Article
Medicine, General & Internal
Raquel Almansa, Carmen Herrero-Rodriguez, Misericordia Martinez-Huelamo, Maria del Pilar Vicente-Andres, Jose Angel Nieto-Barbero, Miryam Martin-Ballesteros, Maria del Mar Rodilla-Carvajal, Amanda de la Fuente, Alicia Ortega, Maria Jesus Alonso-Ramos, James Wacker, Oliver Liesenfeld, Timothy E. Sweeney, Jesus F. Bermejo-Martin, Luis Garcia-Ortiz
Summary: The Fever-7 test is a promising host immune mRNA marker for the early identification of respiratory viral infections in the community, showing high sensitivity and specificity in predicting viral infections.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Gongyu Tang, Minsu Cho, Xiaowei Wang
Summary: OncoDB is an online database resource that integrates multi-omics data from TCGA and GTEx studies to study gene expression dysregulation and viral infection in cancer, providing valuable insights into clinical features and outcomes.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Naiara Abendano, Aitor Esparza-Baquer, Irantzu Bernales, Ramses Reina, Damian de Andres, Begona M. Jugo
Summary: Visna/Maedi virus (VMV) causes a multisystemic inflammatory disorder in sheep, and studying the differential gene expression in infected and diseased sheep may provide insights into the viral infection process. The up-regulation of the OXT gene and enrichment of the complement pathway in gene expression analysis suggest their potential roles in VMV pathogenesis and offer new avenues for developing preventive strategies and effective vaccines.
Article
Virology
Sai-Zhen Zeng, Le-Yun Xie, Tian Yu, Li-li Zhong, Jin-song Li, Zhao-Jun Duan, Bing Zhang, Qi-yi Zeng
Summary: For children with severe HAdV pneumonia, the duration of viral shedding is longer, with slower decrease in viral load and longer persistence for HAdV-7 infection.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Virology
Patricia Kaaijk, Niels Swaans, Alina M. Nicolaie, Jacob P. Bruin, Renee A. J. van Boxtel, Marit M. A. de Lange, Adam Meijer, Elisabeth A. M. Sanders, Marianne A. van Houten, Nynke Y. Rots, Willem Luytjes, Josine van Beek
Summary: This study investigates the presence of influenza and other respiratory viruses in older adults with influenza-like illness (ILI). It found that influenza virus was the most commonly detected virus, followed by rhinovirus, seasonal coronavirus, respiratory syncytial virus, and human metapneumovirus. Coinfections of influenza virus with other viruses were rare. The study also suggests that influenza virus infection may reduce the risk of simultaneous infection with other viruses. However, viral persistence or coinfections did not affect the clinical outcome of ILI.
Article
Immunology
Jocelyne Piret, Guy Boivin
Summary: Multiple respiratory viruses can infect the respiratory tract simultaneously or sequentially and interact with each other. The interaction between a first virus and a second virus may enhance or reduce infection and replication, resulting in positive or negative interactions. The interferon response is likely a mechanism that provides temporary nonspecific immunity to the host. Studying the interactions among respiratory viruses is important for understanding their transmission and control.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Virology
Simin Abbasi, Nazanin Hosseinkhan, Nazanin Zahra Shafiei Jandaghi, Kaveh Sadeghi, Abbas Rahimi Foroushani, Seyed Abbas Hassani, Jila Yavarian, Talat Mokhtari Azad
Summary: The study identified important differentially expressed genes related to rhinitis and asthma exacerbation in children hospitalized with severe acute respiratory infection (SARI) due to human rhinovirus (HRV) infection. The results showed significant effects of viral infection on inflammatory responses, antiviral defense, and the type 1 interferon-signaling pathway in children under 5 years old affected by HRV.
