期刊
JOURNAL OF NATURAL PRODUCTS
卷 81, 期 11, 页码 2553-2559出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.8b00714
关键词
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资金
- National Natural Science Foundation of China [31670355]
- Natural Science Foundation for Distinguished Young Scholars of Shandong Province [JQ201712]
- Open Fund of Key Laboratory of Experimental Marine Biology, CAS [KF2017NO4]
- Youth Innovation Promotion Association of CAS [2013138]
- Self-Fund from Yantai Institute of Coastal Zone Research, CAS [Y755031012]
Six new terpenes, including one harziane diterpene, 3R-hydroxy-9R,10-Rdihydroharzianone (1), one proharziane diterpene, 11R-methoxy-5,9,13-proharzitrien3-ol (2), three cyclonerane sesquiterpenes, 11-methoxy-9-cycloneren-3,7-diol (3), 10-cycloneren-3,5,7-triol (4), and methyl 3,7-dihydroxy-15-cycloneranate (5), and one acorane sesquiterpene, 8-acoren-3,11-diol (6), were isolated from the culture of Trichoderma harzianum X-5, an endophytic fungus obtained from the marine brown alga Laminaria japonica. Their structures and relative configurations were established by analysis of 1D/2D NMR, HREIMS, and IR data, and the absolute configurations were assigned on the basis of ECD curves or biogenetic considerations. These terpenes possess four different carbon skeletons, and compound 2, with a rarely occurring bicyclic framework, represents a possible precursor of tetracyclic harzianes. Compounds 1-6 exhibited growth inhibition of some marine phytoplankton species.
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