Article
Multidisciplinary Sciences
Jacqueline Bijnens, Annick Van den Bruel, Vincent Vander Poorten, Ingeborg Goethals, Steven Van Schandevyl, Catherine Dick, Frank De Geeter
Summary: This study retrospectively evaluated the ability of preoperative imaging modalities to localize parathyroid adenomas and found that F-18-fluorocholine-PET/CT is highly accurate in this regard. It showed that F-18-fluorocholine-PET/CT can obviate the need for total exploration in patients with discordant or negative ultrasound and scintigraphic results.
SCIENTIFIC REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ashwin Singh Parihar, Joyce Mhlanga, Carrie Ronstrom, Lisa R. Schmidt, Robert S. Figenshau, Farrokh Dehdashti, Richard L. Wahl
Summary: The study aimed to evaluate the diagnostic accuracy of Tc-99m-sestamibi SPECT/CT for solid renal masses. The results showed that Tc-99m-sestamibi SPECT/CT had higher sensitivity and specificity in diagnosing nonconcerning lesions compared to contrast-enhanced CT, which can help differentiate malignant and benign renal tumors.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Kang-Wei Chang, Po-Ling Chang, Chi-Jung Tsai, Ya-Ju Tsai, Ping-Hsiu Wu, Hsin-Lun Lee, Yu-Hua Lai, Ching-Yee Oliver Wong, Wen-Sheng Huang
Summary: This study investigated the effects of mannitol on the uptake of [Tc-99m]Tc TRODAT-1 in rat brains, aiming to find a clinically feasible way to improve imaging quality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
John W. Kirkland, Jason M. Zhao, Nathan E. McWhorter, Kevin P. Banks
Summary: Oncocytomas in the parotid gland are rare benign neoplasms composed of mitochondrial-rich oncocytes. Tc-99m-sestamibi scintigraphy and SPECT/CT are effective in localizing these tumors, which typically exhibit focal intense uptake of radiotracer. The hyperattenuating nature of parotid gland oncocytomas can be confirmed through imaging modalities like SPECT/CT.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Qing Ruan, Junhong Feng, Yuhao Jiang, Xuran Zhang, Xiaojiang Duan, Qianna Wang, Guangxing Yin, Di Xiao, Junbo Zhang
Summary: Fibroblast activation protein (FAP) is highly expressed in cancer-associated fibroblasts (CAFs) and has become a promising target for tumor therapy. Two isocyanide-containing FAP inhibitors were synthesized, radiolabeled, and showed good stability and specificity to FAP. These inhibitors demonstrated high target affinity and promising tumor imaging potential in preclinical studies.
MOLECULAR PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Kodai Nishi, Masato Kobayashi, Minori Kikuchi, Asuka Mizutani, Yuka Muranaka, Ikumi Tamai, Keiichi Kawai, Takashi Kudo
Summary: The study revealed that Tc-99m-TF is primarily transported by OCT1 and OCT2 in vitro, and the hepatic accumulation of Tc-99m-TF can be significantly reduced by using an OCT1 inhibitor, resulting in altered pharmacokinetics and improved SPECT image quality.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ju-Ling Cheng, Chien-Chin Hsu, Pei-Wen Wang, Kuo-Chiang Sung, Nan-Tsing Chiu, Lan-Yi Chiu, Yung-Cheng Huang
Summary: The study compared the diagnostic performances and target-to-background ratios between anterior 180 degrees and 360 degrees SPECT/CT imaging for Tc-99m-sestamibi parathyroid imaging. Results showed that the anterior 180 degrees technique provides superior lesion contrast compared to the full-arc 360 degrees technique.
ANNALS OF NUCLEAR MEDICINE
(2021)
Editorial Material
Medicine, General & Internal
Jang Yoo, Miju Cheon
Summary: This case study describes a 16-year-old female patient with primary hyperparathyroidism, who initially had negative results on cervical ultrasonography and Tc-99m-sestamibi single photon emission computed tomography/computed tomography for parathyroid adenoma. However, subsequent C-11-methionine positron emission tomography/CT revealed positive focal uptake indicative of a parathyroid adenoma, which was later confirmed pathologically.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mark Ooms, Dirk von Mallek, Hans-Juergen Kaiser, Frank Hoelzle, Felix M. Mottaghy, Ali Modabber
Summary: This study compared the performance of three different tracers in Sentinel Lymph Node (SLN) detection in cutaneous malignancies of the head. The results showed that TcTM had comparable overall performance to TcSC and TcAC.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Surgery
Shani Goren, Nunzia Cinzia Paladino, Shachar Laks, Thomas Cuny, Josiane Vaillant-Lombard, Clement Mennetrey, Dan Assaf, Elif Hindie, Carole Guerin, Christelle Fargette, David Taieb, Frederic Sebag
Summary: F-18-FCH PET/CT, used as a second-line imaging technique, plays an accurate role in guiding minimally invasive parathyroidectomy. When combined with first-line imaging results, F-18-FCH PET/CT can better predict uniglandular diseases, leading to a higher success rate of minimally invasive surgery and maintaining exceptional cure rates.
WORLD JOURNAL OF SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Keresztely Merkel, David Szollosi, Ildiko Horvath, Balint Jezso, Zsolt Baranyai, Krisztian Szigeti, Zoltan Varga, Imre Hegedus, Parasuraman Padmanabhan, Balazs Gulyas, Ralf Bergmann, Domokos Mathe
Summary: This study reports a new method for labeling platelets using the peptide duramycin, allowing for efficient tracking of platelet biodistribution in vivo using single photon emission tomography (SPECT), and obtaining quantitative biodistribution images.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Medicine, General & Internal
Pawel Cichocki, Zbigniew Adamczewski, Jacek Kusmierek, Anna Plachcinska
Summary: A 61-year-old man was referred for myocardial perfusion scintigraphy to exclude coronary artery disease. However, the initial scan showed significant stress-induced ischemia due to heart motion caused by difficulties in breathing from a slipped mask during the study. Repeat acquisition without motion artifacts revealed no features of ischemia.
Article
Endocrinology & Metabolism
Yuhua Wang, Ye Liu, Na Li, Wanchun Zhang
Summary: This study investigated the differences in biochemical markers and lesion visualization on Tc-99m-MIBI imaging between PHPT and SHPT. The findings showed that PHPT patients had higher positive results and T/NT ratio on Tc-99m-MIBI SPECT/CT imaging compared to SHPT patients. The volume of parathyroid lesions in SHPT was smaller than in PHPT.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mariam Jaber, Jila Taherpour, Berthold Voges, Ivayla Apostolova, Thomas Sauvigny, Patrick M. House, Michael Lanz, Matthias Lindenau, Susanne Klutmann, Tobias Martens, Stefan Stodieck, Ralph Buchert
Summary: The study compared the performance of two tracers in ictal brain perfusion SPECT and found no significant difference in identifying the seizure onset zone (SOZ) between Tc-99m-HMPAO and Tc-99m-ECD. The results did not provide evidence to favor one tracer over the other for this purpose.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Oncology
Michail E. E. Klontzas, Emmanouil Koltsakis, Georgios Kalarakis, Kiril Trpkov, Thomas Papathomas, Apostolos H. H. Karantanas, Antonios Tzortzakakis
Summary: This study combines Tc-99m Sestamibi SPECT/CT and radiomics analysis to characterize benign renal oncocytic neoplasms. The combined model achieves higher accuracy (95%) than the radiomics-only model (75%) and visual evaluation of Tc-99m Sestamibi SPECT/CT alone (90.8%). This approach promises improvement in diagnostic accuracy and reduction in unnecessary surgery for benign tumors.