期刊
JOURNAL OF MAGNETIC RESONANCE
卷 298, 期 -, 页码 23-30出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2018.11.005
关键词
NMR; Time-shared NMR; Pure-shift HSQC; HSQC; J-resolved HSQC; Proton-carbon coupling constants; Proton-nitrogen coupling constants
资金
- Spanish MINECO [CTQ2015-64436-P]
The concepts of pure-shift NMR and time-shared NMR are merged in a single experiment. A C-13/N-15 time-shared version of the real-time BIRD-based broadband homodecoupled HSQC experiment is described. This time-efficient approach affords simultaneously H-1-C-13 and H-1-N-15 pure-shift HSQC spectra in a single acquisition, while achieving substantial gains in both sensitivity and spectral resolution. We also present a related C-13/N-15-F2-coupled homodecoupled version of the CLIP-HSQC experiment for the simultaneous measurement of (1)J(CH) and (1)J(NH) from the simplified doublets observed along the direct dimension. Finally, a novel J-resolved HSQC experiment has been designed for the simple and automated determination of both (1)J(CH)/(1)J(NH) from a 2D J-resolved spectrum. (C) 2018 Elsevier Inc. All rights reserved.
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