Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction

QuantSeq 3′ mRNA sequencing for RNA quantification

(2018) Pamela Moll et al.   NATURE METHODS

Impaired angiopoietin/Tie2 signaling compromises Schlemm’s canal integrity and induces glaucoma

(2017) Jaeryung Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Angiopoietin-1 is required for Schlemm’s canal development in mice and humans

(2017) Benjamin R. Thomson et al.   JOURNAL OF CLINICAL INVESTIGATION

Ascending Vasa Recta Are Angiopoietin/Tie2-Dependent Lymphatic-Like Vessels

(2017) Yael Kenig-Kozlovsky et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Therapeutic targeting of the angiopoietin–TIE pathway

(2017) Pipsa Saharinen et al.   NATURE REVIEWS DRUG DISCOVERY

Vascular heterogeneity and specialization in development and disease

(2017) Michael Potente et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology

(2017) Hellmut G. Augustin et al.   SCIENCE

Plastic roles of pericytes in the blood–retinal barrier

(2017) Do Young Park et al.   Nature Communications

Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment

(2016) Jin-Sung Park et al.   CANCER CELL

Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation

(2016) Minah Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Tie1 controls angiopoietin function in vascular remodeling and inflammation

(2016) Emilia A. Korhonen et al.   JOURNAL OF CLINICAL INVESTIGATION

Alternatively activated macrophages determine repair of the infarcted adult murine heart

(2016) Manabu Shiraishi et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation

(2016) Huanjiao Jenny Zhou et al.   NATURE MEDICINE

Amelioration of sepsis by TIE2 activation–induced vascular protection

(2016) Sangyeul Han et al.   Science Translational Medicine

Drug Repurposing Screen Identifies Foxo1-Dependent Angiopoietin-2 Regulation in Sepsis*

(2015) Chandra C. Ghosh et al.   CRITICAL CARE MEDICINE

Angiopoietin-2 in acute myocardial infarction complicated by cardiogenic shock-a biomarker substudy of the IABP-SHOCK II-Trial

(2015) Janine Pöss et al.   EUROPEAN JOURNAL OF HEART FAILURE

Evolving Therapies for Myocardial Ischemia/Reperfusion Injury

(2015) Borja Ibáñez et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The war against heart failure: the Lancet lecture

(2015) Eugene Braunwald   LANCET

Understanding Local Macrophage Phenotypes In Disease: Shape-shifting macrophages

(2015) Kate Liddiard et al.   NATURE MEDICINE

Heparanase is a host enzyme required for herpes simplex virus-1 release from cells

(2015) Satvik R. Hadigal et al.   Nature Communications

Endothelial destabilization by angiopoietin-2 via integrin β1 activation

(2015) Laura Hakanpaa et al.   Nature Communications

The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells

(2015) Soniya Savant et al.   Cell Reports

Hematopoietic stem and progenitor cells regulate the regeneration of their niche by secreting Angiopoietin-1

(2015) Bo O Zhou et al.   eLife

Genetic Dissection of Tie Pathway in Mouse Lymphatic Maturation and Valve Development

(2014) Bin Shen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Neurons Limit Angiogenesis by Titrating VEGF in Retina

(2014) Keisuke Okabe et al.   CELL

Yap1 Is Required for Endothelial to Mesenchymal Transition of the Atrioventricular Cushion

(2014) Hui Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy

(2014) Gabriela D’Amico et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-Inflammatory Strategies for Ventricular Remodeling Following ST-Segment Elevation Acute Myocardial Infarction

(2014) Ignacio M. Seropian et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

TSC1 controls macrophage polarization to prevent inflammatory disease

(2014) Linnan Zhu et al.   Nature Communications

A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response

(2014) Dan Shao et al.   Nature Communications

Monocyte and Macrophage Heterogeneity in the Heart

(2013) Matthias Nahrendorf et al.   CIRCULATION RESEARCH

Circulating angiopoietins and cardiovascular mortality in cardiogenic shock

(2013) Andreas Link et al.   EUROPEAN HEART JOURNAL

Circulating angiopoietin-2, its soluble receptor Tie-2, and mortality in the general population

(2013) Roberto Lorbeer et al.   EUROPEAN JOURNAL OF HEART FAILURE

Endoplasmic Reticulum (ER) Stress and Hypoxia Response Pathways Interact to Potentiate Hypoxia-inducible Factor 1 (HIF-1) Transcriptional Activity on Targets Like Vascular Endothelial Growth Factor (VEGF)

(2013) Ethel R. Pereira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis

(2013) Tilman Ziegler et al.   JOURNAL OF CLINICAL INVESTIGATION

Angiopoietin-1 elicits pro-inflammatory responses in monocytes and differentiating macrophages

(2013) Seung Hyeok Seok et al.   MOLECULES AND CELLS

EndMT contributes to the onset and progression of cerebral cavernous malformations

(2013) Luigi Maddaluno et al.   NATURE

Vascular endothelial growth factor in heart failure

(2013) Ziad Taimeh et al.   Nature Reviews Cardiology

Angiopoietin-1 Guides Directional Angiogenesis Through Integrin  v 5 Signaling for Recovery of Ischemic Retinopathy

(2013) J. Lee et al.   Science Translational Medicine

Epithelial-to-Mesenchymal and Endothelial-to-Mesenchymal Transition

(2012) Jason C. Kovacic et al.   CIRCULATION

Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

(2012) Moritz Felcht et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Stepwise increase of angiopoietin-2 serum levels is related to haemodynamic and functional impairment in stable chronic heart failure

(2011) Ermanno Eleuteri et al.   EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION

Conditional Deletion of the Focal Adhesion Kinase FAK Alters Remodeling of the Blood-Brain Barrier in Glioma

(2010) J. Lee et al.   CANCER RESEARCH

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia

(2009) H.-Y. Fang et al.   BLOOD

Inhibition of endothelial progenitor cell differentiation by VEGI

(2009) F. Tian et al.   BLOOD

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

(2009) Hellmut G. Augustin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts

(2008) Pipsa Saharinen et al.   NATURE CELL BIOLOGY