APT-weighted MRI: Techniques, current neuro applications, and challenging issues

Rapid and quantitative chemical exchange saturation transfer (CEST) imaging with magnetic resonance fingerprinting (MRF)

(2018) Ouri Cohen et al.   MAGNETIC RESONANCE IN MEDICINE

Chemical exchange saturation transfer fingerprinting for exchange rate quantification

(2018) Zhengwei Zhou et al.   MAGNETIC RESONANCE IN MEDICINE

Improved Differentiation of Low-Grade and High-Grade Gliomas and Detection of Tumor Proliferation Using APT Contrast Fitted from Z-Spectrum

(2018) Jiaxuan Zhang et al.   MOLECULAR IMAGING AND BIOLOGY

Assessing the predictability of IDH mutation and MGMT methylation status in glioma patients using relaxation-compensated multipool CEST MRI at 7.0 T

(2018) Daniel Paech et al.   NEURO-ONCOLOGY

Magnetization Transfer Contrast and Chemical Exchange Saturation Transfer MRI. Features and analysis of the field-dependent saturation spectrum

(2018) Peter C.M. van Zijl et al.   NEUROIMAGE

Multiple Sclerosis

(2018) Daniel S. Reich et al.   NEW ENGLAND JOURNAL OF MEDICINE

Snapshot-CEST: Optimizing spiral-centric-reordered gradient echo acquisition for fast and robust 3D CEST MRI at 9.4 T

(2018) Moritz Zaiss et al.   NMR IN BIOMEDICINE

Towards the complex dependence of MTRasym on T 1w in amide proton transfer (APT) imaging

(2018) Zhongliang Zu   NMR IN BIOMEDICINE

Predicting O6-Methylguanine-DNA Methyltransferase Protein Expression in Primary Low- and High-Grade Gliomas Using Certain Qualitative Characteristics of Amide Proton Transfer-Weighted Magnetic Resonance Imaging

(2018) Lu Su et al.   World Neurosurgery

Amide proton transfer-weighted magnetic resonance image-guided stereotactic biopsy in patients with newly diagnosed gliomas

(2017) Shanshan Jiang et al.   EUROPEAN JOURNAL OF CANCER

Discriminating MGMT promoter methylation status in patients with glioblastoma employing amide proton transfer-weighted MRI metrics

(2017) Shanshan Jiang et al.   EUROPEAN RADIOLOGY

Applying protein-based amide proton transfer MR imaging to distinguish solitary brain metastases from glioblastoma

(2017) Hao Yu et al.   EUROPEAN RADIOLOGY

Amide proton transfer imaging to discriminate between low- and high-grade gliomas: added value to apparent diffusion coefficient and relative cerebral blood volume

(2017) Yoon Seong Choi et al.   EUROPEAN RADIOLOGY

Amide proton transfer imaging for differentiation of benign and atypical meningiomas

(2017) Bio Joo et al.   EUROPEAN RADIOLOGY

Consensus statement on current and emerging methods for the diagnosis and evaluation of cerebrovascular disease

(2017) Manus J Donahue et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Imaging the physiological evolution of the ischemic penumbra in acute ischemic stroke

(2017) Richard Leigh et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Amide proton transfer-weighted MRI detection of traumatic brain injury in rats

(2017) Hong Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain Tumor Imaging

(2017) Kevin M. Brindle et al.   JOURNAL OF CLINICAL ONCOLOGY

Clinical applications of chemical exchange saturation transfer (CEST) MRI

(2017) Kyle M. Jones et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Diagnostic performance between contrast enhancement, proton MR spectroscopy, and amide proton transfer imaging in patients with brain tumors

(2017) Akihiko Sakata et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Amide proton transfer CEST of the cervical spinal cord in multiple sclerosis patients at 3T

(2017) Samantha By et al.   MAGNETIC RESONANCE IN MEDICINE

A comparison of exogenous and endogenous CESTMRI methods for evaluating in vivo pH

(2017) Leila R. Lindeman et al.   MAGNETIC RESONANCE IN MEDICINE

Predicting IDH mutation status in grade II gliomas using amide proton transfer-weighted (APTw) MRI

(2017) Shanshan Jiang et al.   MAGNETIC RESONANCE IN MEDICINE

Improving the detection sensitivity of pH-weighted amide proton transfer MRI in acute stroke patients using extrapolated semisolid magnetization transfer reference signals

(2017) Hye-Young Heo et al.   MAGNETIC RESONANCE IN MEDICINE

Applying Amide Proton Transfer MR Imaging to Hybrid Brain PET/MR: Concordance with Gadolinium Enhancement and Added Value to [18F]FDG PET

