Article
Chemistry, Multidisciplinary
Jaehyun Park, Yunyoung Nah, Won Jong Kim
Summary: Indoleamine 2,3-dioxygenase (IDO) is a promising target for cancer immunotherapy as it promotes an immunosuppressive microenvironment in tumor tissue. In this study, swellable micelles triggered by IDO were developed for targeted cancer therapy, which released an IDO inhibitor to recruit effector T-cells into tumor tissue and enhance therapeutic effect.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Oncology
Yi-Chun Chen, Chang-Jung Chang, Ging-Ho Hsiue, Yi-Ting Chiang
Summary: A stable and pH-responsive mixed micellar system was assembled with degradable copolymers to load the anticancer drug doxorubicin, showing high biosafety and effective drug release behavior in vitro and high tumor accumulation in vivo. This system increased cancer cells' sensitivity to doxorubicin and holds promise for clinical use in cancer therapy.
Article
Nanoscience & Nanotechnology
Jaehyun Park, Seokhee Jo, Yeong Mi Lee, Gurusamy Saravanakumar, Junseok Lee, Dongsik Park, Won Jong Kim
Summary: The study utilized specific enzymes with high activity in cancer for cancer diagnosis and tumor-targeted drug delivery. NQO1, an over-expressed enzyme in certain tumor types, inhibits oxidative stress and reacts with QPA to induce micellar structure dissociation for drug release. These findings suggest that NQO1-responsive polymeric micelles have potential for improving therapeutic efficacy in anticancer drug delivery.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Kan Zhou, Zi-Zhan Li, Ze-Min Cai, Nian-Nian Zhong, Lei-Ming Cao, Fang-Yi Huo, Bing Liu, Qiu-Ji Wu, Lin-Lin Bu
Summary: Lymph node metastasis significantly affects the prognosis of cancer patients, and nanotheranostics can provide precise and effective disease diagnosis and treatment, offering a promising solution for the management of LNM patients and promoting the advancement of personalized medicine.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Chemistry, Physical
Thejus Baby, Yun Liu, Guangze Yang, Dong Chen, Chun-Xia Zhao
Summary: A new microfluidic nanoprecipitation approach has been developed for making polymer NPs with tunable drug loading up to 50%. The synthesized NPs remain very stable under acidic conditions but release the drug in a sustained manner at neutral pH.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Engineering, Biomedical
Sabina Quader, Xueying Liu, Kazuko Toh, Yu-Lin Su, Amit Ranjan Maity, Anqi Tao, West Kristian D. Paraiso, Yuki Mochida, Hiroaki Kinoh, Horacio Cabral, Kazunori Kataoka
Summary: This study developed a novel nanomedicine that can maintain structure stability during systemic circulation and gradually release drugs based on tumor heterogeneous pH, successfully prolonging survival time in orthotopic glioblastoma models.
Article
Nanoscience & Nanotechnology
Sayoni Maitra Roy, Sourav Barman, Purvi Kishore, Bhaskar Chatterjee, Pousali Bag, Tapas Ghatak, Arnab Basu, Surya K. Ghosh, Anjaneyulu Dirisala, Ankan Kumar Sarkar, Ali Hossain Khan, Somasish Ghosh Dastidar, Amit Ranjan Maity
Summary: Current chemotherapeutic strategies against intractable cancers are ineffective due to poor drug delivery and accumulation. By decorating polymeric micelles with folic acid, enhanced uptake and nuclear colocalization in cancer cells can be achieved, leading to improved therapeutic efficacy.
ACS APPLIED NANO MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Lingli Jin, Yanwen Xu, Fengjiao Chen, Dingle Yu, Hongze Liang, Zhenjiang Liang, Ziyu Liu, Haiyan Li, Junying Liu, Hui Tan, Lingling Zhao
Summary: A mitochondria-targeted and pH-triggered charge-convertible polymeric micellar system was developed for doxorubicin delivery and targeted anticancer therapy. It showed sustained drug release and enhanced cellular uptake, accumulation in mitochondria, and efficient release of doxorubicin in tumor cells.
