Article
Biochemistry & Molecular Biology
Xianjuan Shen, Shan Kong, Shuo Ma, Lei Shen, Ming Zheng, Shiyi Qin, Jing Qi, Qiuhong Wang, Xiaopeng Cui, Shaoqing Ju
Summary: The circRNA hsa_circ_0000437 was found to play a significant role in gastric cancer progression, promoting cell proliferation, migration, invasion, and apoptosis resistance. It was also found to induce lymph node metastasis through the HSPA2-ERK signaling pathway. Clinical data showed that hsa_circ_0000437 was enriched in the serum of gastric cancer patients and was associated with lymph node metastasis. These findings suggest that hsa_circ_0000437 may serve as a potential biomarker for lymph node metastasis in gastric cancer patients.
Review
Pathology
Soudeh Ghafouri-Fard, Kasra Honarmand Tamizkar, Elena Jamali, Mohammad Taheri, Seyed Abdulmajid Ayatollahi
Summary: Gastric cancer is closely related to environmental factors such as chronic infection with Helicobacter pylori, and high-throughput genome and transcriptome analysis has provided insights into its molecular mechanisms. However, data on circRNA expression in gastric cancer remains inconsistent, requiring further investigation. CircRNA could potentially serve as biomarkers and therapeutic targets for gastric cancer, yet more experiments are needed for clinical application.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Medicine, Research & Experimental
Jing Liu, Xingwu Zhu, Meinan Yan, Hui Li
Summary: In this study, a predictive model named circPanel was established based on two highly expressed circRNAs (hsa_circ_0005092 and hsa_circ_0002647) in gastric cancer patients with good prognoses, showing potential as a prognostic biomarker with greater accuracy than single circRNAs and traditional tumor markers. Functional analysis and network prediction were also performed for these circRNAs.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Ruiting Guo, Xixi Cui, Xue Li, Wen Zang, Mingjie Chang, Zenghui Sun, Zhifang Liu, Yundong Sun, Jihui Jia, Wenjuan Li
Summary: This study found that Helicobacter pylori can induce the upregulation of circMAN1A2 in gastric cancer cells, and the downregulation of circMAN1A2 can inhibit the growth and invasion of gastric cancer cells. Furthermore, circMAN1A2 promotes the progression of H. pylori-induced gastric cancer by regulating the expression of MTA2. This study suggests that circMAN1A2 may be a potential diagnostic marker and therapeutic target for gastric cancer.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Lei Yang, Yong-ning Zhou, Miao-miao Zeng, Nan Zhou, Bin-sheng Wang, Bo Li, Xiao-liang Zhu, Quan-lin Guan, Chen Chai
Summary: Circular RNA-0002570 (circ-0002570) expression is significantly increased in gastric cancer tissues, and patients with higher circ-0002570 expression have shorter survival. Functionally, inhibition of circ-0002570 leads to suppression of cell proliferation, migration, and invasion, and inhibits tumor growth. Mechanistically, miR-587 is antagonized by circ-0002570, promoting VCAN expression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medical Laboratory Technology
Peina Shi, Haojun Song, Xiaoyun Ding
Summary: The novel circRNA hsa_circ_001888 was significantly downregulated in gastric cancer cell lines, tissues, and plasma samples, indicating its potential as a biomarker for diagnosing gastric cancer and its involvement in gastric cancer development.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Review
Genetics & Heredity
Chun-Yi Xu, Xi-Xi Zeng, Li-Feng Xu, Ming Liu, Feng Zhang
Summary: Gastric cancer is the fourth leading cause of cancer death worldwide, especially prevalent in East Asia, where the lack of specific early-stage symptoms results in most patients being diagnosed at an advanced stage. Therefore, finding more sensitive and reliable biomarkers for gastric cancer screening and diagnosis is urgently needed.