(2017) Hongzan Sun et al.   MOLECULAR IMAGING AND BIOLOGY

Enhancing sensitivity of pH-weighted MRI with combination of amide and guanidyl CEST

(2017) Tao Jin et al.   NEUROIMAGE

Differentiating the histologic grades of gliomas preoperatively using amide proton transfer-weighted (APTW) and intravoxel incoherent motion MRI

(2017) Tianyu Zou et al.   NMR IN BIOMEDICINE

Chemical Exchange Saturation Transfer MRI Signal Loss of the Substantia Nigra as an Imaging Biomarker to Evaluate the Diagnosis and Severity of Parkinson's Disease

(2017) Chunmei Li et al.   Frontiers in Neuroscience

Evolution of Cerebral Ischemia Assessed by Amide Proton Transfer-Weighted MRI

(2017) Guodong Song et al.   Frontiers in Neurology

Tumor Infiltration in Enhancing and Non-Enhancing Parts of Glioblastoma: A Correlation with Histopathology

(2017) Oliver Eidel et al.   PLoS One

Amide proton transfer magnetic resonance imaging in detecting intracranial hemorrhage at different stages: a comparative study with susceptibility weighted imaging

(2017) Xiaoyue Ma et al.   Scientific Reports

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Characterizing amide proton transfer imaging in haemorrhage brain lesions using 3T MRI

(2016) Ha-Kyu Jeong et al.   EUROPEAN RADIOLOGY

Added value of amide proton transfer imaging to conventional and perfusion MR imaging for evaluating the treatment response of newly diagnosed glioblastoma

(2016) Kye Jin Park et al.   EUROPEAN RADIOLOGY

Grading diffuse gliomas without intense contrast enhancement by amide proton transfer MR imaging: comparisons with diffusion- and perfusion-weighted imaging

(2016) Osamu Togao et al.   EUROPEAN RADIOLOGY

Applying amide proton transfer-weighted MRI to distinguish pseudoprogression from true progression in malignant gliomas

(2016) Bo Ma et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Chemical exchange saturation transfer for predicting response to stereotactic radiosurgery in human brain metastasis

(2016) Kimberly L. Desmond et al.   MAGNETIC RESONANCE IN MEDICINE

Amide proton transfer imaging of brain tumors using a self-corrected 3D fast spin-echo dixon method: Comparison With separate B0 correction

(2016) Osamu Togao et al.   MAGNETIC RESONANCE IN MEDICINE

Chemical exchange saturation transfer (CEST) imaging with fast variably-accelerated sensitivity encoding (vSENSE)

(2016) Yi Zhang et al.   MAGNETIC RESONANCE IN MEDICINE

Simultaneous mapping of water shift and B1(WASABI)-Application to field-Inhomogeneity correction of CESTMRI data

(2016) Patrick Schuenke et al.   MAGNETIC RESONANCE IN MEDICINE

Quantitative assessment of the effects of water proton concentration and water T1changes on amide proton transfer (APT) and nuclear overhauser enhancement (NOE) MRI: The origin of the APT imaging signal in brain tumor

(2016) Dong-Hoon Lee et al.   MAGNETIC RESONANCE IN MEDICINE

Accelerating chemical exchange saturation transfer (CEST) MRI by combining compressed sensing and sensitivity encoding techniques

(2016) Hye-Young Heo et al.   MAGNETIC RESONANCE IN MEDICINE

Insight into the quantitative metrics of chemical exchange saturation transfer (CEST) imaging

(2016) Hye-Young Heo et al.   MAGNETIC RESONANCE IN MEDICINE

Quantitative Proteomics Reveals Fundamental Regulatory Differences in Oncogenic HRAS and Isocitrate Dehydrogenase (IDH1) Driven Astrocytoma

(2016) Sophia Doll et al.   MOLECULAR & CELLULAR PROTEOMICS

pH-sensitive MRI demarcates graded tissue acidification during acute stroke ― pH specificity enhancement with magnetization transfer and relaxation-normalized amide proton transfer (APT) MRI

(2016) Yingkun Guo et al.   NEUROIMAGE

Pre- and Posttreatment Glioma: Comparison of Amide Proton Transfer Imaging with MR Spectroscopy for Biomarkers of Tumor Proliferation

(2016) Ji Eun Park et al.   RADIOLOGY

Amide Proton Transfer Imaging of Diffuse Gliomas: Effect of Saturation Pulse Length in Parallel Transmission-Based Technique

