Article
Infectious Diseases
Eline J. van Leerdam, Michelle Gompelman, Renee A. M. Tuinte, Erik H. J. G. Aarntzen, Marvin A. H. Berrevoets, Ianthe Maat, Chantal P. Bleeker-Rovers, Reinout van Crevel, Jaap ten Oever, Ilse J. E. Kouijzer
Summary: [F-18]FDG-PET/CT can help adjust treatment in patients with SAB, especially in cases suspected of having endovascular infection or vascular grafts. Treatment modifications based on [F-18]FDG-PET/CT results for patients with clinical signs can improve treatment efficacy.
Article
Multidisciplinary Sciences
Nesrin Ghanem-Zoubi, Jawad Abu-Elhija, Olga Kagna, Mona Mustafa-Hellou, Majd Qasum, Daniel Haber, Mical Paul, Zohar Keidar
Summary: We explored the predicting factors for the detection of infectious foci on FDG PET/CT among patients with SAB and found that community-acquired bacteremia and high CRP levels were independent predictors for focal infection detection. Additionally, primary bacteremia and blood glucose levels showed an inverse association with focal infection detection.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jin Qi, Elizabeth Kurian, Orhan K. oez
Summary: Hibernomas are rare benign tumors originating from fetal brown adipose tissue. They can occur in various parts of the body, with thigh, shoulder, back, and neck being the most common locations, and are rarely found in the abdominal cavity, retroperitoneum, breast, bones, scrotum, and perirectum. We present a case of a 58-year-old woman with a mediastinal mass, who was incidentally found to have an FDG-avid fat-containing lesion in the omentum abutting the stomach.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Immunology
Nesrin Ghanem-Zoubi, Olga Kagna, Jawad Abu-Elhija, Mona Mustafa-Hellou, Majd Qasum, Zohar Keidar, Mical Paul
Summary: The study found that performing FDG-PET/CT in patients with Staphylococcus aureus bacteremia (SAB) seemed to improve survival rates through guiding treatment duration and interventions.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Shu-Qi Ren, Yuan Ma, Li-Lan Fu, Kong-Zhen Hu, Hao-Ran Liang, Bin Yu, Gang-Hua Tang
Summary: This study compares the efficacy of F-18-FDG and an F-18-labeled PD-L1-binding peptide probe (F-18-PD-L1P) in PET imaging of implant-associated Staphylococcus aureus osteomyelitis (IAOM). The results show that F-18-PD-L1P demonstrates higher %ID/g ratios and provides earlier and more sensitive detection of osteomyelitis caused by S. aureus.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Sameer Taywade, Tanisha Gupta, Rajesh Kumar, Rahul Choudhary, Deepak Kumar
Summary: Nuclear imaging plays a crucial role in evaluating cardiac diseases of infective, inflammatory, innervation, and infiltrative origins. We report a case of persistent pyrexia after percutaneous transluminal coronary angioplasty in a patient with a history of inferior wall myocardial infarction. Molecular imaging techniques, such as F-18-FDG PET/CT and Tc-99m-MIBI myocardial perfusion study, helped in narrowing the differentials and eventually diagnosing the patient with Dressler syndrome.
CLINICAL NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Saurav Jha, Angel Hemrom, Shamim Ahmed Shamim, Adarsh Barwad, Atul Batra
Summary: Renal cell carcinoma (RCC) accounts for 2% of global cancers and deaths. CT and MRI are commonly used for RCC evaluation, while PET/CT is used for assessing metastatic disease. A case study shows that Ga-68-PSMA may be a potential tracer for evaluating RCC, as it demonstrated better visibility of liver lesions compared to F-18-FDG.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sung Ryul Shim, Seong-Jang Kim
Summary: This study evaluated the diagnostic accuracies of F-18-FDG PET or PET/CT for Merkel cell carcinoma (MCC) through a systematic review and meta-analysis. The results showed that F-18-FDG PET/CT had excellent performance in diagnosing MCC and could be useful for exclusion and confirmation of the disease. Further large multicenter studies are needed to validate its diagnostic accuracy.
