期刊
JOURNAL OF MOLECULAR RECOGNITION
卷 32, 期 6, 页码 -出版社
WILEY
DOI: 10.1002/jmr.2775
关键词
highly selective detection; molecularly imprinted TiO2; piezoelectric sensing; surface modification; uric acid biosensor
资金
- Doctoral Foundation Henan Polytechnic University, China [B2016-08]
- Key Foundation of Henan Educational Committee [18A150029]
- Natural Science Foundation of Henan Province of China [182300410201, 182300410202]
- Program for Science Technology Innovation Talents in Universities of Henan Province [18HASTIT007]
- Key Research Project of Henan Province [162102210223]
Combining the surface modification and molecular imprinting technique, a novel piezoelectric sensing platform with excellent molecular recognition capability was established for the detection of uric acid (UA) based on the immobilization of TiO2 nanoparticles onto quartz crystal microbalance (QCM) electrode and modification of molecularly imprinted TiO2 (MIT) layer on TiO2 nanoparticles. The performance of the fabricated biosensor was evaluated, and the results indicated that the biosensor exhibited high sensitivity in UA detection, with a linear range from 0.04 to 45 mu M and a limit of detection of 0.01 mu M. Moreover, the biosensor presented high selectivity towards UA in comparison with other interferents. The analytical application of the UA biosensor confirmed the feasibility of UA detection in urine sample.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据