MATERIALS & DESIGN
(2022)
Review
Immunology
Jihoon Kim, Paul A. Archer, Susan N. Thomas
Summary: Lymph nodes are secondary lymphoid tissues involved in immune cell interaction and related to various diseases. Nanotechnologies hold potential in biomedical applications, particularly in relation to lymph nodes. Consideration of lymph node tissue structure, lymphatic system physiology, and delivery mechanisms is crucial for designing nanocarriers for lymph node delivery.
SEMINARS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Sajini D. Hettiarachchi, Emel Kirbas Cilingir, Heidi Maklouf, Elif S. Seven, Suraj Paudyal, Steven Vanni, Regina M. Graham, Roger M. Leblanc
Summary: This study compared three different covalent carbon dots systems for doxorubicin release and cancer cell viability under acidic and physiological conditions. Results indicated that the pH stimuli C-dots-HBA-dox system showed the highest efficacy in doxorubicin release in acidic pH, while the redox stimuli C-dots-S-S-dox system performed well in physiological conditions.
Review
Pharmacology & Pharmacy
Jaeseong Lee, Sungtaek Kang, Hyeseon Park, Jeong Gil Sun, Eun Chae Kim, Gayong Shim
Summary: Lymph nodes are important organs that control immune cells and provide a pathway for tumors to spread. Nanoparticles offer several advantages for effective lymphatic delivery, including tailored size for migration and targeting of specific cells. Existing contrast agents are not able to selectively target metastatic lymph nodes, but nanoparticles can achieve this goal. Additionally, functionalized nanoparticles can deliver anticancer drugs to metastatic lymph nodes. This review discusses the use of nanoparticles for lymphatic mapping and highlights design considerations for detecting metastatic lymph nodes. Future directions for lymph node-targeting nanoparticles are also suggested.
Article
Multidisciplinary Sciences
Xiaodong Wang, Ying Chen, Yunshu Gao, Huiqing Zhang, Zehui Guan, Zhou Dong, Yuxuan Zheng, Jiarui Jiang, Haoqing Yang, Liming Wang, Xianming Huang, Lirong Ai, Wenlong Yu, Hongwei Li, Changsheng Dong, Zhou Zhou, Xiyang Liu, Guanzhen Yu
Summary: The study proposes a deep-learning framework to analyze lymph node whole-slide images, identifying lymph nodes and tumor regions, and revealing the importance of the tumor-area-to-MLN-area ratio (T/MLN) in predicting the prognosis of gastric cancer patients.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Jian Huang, Zhiyuan Wu, Junwu Xu
Summary: This study investigated the effects of a novel biofilm composite nano-drug delivery system on lymph node metastasis from oral squamous cell carcinoma, showing significant inhibition of proliferation activity in oral squamous cancer cells and control of cancer cell metastasis to cervical lymph nodes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Urology & Nephrology
Kai Yao, Yue Chen, Yunlin Ye, Zhiming Wu, Dong Chen, Hui Han, Zaishang Li, Zhuowei Liu, Yanjun Wang, Zike Qin, Yonghong Li, Zhiyong Li, Fangjian Zhou
Summary: The study provides a detailed map of pelvic lymph node metastasis in patients with penile carcinoma, showing that the external iliac and obturator packages are most commonly involved. Pelvic lymph node metastasis is associated with advanced T-stage. Some patients have crossover metastasis.
JOURNAL OF UROLOGY
(2021)
Review
Medicine, Research & Experimental
Jiajing Sun, Sikai Wu, Zixian Jin, Sijia Ren, William C. Cho, Chengchu Zhu, Jianfei Shen
Summary: Lung cancer has high morbidity and mortality rates, with tumor metastasis being a significant risk factor for death. Even after complete removal of a tumor at an early stage, there is still a risk of recurrence. Lymph node micrometastasis has been found to be associated with poor prognosis, but predicting prognosis and choosing the appropriate surgical and postoperative adjuvant chemotherapy options remain challenging for clinicians.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Polymer Science
Yasuhiro Nakagawa, Jeonggyu Lee, Yihua Liu, Saed Abbasi, Taehun Hong, Horacio Cabral, Satoshi Uchida, Mitsuhiro Ebara
Summary: This study demonstrates the microglial polarization effect of PtdSer-exposing polymeric particles (PSPs), which can upregulate anti-inflammatory microglia and suppress inflammatory microglia through specific receptor activation. This highlights the potential of PSPs for anti-inflammatory therapy.