CLINICAL NUCLEAR MEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Caner Civan, Emine Goknur Isik, Seyfullah Karadogan, Yasemin Sanli, Serkan Kuyumcu
Summary: This article presents a case of a 62-year-old male with progressive left-sided papillary renal cell carcinoma. Ga-68-FAPI-04 and F-18-FDG PET/CT imaging revealed variable FAP expression in all metastatic lesions, including lymph nodes, bone, and thyroid. This case highlights the potential of FAP-targeted imaging for diagnostic and theranostic use in papillary renal cell carcinoma.
CLINICAL NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yun Chen, Shan Zheng, Zenan Wu, Yanmin Lin, Weibing Miao
Summary: A 76-year-old man with yellowish discoloration of sclera and skin for 2 months was referred for F-18-FDG PET/CT to characterize a mass in the pancreas. PET/CT images showed intense FDG uptake in the head of the pancreas, with a lymph nodal mass in the hepatic hilar region, consistent with pancreatic malignancy. Histopathologic findings confirmed diffuse large B-cell lymphoma with no evidence of adenocarcinoma.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Medicine, Research & Experimental
Michelle Gompelman, Renee Tuinte, Erik Aarntzen, Ilse Kouijzer, Eline van Leerdam, Marvin Berrevoets, Jaap Ten Oever, Chantal Bleeker-Rovers, Geert Wanten
Summary: The study demonstrated that [F-18]FDG-PET/CT imaging can assist in detecting septic thrombosis in patients with catheter-related bacteremia, and quantitative measurements are helpful in differentiating between septic and non-septic thrombosis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Halil Komek, Canan Can, Ihsan Kaplan, Cihan Gundogan, Ferat Kepenek, Huseyin Karaoglan, Aykut Demirkiran, Senar Ebinc, Yunus Guzel, Ebubekir Gundes
Summary: [(68) Ga]Ga-DOTA-FAPI-04 PET/CT demonstrates higher sensitivity and specificity in the evaluation of primary lesions and metastases in patients with colorectal cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yacine El Yaagoubi, Caroline Prunier-Aesch, Alain Chetanneau, Laurent Philippe, Francois Bleuet, Eric Menard, Gerard Doll
Summary: A 75-year-old man presented with Staphylococcus aureus bacteremia, fever, and right posterior knee pain. Imaging studies revealed an isolated right calf muscle vein thrombosis and a mycotic aneurysm in the right popliteal artery. Surgical excision of the aneurysm led to successful recovery of the patient.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Infectious Diseases
D. T. P. Buis, E. Sieswerda, I. J. E. Kouijzer, W. Y. Huynh, G. L. Burchell, M. A. H. Berrevoets, J. M. Prins, K. C. E. Sigaloff
Summary: Current studies suggest that [18F]FDG-PET/CT may help reduce mortality in patients with SAB and can more accurately detect metastatic foci.
BMC INFECTIOUS DISEASES
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Caner Civan, Duygu Has Simsek, Emine Goknur Isik, Yasemin Sanli, Serkan Kuyumcu
Summary: A 69-year-old woman with breast cancer had F-18-FDG PET/CT and Ga-68-FAPI-04 PET/CT for evaluation. F-18-FDG PET/CT showed hypermetabolic lymph nodes, while Ga-68-FAPI-04 PET/CT showed negative results for these nodes. Biopsy confirmed metastasis of breast cancer. This case highlights the possibility of false-negative Ga-68-FAPI-04 PET/CT findings in evaluating metastatic spread in breast cancer.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Infectious Diseases
Eline J. van Leerdam, Michelle Gompelman, Renee A. M. Tuinte, Erik H. J. G. Aarntzen, Marvin A. H. Berrevoets, Ianthe Maat, Chantal P. Bleeker-Rovers, Reinout van Crevel, Jaap ten Oever, Ilse J. E. Kouijzer
Summary: [F-18]FDG-PET/CT can help adjust treatment in patients with SAB, especially in cases suspected of having endovascular infection or vascular grafts. Treatment modifications based on [F-18]FDG-PET/CT results for patients with clinical signs can improve treatment efficacy.
