Article
Neurosciences
Jonathan Harnie, Johannie Audet, Alexander N. Klishko, Adam Doelman, Boris I. Prilutsky, Alain Frigon
Summary: The study found that sensorimotor circuits within the spinal cord generate backward locomotion but require additional excitability compared with forward locomotion. Spinal cats showed similar strategies for speed modulation and muscle activations during forward and backward locomotion, indicating a shared spinal locomotor network.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Food Science & Technology
Yuxuan Zhu, Qingyu Su, Jingfang Jiao, Niina Kelanne, Maaria Kortesniemi, Xiaoqing Xu, Baoqing Zhu, Oskar Laaksonen
Summary: This study aimed to explore consumers' preferences and descriptors for different fruit wines. Grape wine and blueberry wine were the most favored, while goji wine was the least liked. Sensory characteristics, especially taste, were found to be the main factors influencing consumer preference for fruit wines. Attitudes towards health, food neophobia, alcohol, and sweetness had less influence on preferences. Users reported higher consumption frequency and liking ratings compared to non-users.
Article
Clinical Neurology
P. Amol Yadav, Shuangyan Li, O. Max Krucoff, A. Mikhail Lebedev, M. Muhammad Abd-El-Barr, A. L. Miguel Nicolelis
Summary: The research shows that different sensory experiences can be evoked by varying the intensity, temporal pattern, and location of spinal cord stimulation; animals can be trained to detect and discriminate different patterns of spinal cord stimulation; the results suggest that spinal cord stimulation can provide intuitive sensory feedback in neuroprosthetic devices.
Review
Neurosciences
Yury Ivanenko, Elena Y. Shapkova, Daria A. Petrova, Daria F. Kleeva, Mikhail A. Lebedev
Summary: Neuromodulation through spinal cord electrical stimulation (SCES) is effective in restoring function, but its effectiveness can be enhanced by combining it with exoskeleton gait training (EGT) that promotes activity-dependent plasticity. Assessing individual characteristics of spinal cord function is important for developing personalized SCES and EGT therapies. Combining SCES and EGT can have a synergistic rehabilitative effect on restoring multiple functions in paralyzed individuals.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Jessica Ausborn, Natalia A. Shevtsova, Simon M. Danner
Summary: Neuronal circuits in the spinal cord play a crucial role in controlling locomotion, integrating supraspinal commands and afferent feedback signals. Computational modeling has complemented experimental studies by providing mechanistic rationales and testable predictions, leading to fundamental insights. With recent advances in molecular and genetic methods, manipulating specific elements of the spinal circuitry has become possible, allowing for investigations into mechanisms at the level of genetically defined neuronal populations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biophysics
Carl Demolder, Alicia Molina, Frank L. Hammond, Woon-Hong Yeo
Summary: This article explores the use of wearable sensing gloves and sensory feedback devices in healthcare, prosthetics, robotics, and virtual reality, highlighting recent technological advancements. It emphasizes the potential of combining these devices for assisting individuals with prostheses and sensory impaired limbs.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Engineering, Biomedical
Ameya C. Nanivadekar, Rohit Bose, Bailey A. Petersen, Elizaveta V. Okorokova, Devapratim Sarma, Tyler J. Madonna, Beatrice Barra, Juhi Farooqui, Ashley N. Dalrymple, Isaiah Levy, Eric R. Helm, Vincent J. Miele, Michael L. Boninger, Marco Capogrosso, Sliman J. Bensmaia, Douglas J. Weber, Lee E. Fisher
Summary: Closed-loop spinal cord stimulation with commercially available electrodes can evoke sensations in the missing foot of three individuals with transtibial amputation, providing them with improved balance and gait and reducing phantom limb pain.
NATURE BIOMEDICAL ENGINEERING
(2023)
Review
Orthopedics
Koki Tan, Soichiro Koyama, Hiroaki Sakurai, Toshio Teranishi, Yoshikiyo Kanada, Shigeo Tanabe
Summary: The analysis of 28 articles involving 228 patients revealed the clinical effectiveness of WREs in gait reconstruction for SCI patients, with a wide range of training procedures. Further improvements are needed for practical use in daily life.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Rehabilitation
Rosanne B. van Dijsseldonk, Johanna E. Vriezekolk, Noel L. W. Keijsers, Alexander C. H. Geurts, Ilse J. W. van Nes
Summary: This study conducted face-to-face interviews with SCI patients who have experience with exoskeleton use to understand their perspectives on the purpose of use and provide suggestions for improvement. Participants identified three future purposes of exoskeleton use: daily activities, exercise, and social interaction. The future exoskeleton should be easy to use, lightweight, safe, comfortable, and affordable. The study suggests that multiple adjustments are necessary to fully utilize the potential of exoskeletons.
DISABILITY AND REHABILITATION
(2023)
Article
Engineering, Biomedical
Xiao-Na Xiang, Hui-Yan Zong, Yi Ou, Xi Yu, Hong Cheng, Chun-Ping Du, Hong-Chen He
Summary: The study findings indicate that exoskeleton-assisted walking significantly improves pulmonary function parameters in spinal cord injury patients, showing potential benefits for individuals with lower thoracic neurological levels of SCI. Additionally, robotic exoskeletons help facilitate walking.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2021)
Article
Chemistry, Analytical
Riccardo Collu, Roberto Paolini, Martina Bilotta, Andrea Demofonti, Francesca Cordella, Loredana Zollo, Massimo Barbaro
Summary: Transcutaneous Electrical Nerve Stimulation (TENS) is a promising technique for eliciting referred tactile sensations in amputees. However, its application in daily life is limited by the lack of portable instrumentation. This study proposes a low-cost, wearable high-voltage compliant current stimulator with four independent channels for proper sensory stimulation.