Article
Engineering, Biomedical
Naoto Yoshinaga, Satoshi Uchida, Anjaneyulu Dirisala, Mitsuru Naito, Kyoko Koji, Kensuke Osada, Horacio Cabral, Kazunori Kataoka
Summary: The study successfully stabilized Polyplex micelles (PMs) by developing RNA oligonucleotide (OligoRNA) derivatives to bridge mRNA and polycation, improving their stability against polyion exchange reaction and ribonuclease attack. This bridging strategy provides a new approach for mRNA delivery by enhancing the efficiency of mRNA introduction in cultured cells and mouse lungs after intratracheal administration.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Sabina Quader, Kazunori Kataoka, Horacio Cabral
Summary: CNS tumors are highly lethal and treatment-resistant, mainly due to the difficulty of delivering drugs to the brain tumor site. Supramolecular nanomedicines show promise in addressing this challenge and improving brain tumor targeting.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Oncology
Masashi Kudo, Genichiro Ishii, Naoto Gotohda, Masaru Konishi, Shinichiro Takahashi, Shin Kobayashi, Motokazu Sugimoto, John D. Martin, Horacio Cabral, Motohiro Kojima
Summary: Histological tumor necrosis (HTN) is identified as a poor prognostic factor in pancreatic cancer patients who have received neoadjuvant therapy (NAT). There is a significant association between HTN and tumor hypoxia.
Article
Infectious Diseases
Mariusz Skwarczynski, Sahra Bashiri, Ye Yuan, Zyta M. Ziora, Osama Nabil, Keita Masuda, Mattaka Khongkow, Natchanon Rimsueb, Horacio Cabral, Uracha Ruktanonchai, Mark A. T. Blaskovich, Istvan Toth
Summary: The development of effective treatments against infectious diseases requires overcoming bacteria's rapid adaptation to antibiotics. Appropriately designed activity enhancers can increase the effectiveness of current antibiotics, reduce antibiotic resistance, improve drug delivery and penetration, and decrease side effects.
Article
Chemistry, Multidisciplinary
Takuya Miyazaki, Shaoyi Chen, Stelios Florinas, Kazunori Igarashi, Yu Matsumoto, Tatsuya Yamasoba, Ze-Qi Xu, Herren Wu, Changshou Gao, Kazunori Kataoka, R. James Christie, Horacio Cabral
Summary: This study presents a Hoechst-based reporter system that can monitor the release and engagement of drugs from nanoparticle delivery systems. The system allows the visualization of drug distribution and binding to subcellular targets, providing insights into the effects of drug-linker and nanoparticle properties on target-bound drug distribution. The findings from this study were applied to develop highly potent, targeted anticancer nanoparticles with optimized drug-linker design, resulting in effective tumor growth inhibition without severe toxicity.
Article
Biochemistry & Molecular Biology
Masaya Sano, Daisuke Akagi, Mitsuru Naito, Katsuyuki Hoshina, Kanjiro Miyata, Kazunori Kataoka, Soichiro Ishihara
Summary: This study used nanomedicine to deliver miR146a-5p in a rat carotid artery balloon injury model and found that it can inhibit inflammatory response and vascular smooth muscle cell migration, as well as reduce reactive oxygen species production and proinflammatory cytokine gene expression. In a rat model, miR146a-5p attenuated NIH and vessel remodeling by reducing proinflammatory cytokine gene expression in injured arteries and monocyte/macrophage infiltration into the vascular wall.
Editorial Material
Chemistry, Multidisciplinary
Luis M. Liz-Marzan, Andre E. Nel, C. Jeffrey Brinker, Warren C. W. Chan, Chunying Chen, Xiaodong Chen, Dean Ho, Tony Hu, Kazunori Kataoka, Nicholas A. Kotov, Wolfgang J. Parak, Molly M. Stevens
Article
Engineering, Biomedical
Pengwen Chen, Wenqian Yang, Taehun Hong, Takuya Miyazaki, Anjaneyulu Dirisala, Kazunori Kataoka, Horacio Cabral
Summary: Intracellular protein delivery is an effective approach for developing innovative therapeutics. Nanocarriers have the potential to deliver proteins inside cells by promoting cellular uptake and overcoming degradation. Controlling the ability of nanocarriers to escape from the endo/lysosomal compartments can enhance delivery precision.
