Article
Microbiology
Hongyu Xie, Mingjing Wei, Lifang Yao, Yi Liu, Xing Xie, Xiao Li
Summary: This study investigates the relationship between single nucleotide polymorphisms (SNPs) in human papillomavirus (HPV) receptor associated genes and HPV susceptibility and clinical outcomes in Chinese women, and explores a new triaging strategy for non-16/18 high-risk HPV infection.
MICROBIOLOGY SPECTRUM
(2023)
Article
Multidisciplinary Sciences
Stephanie S. Liu, Karen K. L. Chan, Tina N. Wei, Ka Yu Tse, Siew F. Ngu, Mandy M. Y. Chu, Lesley S. K. Lau, Annie N. Y. Cheung, Hextan Y. S. Ngan
Summary: High-risk human papillomavirus (HR-HPV) testing has become increasingly important in primary cervical cancer screening. This study validated the performance of Roche Cobas 4800 HPV test and compared it with Digene Hybrid Capture 2 (HC2) high-risk HPV DNA test. The overall agreement between Cobas and HC2 was 92.23%, with Cobas test demonstrating significantly higher specificity in identifying high-grade cervical intraepithelial neoplasia (CIN2+)/CIN3+ cases than HC2 test.
Article
Medicine, General & Internal
Veronique Bouvard, Nicolas Wentzensen, Anne Mackie, Johannes Berkhof, Julia Brotherton, Paolo Giorgi-Rossi, Rachel Kupets, Robert Smith, Silvina Arrossi, Karima Bendahhou, Karen Canfell, Z. Mike Chirenje, Michael H. Chung, Marta del Pino, Silvia de Sanjose, Miriam Elfstrom, Eduardo L. Franco, Chisato Hamashima, Francoise F. Hamers, C. Simon Herrington, Raul Murillo, Suleeporn Sangrajrang, Rengaswamy Sankaranarayanan, Mona Saraiya, Mark Schiffman, Fanghui Zhao, Marc Arbyn, Walter Prendiville, Blanca I. Indave Ruiz, Isabel Mosquera-Metcalfe, Beatrice Lauby-Secretan
Summary: This article reviews the best methods of screening for cervical cancer, with HPV nucleic acid testing being superior whether used alone or in combination with other methods.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Medicine, General & Internal
Rebecca B. Perkins, Nicolas Wentzensen, Richard S. Guido, Mark Schiffman
Summary: Each year in the US, about 100,000 people are treated for cervical precancer, 14,000 are diagnosed with cervical cancer, and 4,000 die from it. Almost all cervical cancers worldwide are caused by certain HPV genotypes. HPV vaccination at ages 9 to 12 can prevent over 90% of cervical precancers and cancers. Cervical cancer can be prevented through screening and treatment of cervical precancer in individuals with a cervix aged 21 to 65.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
Jinichi Sakamoto, Mayumi Saito, Shitai Zhang, Masahiro Takakura, Hiroaki Takagi, Toshiyuki Sasagawa
Summary: This study conducted molecular mapping and HPV genotyping on cervical cancer tissue specimens to confirm previous observations of multiple HPV types or no HPV DNA in invasive cervical cancers (ICC). The findings suggest that different HPV types induce different histological cancers.
Article
Public, Environmental & Occupational Health
Philip E. Castle, Brian Befano, Mark Schiffman, Nicolas Wentzensen, Thomas Lorey, Nancy Poitras, Marianne Hyer, Li C. Cheung
Summary: This study compared the risks of cervical intraepithelial neoplasia grade 2 (CIN2) or more severe diagnoses (CIN2+) between women living with HIV (WLWH) and women not known to have HIV (HIV[-]) following cervical cancer screening. WLWH were more likely to test HPV positive and have abnormal cytology compared to HIV[-] women. The results suggest that both populations could be managed similarly once the screening results are known.
PREVENTIVE MEDICINE
(2022)
Article
Medicine, General & Internal
Sarah J. Bowden, Triada Doulgeraki, Emmanouil Bouras, Georgios Markozannes, Antonios Athanasiou, Harriet Grout-Smith, Konstantinos S. Kechagias, Laura Burney Ellis, Verena Zuber, Marc Chadeau-Hyam, James M. Flanagan, Konstantinos K. Tsilidis, Ilkka Kalliala, Maria Kyrgiou
Summary: Persistent HPV infection is necessary but not sufficient for cervical cancer. Behavioral, environmental, or comorbid exposures may affect the development of cervical cancer. However, the validity of the observational studies describing these associations is still unclear.