FRONTIERS IN GENETICS
(2022)
Article
Medical Laboratory Technology
Lipeng Yao, Yaoyao Xie
Summary: This study found that the circular RNA hsa_circ_0006470 is significantly downregulated in gastric cancer tissues and has the potential to be a diagnostic biomarker for gastric cancer, with high specificity and sensitivity.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Gastroenterology & Hepatology
Jianing Yan, Yongfu Shao, Haoxuan Lu, Qihua Ye, Guoliang Ye, Junming Guo
Summary: The study revealed that hsa_circ_0001020 is significantly upregulated in GC cell lines, tissue samples, and plasma, showing associations with distal metastasis and blood CA19-9. High hsa_circ_0001020 expression in GC patients correlated with decreased survival time, indicating its potential as an independent prognostic factor. The circRNA demonstrated superior screening potential as a biomarker for GC compared to traditional markers like CEA and CA19-9, and may provide insights into oncogenic pathways like the FoxO and p53 signaling pathways.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Cell Biology
Meinan Yan, Liling Niu, Jing Liu, Yuan Yao, Hui Li
Summary: Our study demonstrated that circEVI5 can bind miR-4793-3p as a ceRNA to eliminate the negative regulation of FOXO1, therefore suppressing GC proliferation.
CELL DEATH & DISEASE
(2021)
Review
Oncology
Aliaksandr A. Yarmishyn, Afeez Adekunle Ishola, Chieh-Yu Chen, Nalini Devi Verusingam, Vimalan Rengganaten, Habeebat Aderonke Mustapha, Hao-Kai Chuang, Yuan-Chi Teng, Van Long Phung, Po-Kuei Hsu, Wen-Chang Lin, Hsin- Ma, Shih-Hwa Chiou, Mong-Lien Wang
Summary: Circular RNAs (circRNAs) are a type of RNA molecule that are circular in shape and have been extensively studied due to their important roles in various biological processes. They have also been shown to be implicated in diseases, including cancer. Cancer is a complex process characterized by dysregulation of various molecular mechanisms responsible for maintaining cellular and tissue homeostasis. These dysregulated processes, known as cancer hallmarks, are considered targets for therapeutic intervention. In this review, we summarize the literature on circRNAs implicated in specific cancer hallmarks and their potential as therapeutic targets.
Article
Biochemistry & Molecular Biology
Md. Tofazzal Hossain, Song Li, Md. Selim Reza, Shengzhong Feng, Xiaojing Zhang, Zhe Jin, Yanjie Wei, Yin Peng
Summary: This study suggests that circRNAs, specifically circCEACAM5 and circCOL1A1, may serve as potential biomarkers for the diagnosis and treatment of gastric cancer. The findings highlight the importance of circRNAs in the occurrence and development of gastric cancer.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Medicine, Research & Experimental
Soudeh Ghafouri-Fard, Mohammad Taheri, Bashdar Mahmud Hussen, Jamshid Vafaeimanesh, Atefe Abak, Reza Vafaee
Summary: Circular RNAs (circRNAs) play critical roles in the formation and progression of neoplasms, and have the potential for clinical outcome prediction.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Oncology
Kuanyu Xia, Zuzhen Wang, Bing Liu, Wenjun Wang, Yang Liu, Jianzhou Tang, Jinpeng Yan
Summary: Gastric cancer (GC) is the fifth most common cancer and the fourth leading cause of cancer-related death worldwide, posing a potential threat to human health. Increasing evidence suggests that circular RNAs (circRNAs) play a crucial role in various diseases, particularly cancer, including the proliferation, invasion, and metastasis of cancer cells. Therefore, circRNAs are considered potential biomarkers for GC diagnosis and prognosis, as well as therapeutic targets. This review provides an overview of circRNA biogenesis and functions in GC, highlighting their potential clinical applications as biomarkers and treatment targets.
Article
Oncology
Yibo Ma, Zhe Li, Dongnan Ma, Junming Guo, Weiliang Sun
Summary: The study found that hsa_circ_0003195 plays an important role in the diagnosis and prognosis of gastric cancer, and may be a new diagnostic and prognostic marker. The expression level of hsa_circ_0003195 is down-regulated in tissues and plasma from gastric cancer patients, and is correlated with differentiation, TNM stages, lymphatic metastasis, and distal metastasis.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Surgery
Qi-Yue Chen, Qing Zhong, Zhi-Yu Liu, Ping Li, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Hua-Long Zheng, Guang-Tan Lin, Chao-Hui Zheng, Chang-Ming Huang, Jian-Wei Xie
Summary: This study compared the short-term outcomes of robotic total gastrectomy (RTG) and laparoscopic total gastrectomy (LTG) in gastric cancer patients. The results showed that the RTG group had lower intraoperative blood loss, retrieved more extraperigastric lymph nodes, and had fewer errors during surgery compared to the LTG group. Additionally, the RTG group had a higher technical skill score, lower surgery task load index, and there was no significant difference in postoperative morbidity between the two groups.