(2016) Osamu Togao et al.   PLoS One

Amide Proton Transfer Magnetic Resonance Imaging of Alzheimer′s Disease at 3.0 Tesla: A Preliminary Study

(2015) Min Chen et al.   CHINESE MEDICAL JOURNAL

Chemical exchange saturation transfer (CEST) MR technique for in-vivo liver imaging at 3.0 tesla

(2015) Shu-Zhong Chen et al.   EUROPEAN RADIOLOGY

Molecular MRI differentiation between primary central nervous system lymphomas and high-grade gliomas using endogenous protein-based amide proton transfer MR imaging at 3 Tesla

(2015) Shanshan Jiang et al.   EUROPEAN RADIOLOGY

Grading glial tumors with amide proton transfer MR imaging: different analytical approaches

(2015) Akihiko Sakata et al.   JOURNAL OF NEURO-ONCOLOGY

Highly accelerated chemical exchange saturation transfer (CEST) measurements with linear algebraic modeling

(2015) Yi Zhang et al.   MAGNETIC RESONANCE IN MEDICINE

Quantitative assessment of amide proton transfer (APT) and nuclear overhauser enhancement (NOE) imaging with extrapolated semisolid magnetization transfer reference (EMR) signals: II. Comparison of three EMR models and application to human brain glioma at

(2015) Hye-Young Heo et al.   MAGNETIC RESONANCE IN MEDICINE

Quantitative assessment of amide proton transfer (APT) and nuclear overhauser enhancement (NOE) imaging with extrapolated semi-solid magnetization transfer reference (EMR) signals: Application to a rat glioma model at 4.7 tesla

(2015) Hye-Young Heo et al.   MAGNETIC RESONANCE IN MEDICINE

Simultaneous detection and separation of hyperacute intracerebral hemorrhage and cerebral ischemia using amide proton transfer MRI

(2015) Meiyun Wang et al.   MAGNETIC RESONANCE IN MEDICINE

Assessing Amide Proton Transfer (APT) MRI Contrast Origins in 9 L Gliosarcoma in the Rat Brain Using Proteomic Analysis

(2015) Kun Yan et al.   MOLECULAR IMAGING AND BIOLOGY

Integration of 2-hydroxyglutarate-proton magnetic resonance spectroscopy into clinical practice for disease monitoring in isocitrate dehydrogenase-mutant glioma

(2015) Macarena I. de la Fuente et al.   NEURO-ONCOLOGY

Relaxation-compensated CEST-MRI of the human brain at 7 T: Unbiased insight into NOE and amide signal changes in human glioblastoma

(2015) Moritz Zaiss et al.   NEUROIMAGE

Chemical Exchange Saturation Transfer MR Imaging is Superior to Diffusion-Tensor Imaging in the Diagnosis and Severity Evaluation of Parkinson’s Disease: A Study on Substantia Nigra and Striatum

(2015) Chunmei Li et al.   Frontiers in Aging Neuroscience

Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging

(2015) George W. J. Harston et al.   BRAIN

Chemical exchange saturation transfer MR imaging of Parkinson’s disease at 3 Tesla

(2014) Chunmei Li et al.   EUROPEAN RADIOLOGY

Quantitative Tissue Ph Measurement during Cerebral Ischemia Using Amine and Amide Concentration-Independent Detection (AACID) with MRI

(2014) Nevin McVicar et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Observation of true and pseudo NOE signals using CEST-MRI and CEST-MRS sequences with and without lipid suppression

(2014) Jianhua Lu et al.   MAGNETIC RESONANCE IN MEDICINE

Contributors to contrast between glioma and brain tissue in chemical exchange saturation transfer sensitive imaging at 3Tesla

(2014) Rachel Scheidegger et al.   NEUROIMAGE

Concurrent saturation transfer contrast in in vivo brain by a uniform magnetization transfer MRI

(2014) Jae-Seung Lee et al.   NEUROIMAGE

Comparing different analysis methods for quantifying the MRI amide proton transfer (APT) effect in hyperacute stroke patients

(2014) Y. K. Tee et al.   NMR IN BIOMEDICINE

On the origins of chemical exchange saturation transfer (CEST) contrast in tumors at 9.4 T

(2014) Junzhong Xu et al.   NMR IN BIOMEDICINE

InverseZ-spectrum analysis for spillover-, MT-, andT1-corrected steady-state pulsed CEST-MRI - application to pH-weighted MRI of acute stroke

(2014) Moritz Zaiss et al.   NMR IN BIOMEDICINE

In vivo chemical exchange saturation transfer imaging allows early detection of a therapeutic response in glioblastoma