Article
Computer Science, Information Systems
Tingting Zhang, Youjeong Jeong, Dongchoon Park, Tongin Oh
Summary: A noninvasive and low-cost multi-channel electrical impedance spectroscopy (EIS) probe with multiple active electrodes was proposed for screening cervical intraepithelial neoplasia (CIN). The probe allowed for flexible combination of current injection and voltage measurement, providing well-designed measurement protocols for focused sensitivity. Experimental results demonstrated the high performance of the EIS probe across a wide range of frequencies.
Article
Oncology
Erika Hurtado-Salgado, Luz Cardenas-Cardenas, Jorge Salmeron, Rufino Luna-Gordillo, Eduardo Ortiz-Panozo, Betania Allen-Leigh, Nenetzen Saavedra-Lara, Eduardo L. Franco, Eduardo Lazcano-Ponce
Summary: This study analyzed screening data from Mexico's public cervical cancer prevention program from 2010 to 2015, and found that hrHPV testing with cytological triage can detect twice as many CIN2+ cases compared to screening using cytology alone in women aged 35 to 64.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Editorial Material
Obstetrics & Gynecology
Line W. Gustafson, Lone Kjeld Petersen, Pinar Bor, Berit Andersen, Anne Hammer
Summary: Despite significant declines in cervical cancer incidence and mortality rates due to screening, older women continue to experience high rates of cervical cancer, the reasons for which remain unclear. Age-related changes to the cervix can impair the sensitivity of screening and effectiveness of colposcopy in older women.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Obstetrics & Gynecology
Lijuan Zhuang, Xiulan Weng, Lihua Wang, Xiaoyan Xie, Liying Zhong, Dabin Liu, Yingling Xiu
Summary: The study aimed to investigate the feasibility of HR-HPV mRNA assay for primary screening of cervical cancer. The results showed that HR-HPV mRNA testing had high specificity and sensitivity, making it a potential screening method for cervical cancer in China.
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2022)
Article
Obstetrics & Gynecology
Louise T. Thomsen, Susanne K. Kjaer, Christian Munk, Dorthe Ornskov, Marianne Waldstrom
Summary: Compared to cytology-based screening, HPV-based screening resulted in a 90% increase in CIN3+ detection but also led to a threefold increase in colposcopy referrals. The findings support the implementation of HPV-based screening in Denmark, but adjustments to screening algorithms may be necessary to reduce unnecessary colposcopy referrals.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Medical Laboratory Technology
Hongyu Xie, Xuan Rao, Junyan Li, Lifang Yao, Ying Ji, Juan Zhang, Hui Wang, Xinyu Wang, Xiao Li
Summary: This study evaluated the consistency of high-risk HPV detection between extended and partial HPV genotyping tools and explored the diagnostic accuracy of a risk stratification strategy based on extended HPV genotyping for cervical cancer screening. The results showed good agreement between the two genotyping methods and suggested that extended HPV genotyping could improve the diagnostic accuracy of primary CC screening.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Oncology
Aurelia Vattai, Nadine Kremer, Sarah Meister, Susanne Beyer, Lucia Keilmann, Anna Hester, Mina Temelkov, Helene Heidegger, Elisa Schmoeckel, Mirjana Kessler, Sven Mahner, Udo Jeschke, Linda Hertlein, Thomas Kolben
Summary: The expression of FoxP3 may serve as a predictive factor for assessing the risks of CIN II progression and could potentially be a target for immune therapy in cervical cancer patients. Positive correlation was found between FoxP3-positive cells in epithelium and total FoxP3 expression, suggesting its role in progression and regression of cervical intraepithelial lesions.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Oncology
Hongmin Zeng, Maoyu Liu, Linlin Xiao, Xiaoyuan Zhang, Qing Feng, Shufang Chang
Summary: Research has shown that focused ultrasound is an effective and safe therapy for treating CIN, which can improve the local immune environment of the cervix to some extent.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2022)
Article
Ethnic Studies
Tahira Yeasmeen, Margaret Kelaher, Julia M. L. Brotherton
Summary: This study investigates the different types of racism experienced by Muslim and non-Muslim women living in Victoria, Australia, and the adverse mental health outcome they face after experiencing racism.