Article
Surgery
Jun Lu, Dong Wu, Bin-Bin Xu, Zhen Xue, Hua-Long Zheng, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Ping Li, Chao-Hui Zheng, Chang-Ming Huang
Summary: This study aimed to compare the failure patterns after laparoscopic gastrectomy (LG) and open gastrectomy (OG) in locally advanced gastric cancer (LAGC) patients. Results showed a lower early distant recurrence rate in the LG group and a higher distant recurrence risk in the OG group within the first 2 years in stage IIa-IIIb patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Oncology
Jian-Xian Lin, Jun-Peng Lin, Yong Weng, Chen-Bin Lv, Jian-Hua Chen, Chuan-Yin Zhan, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Wen-Xing Zhou, Xiao-Jing Zhang, Chao-Hui Zheng, Li-Sheng Cai, Yu-Bin Ma, Chang-Ming Huang
Summary: The study developed a non-invasive radiological signature for assessing the immunosuppressive status and prognosis of gastric cancer, and identified patients with stage II and III gastric cancer who are most likely to benefit from adjuvant chemotherapy.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Editorial Material
Oncology
Jian-Xian Lin, Jun-Peng Lin, Yong Weng, Chen-Bin Lv, Jian-Hua Chen, Chuan-Yin Zhan, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Wen-Xing Zhou, Xiao-Jing Zhang, Chao-Hui Zheng, Li-Sheng Cai, Yu-Bin Ma, Chang-Ming Huang
ANNALS OF SURGICAL ONCOLOGY
(2022)
Editorial Material
Oncology
Jun Lu, Zhen Xue, Jian-gao Xie, Bin-bin Xu, Hai-bo Yang, Dong Wu, Hua-Long Zheng, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Ping Li, Chang-Ming Huang, Chao-Hui Zheng
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Jun Lu, Zhen Xue, Jian-gao Xie, Bin-bin Xu, Hai-bo Yang, Dong Wu, Hua-Long Zheng, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Ping Li, Chang-Ming Huang, Chao-Hui Zheng
Summary: This study found that the preoperative muscle-adipose index is a new independent prognostic factor that affects the prognosis of gastric cancer. It is also superior to traditional nutrition and body composition indicators in terms of prognostic evaluation and predictive value of recurrence risk in gastric cancer patients.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Editorial Material
Oncology
Jun-Peng Lin, Jian-Xian Lin, Yong Weng, Chen-Bin Lv, Chang-Ming Huang
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Wen-Wu Qiu, Qi-Yue Chen, Wen-Ze Zheng, Qi-Chen He, Ze-Ning Huang, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ju-Li Lin, Hua-Long Zheng, Guang-Tan Lin, Guo-Sheng Lin, Chao-Hui Zheng, Chang-Ming Huang, Ping Li
Summary: This study investigated the pattern and time point of recurrence in different age groups of postoperative gastric cancer patients. The results showed differences in recurrence characteristics between the young group and the older group. The young group had better overall survival and disease-free survival than the older group. The cumulative incidence of peritoneal recurrence was higher in the young group, while the cumulative incidence of distant recurrence was consistently lower in the young group.
Article
Oncology
Jun Lu, Dong Wu, Shi Chen, Jiao-bao Huang, Bin-bin Xu, Zhen Xue, Hua-Long Zheng, Guo-sheng Lin, Li-li Shen, Jia Lin, Chao-Hui Zheng, Ping Li, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Jian-Wei Xie, Jun-sheng Peng, Chang-Ming Huang
Summary: This study constructed a novel classifier based on deep learning preoperative hematological indices to predict the adjuvant chemotherapy (AC) benefit and recurrence hazard of locally advanced gastric cancer (LAGC) patients. The classifier showed good predictive performance for individualized treatment decision in AC.
