期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 105, 期 2, 页码 267-280出版社
WILEY
DOI: 10.1002/JLB.MR0318-102R
关键词
mycobacterial; endothelial cells; granulocytes; microglia cells; monocytes/macrophages; myeloid cells; neutrophils; T Lymphocytes; Th17 cells
资金
- Francis Crick Institute
- Cancer Research UK [10218]
- Wellcome [10218, 104803, 203135]
- UK Research and Innovation [10218]
- National Institutes of Health [U01AI115940]
- Wellcome Clinicians Ph.D. grant
- National Research Foundation of South Africa through the SARChI Chair of Clinical Neurosciences
- MRC [MC_U117588499] Funding Source: UKRI
Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM), which represents a medical emergency associated with high rates of mortality and disability. Via various mechanisms the Mycobacterium tuberculosis (M.tb) bacillus disseminates from the primary site of infection and overcomes protective barriers to enter the CNS. There it induces an inflammatory response involving both the peripheral and resident immune cells, which initiates a cascade of pathologic mechanisms that may either contain the disease or result in significant brain injury. Here we review the steps from primary infection to cerebral disease, factors that contribute to the virulence of the organism and the vulnerability of the host and discuss the immune response and the clinical manifestations arising. Priorities for future research directions are suggested.
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