Article
Immunology
Han Rim Lee, Jung Eun Yoo, Hayoung Choi, Kyungdo Han, Young-Hyo Lim, Hyun Lee, Dong Wook Shin
Summary: TB survivors have a higher risk of ischemic heart disease (IHD) than matched controls, regardless of potential confounders. This population-based study found that TB survivors are at risk of developing IHD, regardless of factors such as income, place of residence, and lifestyle habits. Strategies should be implemented to reduce the burden of IHD in this population.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Kyuwoong Kim, Hyeyun Jung, Edvige Di Giovanna, Tae Joon Jun, Young-Hak Kim
Summary: GGT levels are associated with an increased risk of ischemic stroke in adult cancer survivors, independent of sex, insurance premium, and alcohol consumption.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Dongjian Han, Fuhang Wang, Zhentao Qiao, Bo Wang, Yi Zhang, Qingjiao Jiang, Miaomiao Liu, Yuansong Zhuang, Quanxu An, Yan Bai, Jiahong Shangguan, Jinying Zhang, Gaofeng Liang, Deliang Shen
Summary: Acute myocardial infarction (AMI) triggers an inflammation response, leading to heart cell damage and adverse cardiac remodeling. Interleukin-5 (IL-5) plays a crucial role in developing eosinophils (EOS) and has proangiogenic properties for tissue healing. This study successfully synthesized a biomimetic IL-5 nanoparticle by camouflaging it in a neutrophilic membrane. Administration of these nanoparticles in an in vivo model promoted EOS accumulation, angiogenesis, and limited adverse cardiac remodeling after AMI. The nanoparticles also acted as neutrophil decoys, absorbing and neutralizing elevated neutrophil-related cytokines in the injured heart. Additionally, they protected cardiomyocytes from excessive inflammatory-induced apoptosis and preserved cardiac function.
BIOACTIVE MATERIALS
(2023)
Article
Cardiac & Cardiovascular Systems
Elvira Forte, Bryant Perkins, Amalia Sintou, Harkaran S. Kalkat, Angelos Papanikolaou, Catherine Jenkins, Mashael Alsubaie, Rasheda A. Chowdhury, Theodore M. Duffy, Daniel A. Skelly, Jane Branca, Mohamed Bellahcene, Michael D. Schneider, Sian E. Harding, Milena B. Furtado, Fu Siong Ng, Muneer G. Hasham, Nadia Rosenthal, Susanne Sattler
Summary: After ischemic injury to the heart, cross-priming dendritic cells play a role in activating cytotoxic CD8(+) T cells by presenting self-antigens from necrotic cardiac cells. Research suggests that activation of cytotoxic CD8(+) T cells by cross-priming DC may exacerbate inflammatory damage of the myocardium and corresponding decline in cardiac function.
Review
Medicine, Research & Experimental
Kowsar Amirzadeh Gougheri, Armin Ahmadi, Mohadeseh Ghafuri Ahmadabadi, Amirhesam Babajani, Ghasem Yazdanpanah, Soheyl Bahrami, Mohammad Hassani, Hassan Niknejad
Summary: Heart diseases are the primary cause of mortality and morbidity worldwide. Exosomes, as a new emerging agent, play significant roles in the diagnosis, treatment, and prognosis of heart diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Lars Lind, Daniela Zanetti, Martin Ingelsson, Stefan Gustafsson, Johan Arnlov, Themistocles L. Assimes
Summary: Large-scale proteomics analysis identified over 40 new proteins associated with cardiovascular diseases. Some of these proteins were specifically related to myocardial infarction, ischemic stroke, and heart failure. These findings have the potential to improve risk prediction for CVD in elderly male populations. Further studies are needed to validate these findings in different age groups and genders.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Plant Sciences
Shuo Zhai, Xiao-Fan Zhang, Fang Lu, Wei-Guo Chen, Xin He, Chun-Feng Zhang, Chong-Zhi Wang, Chun-Su Yuan
Summary: The study demonstrated that GD extract has a protective effect against myocardial infarction by promoting angiogenesis and regulating the VEGF/VEGFR2 signaling pathway, leading to reduced infarct size and enhanced myocardial repair.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Biology
Sabina Andreea Leanca, Irina Afrasanie, Daniela Crisu, Iulian Theodor Matei, Stefania Teodora Duca, Alexandru Dan Costache, Viviana Onofrei, Ionut Tudorancea, Ovidiu Mitu, Minerva Codruta Badescu, Lacramioara Ionela Serban, Irina Iuliana Costache
Summary: Despite improvements in CAD and MI treatment, IHD remains the leading cause of HF, with over 70% of HF patients having IHD as the underlying cause. IHD also leads to worse outcomes, increased morbidity and mortality, and higher healthcare costs. New pharmacological therapies and interventional strategies have shown potential benefits in reducing symptoms and promoting reverse remodeling in HF patients. Cardiac regenerative therapies, such as stem cell transplantation, could also be a new therapeutic resource for managing HF. This review aims to analyze existing data to evaluate the impact of new HF therapies in IHD patients and gain insight into optimal management strategies for this large proportion of HF patients.
