Article
Chemistry, Multidisciplinary
Gang Zhao, Rongguo Ren, Xin Wei, Zhenshan Jia, Ningrong Chen, Yuanyuan Sun, Zhifeng Zhao, Subodh M. Lele, Haizhen A. Zhong, Mary B. Goldring, Steven R. Goldring, Dong Wang
Summary: The study introduces a novel intra-articular hydrogel drug ProGel-Dex, which effectively improves joint inflammation and pain, showing potential for significant impact in clinical management of arthritis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Chemistry, Multidisciplinary
Linlin Sun, Pan Zhao, Menghan Chen, Jiayi Leng, Yixin Luan, Baoxiang Du, Jia Yang, Yong Yang, Rong Rong
Summary: Malignant tumors pose a great threat to human health, and chemotherapy using taxanes is an important treatment option. However, the hydrophobicity, off-target toxicity, and multidrug resistance of taxanes restrict their therapeutic effects. Prodrug-based nanomedicines (PNS) have shown great potential in cancer therapy due to their advantages such as high drug loading efficiency, low immunogenicity, tumor stimuli-responsive drug release, and combinational therapy. This review summarizes the latest developments in taxanes prodrugs-based nanomedicines (TPNS), including polymer-drug conjugate-based nanoformulations, small molecular prodrug-based self-assembled nanoparticles, and prodrug-encapsulated nanosystems. The future challenges of TPNS for clinical translation are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Materials Science, Multidisciplinary
Li-Han Liu, Xian-Zheng Zhang
Summary: The past decade has seen significant advances in the development of carrier-free nanomedicines, which are attractive due to their high biosafety, drug loading capacities, simple compositions, and simplified synthesis procedures. Extensive efforts have been made to expand the scope of carrier-free nanomedicines and improve their therapeutic performance through the exploration of new excipients, therapeutic agents, self-assembly methods, and mechanisms. This review summarizes the research progress and practical applications of carrier-free nanomedicines in cancer therapy.
PROGRESS IN MATERIALS SCIENCE
(2022)
Article
Materials Science, Biomaterials
Zeng Yi, Yaqin Ran, Xiangyu Chen, Qiulan Tong, Lei Ma, Yunfei Tan, Xiaomin Ma, Xudong Li
Summary: The use of polyphenol-based nanoparticles as carriers for delivering dexamethasone with anti-oxidative and anti-inflammatory activities shows promising results in the treatment of rheumatoid arthritis by reducing inflammatory mediators and improving synovial inflammation and cartilage destruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Chemistry, Multidisciplinary
Qin Chen, Shu Xu, Shuo Liu, Yue Wang, Guangxuan Liu
Summary: Malignant tumor remains a major threat to human health. Although targeted therapeutic strategies have developed rapidly, treatments that act on a single target are prone to tumor resistance. Therefore, traditional broadspectrum chemotherapy still plays a critical role in clinical cancer therapy. However, most chemotherapeutic drugs have unsatisfactory therapeutic efficacy and severe off-target toxicity. To overcome this, researchers have focused on developing novel nano-formulations for efficient delivery of chemotherapeutic drugs.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Environmental
Xinzhu Shan, Zhiqiang Zhao, Chen Wang, Jin Sun, Zhonggui He, Cong Luo, Shenwu Zhang
Summary: This review discusses the application of prodrug-engineered nanomedicines in synergistic chemo-phototherapy. They offer advantages of synergistic treatment effect and dosage reduction, but also face challenges in design rationale.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Chemistry, Medicinal
Haibo Zhao, Jing Yu, Renshuai Zhang, Pengwei Chen, Hongfei Jiang, Wanpeng Yu
Summary: The chemotherapeutic drug doxorubicin (DOX) is widely used for treating various cancers, but it has some disadvantages such as off-target toxicity and hydrophobicity. DOX treatment can enhance tumor antigen presentation and activate dendritic cells, as well as facilitate immune-mediated clearance of tumor cells. Despite advances in nanotechnology and biomaterials, the effective delivery of DOX drug molecules remains challenging. This review summarizes recent progress in DOX prodrug-based nanomedicines and provides insights for future development and clinical applications.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Renshuai Zhang, Jing Yu, Zhu Guo, Hongfei Jiang, Chao Wang
Summary: This review summarizes the potential strategies and applications of CPT-based nanoprodrugs for enhanced CPT delivery towards cancer cells. The development of smart CPT-based prodrug nanomedicines with stimuli-responsive release capacity is discussed, aiming to guide materials chemists in developing more powerful nanomedicines with real clinical therapeutic capacities.
