Differential effects of hypothermia on neurovascular unit determine protective or toxic results: Toward optimized therapeutic hypothermia

Functional dissection of astrocyte-secreted proteins: Implications in brain health and diseases

(2018) Mithilesh Kumar Jha et al.   PROGRESS IN NEUROBIOLOGY

How long is sufficient for optimal neuroprotection with cerebral cooling after ischemia in fetal sheep?

(2017) Joanne O Davidson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers

(2017) Jason Pitt et al.   MOLECULAR BIOLOGY OF THE CELL

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Novel method for inducing rapid, controllable therapeutic hypothermia in rats using a perivascular implanted closed-loop cooling circuit

(2016) Jessica A. Lamb et al.   JOURNAL OF NEUROSCIENCE METHODS

Transfer of mitochondria from astrocytes to neurons after stroke

(2016) Kazuhide Hayakawa et al.   NATURE

Results of the ICTuS 2 Trial (Intravascular Cooling in the Treatment of Stroke 2)

(2016) Patrick Lyden et al.   STROKE

Revisiting Cerebral Postischemic Reperfusion Injury: New Insights in Understanding Reperfusion Failure, Hemorrhage, and Edema

(2015) Jilin Bai et al.   International Journal of Stroke

Correcting for Brain Swelling’s Effects on Infarct Volume Calculation After Middle Cerebral Artery Occlusion in Rats

(2015) Devin W. McBride et al.   Translational Stroke Research

EuroHYP-1: European Multicenter, Randomized, Phase III Clinical Trial of Therapeutic Hypothermia plus Best Medical Treatment vs. Best Medical Treatment Alone for Acute Ischemic Stroke

(2014) H. Bart van der Worp et al.   International Journal of Stroke

Protease activated receptor-1 mediates cytotoxicity during ischemia using in vivo and in vitro models

(2014) P.S. Rajput et al.   NEUROSCIENCE

Neuronal Production of Lipocalin-2 as a Help-Me Signal for Glial Activation

(2014) Changhong Xing et al.   STROKE

Phenotypic Polarization of Activated Astrocytes: The Critical Role of Lipocalin-2 in the Classical Inflammatory Activation of Astrocytes

(2013) E. Jang et al.   JOURNAL OF IMMUNOLOGY

Hypothermia for acute ischaemic stroke

(2013) Tzu-Ching Wu et al.   LANCET NEUROLOGY

Hypothermia protects against oxygen–glucose deprivation-induced neuronal injury by down-regulating the reverse transport of glutamate by astrocytes as mediated by neurons

(2013) D. Wang et al.   NEUROSCIENCE

Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest

(2013) Niklas Nielsen et al.   NEW ENGLAND JOURNAL OF MEDICINE

The secretome signature of reactive glial cells and its pathological implications

(2012) Mithilesh Kumar Jha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Thrombin Activity Associated with Neuronal Damage during Acute Focal Ischemia

(2012) B. Chen et al.   JOURNAL OF NEUROSCIENCE

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Concurrent middle cerebral artery occlusion and intra-arterial drug infusion via ipsilateral common carotid artery catheter in the rat

(2012) Jessica A. Van Winkle et al.   JOURNAL OF NEUROSCIENCE METHODS

Optimal timing of hypothermia in relation to myocardial reperfusion

(2011) Matthias Götberg et al.   BASIC RESEARCH IN CARDIOLOGY

Hyperthermia conditioned astrocyte-cultured medium protects neurons from ischemic injury by the up-regulation of HIF-1 alpha and the increased anti-apoptotic ability

(2011) Fang Du et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Engaging neuroscience to advance translational research in brain barrier biology

(2011) Edward A. Neuwelt et al.   NATURE REVIEWS NEUROSCIENCE

Astrocyte–neuron metabolic relationships: for better and for worse

(2011) Igor Allaman et al.   TRENDS IN NEUROSCIENCES

Therapeutic Hypothermia for Acute Ischemic Stroke: Ready to Start Large Randomized Trials?

(2010) H Bart van der Worp et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia

(2010) An-Gaëlle Ceulemans et al.   Journal of Neuroinflammation

Reperfusion and Neurovascular Dysfunction in Stroke: from Basic Mechanisms to Potential Strategies for Neuroprotection

(2010) Joo Eun Jung et al.   MOLECULAR NEUROBIOLOGY

Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway

(2010) R. E. Haskew-Layton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Hypothermia for Brain Ischemia: Where Have We Come and Where Do We Go?

(2010) M. A. Yenari et al.   STROKE

Intravenous Thrombolysis Plus Hypothermia for Acute Treatment of Ischemic Stroke (ICTuS-L)

(2010) Thomas M. Hemmen et al.   STROKE

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Hypothermia as a cytoprotective strategy in ischemic tissue injury

(2009) Xian N. Tang et al.   AGEING RESEARCH REVIEWS

REPRINT: Good Laboratory Practice: Preventing Introduction of Bias at the Bench

(2009) Malcolm R. Macleod et al.   International Journal of Stroke

Comparison of 12, 24 and 48 h of systemic hypothermia on outcome after permanent focal ischemia in rat

(2008) Darren L. Clark et al.   EXPERIMENTAL NEUROLOGY