(2014) K. Sagiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional amide proton transfer MR imaging of gliomas: Initial experience and comparison with gadolinium enhancement

(2013) Jinyuan Zhou et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Chemical exchange saturation transfer MR imaging of articular cartilage glycosaminoglycans at 3T: Accuracy of B0 Field Inhomogeneity corrections with gradient echo method

(2013) Wenbo Wei et al.   MAGNETIC RESONANCE IMAGING

APT-weighted and NOE-weighted image contrasts in glioma with different RF saturation powers based on magnetization transfer ratio asymmetry analyses

(2013) Jinyuan Zhou et al.   MAGNETIC RESONANCE IN MEDICINE

Chemical exchange saturation transfer effect in blood

(2013) Shaokuan Zheng et al.   MAGNETIC RESONANCE IN MEDICINE

Sensitivity and Source of Amine-Proton Exchange and Amide-Proton Transfer Magnetic Resonance Imaging in Cerebral Ischemia

(2013) Xiaopeng Zong et al.   MAGNETIC RESONANCE IN MEDICINE

Variable delay multi-pulse train for fast chemical exchange saturation transfer and relayed-nuclear overhauser enhancement MRI

(2013) Jiadi Xu et al.   MAGNETIC RESONANCE IN MEDICINE

Mapping of amide, amine, and aliphatic peaks in the CEST spectra of murine xenografts at 7 T

(2013) Kimberly L. Desmond et al.   MAGNETIC RESONANCE IN MEDICINE

Amide proton transfer imaging of high intensity focused ultrasound-treated tumor tissue

(2013) Stefanie J.C.G. Hectors et al.   MAGNETIC RESONANCE IN MEDICINE

Quantitative multiparametric MRI assessment of glioma response to radiotherapy in a rat model

(2013) X. Hong et al.   NEURO-ONCOLOGY

Amide proton transfer imaging of adult diffuse gliomas: correlation with histopathological grades

(2013) O. Togao et al.   NEURO-ONCOLOGY

Nuclear Overhauser enhancement (NOE) imaging in the human brain at 7T

(2013) Craig K. Jones et al.   NEUROIMAGE

Assessment of ischemic penumbra in patients with hyperacute stroke using amide proton transfer (APT) chemical exchange saturation transfer (CEST) MRI

(2013) Anna Tietze et al.   NMR IN BIOMEDICINE

Chemical exchange saturation transfer (CEST) and MRZ-spectroscopyin vivo: a review of theoretical approaches and methods

(2013) Moritz Zaiss et al.   PHYSICS IN MEDICINE AND BIOLOGY

A Simple Model for Understanding the Origin of the Amide Proton Transfer MRI Signal in Tissue

(2012) Jinyuan Zhou et al.   APPLIED MAGNETIC RESONANCE

Assessment of MRI Parameters as Imaging Biomarkers for Radiation Necrosis in the Rat Brain

(2012) Silun Wang et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

CEST: From basic principles to applications, challenges and opportunities

(2012) Elena Vinogradov et al.   JOURNAL OF MAGNETIC RESONANCE

Growth properties of SF188/V+ human glioma in rats in vivo observed by magnetic resonance imaging

(2012) Rachel Grossman et al.   JOURNAL OF NEURO-ONCOLOGY

Keyhole chemical exchange saturation transfer

(2012) G. Varma et al.   MAGNETIC RESONANCE IN MEDICINE

Quantitative characterization of nuclear overhauser enhancement and amide proton transfer effects in the human brain at 7 tesla

(2012) Dapeng Liu et al.   MAGNETIC RESONANCE IN MEDICINE

A new method for detecting exchanging amide protons using chemical exchange rotation transfer

(2012) Zhongliang Zu et al.   MAGNETIC RESONANCE IN MEDICINE

Quantitative Bayesian model-based analysis of amide proton transfer MRI

(2012) Michael A. Chappell et al.   MAGNETIC RESONANCE IN MEDICINE

Amide proton transfer imaging of the breast at 3 T: Establishing reproducibility and possible feasibility assessing chemotherapy response

(2012) Adrienne N. Dula et al.   MAGNETIC RESONANCE IN MEDICINE

MR imaging of the amide-proton transfer effect and the pH-insensitive nuclear overhauser effect at 9.4 T

(2012) Tao Jin et al.   MAGNETIC RESONANCE IN MEDICINE

Three-Dimensional Turbo-Spin-Echo Amide Proton Transfer MR Imaging at 3-Tesla and Its Application to High-Grade Human Brain Tumors