Review
Biotechnology & Applied Microbiology
Lingling Huang, Jianmiao Yang, Tiantian Wang, Jianqing Gao, Donghang Xu
Summary: Lipidic prodrugs are an effective strategy to optimize the properties of therapeutic agents in cancer treatment, improving their physicochemical properties and antitumor activities while reducing systemic toxicity. However, the rational design of small-molecule lipidic prodrugs has not received enough attention. This review provides an overview of conjugation strategies for small-molecule lipidic prodrugs fabrication and highlights their rational design in response to physiological barriers of chemotherapeutic agents.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Renshuai Zhang, Xiaohua Zhao, Ang Jia, Chao Wang, Hongfei Jiang
Summary: Hyaluronic acid (HA) is a natural polysaccharide that has gained significant attention for its improved tumor targeting capacity, enzyme degradation capacity, and excellent biocompatibility. Its receptor, CD44, is overexpressed in various cancer cells and is closely related to tumor progress and metastasis. Therefore, researchers have designed HA-based drug delivery platforms for CD44-mediated tumor targeting. HA-based nanoprodrugs possess distinct advantages such as good bioavailability, long circulation time, and controlled drug release and retention ability, and have been extensively studied in the past years.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Biomaterials
Heng Zhao, Saad Sene, Angelika M. Mielcarek, Sylvain Miraux, Nicolas Menguy, Dris Ihiawakrim, Ovidiu Ersen, Christine Pechoux, Nathalie Guillou, Joseph Scola, Jean-Marc Greneche, Farid Nouar, Simona Mura, Florent Carn, Florence Gazeau, Eddy Dumas, Christian Serre, Nathalie Steunou
Summary: In this study, a hierarchically porous nano-object (USPIO@MIL) was designed through a one-pot, cost-effective and environmentally friendly protocol, combining a benchmark nanoMOF (MIL-100(Fe)) and ultra-small superparamagnetic iron oxide (USPIO) nanoparticles (maghemite). The USPIO@MIL nano-object exhibited valuable features such as high colloidal stability, high biodegradability, low toxicity, high drug loading capacity, stimuli-responsive drug release, and superparamagnetic properties. It also showed high anti-inflammatory and anti-tumoral activities when loaded with anti-tumoral and anti-inflammatory drugs (doxorubicin and methotrexate), and demonstrated excellent relaxometric properties as an efficient contrast agent for magnetic resonance imaging.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Zheng Huang, Huaisong Hu, Tong Xian, Zhigang Xu, Dianyong Tang, Bochu Wang, Yimei Zhang
Summary: Palbociclib, the first marketed CDK4/6 kinase inhibitor, is not effective in treating triple negative breast cancer (TNBC). Therefore, combinatorial chemotherapy is necessary for TNBC treatment. In this study, a carrier-free nanomedicine was developed using palbociclib dimers and Ce6 for enhanced combined chemo-photodynamic therapy of breast cancer. The nanoplatform showed efficient therapeutic agent loading capacity, high cellular uptake, and significant therapeutic performance against breast cancer cells. The results demonstrated that the nanomedicine presented a better inhibitory effect on cancer cell growth through synergistic chemo-photodynamic therapy.
Article
Pharmacology & Pharmacy
Saadat Hussain, Mujeeb Ur-Rehman, Aqsa Arif, Catherine Cailleau, Cynthia Gillet, Rudaba Saleem, Hira Noor, Farwa Naqvi, Almas Jabeen, M. Iqbal Atta-ur-Rahman, M. Iqbal Choudhary, Elias Fattal, Nicolas Tsapis
Summary: New lipidic prodrugs of diclofenac were synthesized by grafting aliphatic chains to diclofenac through an ester bond. The nanoparticles of the prodrugs were successfully formulated and exhibited good stability. The prodrug nanoparticles showed dose-dependent inhibition of TNF-α comparable to standard diclofenac sodium.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Nanoscience & Nanotechnology
Yuling Liu, Xin Nie, Yihan Wu, Longfei Lin, Qian Liao, Jingjing Li, Simon Ming-Yuen Lee, Hui Li, Jinming Zhang
Summary: GBA2/NPs formed through self-assembly show promising therapeutic potential in the treatment of rheumatoid arthritis, with good drug delivery efficiency and anti-inflammatory effects.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Multidisciplinary
A. Libanska, E. Randarova, S. Skoroplyas, M. Bartos, J. Lunackova, F. Lager, G. Renault, D. Scherman, T. Etrych
Summary: This study presents biocompatible and stimuli-sensitive polymer conjugates with an anti-inflammatory drug, dexamethasone, which are designed for prolonged blood circulation, enhanced inflammatory site accumulation, site-specific drug release, and subsequent elimination via urine excretion. The polymer nanomedicines demonstrated the ability to reduce joint inflammation and arthritis-induced bone damage in a mouse model of rheumatoid arthritis.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Immunology
Amelie Bonaud, Melanie Khamyath, Marion Espeli
Summary: Plasma cells and their antibodies play a crucial role in protection against infection, but can also be involved in diseases such as autoimmune diseases and multiple myeloma. The differentiation and survival of plasma cells are regulated by transcriptional switches and morphological changes. Although some cellular and molecular mechanisms have been identified, the mechanisms by which plasma cells survive and secrete large quantities of antibodies for extended periods of time remain unclear. This review aims to discuss the current understanding of plasma cell cellular biology, the challenges faced by research in this field, and the potential opportunities for studying the fundamental mechanisms underlying plasma cell survival and function.