Article
Environmental Sciences
Yue Li, Yonglin Zhang, Jinxiang Cheng, Chaohui Zheng, Mingjun Li, Honglei Xu, Renjie Wang, Dongsheng Chen, Xiaotong Wang, Xinyi Fu, Yuehua Zhao, Rui Wu, Xiaowen Yang, Lan Shi
Summary: Ship exhaust emissions have a significant impact on global climate and human health. This study compiled and categorized inventory compilation methods of ship emissions and conducted a comparative analysis. Different methods varied in terms of applicability, accuracy, and resolution of results. The study recommended specific methods for different scales of ship emissions inventory compilations based on their performance in validation cases.
Article
Oncology
Guo-Sheng Lin, Jun Lu, Jia Lin, Hua-Long Zheng, Bin-Bin Xu, Zhen Xue, Dong Wu, Lili Shen, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Qi-Yue Chen, Chang-Ming Huang
Summary: The preoperative DDI-to-albumin ratio (DAR) is a new biomarker for predicting long-term survival in gastric cancer (GC). A DAR > 0.0145 aids in the timely detection of early recurrence and peritoneal recurrence after surgery, guiding personalized follow-up strategies.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Jia-Bin Wang, You-Xin Gao, Yin-Hua Ye, Tong-Xing Lin, Ping Li, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ju-Li Lin, Ze-Ning Huang, Hua-Long Zheng, Jian-Wei Xie, Chao-Hui Zheng, Chang-Ming Huang
Summary: The study demonstrates that CDK5RAP3 plays a tumor suppressor role in gastric cancer and is related to the infiltration and polarization of macrophages. CDK5RAP3 inhibits TAMs polarization to M2 phenotype and promotes M1 polarization. In addition, CDK5RAP3 reduces monocyte recruitment to tumor tissue by inhibiting the CCL2/CCR2 axis.
CANCER GENE THERAPY
(2023)
Article
Oncology
Jian-Xian Lin, Jun-Peng Lin, Qing-Qi Hong, Peng Zhang, Zi-Zhen Zhang, Liang He, Quan Wang, Liang Shang, Lin-Jun Wang, Ya-Feng Sun, Zhi-Xiong Li, Jun-Jie Liu, Fang-Hui Ding, En-De Lin, Yong-An Fu, Shuang-Ming Lin, Ping Li, Zu-Kai Wang, Chao-Hui Zheng, Chang-Ming Huang, Jian-Wei Xie
Summary: This study developed a nomogram to predict postoperative recurrence of hepatoid adenocarcinoma of the stomach (HAS) and guide individualized surveillance strategies. The nomogram accurately stratified patients into low-, middle-, and high-risk groups of postoperative recurrence. Middle- and high-risk patients had higher rates of recurrence and metastasis, particularly multiple site metastasis, within 36 months after the operation.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fu-Hai Wang, Hua-Long Zheng, Jin-Tao Li, Ping Li, Chao-Hui Zheng, Qi-Yue Chen, Chang-Ming Huang, Jian-Wei Xie
Summary: In this study, a radiomics nomogram based on preoperative CT radiomic features was developed to predict recurrence and adjuvant therapy benefit in high/intermediate-risk gastrointestinal stromal tumors (GISTs). The constructed nomogram showed higher accuracy in predicting recurrence-free survival (RFS) compared to the clinicopathological nomogram. This model can assist clinical decision-making for GIST patients.
Article
Oncology
Jiabin Wang, Qingzhu Qiu, Ningzi Lian, Huagen Wang, Qiaoling Zheng, Yinghong Yang, Yubin Ma, Yajun Zhao, Ping Li, Jianxian Lin, Jun Lu, Qiyue Chen, Longlong Cao, Mi Lin, Changming Huang, Jianwei Xie
Summary: Inhibition of the immune microenvironment is the main cause of tumor recurrence after surgery in patients with gastric cancer. By evaluating immunosuppressive indicators and immune biomarkers, we constructed an immunosuppressive recurrence score and found that it can accurately and reliably predict recurrence. An elevated score is associated with locoregional recurrence and chemotherapy failure.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)