Article
Biology
Kimberley R. G. Cortenbach, Alexander H. J. Staal, Teske Schoffelen, Mark A. J. Gorris, Lieke L. Van der Woude, Anne F. M. Jansen, Paul Poyck, Robert Jan Van Suylen, Peter C. Wever, Chantal P. Bleeker-Rovers, Mangala Srinivas, Konnie M. Hebeda, Marcel van Deuren, Jos W. Van der Meer, Jolanda M. De Vries, Roland R. J. Van Kimmenade
Summary: This study found that persistent local infection with C. burnetii is associated with an immune-suppressed microenvironment, despite the presence of pro-inflammatory effector cells.
Article
Medicine, General & Internal
Jesper M. Weehuizen, Rik van Spronsen, Andy I. M. Hoepelman, Chantal P. Bleeker-Rovers, Jan Jelrik Oosterheert, Peter C. Wever
Summary: This retrospective study analyzed the association between previous Coxiella burnetii infection and outcome in COVID-19 patients in the Netherlands. The results showed that previous C. burnetii infection did not influence the risk of ICU admission and/or mortality for patients with COVID-19 presenting at the emergency department.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Ruud Raijmakers, Megan Roerink, Stephan Keijmel, Leo Joosten, Mihai Netea, Jos van der Meer, Hans Knoop, Hans Klein, Chantal Bleeker-Rovers, Janine Doorduin
Summary: This study investigated signs of neuroinflammation in female patients with CFS and QFS compared to healthy women using PET with the TSPO ligand C-11-(R)-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinoline-carbox-amide ([C-11]-PK11195). The results showed no significant difference in neuroinflammation between patients with CFS or QFS and healthy controls.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Article
Immunology
Simone J. C. F. M. Moorlag, Esther Taks, Thijs ten Doesschate, Thomas W. van der Vaart, Axel B. Janssen, Lisa Mueller, Philipp Ostermann, Helga Dijkstra, Heidi Lemmers, Elles Simonetti, Marc Mazur, Heiner Schaal, Rob ter Heine, Frank L. van de Veerdonk, Chantal P. Bleeker-Rovers, Reinout van Crevel, Jaap ten Oever, Marien de Jonge, Marc J. Bonten, Cornelis H. van Werkhoven, Mihai G. Netea
Summary: This study found that BCG vaccination had no significant effect in preventing respiratory tract infections, including COVID-19, in older adults. However, it was found that individuals who received the BCG vaccine had stronger antibody responses after COVID-19 infection.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Jesper M. Weehuizen, Sonja E. van Roeden, Sander J. Hogewoning, Wim van der Hoek, Marc J. M. Bonten, Andy I. M. Hoepelman, Chantal P. Bleeker-Rovers, Peter C. Wever, Jan Jelrik Oosterheert
Summary: Through a detailed analysis of the risk of mature B-cell NHL after a large Q fever outbreak in the entire Dutch population over a 16-year period, no evidence was found for an association between C. burnetii and NHL.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Correction
Nutrition & Dietetics
Michelle Gompelman, Heiman F. L. Wertheim, Chantal P. Bleeker-Rovers, Geert J. A. Wanten
Article
Infectious Diseases
Sheila B. Buijs, Jesper M. Weehuizen, Tim K. Jensen, Mette Boye, Mirjam H. A. Hermans, Peet T. G. A. Nooijen, Andy IM. Hoepelman, Chantal P. Bleeker-Rovers, Jan Jelrik Oosterheert, Peter C. Wever
Summary: This study assesses the value of fluorescence in situ hybridization (FISH) for detecting Coxiella burnetii in tissue samples from chronic Q fever patients. The results indicate that FISH has limited sensitivity and specificity, and its value in routine diagnostics for chronic Q fever is limited.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Nutrition & Dietetics
Michelle Gompelman, Erna Causevic, Chantal P. Bleeker-Rovers, Geert J. A. Wanten
Summary: This study aimed to analyze the data of central-line associated bloodstream infections (CLABSIs) in patients with intestinal failure receiving home parenteral nutrition (HPN) and identify risk factors for therapeutic failure to guide safer and more accurate management strategies. The results showed a high rate of successful catheter salvage, but it was associated with a shorter CLABSI-free survival. Treatment regimens containing glycopeptide antibiotics can increase the likelihood of adequate empiric coverage.