Article
Chemistry, Multidisciplinary
Yuto Honda, Sayaka Onodera, Hiroyasu Takemoto, Noor Faizah Che Harun, Takahiro Nomoto, Makoto Matsui, Keishiro Tomoda, Yudi Sun, Yutaka Miura, Nobuhiro Nishiyama
Summary: This study aims to develop a technology to control the activity of small interfering RNA (siRNA) in a thermo-responsive manner, even at temperatures close to body temperature. By conjugating siRNA with a thermally responsive copolymer, the activity of siRNA can be enhanced based on temperature changes. This technique offers a promising approach to selectively induce therapeutic effects of siRNA in vivo.
PHARMACEUTICAL RESEARCH
(2023)
Article
Engineering, Biomedical
Haochen Guo, Wen Xu, Takahiro Nomoto, Kaito Kanamori, Yan Ming Voon, Yuto Honda, Naoki Yamada, Hiroyasu Takemoto, Makoto Matsui, Nobuhiro Nishiyama
Summary: Cancer cells overexpress LAT1 to take up neutral amino acids, and targeting LAT1 with drug delivery systems has promising potential for cancer diagnosis and therapy. This study developed polymers with Met or Cys structures to test their affinity with LAT1. The Met-modified polymers exhibited higher cellular uptake efficiency in an LAT1-selective manner and showed tumor-selective accumulation in vivo, suggesting their potential for LAT1-targeting drug delivery systems.
Article
Oncology
Takahiro Nomoto, Kana Komoto, Tomoya Nagano, Takuya Ishii, Haochen Guo, Yuto Honda, Shun-ichiro Ogura, Masahiro Ishizuka, Nobuhiro Nishiyama
Summary: This study suggests that the use of a polymeric iron chelator can enhance the effectiveness of 5-ALA-induced photodynamic therapy by modulating the intratumoral iron levels. The polymeric iron chelator effectively deactivates intracellular labile iron and increases the accumulation of PpIX, improving the cytotoxicity upon photoirradiation.
Editorial Material
Chemistry, Multidisciplinary
Warren C. W. Chan, Natalie Artzi, Chunying Chen, Xiaodong Chen, Dean Ho, Tony Hu, Kazunori Kataoka, Luis M. Liz-Marzan, Rahmi Oklu, Wolfgang J. Parak
Article
Pharmacology & Pharmacy
Hsi-Kai Tsou, Cheng-Hsin Wu, Long Yi Chan, Kazunori Kataoka, Nanae Itokazu, Minoru Tsuzuki, Hsuan Hu, Guan-Yu Zhuo, Keiji Itaka, Chin-Yu Lin
Summary: Large-area craniofacial defects pose a challenge for orthopaedists. In order to develop a safe and effective tissue engineering strategy, cytokines and chemokines can be utilized to attract endogenous stem cells for bone regeneration. The combination of BMP2 and TGF-beta3 mRNA nanomedicine promotes bone formation and provides an alternative cell-free tissue engineering method for craniofacial defect healing.
Article
Chemistry, Multidisciplinary
Shan Gao, Yutaka Miura, Akira Sumiyoshi, Satoshi Ohno, Keisuke Ogata, Takahiro Nomoto, Makoto Matsui, Yuto Honda, Minoru Suzuki, Megumi Iiyama, Kensuke Osada, Ichio Aoki, Nobuhiro Nishiyama
Summary: Nano-sized contrast agents (NCAs) have the potential to enhance tumor contrast during magnetic resonance imaging. This study introduces a novel molecular mechanism to enhance the relaxation of NCAs, resulting in sharp tumor imaging. The self-folding molecular design allows for minimal loading of gadolinium complexes and selective accumulation in tumor tissues, providing effective anti-tumor results through gadolinium neutron capture therapy.
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