IMMUNOLOGY LETTERS
(2023)
Article
Medicine, Research & Experimental
Melanie Khamyath, Amelie Bonaud, Karl Balabanian, Marion Espeli
Summary: CXCR4 plays a crucial role in cell migration and the development of the immune system. It is involved in B lymphocyte biology from their differentiation to plasma cell formation. Mutations in CXCR4 can lead to a rare immunodeficiency called the WHIM Syndrome, affecting receptor desensitization and increasing response to its ligand CXCL12. This review emphasizes the regulatory role of CXCR4 desensitization in humoral immune responses, using the WHIM Syndrome as an example, and highlights the importance of fine-tuning CXCR4 signaling for long-term antibody-mediated protection.
M S-MEDECINE SCIENCES
(2023)
Article
Multidisciplinary Sciences
Amelie Bonaud, Laetitia Gargowitsch, Simon M. Gilbert, Elanchezhian Rajan, Pablo Canales-Herrerias, Daniel Stockholm, Nabila F. Rahman, Mark O. Collins, Hakan Taskiran, Danika L. Hill, Andres Alloatti, Nagham Alouche, Stephanie Balor, Vanessa Soldan, Daniel Gillet, Julien Barbier, Francoise Bachelerie, Kenneth G. C. Smith, Julia Jellusova, Pierre Bruhns, Sebastian Amigorena, Karl Balabanian, Michelle A. Linterman, Andrew A. Peden, Marion Espeli
Summary: We identified SNARE Sec22b as a critical regulator of plasma cell maintenance and function. In the absence of Sec22b, plasma cells were hardly detectable and serum antibody titers were dramatically reduced, leading to a failure in mounting a protective immune response. Mechanistically, Sec22b contributes to efficient antibody secretion and is involved in regulating plasma cell transcriptional identity, as well as the morphology of the endoplasmic reticulum and mitochondria.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Pharmacology & Pharmacy
Mohamed Beladjine, Claire Albert, Maxime Sintes, Ghozlene Mekhloufi, Claire Gueutin, Valerie Nicolas, Alexis Canette, Michael Trichet, Nicolas Tsapis, Laurence Michel, Florence Agnely, Nicolas Huang
Summary: The innovative Pickering emulsions can co-encapsulate two active pharmaceutical ingredients for topical use. The emulsions are stable and biocompatible, with no negative effects on human keratinocytes. These emulsions show promise as a multidrug delivery system for chronic inflammatory skin diseases.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Kamila Bohne Japiassu, Francois Fay, Alessandro Marengo, Sebastiao A. Mendanha, Catherine Cailleau, Younes Louaguenouni, Qinglin Wang, Stephanie Denis, Nicolas Tsapis, Thais Leite Nascimento, Eliana Martins Lima, Elias Fattal
Summary: In this study, lipid nanoparticulate platforms loaded with dexamethasone were developed and evaluated. The dexamethasone-loaded liposomes, with sizes below 150 nm, were coated with polyethylene glycol, hyaluronic acid, or a mixture of both to cross the pulmonary mucus layer and target alveolar proinflammatory macrophages expressing CD44. In vitro experiments showed that encapsulated dexamethasone in liposomes, especially in HA-bearing ones, improved anti-inflammatory efficacy compared to the free drug. In vivo data demonstrated that dexamethasone-loaded liposomes exhibited improved consistency in efficacy compared to free dexamethasone.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Barbara Tessier, Nicolas Tsapis, Elias Fattal, Laurence Moine
Summary: Glucocorticoids (GC) are commonly used drugs for inflammatory diseases, but their prolonged use can lead to severe side effects. Recent advancements in GC prodrugs and conjugates, administered as free forms or nanoparticles, have improved drug delivery, controlled release, and targeting in inflammatory sites. This review highlights the potential of these novel strategies and discusses their design strategies and recent advances.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Immunology
Alyssa Silva-Cayetano, Sigrid Fra-Bido, Philippe A. Robert, Silvia Innocentin, Alice R. Burton, Emily M. Watson, Jia Le Lee, Louise M. C. Webb, William S. Foster, Ross C. J. McKenzie, Alexandre Bignon, Ine Vanderleyden, Dominik Alterauge, Julia P. Lemos, Edward J. Carr, Danika L. Hill, Isabella Cinti, Karl Balabanian, Dirk Baumjohann, Marion Espeli, Michael Meyer-Hermann, Alice E. Denton, Michelle A. Linterman
Summary: Linterman and colleagues find that dysregulated CXCR4 expression in aged T-FH cells leads to their mislocation in germinal centers, impairing their ability to support B cell help and antibody production. The decline in the germinal center response with age results in poor vaccine-induced immunity in older individuals. However, this age-dependent defect can be reversed by providing T-FH cells that colocalize with follicular dendritic cells using CXCR5, highlighting the importance of T-FH cell localization in the antibody response and expansion of the FDC network.