CLINICAL NUTRITION ESPEN
(2022)
Article
Infectious Diseases
Carsten van Rossum, Corianne Meijer, Ingrid Jm van Weerdenburg, Edmee C. Bowles, Chantal P. Rovers, Jaap ten Oever, Kim Stol, Nannet D. J. van der Geest, Matthew B. McCall, Alma Tostmann
Summary: We analyzed SARS-CoV-2 PCR Cq values in 3,183 healthcare workers who tested positive from January to August 2022. Median Cq values were lower in symptomatic HCW compared to asymptomatic HCW. The difference in Cq values between HCW with mild vs moderate/severe symptoms was statistically significant but negligible. Testing all symptomatic HCW, regardless of symptom severity, is necessary to prevent nosocomial infections. This information can help guide decisions on testing and isolation in healthcare systems under ongoing pressure.
Article
Public, Environmental & Occupational Health
Wing-Kee Yiek, Mirjam Tromp, Riet Strik-Albers, Koen van Aerde, Nannet Van der Geest-Blankert, Heiman F. L. Wertheim, Corianne Meijer, Alma Tostmann, Chantal P. Bleeker-Rovers
Summary: This study evaluated the success rate of MRSA decolonization and identified contributing factors to treatment success and failure. Patients with refugee status and children treated at the pediatric clinic were found to have a higher risk of MRSA decolonization treatment failure.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2022)
Article
Immunology
Tanja A. Kuut, Fabiola Mueller, Irene Csorba, Annemarie Braamse, Arnoud Aldenkamp, Brent Appelman, Eleonoor Assmann-Schuilwerve, Suzanne E. Geerlings, Katherine B. Gibney, Richard A. A. Kanaan, Kirsten Mooij-Kalverda, Tim C. Olde Hartman, Dominique Pauelsen, Maria Prins, Kitty Slieker, Michele van Vugt, Stephan P. Keijmel, Pythia Nieuwkerk, Chantal P. Rovers, Hans Knoop
Summary: This study investigated the efficacy of cognitive-behavioral therapy (CBT) for severe fatigue following COVID-19. The results showed that CBT significantly reduced fatigue severity in patients and the effect was sustained for 6 months. This is important for individuals with severe post-COVID-19 fatigue.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Nutrition & Dietetics
Michelle Gompelman, Guus T. J. Wezendonk, Yannick Wouters, Judith Beurskens-Meijerink, Konstantinos C. Fragkos, Farooq Z. Rahman, Jordy P. M. Coolen, Ingrid J. M. van Weerdenburg, Heiman F. L. Wertheim, Wietske Kievit, Reinier P. Akkermans, Mireille J. Serlie, Chantal P. Bleeker-Rovers, Geert J. A. Wanten
Summary: This study aimed to determine the most effective and safe long-term Staphylococcus aureus decolonization regimen. The results showed that the continuous suppression strategy had a higher long-term decolonization rate and better tolerance, making it suitable for patients receiving home parenteral nutrition.
CLINICAL NUTRITION
(2023)
Letter
Immunology
Tanja A. Kuut, Fabiola Muller, Pythia Nieuwkerk, Chantal P. Rovers, Hans Knoop
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Julia W. Korzilius, Michelle Gompelman, Guus T. J. Wezendonk, Nynke G. L. Jager, Chantal P. Rovers, Roger J. M. Brueggemann, Geert J. A. Wanten
Summary: This study aimed to determine the bioavailability of orally administered antimicrobial agents commonly used for treatment in SBS patients. The results showed that the bioavailability of selected antimicrobial agents in certain SBS patients appeared to be better than expected, providing a feasible treatment option. However, therapeutic drug monitoring should be part of the treatment process to safeguard adequate exposure in all patients, due to the large observed differences between patients.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
