期刊
JOURNAL OF FOOD AND DRUG ANALYSIS
卷 27, 期 1, 页码 48-59出版社
FOOD & DRUG ADMINSTRATION
DOI: 10.1016/j.jfda.2018.11.005
关键词
Drug-metabolizing enzyme; Inflammation; Membrane transporter; Pharmacokinetics
资金
- Ministry of Science and Technology of Taiwan [MOST105-2320-B-002-019]
Drug-metabolizing enzymes (DMEs) and membrane transporters play important roles in the absorption, distribution, metabolism, and excretion processes that determine the pharmacokinetics of drugs. Inflammation has been shown to regulate the expression and function of these drug-processing proteins. Given that inflammation is a common feature of many diseases, in this review, the general mechanisms for inflammation-mediated regulation of DMEs and transporters are described. Also, evidences regarding the aberrant expression of these drug-processing proteins in several inflammatory diseases and age-related disorders are provided. Copyright (C) 2018, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC.
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