期刊
JOURNAL OF NATURAL PRODUCTS
卷 82, 期 1, 页码 45-50出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.8b00460
关键词
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资金
- National Natural Science Foundation of China [81872762, 31870513, 81561148013, 21502239]
- Key Projects of Technological Innovation of Hubei Province [2016ACA138]
- Fundamental Research Funds for the Central University, South-Central University for Nationalities [CZP18005, CZT18013, CZT18014]
- HPC of Kunming Institute of Botany
- Supercomputing Environment of Chinese Academy of Science (ScGrid)
Two new Tricholoma terpenoids, tricholopardins A and B, were isolated from the fruiting bodies of the basidiomycetes Tricholoma pardinum. Their structures were elucidated by spectroscopic methods, as well as electronic circular dichroism and optical rotatory dispersion calculations. Tricholopardin A potently inhibited nitric oxide production in lipopolysaccharide-induced RAW264.7 macrophages with an IC50 of 0.08 mu M. Its anti-inflammatory effects on three inflammatory mediators were also evaluated. A plausible biosynthetic pathway for these products is discussed.
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