Review
Biochemistry & Molecular Biology
Urszula Florczyk-Soluch, Katarzyna Polak, Jozef Dulak
Summary: Dystrophin deficiency, a key factor in Duchenne muscular dystrophy (DMD), leads to heart problems with cardiac dysfunction being a primary symptom. While there are some cardiac treatments available, the prognosis remains poor, highlighting the need for direct therapeutic targeting of dystrophin deficiency and its effects.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Chemistry, Applied
Yufa Sun, Peiyu Zhang, Xingyu Wang, Fatimah A. M. Al-Zahrani, Nora H. de Leeuw, Long Lin
Summary: This study explores the color development mechanism of Dihydroxyacetone (DHA) through its reaction with amino acids to form colored compounds. Key colored compounds were identified and their formation pathways proposed. In-depth understanding of the color properties of these compounds was obtained through color dilution analysis and evaluation using the CIELAB color space.
Article
Chemistry, Applied
Wenlong Wang, Cunyao Li, Heng Zhang, Jiangwei Zhang, Lanlu Lu, Zheng Jiang, Lifeng Cui, Hongguang Liu, Li Yan, Yunjie Ding
Summary: Porous organic cages (POCs) are soluble molecules with significant potential for homogeneous catalysis. POC-DICP as a catalyst in hydroformylation reactions exhibits high selectivity and reusability.
CHINESE JOURNAL OF CATALYSIS
(2021)
Article
Chemistry, Multidisciplinary
Hongqiang Jin, Runqing Zhao, Peixin Cui, Xiaolong Liu, Jie Yan, Xiaohu Yu, Ding Ma, Weiguo Song, Changyan Cao
Summary: The study reports a new Sabatier phenomenon in hydrogenation reactions induced by single-atom density at the atomic scale. A series of Ir single-atom catalysts (SACs) with a predominantly Ir-1-P-4 coordination structure are produced. The study reveals the Sabatier principle as an insightful guidance for the rational design of more efficient and practicable SACs for hydrogenation reactions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Materials Science, Multidisciplinary
Jianqi Xi, Cheng Liu, Dane Morgan, Izabela Szlufarska
Summary: This study explores the atomic-scale mechanisms of SiC hydrothermal corrosion, highlighting the crucial role of hydrogen scission reactions in breaking Si-C bonds and the direct dissolution of SiC into soluble silicic acid. The research provides a foundation for the design of materials resistant to water corrosion.
Article
Engineering, Environmental
Yawei Gao, Yangying Zhao, Xiao-mao Wang, Chuyang Tang, Xia Huang
Summary: Nanofiltration membranes with small pores and highly negatively charged surfaces were synthesized using a two-step fabrication strategy. The optimized membrane exhibits high salt/organic rejection selectivity and water permeance, making it suitable for potable water systems.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xue-Rui Tian, Xiao-Lei Jiang, Sheng-Li Hou, Zhuo-Hao Jiao, Jie Han, Bin Zhao
Summary: This study investigates the influence of Lewis acid-base sites in catalysts on the chemical fixation of CO2. It demonstrates that with the introduction of Lewis base sites, the catalytic ability of a metal-organic framework (MOF) is improved, leading to enhanced efficiency in the conversion of CO2.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Tzuriel S. Metzger, Reema Siam, Yuval Kolodny, Naama Goren, Nir Sukenik, Shira Yochelis, Raed Abu-Reziq, David Avnir, Yossi Paltiel
Summary: This study utilizes the chiral induced spin selectivity (CISS) effect to form chiral centers in catalytic reactions, demonstrating that the directionality of electron spin can break enantiomeric symmetry and enable asymmetric catalysis without the need for chiral reagents, solvents, or catalysts.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Review
Immunology
Ageliki Tsagaratou
Summary: TET proteins are DNA demethylases that oxidize 5mC to generate 5hmC and regulate gene expression to influence cell development and lineage determination. Future research needs to further explore the precise gene regulatory mechanisms employed by TET proteins.
