Article
Biochemistry & Molecular Biology
Ana Karina Aranda-Rivera, Alfredo Cruz-Gregorio, Omar Emiliano Aparicio-Trejo, Ariadna Jazmin Ortega-Lozano, Jose Pedraza-Chaverri
Summary: In the UUO model, overproduction of ROS leads to alterations in signaling pathways, promoting inflammation, oxidative stress, and apoptosis, contributing to fibrosis development. Impairment of mitochondrial metabolism is also involved in this process.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Neurosciences
Yen-Peng Liao, Shin-ichi Urayama, Tadashi Isa, Hidenao Fukuyama
Summary: The study proposed an optimal model mapping method to improve the reliability of perfusion parameter estimation in IVIM study, finding Gaussian, Kurtosis, and Gamma models optimal for different brain tissues. Using the optimal model mapping method resulted in more reliable estimations of perfusion fraction and pseudo diffusion coefficient compared to conventional methods, potentially providing additional information for clinical diagnosis.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martin Loh, Tobit Fuehres, Christoph Stuprich, Michael Uder, Marc Saake, Frederik Bernd Laun
Summary: This study compared the differences in IVIM parameters in the liver between different slice settings, and found that there were no significant differences in the parameters between studies using few slices and many slices.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Immunology
Xiaofei Li, Jing Zhao, Said Movahedi Naini, Gianmarco Sabiu, Stefan G. Tullius, Su Ryon Shin, Jonathan S. Bromberg, Paolo Fiorina, George C. Tsokos, Reza Abdi, Vivek Kasinath
Summary: The study revealed that after unilateral ureteral obstruction in the kidney, fibroblastic reticular cells (FRCs) in the kidney-draining lymph node also become fibrogenic, contributing to fibrosis that closely mirrors changes in the kidney. Additionally, immune cell populations in the affected lymph node were significantly higher compared to the unaffected contralateral kidney-draining lymph node. This suggests a possible mechanism for fibrosis involving the TGF beta/TGF beta R signaling pathway, and future studies are needed to delve deeper into this connection between FRCs and lymph node fibrosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Qing Hu, Peipei Jiang, Yongjing Feng, Yan Xu, Nan Zhou, Weibo Chen, Li Zhu, Yali Hu, Zhengyang Zhou
Summary: IVIM MR imaging shows potential in evaluating endometrial fibrosis, with a combination model of ADC, D, and f values demonstrating good diagnostic accuracy. ADC performed better than ET in diagnosis, and reproducibility of IVIM parameters was good to excellent, indicating their potential as imaging biomarkers for noninvasive assessment of endometrial fibrosis.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ariadna Jazmin Ortega-Lozano, Alexis Paulina Jimenez-Uribe, Ana Karina Aranda-Rivera, Leopoldo Gomez-Caudillo, Emmanuel Rios-Castro, Edilia Tapia, Belen Bellido, Omar Emiliano Aparicio-Trejo, Laura Gabriela Sanchez-Lozada, Jose Pedraza-Chaverri
Summary: The study examined the impact of UUO at different time points on the mitochondrial proteome of rat kidneys, revealing changes in proteins related to oxidative phosphorylation, the tricarboxylic acid cycle, and fatty acid metabolism, all of which are associated with bioenergetics during ON.
Article
Endocrinology & Metabolism
Wenqi Wu, Tong Gong, Jinliang Niu, Wenjin Li, Jianting Li, Xiaoli Song, Sha Cui, Wenjin Bian, Jun Wang
Summary: The evaluation of bone marrow microstructure and gender-related cellular and capillary networks in healthy young adults can help to better understand the process of bone metabolism. IVIM provides a non-invasive method to assess bone marrow microstructure, such as cellularity and perfusion, without requiring intravenous contrast agent injection.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tobit Fuehres, Andreas Julian Riexinger, Martin Loh, Jan Martin, Andreas Wetscherek, Tristan Anselm Kuder, Michael Uder, Bernhard Hensel, Frederik Bernd Laun
Summary: The purpose of this study was to investigate the TE-dependence of IVIM parameters and to check if the triexponential pseudodiffusion compartments are associated with arterial and venous blood. TE-dependence was observed for f, f(1) and f(2), while D, D*, D1* and D2* showed no significant TE-dependence. It was found that f(1) and f(2) exhibit a similar TE-dependence as f, suggesting that the triexponential pseudodiffusion compartments are most probably not associated with arterial and venous blood.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julia Stabinska, Helge J. Zoellner, Thomas A. Thiel, Hans-Jorg Wittsack, Alexandra Ljimani
Summary: The reliability of IVIM model parameter estimation for DWI in the kidney was improved using a novel IDEAL approach. The numerical simulations and in vivo data analysis showed that the IDEAL-based IVIM parameter estimates were more robust and accurate compared to conventional approaches.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Oncology
Dongdong Wang, Yiping Lu, Xuanxuan Li, Nan Mei, Pu-Yeh Wu, Daoying Geng, Hao Wu, Bo Yin
Summary: This study investigates the feasibility of using intravoxel incoherent motion (IVIM) and R2* Mapping to detect HIF-1 alpha expression levels in gliomas. The results show that IVIM and R2* Mapping can accurately evaluate HIF-1 alpha levels, which can aid in the detection of hypoxia niches in gliomas and guide treatment decisions.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Juan Li, Liangjie Lin, Xuemei Gao, Shenglei Li, Jingliang Cheng
Summary: This study found that amide proton transfer (APT) weighted and intravoxel incoherent motion (IVIM) imaging have significant value in evaluating prognostic factors for rectal adenocarcinoma. They can help determine histopathological type, tumor grade, and extramural vascular invasion status.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Reynold I. I. Lopez-Soler, Azadeh Nikouee, Matthew Kim, Saman Khan, Lakshmi Sivaraman, Xiangzhong Ding, Qun Sophia Zang
Summary: This study found that enhancing autophagy can reduce fibrosis caused by renal injury. By observing mice after kidney surgery, it was found that the use of active mutant Beclin-1 can inhibit the fibrosis process, alleviate inflammation and cellular stress response caused by kidney injury. These findings provide new methods for treating fibrosis after kidney transplantation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Shilan Li, Di Tian, Xin Li, Jia Li, Qingwei Song, Yunlong Xia, Zhiyong Li
Summary: The condition of myocardial microcirculation in breast cancer patients after anthracycline chemotherapy was investigated using intravoxel incoherent motion (IVIM) imaging. The study found a decreasing trend in myocardial microcirculation during chemotherapy, indicating the potential usefulness of IVIM technology for cardiovascular risk monitoring and prognosis assessment in these patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haoyuan Huang, Baoer Liu, Yikai Xu, Wu Zhou
Summary: This study proposes a deep-learning model with synthetic-to-real domain adaptation to fit the IVIM model parameters of DWI. The results demonstrate that the proposed method outperforms previously reported methods in terms of fitting accuracy and noise robustness.
Article
Clinical Neurology
K. Yamashita, R. Kamei, H. Sugimori, T. Kuwashiro, S. Tokunaga, K. Kawamata, K. Furuya, S. Harada, J. Maehara, Y. Okada, T. Noguchi
Summary: The study evaluated the usefulness of intravoxel incoherent motion MR imaging in patients with acute ischemic stroke, showing high interobserver agreement and potential clinical utility in determining treatment strategies for patients, particularly in assessing the presence of presumed penumbral regions.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)