Review
Immunology
Yu Deng, Ying Wang, Lupeng Li, Edward A. Miao, Pengda Liu
Summary: Post-translational modifications play a crucial role in controlling the activation of cytosolic nucleic acid sensors, allowing for a highly sensitive innate immune response while avoiding pathologic inflammation. These modifications, including phosphorylation, ubiquitination, SUMOylation, and others, form a complex regulatory network.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Biao Zhang, Jin-Biao Liu, Lina Zhou, Xu Wang, Shazheb Khan, Wen-Hui Hu, Wen-Zhe Ho
Summary: Activation of cytosolic DNA sensors inhibits HIV infection and replication in macrophages by inducing the production of interferons and other antiviral factors.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Rheumatology
Erika Huijser, Iris L. A. Bodewes, Mirthe S. Lourens, Cornelia G. Van Helden-Meeuwsen, Thierry P. P. van den Bosch, Dwin G. B. Grashof, Harmen J. G. van de Werken, Ana P. Lopes, Joel A. G. van Roon, Paul L. A. van Daele, Zana Brkic, Willem A. Dik, Marjan A. Versnel
Summary: pSS monocytes and pDCs are highly responsive to stimulation of the STING pathway, and this sensitivity is not limited to patients with IFN-I pathway activation.
Article
Infectious Diseases
Yinjuan Song, Yuhui Dong, Yi Liao, Zhengmin Liang, Jiao Yao, Xiangmei Zhou
Summary: The study revealed that apoptotic caspases inhibit IFN-β production during Mycobacterium bovis infection by regulating mitochondrial stress and p-IRF3 nuclear translocation.
JOURNAL OF INFECTION
(2021)
Article
Microbiology
Yan Guo, Yuri F. van der Heijden, Fernanda Maruri, Limin Jiang, Robert Morrison, Timothy R. Sterling
Summary: This study marks the first discovery of three RNA editing events in Mycobacterium tuberculosis, providing novel insights into gene expression regulation in this bacterium species.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Immunology
Elisa Petruccioli, Linda Petrone, Teresa Chiacchio, Chiara Farroni, Gilda Cuzzi, Assunta Navarra, Valentina Vanini, Umberto Massafra, Marianna Lo Pizzo, Giuliana Guggino, Nadia Caccamo, Fabrizio Cantini, Fabrizio Palmieri, Delia Goletti
Summary: Patients with immune-mediated inflammatory diseases (IMID), such as rheumatoid arthritis (RA), have a higher risk of developing active tuberculosis (TB) compared to the general population. Studying the M. tuberculosis (Mtb) specific T-cell response may help identify immune biomarkers of Mtb burden or clearance in different TB statuses and risk groups.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Microbiology
Jialu Ma, Shasha Zhao, Xiao Gao, Rui Wang, Juan Liu, Xiangmei Zhou, Yang Zhou
Summary: Infection with Mycobacterium tuberculosis leads to granulomatous lung lesions and systemic inflammatory responses. The activation of inflammasomes, particularly NLRP3 and AIM2, plays a crucial role in regulating inflammation and host defense against the infection. Interferons inhibit MTB-induced inflammasome activation and IL-1 signaling, contributing to the control of MTB replication.
Article
Immunology
Priyanka Talukdar, Beth F. Junecko, Daniel S. Lane, Pauline Maiello, Joshua T. Mattila
Summary: IFN-λ is expressed in granulomas and may influence myeloid cell function and immunity in tuberculosis. The expression of IFN-λ varies in different granuloma microenvironments, primarily expressed by macrophages and neutrophils, with differences in subcellular localization.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Dorcas O. Owusu, Ernest Adankwah, Wilfred Aniagyei, Isaac Acheampong, Difery Minadzi, Augustine Yeboah, Joseph F. Arthur, Millicent Lamptey, Monika M. Vivekanandan, Mohammed K. Abass, Francis Kumbel, Francis Osei-Yeboah, Amidu Gawusu, Linda Batsa Debrah, Alexander Debrah, Ertan Mayatepek, Julia Seyfarth, Richard O. Phillips, Marc Jacobsen
Summary: In Nigeria, BCG vaccination leads to immune conversion and changes in the phenotype of tuberculosis-specific T cells. A study comparing BCG-vaccinated and non-vaccinated infants showed that BCG vaccination causes delayed immune conversion and differences in cell phenotype among tuberculosis patients.
Article
Multidisciplinary Sciences
Changhoon Oh, Ambika Verma, Mohib Hafeez, Brandon Hogland, Youssef Aachoui
Summary: Shigella flexneri employs OspC3 to inhibit caspase-11 activity, preventing pyroptosis and aiding in bacterial dissemination and evasion of clearance.
Article
Immunology
Ravi Prakash Arya, Anismrita Lahon, Ashok Kumar Patel
Summary: In this study using MEG-01 cells, DENV infection was found to increase the expression of innate receptors RIG-I and MDA-5, leading to upregulation of IFN-beta and ISG-15. Additionally, DENV infection was observed to significantly decrease the expression of CD61, an activation marker of megakaryocytes. These findings suggest that DENV infection activates type-I interferon in megakaryocytes, potentially impacting maturation and development.
IMMUNOLOGY LETTERS
(2021)
Review
Biochemistry & Molecular Biology
Le Yu, Pengda Liu
Summary: cGAS is a major cytosolic DNA sensor that, when hyperactivated, contributes to autoimmune diseases but serves as an adjuvant for anticancer immune therapy; inactivation of cGAS signaling causes difficulty in sensing and clearing infections, as well as facilitating tumor immune evasion, therefore cGAS activation is tightly controlled.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Immunology
Catherine Vilcheze, Bo Yan, Rosalyn Casey, Suzie Hingley-Wilson, Laurence Ettwiller, William R. Jacobs
Summary: This study provides detailed insights into the transcriptome changes of Mycobacterium tuberculosis under persisting stresses, highlighting genes and gene cohorts involved in stress response. These findings are valuable for the design of novel drug targets and vaccine development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Hamza A. Babiker, Amina Al-Jardani, Saleh Al-Azri, Robert A. Petit III, Eltaib Saad, Sarah Al-Mahrouqi, Reham A. H. Mohamed, Salama Al-Hamidhi, Abdullah A. Balkhair, Najma Al Kharusi, Laila Al Balushi, Samiya Al Zadjali, Lucia Perez-Pardal, Albano Beja-Pereira, Ahmed Babiker, Wendy A. Szymczak
Summary: This study used whole-genome sequencing to assess the transmission dynamics of tuberculosis (TB) in Oman and found that expatriates from high TB-burden countries may play a role in TB transmission. The study also revealed relatedness between TB strains in Oman and expatriate countries of origin, which can inform TB control policies and contribute to achieving the goal of ending TB.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Hamza A. Babiker, Amina Al-Jardani, Saleh Al-Azri, Robert A. Petit, Eltaib Saad, Sarah Al-Mahrouqi, Reham A. H. Mohamed, Salama Al-Hamidhi, Abdullah A. Balkhair, Najma Al Kharusi, Laila Al Balushi, Samiya Al Zadjali, Lucia Perez-Pardal, Albano Beja-Pereira, Ahmed Babiker
Summary: This study used whole-genome sequencing (WGS) to assess tuberculosis (TB) transmission dynamics in Oman. The results revealed evidence of transmission between expatriates and Omani nationals, which was supported by epidemiological investigation. Relatedness was also observed between local and global isolates. The findings suggest that WGS can complement epidemiological analysis and assist in achieving the goal of ending TB in Oman.
MICROBIOLOGY SPECTRUM
(2023)
