期刊
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
卷 61, 期 3, 页码 239-250出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JOM.0000000000001529
关键词
agricultural workers; chronic kidney disease; global health; prevention
资金
- Pantaleon
- Centers for Disease Control and Prevention (CDC) [U19 OH01127]
- Mountain and Plains Education and Research Center [T42 OH009229]
Objective: Identify early biomarkers and mechanisms of acute kidney injury in workers at risk of developing chronic kidney disease of unknown origin (CKDu). Methods: We assessed cross-shift changes in kidney function and biomarkers of injury in 105 healthy sugarcane workers. We obtained pre-harvest clinical data as well as daily environmental, clinical, and productivity data for each worker. Results: The average percent decline in cross-shift estimated glomerular filtration rate (eGFR) was 21.8% (standard deviation [SD] 13.6%). Increasing wet bulb globe temperature (WBGT), high uric acid, decreased urine pH, urinary leukocyte esterase, and serum hyperosmolality were risk factors for decline in kidney function. Conclusions: Sugarcane workers with normal kidney function experience recurrent subclinical kidney injury, associated with elevations in biomarkers of injury that suggest exposure to high temperatures and extreme physical demands.
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