implications of masticatory muscle reattachment.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Hao Guan, Ikuo Yonemitsu, Yuhei Ikeda, Takashi Ono
Summary: This study aimed to investigate the effects of functional mandibular lateral shift (FMLS) on masticatory muscles in growing rats and whether these effects can be reversed. FMLS was shown to lead to changes in muscle mass, fiber size, fiber type, and gene expression in the masticatory muscles. However, these changes were found to revert to normal conditions after a recovery period. Therefore, early orthodontic treatment for FMLS is recommended to prevent asymmetric alterations in masticatory muscles.
Review
Dentistry, Oral Surgery & Medicine
Michael Owen, Benjamin Gray, Nawaz Hack, Leonel Perez, Rhonda J. Allard, James M. Hawkins
Summary: This is the first systematic review that examines the association between BoNTA injection into the masticatory muscles and mandibular bone quality. Although the data were analyzed from a limited number of studies with a small sample size and the quality of the included studies was very low, the majority of available evidence suggests that BoNTA injection results in bony changes. Further research is needed to confirm a dose-dependence effect and the impact of gender and age.
JOURNAL OF ORAL REHABILITATION
(2022)
Article
Health Care Sciences & Services
Tae-Hoon Kim, Youn Joong Kim, Yun-Heon Song, Ilho Tae, Ho-Kyung Lim, Seok-Ki Jung
Summary: This study aimed to evaluate the 3-dimensional bony changes of the mandibular condyle in TMJ-OA patients treated with SS therapy. The results showed that after SS treatment, there was both bone resorption and bone formation on the mandibular condyle head surface, causing morphological changes in the condyle head. However, there was no statistically significant difference in condylar volume between the two groups.
Article
Food Science & Technology
Marie Beret, Florent Barry, Maria-Jose Garcia-Fernandez, Henry Chijcheapaza-Flores, Nicolas Blanchemain, Feng Chai, Romain Nicot
Summary: This study investigated the effect of intra-articular injection of botulinum toxin A (BoNT/A) in an animal model of temporomandibular joint osteoarthritis. The results showed that rats receiving intra-articular BoNT/A had a significant decrease in pain compared to those receiving placebo, starting from day 7 and lasting until day 21. Histological and radiographic analysis also demonstrated a reduction in joint inflammation in the BoNT/A group. The study suggests that intra-articular BoNT/A injection can alleviate pain and inflammation in temporomandibular osteoarthritis.
Article
Medicine, General & Internal
R. Rajashri, Senthilnathan Periasamy, Santhosh P. Kumar
Summary: Bifid mandibular condyle is a rare occurrence, potentially serving as a hidden cause for bilateral temporomandibular joint pain. Both conservative and surgical treatments can alleviate symptoms.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Enrico De Carli, Aikaterini Lagou, Stavros Kiliaridis, Balazs J. Denes
Summary: This study investigated the effects of unilateral masticatory function on the condylar process morphology in growing and adult rats. The cross-sectional surface of the condyle did not increase on the extraction side in young rats, but no such differences were found in adults. Young rats had shorter and smaller condylar structures compared to adult rats and showed significant growth during the experimental period. This suggests that the condyle becomes thinner while maintaining its length in growing individuals without occlusal stimuli.
ORTHODONTICS & CRANIOFACIAL RESEARCH
(2023)
Review
Medicine, General & Internal
Juan Jose Valenzuela-Fuenzalida, Kora-lle Keller Navarro, Pia Urbina, Martin Trujillo-Riveros, Pablo Nova-Baeza, Mathias Orellana-Donoso, Macarena Rodriguez-Luengo, Alvaro Beccerra Farfan, Juan A. Sanchis-Gimeno
Summary: This study describes the prevalence of anatomical variants in the bifid mandibular condyle (BMC) and reports that there is no direct association between the presence of BMC and temporomandibular joint (TMJ) pathology or symptoms.