Article
Cardiac & Cardiovascular Systems
Ekaterina Kushnareva, Vladimir Kushnarev, Anna Artemyeva, Lubov Mitrofanova, Olga Moiseeva
Summary: Immune checkpoint inhibitors are promising agents in anti-cancer therapy, but they can cause cardiotoxicity. This study found that cardiovascular diseases may increase myocardial PD-L1 expression, suggesting a potential basis for complications development in checkpoint inhibitors therapy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Erij Messadi
Summary: Ischemic heart disease, particularly myocardial infarction, is a major cause of death worldwide. Snake venoms contain biologically active proteins and peptides that have potential therapeutic applications for treating ischemic heart disease and related conditions. This review discusses the mechanisms of action and therapeutic targets of snake venom toxins, as well as the current status of snake venom-derived drugs in clinical development.
Article
Cardiac & Cardiovascular Systems
Prachi Umbarkar, Suma Ejantkar, Sulivette Y. Ruiz Ramirez, Angelica Toro Cora, Qinkun Zhang, Sultan Tousif, Hind Lal
Summary: Myocardial infarction (MI) is a major cause of death worldwide, and GSK-3 has shown potential as a therapeutic target for cardiovascular diseases. In this study, it was found that GSK-3α in cardiac fibroblasts plays a critical role in the pathological remodeling of ischemic hearts.
BASIC RESEARCH IN CARDIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Texali C. Garcia-Garduno, Jorge R. Padilla-Gutierrez, Diego Cambron-Mora, Yeminia Valle
Summary: The global prevalence of heart failure is increasing, especially in medium-low sociodemographic areas, where risk factors are rising. Heart failure is associated with various comorbidities, including cancer, presenting challenges in treatment and quality of life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Jian Huang, Ying Gui, Jing Wu, Yubo Xie
Summary: In this study, researchers used Mendelian randomization to evaluate the causal effect of atopic dermatitis (AD) on ischemic stroke and coronary heart disease. The study found no causal association between genetically predicted AD and these diseases.
FRONTIERS IN GENETICS
(2022)
Article
Cardiac & Cardiovascular Systems
Gentaro Ikeda, Michelle R. Santoso, Yuko Tada, Albert M. Li, Evgeniya Vaskova, Ji-Hye Jung, Connor O'Brien, Elizabeth Egan, Jiangbin Ye, Phillip C. Yang
Summary: This study demonstrated that extracellular vesicle-mediated transfer of autologous mitochondria can enhance cardiac function by restoring myocardial bioenergetics. The therapy shows potential as a precision therapeutic for mitochondria-related diseases such as heart failure.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Wen Su, Jie-Gao Zhu, Xue-Qiao Zhao, Hui Chen, Wei-Ping Li, Hong-Wei Li
Summary: This study showed that there is a U-shaped relationship between serum calcium levels and all-cause mortality in patients with acute coronary syndrome, with maintaining serum calcium around 2.35 mmol/L associated with reduced mortality risk.