Article
Multidisciplinary Sciences
Cheng-hui Yan, Hai-Wei Liu, Xiao-xiang Tian, Jiayin Li, Ye Ding, Yi Li, Zhu Mei, Ming-Hui Zou, Ya-ling Han
Summary: This study investigates the potential reasons for the inconsistent effects of fish oil (FO) in patients with cardiovascular disease. The findings suggest that AMP-activated protein kinase (AMPK) alpha 2 is necessary for the anti-inflammatory and anti-atherosclerotic effects of FO.
NATURE COMMUNICATIONS
(2022)
Review
Medicine, Research & Experimental
Priyanka Saklani, Heena Khan, Saurabh Gupta, Amarjot Kaur, Thakur Gurjeet Singh
Summary: Neuropeptides play a crucial neuroprotective role in ischemic injury, providing powerful protection by modulating various signaling pathways.
Review
Gastroenterology & Hepatology
Amalia Di Petrillo, Amit Kumar, Sara Onali, Agnese Favale, Massimo Claudio Fantini
Summary: Inflammatory bowel disease, including Crohn's disease and ulcerative colitis, is characterized by chronic inflammation in the gut. The G protein-coupled receptor (GPR) 120 is involved in metabolic disorders and has also been found to regulate immune system activity and inflammation. GPR120 plays a role in suppressing proinflammatory responses and promoting anti-inflammatory cytokine production, suggesting it as a potential therapeutic target for inflammatory bowel disease.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Neurosciences
Yanling Wang, Ho Jun Yun, Yuchuan Ding, Huishan Du, Xiaokun Geng
Summary: This study demonstrates that montelukast sodium protects brain tissue by regulating the inflammatory reaction after stroke. It promotes the polarization of microglial cells/macrophages to the M2 phenotype and reduces infarct volume in mice. Montelukast sodium may be a reasonable strategy for the treatment of ischemic stroke.
Article
Biochemistry & Molecular Biology
Susana Castelo Branco Ramos Nakandakari, Rafael Calais Gaspar, Gabriel Keine Kuga, Camila de Oliveira Ramos, Renan Fudoli Vieira, Thaiane da Silva Rios, Vitor Rosetto Munoz, Marcella Ramos Sant'ana, Fernando Moreira Simabuco, Adelino Sanchez Ramos da Silva, Leandro Pereira Moura, Eduardo Rochete Ropelle, Jose Rodrigo Pauli, Dennys Esper Cintra
Summary: Long-term high-fat diet affects adipose tissue and leads to metabolic disorders. Short-term high-fat diet affects neuronal signaling pathways. Flaxseed oil containing omega-3 fatty acids protects against increased food intake and fasting glucose, but not inflammation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Oncology
Fanwei Meng, Junfeng Ke, Jinze Li, Changhui Zhao, Jiaqing Yan, Liping Wang
Summary: Cerebral ischemia-reperfusion injury (CIRI) is a brain injury that occurs during thrombolytic therapy for acute ischemic stroke and has a significant impact on human health. DhHP-3, a peroxidase-mimicking enzyme, has shown strong antioxidant properties in vitro. This study established in vitro and in vivo models to investigate the beneficial effects of DhHP-3 on CIRI. The results demonstrated that DhHP-3 reduced reactive oxygen species, suppressed apoptosis, and attenuated the DNA damage response in cells and animal models. In conclusion, DhHP-3 inhibits CIRI by suppressing ROS-induced apoptosis.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Federica Rubbino, Valentina Garlatti, Valeria Garzarelli, Luca Massimino, Salvatore Spano, Paolo Iadarola, Maddalena Cagnone, Martin Giera, Marieke Heijink, Simone Guglielmetti, Vincenzo Arena, Alberto Malesci, Luigi Laghi, Silvio Danese, Stefania Vetrano
Summary: This study highlights the role of GPR120 in the progression of colorectal cancer. Loss of GPR120 in the gut leads to increased intestinal permeability, microbiota translocation, and dysbiosis, which results in hyperproliferation of epithelial cells through the activation of beta-catenin signaling. Therefore, the loss of GPR120 is an early event in CRC development but does not promote invasive cancer.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Burak Dogan, Esra Sinem Kemer Dogan, Ozlem Ozmen, Ozlem Fentoglu, Fatma Yesim Kirzioglu, Mustafa Calapoglu
Summary: Omega-3 and probiotics, when combined, showed a synergistic effect on host modulation in improving periodontal health. The prophylactic administration of omega-3 and probiotic combination reduced alveolar bone loss and improved serum IL1 beta, IL6, and IL10 levels more than their single use.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2022)
Article
Neurosciences
Jiajia Wang, Shiquan Wang, Haiyun Guo, Yi Li, Zhenhua Jiang, Ting Gu, Binxiao Su, Wugang Hou, Haixing Zhong, Dandan Cheng, Xijing Zhang, Zongping Fang
Summary: The study demonstrated that rosmarinic acid (RA) treatment significantly improved neurological and depressive symptoms after stroke, and reduced brain infarct volume. RA exerted its protective effects against ischemia by enhancing the activities of antioxidant enzymes and glutathione levels. Additionally, RA alleviated depression behaviors through Nrf2-mediated pathways.