Article
Dentistry, Oral Surgery & Medicine
Sadi Memis
Summary: This study investigated the effects of arthrocentesis with intra-articular hyaluronic acid (HA) injection on mandibular condyles using fractal dimension (FD) analysis. The study found that the mean FD values in the mandibular condyles increased over time after arthrocentesis with HA injections. The FD analysis method is recommended as an adjunct and guide for oral and maxillofacial surgeons in radiological examinations.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Sa Cha, Sueng-Min Lee, Jiangyue Wang, Qing Zhao, Ding Bai
Summary: Aging is a major cause of TMJ disability and pain in older people. The circadian rhythm in TMJ structures changes significantly with age, affecting tissue structure and chondrogenesis capability. Bmal1-overexpressed BMSCs show potential in repairing age-related TMJ condylar degeneration, suggesting a promising clinical approach in tissue regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Orthopedics
Jun Zhang, Yu Hu, Zihan Wang, Xuelian Wu, Chun Yang, Hefeng Yang
Summary: This study suggests that abnormal hypoxic conditions and apoptosis are associated with cartilage degeneration in osteoarthritis lesions.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Raffaele Rauso, Giorgio Lo Giudice, Gianpaolo Tartaro, Nicola Zerbinati, Giovanni Francesco Nicoletti, Romolo Fragola
Summary: This study aimed to compare the efficacy of different injection techniques in reducing masticatory muscle hypertrophy, with results indicating the difficulty of comparing efficacy of multi-point injection techniques. It is suggested to use the lowest number of injection sites possible until stronger evidence is presented. Uniformity in pre- and post-operative protocols is crucial for establishing a reliable research setting.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2022)
Article
Anesthesiology
D. Nepogodiev, Joana F. F. Simoes, Elizabeth Li, Maria Picciochi, James C. Glasbey, Glauco Baiocchi, Ruth Blanco-Colino, Daoud Chaudhry, Ehab AlAmeer, Kariem El-Boghdadly, Funmilola Wuraola, Dhruva Ghosh, Rohan R. Gujjuri, Ewen M. Harrison, Herman Lule, Haytham Kaafarani, Mohammad Khosravi, Irmgard Kronberger, Sezai Leventoglu, Harvinder Mann, Kenneth A. Mclean, Mengistu Gebreyohanes Mengesha, Maria Marta Modolo, Faustin Ntirenganya, Lisa Norman, Oumaima Outani, Riinu Pius, Peter Pockney, Ahmad Uzair Qureshi, April Camilla Roslani, Sohei Satoi, Catherine Shaw, Aneel Bhangu, Omar M. Omar, Waheed-Ul-Rahman Ahmed, Leah Argus, Alasdair Ball, Edward P. Bywater, Ruth Blanco-Colino, Amanpreet Brar, Daoud Chaudhry, Brett E. Dawson, Irani Duran, Muhammed Elhadi, James C. Glasbey, Rohan R. Gujjuri, Conor S. Jones, Ewen M. Harrison, Sivesh K. Kamarajah, James M. Keatley, Samuel Lawday, Harvinder Mann, Ella J. Marson, Kenneth A. Mclean, Lisa Norman, Riinu Ots, Oumaima Outani, Maria Picciochi, Irene Santos, Catherine Shaw, Elliott H. Taylor, Isobel M. Trout, Chris Varghese, Mary L. Venn, William Xu, Irida Dajti, Arben Gjata, Salah Eddine Oussama Kacimi, Luis Boccalatte, Daniel Cox, Peter Pockney, Philip Townend, Felix Aigner, Irmgard Elisabeth Kronberger, Elgun Samadov, Amer Alderazi, Kamral Hossain, Greg Padmore, Gabrielle van Ramshorst, Ismail Lawani, Anis Cerovac, Samir Delibegovic, Glauco Baiocchi, Gustavo Mendonca Ataide Gomes, Igor Lima Buarque, Muhammad Gohar, Mihail Slavchev, Chukwuemeka Nwegbu, Arnav Agarwal, Amanpreet Brar, Janet Martin, Joshua Ng-Kamstra, Maricarmen Olivos, Wenhui Lou, Dong-Lin Ren, Jose Andres Calvache, Carlos J-Perez Rivera, Ana Danic Hadzibegovic, Tomislav Kopjar, Jakov Mihanovic, Pablo Mijahil Aviles Jimenez, Nikolaos Gouvas, Jaroslav Klat, Rene Novysedlak, Nicolas Amisi, Peter Christensen, Alaa El-Hussuna, Sylvia Batista, Eddy Lincango-Naranjo, Sameh Emile, Danilo Alfonso Arevalo Sandoval, Hailu