IMMUNOLOGICAL REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Satomi Niwayama, Yoshikazu Hiraga
Summary: Water-mediated organic reactions play a significant role in environmental protection. Desymmetrization reactions are cost-effective due to the low cost of starting materials and have been previously reported to be highly efficient and practical in selective monohydrolysis reactions of symmetric diesters. The mechanisms of these reactions are hypothesized to proceed through micellar aggregates that govern the high selectivities by directing hydrophilic carboxylate anions outward and hydrophobic groups inward.
Review
Chemistry, Multidisciplinary
Xin Li, Xiang David Li
Summary: The hereditary blueprint of a eukaryotic cell is encoded in genomic DNA compacted into chromatin with histone proteins. Histone posttranslational modifications (PTMs) regulate DNA-templated processes and are associated with human disease pathogenesis. The dynamic fluctuations of histone PTMs emphasize the importance of fully deciphering the histone code.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Tainah Dorina Marforio, Michele Tomasini, Andrea Bottoni, Francesco Zerbetto, Edoardo Jun Mattioli, Matteo Calvaresi
Summary: Nanoscale control of chemical reactivity and manipulation of reaction pathways can be achieved through the confinement of guest molecules inside carbon nanotubes (CNTs), which mechanically hinders molecular movements and reduces the free energy of the system. In this study, we investigated the effect of CNT confinement on nucleophilic substitution (S(N)2) and elimination (syn-E2 and anti-E2) reactions. The results show that the size of the nanoreactor, represented by the CNT diameter, is the key factor in controlling the energy profiles of the reactions.
Article
Environmental Sciences
Xingjie Wu, Pengfei Liu, Carl-Eric Wegner, Yu Luo, Ke-Qing Xiao, Zhenling Cui, Fusuo Zhang, Werner Liesack, Jingjing Peng
Summary: The study shows that organic material amendments significantly influence the link between microbial life history strategies and soil organic carbon storage, with a one-time peat-vermiculite application notably increasing organic carbon storage efficiency.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Multidisciplinary
Jun Lu, Huacheng Zhang, Xiaoyi Hu, Binbin Qian, Jue Hou, Li Han, Yinlong Zhu, Chenghua Sun, Lei Jiang, Huanting Wang
Summary: A three-dimensional sub-1 nm nanofluidic device was developed to achieve high monovalent metal ion selectivity and conductivity, with an ultrahigh K+/Mg2+ selectivity up to 1554.9. This high metal ion selectivity is attributed to factors such as size exclusion, charge selectivity, and ion binding in the negatively charged MOF channels, showing potential for ultimate ion separation and energy conversion in diverse MOF-based nanofluidic devices.
Article
Chemistry, Multidisciplinary
Tapashree Mondal, Sourav Biswas, Manoj V. Mane, Sujit S. Panja
Summary: In this study, a novel organic functional molecule named PHCS was synthesized and extensively investigated for its photophysical properties in different states. The molecule demonstrated diverse photophysics in different microenvironments, resulting in altered fluorescence emission behaviors. The photophysics of PHCS were attributed to a combination of different mechanisms. The study provides insights into modulating the external microenvironment to optimize the optical responses of organic functional molecules.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Haosheng Liang, Jordan Rio, Lionel Perrin, Pierre-Adrien Payard
Summary: Halide salts facilitate the oxidative addition of organichalides to Pd(0) through a combination of anionic, cationic, and Pd-Pd cooperative effects. Chlorides promote phosphine release, leading to a mixture of mononuclear and dinuclear Pd(0) complexes. Anionic Pd(0) dinuclear complexes exhibit cooperativity between Pd(0) centers, favoring the oxidative addition of iodobenzene.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Julie Heron, David Balcells
Summary: Copper-catalyzed azide-alkyne cycloaddition (CuAAC) is a versatile reaction in click chemistry, and this study using density functional theory (DFT) revealed a single concerted step mechanism for the reaction. The research also showed that the formation of 1,4-triazole isomer of the product is selective, highlighting the flexible nature of the bonding within the coordination sphere of the bimetallic core of the catalyst.