Article
Biochemistry & Molecular Biology
Yilong Zhao, Huajun Yang, Wei Shan, Anchen Guo, Qun Wang
Summary: Moderate ethanol preconditioning protects against ischemic brain injury by upregulating the expression of BKCa channels in rats.
NEUROCHEMICAL RESEARCH
(2022)
Article
Neurosciences
Kazunori Kikuchi, Takuya Tatebe, Yuki Sudo, Miyabishara Yokoyama, Kiwami Kidana, Yung Wen Chiu, Sho Takatori, Makoto Arita, Yukiko Hori, Taisuke Tomita
Summary: Alzheimer's disease is characterized by amyloid-beta deposition in the brain. The clearance rate of amyloid-beta is decreased in sporadic AD patients, indicating that dysregulation of the clearance mechanisms affects the disease process. Astrocytes play a crucial role in clearing amyloid-beta, and GPR120 signaling negatively regulates the A beta-degrading activity of MMPs in astrocytes, providing a potential therapeutic target for Alzheimer's disease.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Alvaro Baeza Garcia, Edwin Siu, Xin Du, Lin Leng, Blandine Franke-Fayard, Chris J. Janse, Shanshan W. Howland, Laurent Renia, Elias Lolis, Richard Bucala
Summary: Cerebral malaria, the deadliest complication of Plasmodium parasite infection, may be caused by neuroinflammation leading to cerebral edema and blood-brain barrier dysfunction. Plasmodium MIF can enhance inflammatory response by signaling through host MIF receptor CD74, contributing to the development of cerebral malaria. Studies using CD74 deficient hosts and PMIF deficient parasites suggest a potential mechanism for the onset of experimental cerebral malaria and liver stage Plasmodium development.
Review
Biochemistry & Molecular Biology
Kamila P. Liput, Adam Lepczynski, Magdalena Ogluszka, Agata Nawrocka, Ewa Polawska, Agata Grzesiak, Brygida Slaska, Chandra S. Pareek, Urszula Czarnik, Mariusz Pierzchala
Summary: It is recommended to reduce saturated fatty acids (SFA) and increase polyunsaturated fatty acids (PUFAs) n-3 and n-6 in the diet to lower the risk of metabolic disorders. Western-type diet often contains excessive n-6 PUFAs and a high n-6/n-3 ratio. Oxylipins derived from n-3 and n-6 PUFAs play a role in inflammation, while PUFAs have varying effects on cell growth, proliferation, and neoplastic lesion progression, as observed in in vitro studies, animal models, and epidemiological studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Xueju Yu, Fengyao Liu, Yuting Liu, Bingqing Bai, Han Yin, Haochen Wang, Yingqing Feng, Huan Ma, Qingshan Geng
Summary: The study demonstrates that Omega-3 fatty acids can attenuate apoptosis in cardiomyocytes under hypoxic conditions by up-regulating miR-210-3p and targeting the CASP8AP2 signaling pathway.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Umadevi Wesley, Ian C. Sutton, Katelin Cunningham, Jacob W. Jaeger, Allan Q. Phan, James F. Hatcher, Robert J. Dempsey
Summary: The study demonstrates the neuroprotective role of Gal3 in ischemic stroke by modulating angiogenic and apoptotic pathways, leading to improved functional recovery in rat brains.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Review
Microbiology
Fanhua Wei, Chengjiang Gao, Yujiong Wang
Summary: Influenza virus infection can lead to cytokine storms, contributing to severe outcomes. Immunomodulatory drugs offer a promising approach for treating hypercytokinemia induced by acute viral infections.
CRITICAL REVIEWS IN MICROBIOLOGY
(2022)
Article
Immunology
Chao Sui, Tongyang Xiao, Shengyuan Zhang, Hongxiang Zeng, Yi Zheng, Bingyu Liu, Gang Xu, Chengjiang Gao, Zheng Zhang
Summary: This study reveals that SARS-CoV-2 inhibits the host interferon response by using NSP13 to recruit TBK1 for autophagic degradation. The findings provide new insights into the transmission and pathogenesis of SARS-CoV-2 infection.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Virology
Lulu Han, Yi Zheng, Jian Deng, Mei-Ling Nan, Yang Xiao, Meng-Wei Zhuang, Jing Zhang, Wei Wang, Chengjiang Gao, Pei-Hui Wang
Summary: A characteristic feature of COVID-19 is the dysregulated immune response and overwhelming inflammatory cytokine storm. This study demonstrates that the ORF10 protein of SARS-CoV-2 interacts with STING, impairing the cGAS-STING signaling pathway and weakening the innate antiviral immunity.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Microbiology
Yi Zheng, Chengjiang Gao
Summary: SARS-CoV-2 poses a threat to human health and the global economy, but effective treatments are still lacking. Recent studies suggest that phase separation plays a critical role in regulating antiviral signaling and viral replication, highlighting its significance in virus-host interaction.
