期刊
JOURNAL OF NEUROSCIENCE
卷 39, 期 6, 页码 1030-1043出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2143-18.2018
关键词
amygdala; anxiety; bed nucleus of the stria terminals; chemogenetics; corticotropin releasing factor
资金
- National Institutes of Health [AA13588, AA026075, AA023223]
- National Science Foundation [DGE-1110007]
The central amygdala (CeA) is important for fear responses to discrete cues. Recent findings indicate that the CeA also contributes to states of sustained apprehension that characterize anxiety, although little is known about the neural circuitry involved. The stress neuropeptide corticotropin releasing factor (CRF) is anxiogenic and is produced by subpopulations of neurons in the lateral CeA and the dorsolateral bed nucleus of the stria terminalis (dlBST). Here we investigated the function of these CRF neurons in stress-induced anxiety using chemogenetics in male rats that express Cre recombinase from a Crh promoter. Anxiety-like behavior was mediated by CRF projections from the CeA to the dlBST and depended on activation of CRF1 receptors and CRF neurons within the dlBST. Our findings identify a CRFCeA -> CRFdlBST circuit for generating anxiety-like behavior and provide mechanistic support for recenthuman and primate data suggesting that the CeA and BST act together to generate states of anxiety.
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