(2012) Xuna Zhao et al.   MOLECULAR IMAGING AND BIOLOGY

Magnetic resonance imaging of glutamate

(2012) Kejia Cai et al.   NATURE MEDICINE

2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas

(2012) Changho Choi et al.   NATURE MEDICINE

Exchange rates of creatine kinase metabolites: feasibility of imaging creatine by chemical exchange saturation transfer MRI

(2012) Mohammad Haris et al.   NMR IN BIOMEDICINE

Quantitative separation of CEST effect from magnetization transfer and spillover effects by Lorentzian-line-fit analysis of z-spectra

(2011) Moritz Zaiß et al.   JOURNAL OF MAGNETIC RESONANCE

Isolating chemical exchange saturation transfer contrast from magnetization transfer asymmetry under two-frequency rf irradiation

(2011) Jae-Seung Lee et al.   JOURNAL OF MAGNETIC RESONANCE

Saturation power dependence of amide proton transfer image contrasts in human brain tumors and strokes at 3 T

(2011) Xuna Zhao et al.   MAGNETIC RESONANCE IN MEDICINE

In vivo three-dimensional whole-brain pulsed steady-state chemical exchange saturation transfer at 7 T

(2011) Craig K. Jones et al.   MAGNETIC RESONANCE IN MEDICINE

Amide proton transfer imaging with improved robustness to magnetic field inhomogeneity and magnetization transfer asymmetry using saturation with frequency alternating RF irradiation

(2011) Rachel Scheidegger et al.   MAGNETIC RESONANCE IN MEDICINE

Optimization of pulse train presaturation for CEST imaging in clinical scanners

(2011) Benjamin Schmitt et al.   MAGNETIC RESONANCE IN MEDICINE

Chemical exchange saturation transfer (CEST): What is in a name and what isn't?

(2011) Peter C. M. van Zijl et al.   MAGNETIC RESONANCE IN MEDICINE

Development of chemical exchange saturation transfer at 7T

(2011) Adrienne N. Dula et al.   MAGNETIC RESONANCE IN MEDICINE

Magnetic resonance imaging of the Amine–Proton EXchange (APEX) dependent contrast

(2011) Tao Jin et al.   NEUROIMAGE

Imaging acute ischemic tissue acidosis with pH-sensitive endogenous amide proton transfer (APT) MRI—Correction of tissue relaxation and concomitant RF irradiation effects toward mapping quantitative cerebral tissue pH

(2011) Phillip Zhe Sun et al.   NEUROIMAGE

Defining an Acidosis-Based Ischemic Penumbra from pH-Weighted MRI

(2011) Jinyuan Zhou et al.   Translational Stroke Research

High-throughput screening of chemical exchange saturation transfer MR contrast agents

(2010) Guanshu Liu et al.   Contrast Media & Molecular Imaging

Updated Response Assessment Criteria for High-Grade Gliomas: Response Assessment in Neuro-Oncology Working Group

(2010) Patrick Y. Wen et al.   JOURNAL OF CLINICAL ONCOLOGY

Fast multislice pH-weighted chemical exchange saturation transfer (CEST) MRI with Unevenly segmented RF irradiation

(2010) Phillip Zhe Sun et al.   MAGNETIC RESONANCE IN MEDICINE

Fast 3D chemical exchange saturation transfer (CEST) imaging of the human brain

(2010) He Zhu et al.   MAGNETIC RESONANCE IN MEDICINE

Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides

(2010) Jinyuan Zhou et al.   NATURE MEDICINE

MR imaging of high-grade brain tumors using endogenous protein and peptide-based contrast

(2010) Zhibo Wen et al.   NEUROIMAGE

Brain α-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation

(2009) Junchao Tong et al.   BRAIN

Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments

(2009) Mina Kim et al.   MAGNETIC RESONANCE IN MEDICINE

Chemical Exchange Saturation Transfer Contrast Agents for Magnetic Resonance Imaging

(2008) A. Dean Sherry et al.   Annual Review of Biomedical Engineering

Investigation of optimizing and translating pH-sensitive pulsed-chemical exchange saturation transfer (CEST) imaging to a 3T clinical scanner

(2008) Phillip Zhe Sun et al.   MAGNETIC RESONANCE IN MEDICINE

Practical data acquisition method for human brain tumor amide proton transfer (APT) imaging

(2008) Jinyuan Zhou et al.   MAGNETIC RESONANCE IN MEDICINE

Imaging in the era of molecular oncology

(2008) Ralph Weissleder et al.   NATURE

Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST)

(2008) W. Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amide proton transfer imaging of 9L gliosarcoma and human glioblastoma xenografts

(2007) Amandeep Salhotra et al.   NMR IN BIOMEDICINE