Article
Virology
Jian Deng, Sheng-Nan Zheng, Yang Xiao, Mei-Ling Nan, Jing Zhang, Lulu Han, Yi Zheng, Yanying Yu, Qiang Ding, Chengjiang Gao, Pei-Hui Wang
Summary: SARS-CoV-2 NSP8 inhibits the production of type I and III interferons by targeting RIG-I/MDA5, TRIF, and STING signaling molecules. It disrupts the assembly of RIG-I/MDA5-MAVS complex, resulting in impaired phosphorylation and nuclear translocation of IRF3. NSP8 also directly interacts with TRIF and STING to suppress their signaling transduction.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Jian Deng, Yi Zheng, Sheng-Nan Zheng, Mei-Ling Nan, Lulu Han, Jing Zhang, Yunyun Jin, Ji-An Pan, Chengjiang Gao, Pei-Hui Wang
Summary: The NSP7 protein of SARS-CoV-2 inhibits the production of interferons, crucial components of antiviral immunity, by targeting multiple signaling pathways. It disrupts the normal functioning of RIG-I/MDA5, TLR3-TRIF, and cGAS-STING pathways, leading to a dampened interferon response. Additionally, NSP7 decreases immune activation and facilitates virus replication.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Mutian Jia, Yuanyuan Wang, Jie Wang, Danhui Qin, Mengge Wang, Li Chai, Yue Fu, Chunyuan Zhao, Chengjiang Gao, Jihui Jia, Wei Zhao
Summary: This study demonstrates that STING-triggered autophagy plays a crucial role in eliminating pathogens and limiting STING-induced interferon responses. Specifically, myristic acid attenuates IFN responses while enhancing STING-dependent autophagy, contributing to immune homeostasis. Mechanistically, myristic acid promotes N-myristoylation of ARF1, which controls STING membrane trafficking and enhances autophagy degradation of the STING complex. Targeting myristic acid and N-myristoylation could be a promising approach for treating diseases caused by aberrant STING activation.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Lingli Kong, Chao Sui, Tian Chen, Lei Zhang, Wei Zhao, Yi Zheng, Bingyu Liu, Xiaochen Cheng, Chengjiang Gao
Summary: Researchers have identified TRIM10 as a positive regulator of STING signaling, showing that it enhances the STING-dependent type I interferon response by promoting STING aggregation and interaction with TBK1. TRIM10-deficient cells and mice are more susceptible to viral infections and exhibit faster melanoma growth.
Article
Immunology
Feng Liu, Wanxin Zhuang, Bin Song, Yuan Yang, Junqi Liu, Yi Zheng, Bingyu Liu, Jie Zheng, Wei Zhao, Chengjiang Gao
Summary: In this study, the researchers discovered that K63-linked polyubiquitin chains loaded on MAVS can be recognized by RIG-I to initiate MAVS aggregation. They also identified Ube2N as a major enzyme involved in the polyubiquitination of MAVS and found that it cooperates with Riplet and TRIM31 to promote unanchored polyubiquitination. Additionally, they identified USP10 as a deubiquitinating enzyme that removes unanchored polyubiquitin chains from MAVS.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Immunology
Yi Zheng, Xuejing Zhang, Chengjiang Gao
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Immunology
Wanxin Zhuang, Lei Zhang, Yi Zheng, Bingyu Liu, Chunhong Ma, Wei Zhao, Suxia Liu, Feng Liu, Chengjiang Gao
Summary: Inflammasomes are crucial for the innate immune system, and dysregulation of their activation can have negative impacts on human health. This study reveals that USP3 acts as a key regulator of ASC ubiquitination, enhancing its stability and promoting inflammasome activation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Biochemical Research Methods
Zhenzhen Yan, Hansen Liu, Chengjiang Gao
Summary: This article presents a protocol for detecting the aggregation of TBK1 upon viral infection using HSV-1 infected mouse peritoneal macrophages, which can be adapted for other proteins and viruses.
Article
Biochemistry & Molecular Biology
Yi Zheng, Jian Deng, Lulu Han, Meng-Wei Zhuang, Yanwen Xu, Jing Zhang, Mei-Ling Nan, Yang Xiao, Peng Zhan, Xinyong Liu, Chengjiang Gao, Pei-Hui Wang
Summary: This study reveals the involvement of the stress response pathway and innate antiviral immunity in the pathogenic mechanism of SARS-CoV-2. NSP5 and N protein of SARS-CoV-2 were found to attenuate the formation of antiviral stress granules (avSG). NSP5 suppressed avSG formation and disrupted the RIG-I-MAVS complex to weaken the RIG-I-mediated antiviral response, while N protein specifically targeted cofactors upstream of RIG-I and affected the recognition of dsRNA by RIG-I.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)