Article
Infectious Diseases
Sonia Burrel, Pierre Hausfater, Martin Dres, Valerie Pourcher, Charles-Edouard Luyt, Elisa Teyssou, Cathia Soulie, Vincent Calvez, Anne-Genevieve Marcelin, David Boutolleau
Summary: The study found that during the early outbreak of COVID-19, there were co-infections of SARS-CoV-2 with other respiratory viruses in patients, and lower respiratory tract samples could improve the accuracy of diagnosing COVID-19.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Louisa L. Y. Chan, Danielle E. Anderson, Hong Sheng Cheng, Fransiskus Xaverius Ivan, Si Chen, Adrian E. Z. Kang, Randy Foo, Akshamal M. Gamage, Pei Yee Tiew, Mariko Siyue Koh, Ken Cheah Hooi Lee, Kristy Nichol, Prabuddha S. Pathinayake, Yik Lung Chan, Tsin Wen Yeo, Brian G. Oliver, Peter A. B. Wark, Linbo Liu, Nguan Soon Tan, Lin-Fa Wang, Sanjay H. Chotirmall
Summary: This study successfully established nasopharyngeal and bronchial organoids derived from healthy individuals and COPD patients. COPD organoids exhibited hallmark features of the disease, including goblet cell hyperplasia and reduced ciliary beat frequency. Single-cell transcriptomics revealed altered cellular differentiation trajectories in COPD organoids, and SARS-CoV-2 infection showed more productive replication in bronchial organoids. Exposure to viral and bacterial pathogens induced greater pro-inflammatory responses in COPD organoids.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Soo-Jin Oh, Eun-Na Lee, Joo-Hoo Park, Jae Kyung Lee, Geum Joon Cho, Il-Ho Park, Ok Sarah Shin
Summary: Respiratory virus infections, which cause localized and pandemics, are a significant cause of mortality and morbidity globally. Recently, small extracellular vesicles derived from human umbilical cord mesenchymal stem cells (U-exo) have gained attention as a cell-free therapeutic strategy due to their safety and efficacy potential. This study found that U-exo exhibits antiviral activities against influenza A/B virus (IFV) and human seasonal coronavirus (HCoV) infections, potentially through the suppression of viral replication and the enhancement of IFN signaling and ISGs production.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Medicine, Research & Experimental
Sajad Najafi, Shing Cheng Tan, Shahin Aghamiri, Pourya Raee, Zahra Ebrahimi, Zahra Kargar Jahromi, Yazdan Rahmati, Javid Sadri Nahand, Ahmad Piroozmand, Vahid Jajarmi, Hamed Mirzaei
Summary: The article reviews the research progress of CRISPR-Cas technology in treating viral infections, discusses delivery strategies and challenges, and proposes future research directions.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Fisheries
Mario Caruffo, Dinka Mandakovic, Pablo Cabrera, Igor Pacheco, Liliana Montt, Ignacio Chavez-Baez, Madelaine Mejias, Francisca Vera-Tamargo, Javiera Perez-Valenzuela, Alonso Carrasco-Labra, Rodrigo Pulgar
Summary: This systematic review analyzed the gene expression responses to infectious diseases in teleosts using various pathogens and provided insights into potential unknown functions related to fish infections, highlighting the importance of future research in this area.
REVIEWS IN AQUACULTURE
(2021)
Article
Multidisciplinary Sciences
Miguel Reyes, Samantha M. Leff, Matteo Gentili, Nir Hacohen, Paul C. Blainey
Summary: Cells respond to various signals by adopting complex transcriptional states. Most single-cell profiling is done at baseline, ignoring cells' potential functional responses. Single-cell genomics combined with multiplexing techniques provide a useful tool for characterizing cell states across experimental conditions.
Article
Microbiology
Colleen A. Mangold, Molly M. Rathbun, Daniel W. Renner, Chad V. Kuny, Moriah L. Szpara
Summary: Research reveals that different strains of HSV-1 exhibit distinct viral and host transcriptional characteristics in the same neuronal cells, highlighting the significant impact of virus strain and cell type on neurovirulence.
Editorial Material
Biochemistry & Molecular Biology
Gualberto Ruano, Toan Ha
Summary: Testing for respiratory viruses and SARS-CoV-2 in clinical and epidemiological settings serves different purposes for symptomatic and asymptomatic patients. Symptomatic patients are best tested with respiratory virus panels to establish the pathogen for personalized treatment, while asymptomatic patients are tested for a single infectious pathogen to determine carrier status for containment measures.