ETHNICITY & HEALTH
(2023)
Editorial Material
Medicine, General & Internal
Karen Canfell, Bette Liu, Emily Banks
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Article
Multidisciplinary Sciences
David M. Goldsbury, Amy Vassallo, Marianne Weber, Julia Steinberg, Penelope Webb, Anna DeFazio, Karen Canfell
Summary: This study aimed to estimate the direct health system costs of women diagnosed with ovarian cancer in Australia during 2006-2013, and found that the costs are substantial. Continued investment in ovarian cancer research, including prevention, early detection, and personalized treatments, is necessary to reduce the burden of the disease.
Article
Substance Abuse
Stephen Wade, Marianne F. Weber, Peter Sarich, Michael Caruana, Christina Watts, Pavla Vaneckova, Preston Ngo, Sonya Cressman, Michelle Scollo, Emily Banks, Coral E. Gartner, Paul B. Grogan, Tony Blakely, Martin C. Tammemagi, Karen Canfell
Summary: This study aimed to compare 50-year forecasts of Australian tobacco smoking rates in relation to smoking initiation and cessation trends and a national target of <= 5% adult daily prevalence by 2030. Using a compartmental model and population predictions, the study estimated smoking prevalence to 2066 and compared scenarios of different trends in initiation and cessation rates. The results showed that current trends will not achieve the target by 2030, and urgent strategies are needed to prevent initiation and facilitate cessation.
Article
Multidisciplinary Sciences
Sophie O'Haire, Fanny Franchini, Yoon-Jung Kang, Julia Steinberg, Karen Canfell, Jayesh Desai, Stephen Fox, Maarten IJzerman
Summary: NTRK gene fusions are rare somatic mutations found in various cancer types, and targeted therapies for them are emerging. However, integrating these treatments into healthcare systems poses challenges due to uncertain prevalence and optimal testing methods. To address this, a systematic review was conducted to determine the prevalence of NTRK fusions and guide efficient diagnostic screening. The review included 160 studies and found that NTRK fusion-positive cancers are rare and widely distributed across solid tumors. However, small-scale and heterogeneous data make it difficult to predict prevalence accurately. Further large-scale, standardized genomic data are needed to better understand NTRK fusion epidemiology.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Carolyn Nickson, Megan A. Smith, Eleonora Feletto, Louiza S. Velentzis, Kate Broun, Sabine Deij, Paul Grogan, Michaela Hall, Emily He, D. James St John, Jie-Bin Lew, Pietro Procopio, Kate T. Simms, Joachim Worthington, G. Bruce Mann, Karen Canfell, Talia Malagon
Summary: Australia introduced COVID-19 infection prevention and control measures and conducted a modelled evaluation of the impact of disruptions to cancer screening programmes. The findings showed that a 12-month screening disruption would reduce breast and colorectal cancer diagnoses, but increase cervical cancer diagnoses. Maintaining screening participation is critical to preventing an increase in the burden of cancer at a population level.
Article
Public, Environmental & Occupational Health
Susan Yuill, Sam Egger, Megan A. Smith, Louiza Velentzis, Marion Saville, Erich Kliewer, Deborah Bateson, Karen Canfell
Summary: This study compared the participation in the National Cervical Screening Program (NCSP) between immigrants and Australian-born women. The results showed that women from New Zealand, Oceania, Middle East/North Africa, Southeast Asia, Chinese Asia, Japan/South Korea, and Southern/Central Asia had lower screening participation rates, while women from Malta and South America had higher participation rates. Non-English-speaking-at-home women were less likely to be screened. Even after living in Australia for over 20 years, immigrant groups still had lower screening rates compared to Australian-born women. This study suggests that there is room for improvement in screening participation for these groups.