Article
Chemistry, Analytical
Ali Muhieddine, Natalie Fournier, Hani Dakroub, Ali Assi, Jean-Louis Paul, Ali Tfayli, Pierre Chaminade, Sana Tfaili
Summary: Atherosclerosis, the leading cause of morbidity and mortality in industrialized countries, is associated with the presence of cholesterol-laden foam cells in atherosclerotic plaques. It has been found that EPA inhibits cholesterol esters hydrolysis in macrophages, potentially impairing cholesterol efflux from plaques and hindering the antiatherogenic process.
Article
Immunology
Amelie Bonaud, Pierre Larraufie, Melanie Khamyath, Ugo Szachnowski, Shaun M. Flint, Nadege Brunel-Meunier, Francois Delhommeau, Annie Munier, Tapio Loennberg, Claire Toffano-Nioche, Daniel Gautheret, Karl Balabanian, Marion Espeli
Summary: Using single cell RNAseq and in silico transinteractome analyses, the researchers identified Leptin receptor positive (LepR(+)) mesenchymal cells as the stromal cell subset most likely to interact with long-lived plasma cells (PCs) within the bone marrow. Furthermore, they found that PCs may use different sets of integrins and adhesion molecules to interact with these stromal cells based on their isotype. These findings provide new insights into the specific targeting of bone marrow PCs.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Saadat Hussain, Mujeeb Ur-Rehman, Aqsa Arif, Catherine Cailleau, Cynthia Gillet, Rudaba Saleem, Hira Noor, Farwa Naqvi, Almas Jabeen, M. Iqbal Atta-ur-Rahman, M. Iqbal Choudhary, Elias Fattal, Nicolas Tsapis
Summary: New lipidic prodrugs of diclofenac were synthesized by grafting aliphatic chains to diclofenac through an ester bond. The nanoparticles of the prodrugs were successfully formulated and exhibited good stability. The prodrug nanoparticles showed dose-dependent inhibition of TNF-α comparable to standard diclofenac sodium.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Baptiste Robin, Ludivine Mousnier, Hung Le, Nadege Grabowski, David Chapron, Ophelie Bellance-Mina, Nicolas Huang, Florence Agnely, Elias Fattal, Nicolas Tsapis
Summary: Most nanoparticles used for drug delivery are spherical, but elongated particles have advantages in cellular uptake. In this study, we synthesized biocompatible polylactide-b-poly(ethylene glycol) (PLA-PEG) polymers with carboxylate moieties and used them to form worm-like nanoparticles. By adjusting the molar mass of the PLA block, we obtained worm-like nanoparticles with varying aspect ratios. The proportion of worm-like particles increased as the molar mass of the PLA block decreased, contrary to the usual behavior of block polymers. These anisotropic nanoparticles showed increased cellular uptake compared to their spherical counterparts, highlighting their potential for drug delivery applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Mujeeb Ur-Rehman, Franceline Reynaud, Sinda Lepetre, Sonia Abreu, Pierre Chaminade, Elias Fattal, Nicolas Tsapis
Summary: In this study, lipid-drug conjugates (LDCs) of dexamethasone (DXM) with different lipid-drug linkages were synthesized and turned into nanoscale particles. The encapsulation efficacy of LDCs was above 95%, with good stability and no recrystallization observed. Ester and carbonate LDC nanoparticles exerted anti-inflammatory activity, while the carbamate LDC nanoparticles were toxic to macrophages and discarded. The release rate of DXM from ester particles was faster than that from carbonate particles, leading to a lower exposure to DXM from carbonate LDC nanoparticles in pharmacokinetics and biodistribution studies.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Geraldine Landon, Guillaume Phan, Francois Fay, Celine Bouvier-Capely, Elias Fattal
Summary: Decorporating treatment is crucial for internal contamination with radionuclides. The existing therapies often lack effectiveness, and conventional research strategies are time-consuming and costly. Drug repurposing and nanotechnologies offer promising approaches for improving the delivery and efficacy of active substances.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
