Article
Polymer Science
WeiCong Zhang, Ying Wang, Juan Guo, Chao Huang, Yong Hu
Summary: New pH-sensitive polysaccharide supramolecular hydrogel microparticles (HMPs) were constructed based on carboxymethyl beta-cyclodextrin/chitosan inclusion complex (CM-beta-CD/CS) and EDTA-chitosan (EDCS) in aqueous solution, showing highlighted pH-dependent release characteristics for potential protein drug delivery applications.
Review
Biotechnology & Applied Microbiology
Yazid Zaiki, Athirah Iskandar, Tin Wui Wong
Summary: Chitosan, as a biotechnological derivative of chitin, has various pharmaceutical and biomedical applications. It can encapsulate and deliver cancer therapeutics with specific drug targeting at the tumor microenvironment, enhancing cancer cytotoxic drug actions. To minimize off-target effects and drug-related adverse reactions, it is clinically necessary to achieve highly targeted drug delivery at the lowest possible drug doses.
BIOTECHNOLOGY ADVANCES
(2023)
Article
Chemistry, Applied
Shyi-Tien Chen, Hsiu-Wen Chien, Chih-Yu Cheng, Hui-Min Huang, Tzu-Yu Song, Yi-Cheng Chen, Chien-Hui Wu, Yi-Huang Hsueh, Yan-Hsiung Wang, Shih-Fu Ou
Summary: Chitosan/drug coatings synthesized via electrophoretic deposition on alkali-treated Ti surfaces exhibited improved antibacterial activities and corrosion resistances. With desirable adhesion, high drug loading capacity, and prolonged drug release, these proposed coatings can effectively limit bacterial adhesion and proliferation on Ti surfaces.
PROGRESS IN ORGANIC COATINGS
(2021)
Article
Pharmacology & Pharmacy
Camila Diedrich, Isabella C. Zittlau, Najeh M. Khalil, Adam F. G. Leontowich, Rilton A. de Freitas, Ildiko Badea, Rubiana M. Mainardes
Summary: In this study, chitosan-based nanoemulsion (NECh-LUT) was successfully developed with small particle size, good stability, and high encapsulation efficiency. In vitro release studies demonstrated the ability of NECh-LUT to achieve sustained release, indicating its potential as a novel therapeutic option for various disorders.
Article
Biotechnology & Applied Microbiology
Helton Jose Wiggers, Pascale Chevallier, Francesco Copes, Fernanda Heloisa Simch, Felipe da Silva Veloso, Giovana Maria Genevro, Diego Mantovani
Summary: Natural polymer-based films, specifically chitosan films, have been extensively studied as coatings for biomedical applications due to their favorable biological and mechanical properties. In this study, chitosan films crosslinked with quercetin were used as controlled release systems for the antibiotic drug trimethoprim. The results show that quercetin increases the crosslinking degree of chitosan films in a dose-dependent manner, affecting the release kinetics of the loaded drug while maintaining its antibacterial effects. This work demonstrates the potential of quercetin-crosslinked chitosan films as antibiotic-releasing coatings for biomedical applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Fatima Fernandez-Alvarez, Gracia Garcia-Garcia, Jose L. Arias
Summary: The study successfully constructed a maghemite/PLGA/chitosan nanostructure with good stability, magnetism, and drug release behavior, showing significant anti-lung adenocarcinoma effect of cisplatin loading on the matrix.
Article
Biophysics
Lumin Yang, Xiaoduo Zhao, Jing Zhang, Shuanhong Ma, Lei Jiang, Qiangbing Wei, Meirong Cai, Feng Zhou
Summary: In this study, a novel biomimetic nanoparticles lubricant, CS-PS, was synthesized and demonstrated to have excellent lubrication performance and drug carrier properties, making it a promising option for the treatment of osteoarthritis.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Andrea Loncarevic, Zoran Malbasa, Marin Kovacic, Karla Ostojic, Ange Angaits, Zeljko Skoko, Joanna Szpunar, Inga Urlic, Gloria Gallego Ferrer, Anamarija Rogina
Summary: Polymer hydrogels crosslinked by therapeutic metal ions have gained attention for their unique properties. Chitosan hydrogels have been widely studied in biomedical applications. This study investigated the properties of bimetallic-chitosan complex hydrogels with different cupric and zinc ions content. The results showed changes in morphology, formation of bimetallic-chitosan aerogels, decreased swelling ability and increased shear modulus with higher Cu content, and a strong physical crosslink between metal ions and chitosan chains.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Polymer Science
Bingren Tian, Yumei Liu, Jiayue Liu
Summary: The paper discusses the different forms of anticancer drug carriers using chitosan as the basic material, highlighting their role in cancer treatment and the release of anticancer drugs from these carriers. It also proposes the application prospects of chitosan-based delivery systems for anticancer drugs by comparatively evaluating the role of chitosan in anticancer drug delivery.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Materials Science, Ceramics
Shirin Khanmohammadi, Hossein Aghajani, Morteza Farrokhi-Rad
Summary: In this study, vancomycin-loaded mesoporous bioglass/hydroxyapatite whiskers/chitosan composite coatings were fabricated on titanium substrate using electrophoretic deposition. The coatings exhibited good drug delivery capability and antibacterial potency, without toxic effects on osteoblast cells.
CERAMICS INTERNATIONAL
(2022)
Article
Polymer Science
Meiyan Wu, Wangfang Deng, Yidong Zhang, Chao Chen, Zhexuan Liu, Pedram Fatehi, Bin Li
Summary: In this study, cellulose nanofibrils and chitosan composite beads were prepared using a simple and efficient method and exhibited large surface area, uniform pores, strong mechanical properties, and water resistance. These beads showed high efficiency in drug encapsulation and controlled release under acidic conditions.
Article
Biochemistry & Molecular Biology
Mostafa Saeedi, Mohammad Reza Moghbeli, Omid Vahidi
Summary: In this study, chitosan was crosslinked using glycyrrhizic acid as a new crosslinking agent, and the obtained hydrogels showed biocompatibility for controlled release of gallic acid in transdermal therapy. The crosslinking of chitosan with glycyrrhizic acid formed a covalent amide linkage, resulting in the formation of a crosslinked hydrogel network structure.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Mariusz Sandomierski, Katarzyna Adamska, Maria Ratajczak, Adam Voelkel
Summary: Chitosan scaffolds have great potential in biomedical applications, particularly in bone tissue engineering. This study successfully achieved controlled drug release in chitosan scaffolds by incorporating drug carriers, specifically for the osteoporosis drug risedronate. The addition of zeolite to the chitosan scaffold resulted in better drug retention compared to hydroxyapatite, demonstrating promising results for the potential use of this material in bone tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Yingqi Mi, Jingjing Zhang, Lulin Zhang, Qing Li, Yuanzheng Cheng, Zhanyong Guo
Summary: Chitosan nanoparticles loaded with adriamycin exhibited a burst effect followed by steady release, and demonstrated enhanced antioxidant activities and cytotoxicities against cancer cells. With reduced cytotoxicity and enhanced biological activity, these novel nanoparticles could serve as promising candidates for drug loading/release in drug delivery systems.
Article
Chemistry, Analytical
Xin Shi, Beibei Ma, Hongyu Chen, Wei Tan, Shiqing Ma, Guorui Zhu
Summary: This paper presents the development of a microfluidic/chitosan device for drug release to inhibit infections and guide bone regeneration. The device offers controlled drug release, flexible clinical use, low cost, and excellent antibacterial performance and biocompatibility.