Article
Chemistry, Inorganic & Nuclear
Alexis D. Oswald, Ludmilla Verrieux, Pierre-Alain R. . Breuil, Helene Olivier-Bourbigou, Julien Thuilliez, Florent Vaultier, Mostafa Taoufik, Lionel Perrin, Christophe Boisson
Summary: A yttrium complex was synthesized and evaluated for its reactivity and selectivity in isoprene polymerization. Both experimental and computational investigations identified the mechanism and stable heterobimetallic complexes formed.
Article
Chemistry, Physical
Bastian Bjerkem Skjelstad, Trygve Helgaker, Satoshi Maeda, David Balcells
Summary: This article investigates the mechanism of alkane hydroxylation by complexes similar to the oxygen-evolving complex of photosystem II using automated reaction mechanism discovery methods and density-functional theory. The study finds that Fe(O)Co3O4 cubane is a promising candidate for catalytic oxidation of methane to methanol.
Article
Chemistry, Multidisciplinary
Anais Coffinet, David Specklin, Quentin Le De, Soukaina Bennaamane, Luna Munoz, Laure Vendier, Eric Clot, Nicolas Mezailles, Antoine Simonneau
Summary: Two different dinitrogen-derived molybdenum nitrido complexes with different geometries, ligand spheres, and oxidation states were found to bond with the strong Lewis acid B(C6F5)(3) through their N ligand. The stable adducts were then used for heterolytic E-H bond splitting of hydrosilanes (E=Si) and HB(C6F5)(2) in a frustrated Lewis pair-type manner. The results showed successful Si-H bond activation and substitution of B(C6F5)(3) by HB(C6F5)(2), depending on the nature of the nitrido complex. No B-H bond splitting was observed. The computed thermodynamics by DFT were consistent with the experimental outcomes.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Ming-Yu Chen, Sylvain Charvet, Pierre-Adrien Payard, Marie-Eve L. Perrin, Julien C. Vantourout
Summary: A robust electrochemically driven nickel-catalyzed halogen exchange reaction has been reported, allowing the conversion of heavy halogens or polar atoms to lighter and more lipophilic chloride groups to modify properties or block undesired reactivity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Sarah E. Jenny, Juan M. Serviano, Ainara Nova, Graham E. Dobereiner
Summary: This study proposes a reaction pathway for a precatalyst that exhibits high Z selectivity in alkene isomerization. Computational modeling suggests that the isomerization occurs through an allyl hydride shift mechanism, where hydride migration from one position to another takes place. This is the first study to propose such a hydride migration mechanism in alkene isomerization.
Article
Chemistry, Physical
Linn Neerbye Berntsen, Ainara Nova
Summary: We studied the mechanism of selective Cu-catalyzed N-arylation of hydantoins using unsymmetrical aryl(TMP)iodonium salts and found that deprotonation of hydantoin precedes the oxidative addition of the aryl(TMP)iodonium salt. The rate-limiting steps are the oxidative addition to a Cu(I) imido intermediate and ligand rearrangements. Our findings are consistent with experimental observations and provide insights for enhancing the efficiency of arylation reactions by tuning the diaryliodonium salt.