JOURNAL OF MEDICAL SCREENING
(2023)
Article
Economics
Preston Ngo, Deme Karikios, David Goldsbury, Stephen Wade, Zarnie Lwin, Brett G. M. Hughes, Kwun M. Fong, Karen Canfell, Marianne Weber
Summary: New therapies have improved the standard of care for lung cancer since 2016, leading to a need for up-to-date evidence in health economic modelling. A discrete event simulation of advanced lung cancer treatment was developed to estimate survival outcomes and healthcare costs in the Australian setting, which can be updated as new therapies are introduced.
Article
Virology
Xiangqun Ju, Sneha Sethi, Annika Antonsson, Joanne Hedges, Karen Canfell, Megan Smith, Gail Garvey, Richard M. Logan, Lisa M. Jamieson
Summary: This study investigated the natural history and risk factors of oral HPV infections in an Australian Indigenous cohort. Data was collected from Indigenous Australians aged 18+ years through face-to-face interviews and saliva samples. The prevalence, incidence, and persistence of oral HPV infection were high in this population, with oral sex behaviors and recreational drug use identified as risk factors for high-risk HPV infection.
Meeting Abstract
Respiratory System
Sonya Cressman, Marianne Weber, Preston Ngo, Alain Tremblay, Stephen Wade, Renee Manser, Emily Stone, Sukhinder Atkar-Khattra, Deme Karikios, Cheryl Ho, Silvia Behar Harpaz, Michael Caruana, Aleisha Fernandes, Jing Yi Weng, Annette McWilliams, Renelle Meyers, John Mayo, John Yee, Ren Yuan, Henry Marshall, Kwun Fong, Stephen Lam, Karen Canfell, Martin Tammemagi
Meeting Abstract
Respiratory System
Annette McWilliams, Jacqueline Logan, Fraser Brims, Henry Marshall, Linda Passmore, Barbara Page, Emily Stone, Renee Manser, Paul Fogarty, Sriyani Parsons, Sukhinder Atkar-Khattra, Sonya Cressman, Renelle Myers, Martin Tammemagi, Marianne Weber, Karen Canfell, Kwun Fong, Stephen Lam
Meeting Abstract
Respiratory System
Preston Ngo, Deme Karikios, David Goldsbury, Stephen Wade, Brett Hughes, Zarnie Lwin, Karen Canfell, Nick Pavlakis, Marianne Weber
Meeting Abstract
Respiratory System
Pavla Vaneckova, Stephen Wade, Michael Caruana, Preston Ngo, Silvia Behar Harpaz, Peter Sarich, Qingwei Luo, David Goldsbury, Elvin Cheng, Xue Qin Yu, Katherine Barron, Mei Ling Yap, Paul Grogan, Emily Banks, Kwung Fong, Henry Marshall, Deme Karikios, Nicole Rankin, Sonya Cressman, Martin Tammemagi, Annette McWilliams, Marianne Weber, Karen Canfell
Article
Primary Health Care
Claire Zammit, Nicola Creagh, Claire Nightingale, Tracey McDermott, Marion Saville, Julia Brotherton, Margaret Kelaher
Summary: Self-collection for cervical screening has been available in Australia since 2017 and has been well-received by practitioners. However, there are varying levels of knowledge and awareness about self-collection among primary care workers. Practitioners play a crucial role in promoting self-collection and addressing practical barriers, but there are concerns about follow-up for HPV-positive patients and obtaining accurate screening histories.
PRIMARY HEALTH CARE RESEARCH AND DEVELOPMENT
(2023)
Article
Oncology
Ovidiu Tatar, Ben Haward, Patricia Zhu, Gabrielle Griffin-Mathieu, Samara Perez, Emily McBride, Aisha K. Lofters, Laurie W. Smith, Marie-Helene Mayrand, Ellen M. Daley, Julia M. L. Brotherton, Gregory D. Zimet, Zeev Rosberger
Summary: The study aimed to develop and validate two scales measuring attitudes and beliefs towards HPV testing and self-sampling. Exploratory Factor Analysis (EFA) and parallel analysis were used to determine the optimal number of factors, and Item Response Theory (IRT) was applied to select items. After data cleaning, 1027 responses were analyzed. Confirmatory Factor Analysis (CFA) showed a good model fit for both final scales. These scales will be a valuable resource to examine attitudes and beliefs in anticipation of, and to evaluate, HPV test-based cervical screening.