Article
Multidisciplinary Sciences
Christina Hamlet, Lisa Fauci, Jennifer R. Morgan, Eric D. Tytell
Summary: Spinal injuries can cause loss of locomotor ability in vertebrates. A study on lampreys suggests that amplifying sensory feedback can help restore swimming function even if the descending signal is lost, although the exact mechanism is still unknown.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Engineering, Biomedical
Tristan Vouga, Jemina Fasola, Romain Baud, Ali Reza Manzoori, Julien Pache, Mohamed Bouri
Summary: This article presents the latest design and testing results of a competing device in the CYBATHLON competition. The device showed significant performance improvement through training and technology enhancements, highlighting its importance in improving the lives of individuals with paraplegia.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2022)
Article
Computer Science, Artificial Intelligence
Matteo Laffranchi, Stefano D'Angella, Christian Vassallo, Chiara Piezzo, Michele Canepa, Samuele De Giuseppe, Mirco Di Salvo, Antonio Succi, Samuele Cappa, Giulio Cerruti, Silvia Scarpetta, Lorenzo Cavallaro, Nicolo Boccardo, Marialaura D'Angelo, Claudia Marchese, Jody A. Saglia, Eleonora Guanziroli, Giacinto Barresi, Marianna Semprini, Simone Traverso, Stefano Maludrottu, Franco Molteni, Rinaldo Sacchetti, Emanuele Gruppioni, Lorenzo De Michieli
Summary: The paper introduces TWIN, a modular lower limb exoskeleton designed for spinal-cord injury (SCI) patients, developed through participatory investigations and user-centered design methods. The approach proved to be effective in adapting design goals towards user needs, resulting in an exoskeleton with modular mechatronics and novel lateral quick release systems with high potential for usability in its intended use.
FRONTIERS IN NEUROROBOTICS
(2021)
Article
Computer Science, Artificial Intelligence
Soichiro Koyama, Shigeo Tanabe, Takeshi Gotoh, Yuta Taguchi, Masaki Katoh, Eiichi Saitoh, Yohei Otaka, Satoshi Hirano
Summary: Wearable robotic exoskeletons (WREs) have been developed as assistive devices for gait reconstruction in patients with spinal cord injury, improving walking independence. Studies show that the Wearable Power-Assist Locomotor (WPAL) can enhance continuous walking distance and time for patients with a wide range of spinal cord injuries.
FRONTIERS IN NEUROROBOTICS
(2022)
Article
Neurosciences
Rosanne B. van Dijsseldonk, Hennie Rijken, Ilse J. W. van Nes, Henk van de Meent, Noel L. W. Keijsers
FRONTIERS IN NEUROSCIENCE
(2017)
Article
Clinical Neurology
Rosanne B. van Dijsseldonk, Lysanne A. F. de Jong, Brenda E. Groen, Marije Vos-van der Hulst, Alexander C. H. Geurts, Noel L. W. Keijsers
FRONTIERS IN NEUROLOGY
(2018)
Article
Rehabilitation
Rosanne B. van Dijsseldonk, Hennie Rijken, Ilse J. W. van Nes, Henk van de Meent, Noel L. W. Keijsers
Summary: Learning to use an exoskeleton is time-consuming and varies between users. Factors such as age, BMI, and active lifestyle play important roles in predicting exoskeleton skill performance during training and at the end of the training period.
DISABILITY AND REHABILITATION
(2021)
Article
Neurosciences
L. A. F. de Jong, R. B. van Dijsseldonk, N. L. W. Keijsers, B. E. Groen
Article
Multidisciplinary Sciences
Rosanne B. van Dijsseldonk, Ilse J. W. van Nes, Alexander C. H. Geurts, Noel L. W. Keijsers
SCIENTIFIC REPORTS
(2020)
Article
Rehabilitation
Rosanne B. van Dijsseldonk, Johanna E. Vriezekolk, Noel L. W. Keijsers, Alexander C. H. Geurts, Ilse J. W. van Nes
Summary: This study conducted face-to-face interviews with SCI patients who have experience with exoskeleton use to understand their perspectives on the purpose of use and provide suggestions for improvement. Participants identified three future purposes of exoskeleton use: daily activities, exercise, and social interaction. The future exoskeleton should be easy to use, lightweight, safe, comfortable, and affordable. The study suggests that multiple adjustments are necessary to fully utilize the potential of exoskeletons.
DISABILITY AND REHABILITATION
(2023)
Article
Clinical Neurology
Ilse J. W. van Nes, Rosanne B. van Dijsseldonk, Frank H. M. van Herpen, Hennie Rijken, Alexander C. H. Geurts, Noel L. W. Keijsers
Summary: This study aimed to examine the changes in quality of life among patients with chronic complete spinal cord injury (SCI) after an eight-week period of robotic exoskeleton training. The results showed significant improvements in quality of life, particularly in pain, social functioning, mental health, and general health perception, after the training.
JOURNAL OF SPINAL CORD MEDICINE
(2022)
Article
Clinical Neurology
F. H. M. van Herpen, R. B. van Dijsseldonk, H. Rijken, N. L. W. Keijsers, J. W. K. Louwerens, I. J. W. van Nes
SPINAL CORD SERIES AND CASES
(2019)
Article
Psychology, Multidisciplinary
Katinka van der Kooij, Rosanne van Dijsseldonk, Milou van Veen, Frans Steenbrink, Coen de Weerd, Krista E. Overvliet
FRONTIERS IN PSYCHOLOGY
(2019)