Article
Chemistry, Physical
Yunfei Bai, Esben Taarning, Mahika Luthra, Lars F. Lundegaard, Anna Katerinopoulou, Hanne Falsig, Ainara Nova, Juan S. Martinez-Espin
Summary: The crystal structure of Sn-Beta materials was investigated using PXRD, and a strong correlation between lattice parameters and the concentration of tin and defects was observed. PT Sn-Beta samples with more defects showed extended interlayer distance and expansion of translation symmetry, resulting in larger unit cell dimensions. In contrast, HT Sn-Beta samples with fewer defects showed minimal effect of tin site density on unit cell volume.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Physical
Renhe Tang, Julien Petit, Yi Yang, Achim Link, Florian Bachle, Marie-Eve L. Perrin, Abderrahmane Amgoune, Anis Tlili
Summary: The nickel-catalyzed trifluoromethylselenolation of aryl and vinyl triflates has been studied in this research, including the development of synthesis methods and understanding the reaction mechanism. The Xantphos/Ni(COD)(2) catalytic system is found to be efficient in synthesizing aryl and vinyl trifluoromethylselenides, and the key steps of the catalytic cycle have been investigated through experimental and computational mechanistic studies. The results support a Ni-0/Ni-II process.
Article
Chemistry, Physical
Jordan Rio, Haosheng Liang, Marie-Eve L. Perrin, Luca A. A. Perego, Laurence Grimaud, Pierre-Adrien Payard
Summary: This perspective presents a summary of selected mechanistic studies of the Pd(0)-to-Pd(II) oxidative addition process involving organic halides and pseudohalides, with a focus on systems relevant to catalytic reactions. The results are classified and described according to the nature of supporting ligands, highlighting general trends and the most relevant examples. The survey includes the formation of active species from precatalysts and the influence of different species present under catalytic conditions on the oxidative addition process, providing guidelines for improving the understanding and efficiency of catalytic reactions.
Article
Chemistry, Organic
Jordan Francois, Jordan Rio, Erwann Jeanneau, Marie-Eve L. Perrin, Maiwenn Jacolot, Pierre-Adrien Payard, Florence Popowycz
Summary: Taking advantage of our preliminary observations, we successfully achieved the direct C-C borrowing hydrogen functionalization on isosorbide using an Ir-based organometallic homogeneous catalyst with excellent diastereocontrol. The reaction involves a catalytic dehydrogenation, in situ aldol condensation/crotonisation, and a catalytic dehydrogenation to yield the desired homologated product. Through a computational mechanistic investigation, we elucidated the stereoelectronic effects and the roles of the Na counter-cation in guiding the hydride addition and coordinating the substrate's oxygen atoms, thus rationalizing the experimental selectivity at the molecular level.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Organic
Gaetano Angelici, Nicholus Bhattacharjee, Maxime Pypec, Laurent Jouffret, Claude Didierjean, Franck Jolibois, Lionel Perrin, Olivier Roy, Claude Taillefumier
Summary: The synthesis and conformational study of N-substituted beta-alanines with tert-butyl side chains are described in this article. Experimental solution NMR spectroscopy, X-ray crystallography, and molecular modeling were used to investigate the conformational preferences of these compounds. It was found that despite their higher flexibility, they still adopt preferred secondary structures including helical and ribbon-like conformations.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Rosie J. Somerville, Andryj M. Borys, Marina Perez-Jimenez, Ainara Nova, David Balcells, Lorraine A. Malaspina, Simon Grabowsky, Ernesto Carmona, Eva Hevia, Jesus Campos
Summary: This article reports a study on a complex molecule of lithium nickelate benzyne. By evaluating its reactivity, the researchers discovered that this classical molecule is actually a unique octanuclear complex and confirmed it through X-ray crystallography and NMR studies. This finding provides new insights into organonickel chemistry and catalysis.
Article
Polymer Science
Nicolas Baulu, Marie-Noelle Poradowski, Ludmilla Verrieux, Julien Thuilliez, Francois Jean-Baptiste-dit-Dominique, Lionel Perrin, Franck D'Agosto, Christophe Boisson
Summary: Two divalent bis-metalated chain transfer agents were designed, synthesized, and applied in the polymerization reaction. Their coordination chain transfer (co)polymerization features and initiation mechanism were studied, and the intermediates formed in the reaction were investigated theoretically using computational chemistry methods.