Dhufera, Samuel Hailu, Mengistu G. Mengesha, Joonas H. Kauppila, Alexis P. Arnaud, Zaza Demetrashvili, Markus Albertsmeier, Hans Lederhuber, Markus W. Loeffler, Daniel Kwesi Acquah, Bernard Ofori, Stephen Tabiri, Symeon Metallidis, Georgios Tsoulfas, Maria-Lorena Aguilera-Arevalo, Gustavo Recinos, Tamas Mersich, Daniel Wettstein, Dhruva Ghosh, Gabriele Kembuan, Peiman Brouki Milan, Mohammad Hossein Khosravi, Masoud Mozafari, Ahmed Hilmi, Helen Mohan, Oded Zmora, Gaetano Gallo, Francesco Pata, Gianluca Pellino, Yuki Fujimoto, Naoto Kuroda, Sohei Satoi, Mohamad K. Abou Chaar, Faris Ayasra, Ildar Fakhradiyev, Intisar Hisham Said Hamdun, Jang Jin-Young, Mohammad Jamal, Lina Karout, Muhammed Elhadi, Aiste Gulla, Fanjandrainy Rasoaherinomenjanahary, Luc Herve Samison, April Camilla Roslani, Iran Irani Duran Sanchez, Diana Samantha Gonzalez, Laura Martinez, Maria Jose Martinez, Alejandra Nayen, Antonio Ramos-De la Medina
Summary: The study suggests that surgery should be delayed for at least 7 weeks following SARS-CoV-2 infection, with patients experiencing ongoing symptoms >= 7 weeks from diagnosis potentially benefitting from further delay.
Article
Multidisciplinary Sciences
Julia Stuhltraeger, Ellen Schulz-Kornas, Ottmar Kullmer, Marcel M. Janocha, Roman M. Wittig, Kornelius Kupczik
Summary: This study combines macroscopic and microscopic wear analyses to explore tooth use differences between historical western chimpanzees from Liberia and the extant chimpanzees of Ta1 National Park in Ivory Coast. The results indicate similar long-term feeding behavior but significant short-term differences between the populations, potentially linked to historical events during dry periods in Liberia. Furthermore, differences in 3D surface textures between Liberian males and females suggest a higher consumption of insects by females, in line with patterns observed in Ta1 chimpanzees.
Article
Anthropology
Robert C. Power, Roman M. Wittig, Jeffery R. Stone, Kornelius Kupczik, Ellen Schulz-Kornas
Summary: By analyzing phytoliths in chimpanzee fecal samples, researchers can assess how plant phytoliths in the diet are reflected in dental calculus and feces, improving research strategies and providing valuable information for future studies.
ARCHAEOLOGICAL AND ANTHROPOLOGICAL SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Alfredo Sierra-Cristancho, Luis Gonzalez-Osuna, Julian Balanta-Melo, Emilio A. Cafferata, Carolina Rojas, Samanta Melgar-Rodriguez, Paola Carvajal, Rolando Vernal
Summary: This study describes the dentine thickness in mandibular first premolars with C-shaped root canals and identifies the areas with thinner canal walls as potential danger zones. In addition, it analyzes the internal and external anatomical characteristics of these teeth and their association with dentine thickness.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Review
Endocrinology & Metabolism
Sophia X. Sui, Julian Balanta-Melo, Julie A. Pasco, Lilian Plotkin
Summary: Cognitive impairment is associated with obesity, sarcopenia, and osteoporosis. Recent literature suggests that musculoskeletal deficits and cognitive impairment share pathophysiological pathways and risk factors. Improving musculoskeletal health can prevent or slow cognitive impairment.
CURRENT OSTEOPOROSIS REPORTS
(2022)
Article
Multidisciplinary Sciences
Adam van Casteren, Jonathan R. Codd, Kornelius Kupczik, Guy Plasqui, William Sellers, Amanda G. Henry
Summary: Chewing different items can result in varying metabolic costs, and chewing by human subjects represents a measurable energy sink. Chewing tasteless and odorless gum increases metabolic rate, with energy expenditure increasing with gum stiffness and requiring greater muscle recruitment. This adds an previously unexplored energetic dimension to the interpretation of hominin dentofacial fossils.