Article
Oncology
Karl R. VanDerMeid, Michael R. Elliott, Andrea M. Baran, Paul M. Barr, Charles C. Chu, Clive S. Zent
CANCER IMMUNOLOGY RESEARCH
(2018)
Article
Hematology
Alain Mina, Leyla Shune, Haitham Abdelhakim, Tara L. Lin, Sid Ganguly, Andrea Baran, Anurag Singh, Sunil Abhyankar, Joseph P. McGuirk, Dennis Allin, Omar S. Aljitawi
ANNALS OF HEMATOLOGY
(2019)
Article
Oncology
AnnaLynn M. Williams, Andrea M. Baran, Carla Casulo, Patrick Reagan, Jonathan W. Friedberg, Margaret Helber, Jeremiah Moore, Elizabeth Baloga, Clive S. Zent, Paul M. Barr
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2019)
Review
Oncology
Kerry Schaffer, Narmadha Panneerselvam, Kah Poh Loh, Rachel Herrmann, Ian R. Kleckner, Richard Francis Dunne, Po-Ju Lin, Charles E. Heckler, Nicholas Gerbino, Lauren B. Bruckner, Eugene Storozynsky, Bonnie Ky, Andrea Baran, Supriya Gupta Mohile, Karen Michelle Mustian, Chunkit Fung
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2019)
Article
Oncology
Hannah E. Rhinehart, Michelle A. Phillips, Nathaniel Wade, Andrea Baran
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2019)
Article
Hematology
Haitham Abdelhakim, Leyla Shune, Sajjad Bhatti, Amy Rose Cantilena, Andrea Baran, Tara L. Lin, Siddhartha Ganguly, Anurag K. Singh, Sunil Abhyankar, Clint Divine, Brea Lipe, Joseph McGuirk, Dennis Allin, Omar S. Aljitawi
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2019)
Letter
Oncology
Kah Poh Loh, Andrea Baran, Christina Y. Lee, Alfadel Alshaibani, Sarah C. Rutherford, John Hu, Carla Casulo, Paul M. Barr, Jonathan W. Friedberg, Patrick M. Reagan
LEUKEMIA & LYMPHOMA
(2019)
Letter
Hematology
AnnaLynn M. Williams, Andrea M. Baran, Mahlon Schaffer, Jocelyn Bushart, Lynn Rich, Jeremiah Moore, Paul M. Barr, Clive S. Zent
AMERICAN JOURNAL OF HEMATOLOGY
(2020)
Article
Immunology
J. R. Andolina, R. Walia, J. Oliva, A. Baran, J. Liesveld, M. W. Becker, A. Busacco, M. Coppage
Article
Oncology
Thomas D. Rodgers, AnnaLynn M. Williams, Andrea Baran, Patrick M. Reagan, Carla Casulo, Clive S. Zent, Andrew Evans, Jonathan W. Friedberg, Paul M. Barr
Summary: A retrospective review of 79 patients found that patients receiving novel combination therapy and previously untreated patients were more likely to develop severe adverse events. This suggests caution against the use of untested PI3K inhibitor combinations in routine practice.
LEUKEMIA & LYMPHOMA
(2021)
Article
Oncology
Jane L. Liesveld, Andrea Baran, Mitra Azadniv, Haley Misch, Katherine Nedrow, Michael Becker, Kah Poh Loh, Kristen M. O'Dwyer, Jason H. Mendler
Summary: The phase II study aimed to investigate whether sequential exposure to decitabine followed by rapamycin would result in better responses in AML patients. Despite not meeting its primary endpoint, the survival rates in relapsed/refractory cases seem comparable to other salvage regimens, and the de novo group had a significantly higher composite CR rate compared to decitabine alone.
Article
Biology
Arun H. Patil, Andrea Baran, Zachary P. Brehm, Matthew N. McCall, Marc K. Halushka
Summary: This study provides the most complete reference to date of miRNA expression patterns by human primary cell types, shedding light on the regulatory role of miRNAs in different cell types.
Article
Oncology
Hong Zhang, Sohyun Kang, Naba Ali, Andrea Baran, Kevin Bylund, David Gentile, Gregory Previte, Ahmad Matloubieh, Alex Gray, Nancy Marou
ADVANCES IN RADIATION ONCOLOGY
(2020)
Article
Medicine, Research & Experimental
Kristin M. Scheible, Jason Emo, Nathan Laniewski, Andrea M. Baran, Derick R. Peterson, Jeanne Holden-Wiltse, Sanjukta Bandyopadhyay, Andrew G. Straw, Heidie Huyck, John M. Ashton, Kelly Schooping Tripi, Karan Arul, Elizabeth Werner, Tanya Scalise, Deanna Maffett, Mary Caserta, Rita M. Ryan, Anne Marie Reynolds, Clement L. Ren, David J. Topham, Thomas J. Mariani, Gloria S. Pryhuber