Article
Biochemistry & Molecular Biology
Camilo Morales-Jimenez, Julian Balanta-Melo, Manuel Arias-Calderon, Nadia Hernandez, Fernan Gomez-Valenzuela, Alejandro Escobar, Enrique Jaimovich, Sonja Buvinic
Summary: The present study reveals that osteoclasts can promote skeletal muscle protein synthesis by releasing ATP. This ATP release activates a series of cellular signaling pathways that lead to protein synthesis in skeletal muscle. These findings have significant implications for the understanding and clinical implications of the interaction between bone and muscle.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anatomy & Morphology
Laura Marechal, Jean Dumoncel, Frederic Santos, Williams Astudillo Encina, Andrej Evteev, Alice Prevost, Viviana Toro-Ibacache, Rudolph G. Venter, Yann Heuze
Summary: In this study, the researchers investigated the morphological variation of nasal airways in different geographic populations. They found subtle but statistically significant differences in nasal shape between the populations. The French and Russian samples had longer and narrower nasal airways, while the Cambodian sample had wider and shorter nasal airways. The Chilean sample showed the greatest intra-population variation, and the South African sample overlapped with the French, Russian, and Cambodian variation. Interestingly, there was no correlation between nasal airway volume and geographic groups, raising questions about climate-related oxygen consumption demands.
JOURNAL OF ANATOMY
(2023)
Article
Endocrinology & Metabolism
Manuel Arias-Calderon, Mariana Casas, Julian Balanta-Melo, Camilo Morales-Jimenez, Nadia Hernandez, Paola Llanos, Enrique Jaimovich, Sonja Buvinic
Summary: Fibroblast growth factor 21 (FGF21) is a hormone involved in the regulation of lipid, glucose, and energy metabolism. Recent studies have shown that FGF21 is also synthesized and secreted by skeletal muscles through a signaling pathway involving extracellular ATP (eATP) and the Akt/mTOR pathway. This study investigated the effect of electrical stimulation on the production and secretion of FGF21 in skeletal muscles, and found that it increased both mRNA and protein levels of FGF21 through eATP signaling and the PI3K/Akt pathway. These findings provide new insights into the regulation of FGF21 production in skeletal muscles and may lead to the identification of new targets for studying physiological and pathological conditions associated with FGF21.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Julian Balanta-Melo, Andrea Eyquem-Reyes, Noelia Blanco, Walter Vasquez, Kornelius Kupczik, Viviana Toro-Ibacache, Sonja Buvinic
Summary: Research on mice found that unilateral muscle dysfunction can lead to atrophy signs in the affected muscle and other masticatory muscles. This study suggests the need for further clinical research to determine the safety of botulinum toxin type A in dental practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Padmini Deosthale, Julian Balanta-Melo, Amy Creecy, Chongshan Liu, Alejandro Marcial, Laura Morales, Julita Cridlin, Sylvia Robertson, Chiebuka Okpara, David J. Sanchez, Mahdi Ayoubi, Joaquin N. Lugo, Christopher J. Hernandez, Joseph M. Wallace, Lilian I. Plotkin
Summary: FMR1 gene mutations lead to fragile X syndrome and cognitive disorders, but in mice, the absence of FMR1 gene leads to increased bone density and improved bone properties. The absence of FMR1 gene also increases osteoblast differentiation and bone formation, resulting in higher bone mass and strength.
Meeting Abstract
Biochemistry & Molecular Biology
Sonja Buvinic, Noelia Blanco, Walter Vasquez, Esteban Quezada, Andrea Eyquem, Lilian Plotkin, Kornelius Kupczik, Viviana Toro-Ibacache, Julian Balanta-Melo
Meeting Abstract
Endocrinology & Metabolism
Julian Balanta-Melo, Noelia Blanco, Andrea Eyquem, Walter Vasquez, Esteban Quezada, Kornelius Kupczik, Viviana Toro-Ibacache, Sonja Buvinic
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Biology
Michael A. Berthaume, Kornelius Kupczik
Summary: This study quantified the molar biomechanical performance of two Plio-Pleistocene hominins, Paranthropus robustus and Australopithecus africanus, to investigate potential dietary differences between them. The results showed that Paranthropus robustus required more force and energy to fracture food items but had a higher force transmission rate. Three evolutionary scenarios concerning the dietary ecologies of these hominins were proposed based on the findings, highlighting the importance of a holistic approach to reconstructing hominin dietary ecology.